1.Imaging findings of mimickers of hepatocellular carcinoma.
Tae Kyoung KIM ; Eunchae LEE ; Hyun Jung JANG
Clinical and Molecular Hepatology 2015;21(4):326-343
Radiological imaging plays a crucial role in the diagnosis of hepatocellular carcinoma (HCC) as the noninvasive diagnosis of HCC in high-risk patients by typical imaging findings alone is widely adopted in major practice guidelines for HCC. While imaging techniques have markedly improved in detecting small liver lesions, they often detect incidental benign liver lesions and non-hepatocellular malignancy that can be misdiagnosed as HCC. The most common mimicker of HCC in cirrhotic liver is nontumorous arterioportal shunts that are seen as focal hypervascular liver lesions on dynamic contrast-enhanced cross-sectional imaging. Rapidly enhancing hemangiomas can be easily misdiagnosed as HCC especially on MR imaging with liver-specific contrast agent. Focal inflammatory liver lesions mimic HCC by demonstrating arterial-phase hypervascularity and subsequent washout on dynamic contrast-enhanced imaging. It is important to recognize the suggestive imaging findings for intrahepatic cholangiocarcinoma (CC) as the management of CC is largely different from that of HCC. There are other benign mimickers of HCC such as angiomyolipomas and focal nodular hyperplasia-like nodules. Recognition of their typical imaging findings can reduce false-positive HCC diagnosis.
Carcinoma, Hepatocellular/*diagnosis/radiography
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Diagnosis, Differential
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Hemangioma/complications/radiography/ultrasonography
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Hepatitis B/complications
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Humans
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Inflammation/radiography/ultrasonography
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Liver/radiography/ultrasonography
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Liver Cirrhosis/complications/radiography
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Liver Neoplasms/*diagnosis/radiography
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Magnetic Resonance Imaging
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Non-alcoholic Fatty Liver Disease/radiography/ultrasonography
2.The Predictors of Effectiveness on Urokinase Instillation Therapy into Loculated Pleural Effusion.
Kee San SONG ; Jei So BANG ; Seung Min KWAK ; Chul Ho CHO ; Chan Sup PARK
Tuberculosis and Respiratory Diseases 1997;44(3):621-628
BACKGROUND: As the pleural inflammation progresses, exudative pleural fluid becomes loculated rapidly with pleural thickening. Complete drainage is important 13 prevent pleural fibrosis, entrapment and depression of lung function Intrapleural urokinase instillation therapy has been advocated as a method to facilitate drainage of gelatinous pleural fluid and to allow enzymatic debriment of pleural surface. This study was designed to investigate the Predictors of effeotiveness of intrapleural urokinase in treatment of loculated pleural effusion METHOD: Thirty-five patients received a single radiographically guided pig-tail catheter ranging in size from 10 to 12 French Twenty-two patients had tuberculous pleural effusions, and 13 had non-tuberculous postpneumonic empyemas. A total of 240,000 units of urokinase was dissolved in 240 ml of normal saline and the aliquots of 80mL was instilled into the pleura1 cavity via pig-tail catheter per every 8hr. Effectiveness of intrapleural urokinase instillation therapy was assessed by biochemical markers, ultrasonography, and technical details. A greater than 50% improvement on follow-up chest radiographs was defined as success group. RESULT: Twenty-seven of 35 (77.1%) patients had successful outcome to urokinase instillation therapy. Duration of symptoms before admission was shorter in sucess group (11.8α6.9day) than in failure group (26.62α16.5day) (P<0.05). Amount of drained fluid during urokinsse therapy was larger in success group (917.1α392.7ml) than in failure group (613.8α259.7ml) (P<0.05). Pleural fluid glucose was higher in success group (89.7 α35.9mg/dl) than in failure group (41.2α47.1mg/dl) (P<0.05). Pleural fluid LDH was lower in success group (878.4α654.31U/L) than in failure group (2711.1α973.1IU/L) (P<0.05). Honeycomb septated pattern on chest ultrasonography was observed in six of eight failure group, but none of success group(P<0.05). CONCLUSION: Longer duration of symptoms before admission smaller amount of drained fluid during urokinase therapy, lower glucose value, higher LDH value in pleural fluid examination and honeycomb septation pattern on chest ultrasonography were predictors for failure group of intrapleural urokinase instillation therapy.
Biomarkers
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Catheters
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Depression
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Drainage
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Empyema
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Fibrosis
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Follow-Up Studies
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Gelatin
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Glucose
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Humans
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Inflammation
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Lung
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Pleural Effusion*
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Radiography, Thoracic
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Thorax
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Ultrasonography
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Urokinase-Type Plasminogen Activator*
3.Bilateral primary pigmented nodular adrenocortical disease: a case of report describing a rare cause of Cushing's syndrome.
Yong Koo PARK ; Youn Wha KIM ; Jin Woo KIM ; Young Kil CHOI ; Young Tae KO ; Seok Whan KO ; Moon Ho YANG
Journal of Korean Medical Science 1994;9(6):450-457
A case of Cushing's syndrome due to bilateral pigmented nodular adrenal disease in a 35-year-old male is presented. The adrenals showed multiple, black, variable sized nodules. Histologically the cells contained lipofuscin and either had a clear cytoplasm or an eosinophilic cytoplasm with a prominent nucleus. Lymphocytic infiltration and fatty metaplasia within the nodules are two of the prominent histological features. There is extreme internodular atrophy which suggests that primary pigmented nodular adrenocortical disease is a non-adrenocorticotropic hormone dependent condition. Since the disorder appears to involve primarily the cortex of both adrenals, the treatment of choice is bilateral adrenalectomy followed by steroid replacement. The characteristic clinicopathological manifestations that separate this diagnosis from other types of adrenal disease are also discussed. This is the first reported case in Korea to be documented with the pertinent clinicopathological findings.
Adipose Tissue/pathology
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Adrenal Cortex/chemistry/*pathology/radiography/secretion/ultrasonography
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Adrenalectomy
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Adult
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Atrophy
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Case Report
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Cushing Syndrome/*etiology/surgery
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Dexamethasone/diagnostic use
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Furosemide/diagnostic use
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Human
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Hydrocortisone/secretion
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Inflammation
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Lipofuscin/*analysis
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Male
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Metaplasia
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Organelles/ultrastructure