1.Maternal Serum and Amniotic Fluid Inhibin A Levels in Women who Subsequently Develop Severe Preeclampsia.
Shin Young KIM ; Hyun Mee RYU ; Jae Hyug YANG ; Moon Young KIM ; Hyun Kyong AHN ; Joong Sik SHIN ; Jun Seek CHOI ; So Yeon PARK ; Jin Mi KIM ; Bom Yi LEE ; Do Jin KIM
Journal of Korean Medical Science 2006;21(3):452-456
The purpose of this study was to evaluate whether maternal serum (MS) and amniotic fluid (AF) inhibin A levels are elevated in patients who subsequently develop severe preecalmpsia, and to investigate the correlation between MS and AF inhibin A levels in the second trimester. The study included 40 patients who subsequently developed severe preecalmpsia and 80 normal pregnant women. Inhibin A levels in MS and AF were measured with enzyme-linked immunosorbent assay (ELISA). The MS and AF inhibin A levels in patients who developed severe preeclampsia were significantly higher than those in the control group (both for p<0.001). There was a positive correlation between MS and AF inhibin A levels in patients who developed severe preeclampsia (r=0.397, p=0.011), but not in the control group (r=0.185, p=0.126). The best cutoff values of MS and AF inhibin A levels for the prediction of severe preeclampsia were 427 pg/mL and 599 pg/mL, respectively; the estimated ORs that were associated with these cut-off values were 9.95 (95% CI 3.8-25.9, p<0.001) and 6.0 (95% CI 2.3-15.8, p<0.001). An elevated level of inhibin A in MS and AF at the time of second trimester amniocentesis may be a risk factor for the subsequent development of severe preeclampsia.
Risk Factors
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Pregnancy Trimester, Second
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Pregnancy Outcome
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Pregnancy
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Pre-Eclampsia/*blood/*metabolism
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Middle Aged
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Maternal Age
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Inhibins/*biosynthesis/*blood
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Humans
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Gestational Age
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Female
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Case-Control Studies
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Amniotic Fluid/*metabolism
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Amniocentesis
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Adult