2.Pathologic findings after recession and resection of extraocular muscles in rabbits.
Sung Wook YANG ; Bong Leen CHANG
Korean Journal of Ophthalmology 1989;3(2):75-79
A study on the pathologic findings after recession and resection of extraocular muscles in rabbits was performed. Fibrosis of the extraocular muscles increased with time, which showed no difference between the recessed and resected muscles. Inflammation and foreign body reaction decreased with time, which showed no difference between the recessed and resected muscles. Adhesions of extraocular muscles to the sclera were observed from one month after the operation. The resected muscles showed milder adhesion to the sclera than the recessed ones. The operated extraocular muscles showed atrophies at one month, which showed no difference between the recessed and resected muscles. According to our results, when reoperation is needed, fibrosis of the extraocular muscles after recession and resection should be considered when making a decision on the amount of muscle to be recessed and resected.
Animals
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Atrophy/etiology
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Fibrosis/etiology
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Foreign-Body Reaction/pathology
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Inflammation/etiology/pathology
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Oculomotor Muscles/pathology/*surgery
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Postoperative Complications/*pathology
;
Rabbits
;
Reoperation
3.The relationship between serum HBsAg levels and liver inflammation and fibrosis in patients with chronic hepatitis B.
Li-Hua ZHONG ; Yan-Ming JIANG ; Guo-Qiang LOU ; Xiu-Li YU ; Hong LIU ; Jian-Chun GUO ; Meng-Fei ZHU ; Yun-Hao XUN
Chinese Journal of Experimental and Clinical Virology 2013;27(2):92-94
OBJECTIVETo investigate the relation of hepatitis B surface antigen (HBsAg) level with chronic hepatitis B (CHB) and liver inflammation and fibrosis.
METHODSA total of 301 patients who diagnosed CHB and underwent liver biopsy were enrolled into the study. Meantimes, the biochemical markers, ferritin (FERR), serum HBsAg and HBV DNA quantitation were detected. The relation between HBsAg level and liver pathology were determined by spearman rank correlation analysis. The receiver operating characteristic curve was used to evaluate the accuracy of HBsAg level for liver inflammation and fibrosis.
RESULTSThe body mass index (BMI), age, gender, genotype and family history had no effective on liver inflammation and fibrosis (P < 0.05). With the progressing of inflammation and fibrosis, the serum AST and ALT raise obviously (chi2 = 71.193, 96.344, 47.847, 63.981; P = 0.000, 0.000, 0.000, 0.000). When fibrosis reached to S4, the level of HBV DNA decreased obviously (chi2 = 33. 322; P = 0.000). With the aggravation of inflammation and fibrosis, the serum HBsAg gradually descended (chi2 = 68.173,15.719; P = 0.000, 0.000). The areas under operating characteristics curves of HBsAg predicted < or = G3 and < or = S3 were 0.732 and 0.793, and the specificity were 0.778, 0.891, and sensitivity were 0.685, and 0.633, respectively.
CONCLUSIONThe level of HBsAg of Chinese CHB patients descended gradually with the aggravation of liver inflammation and fibrosis. The serum HBsAg had a higher specificity to predict < or = G3 and < or = S3 of CHB patients. But there had superiority of predicting fibrosis than inflammation.
Adult ; Female ; Hepatitis B Surface Antigens ; blood ; Hepatitis B, Chronic ; blood ; complications ; pathology ; Humans ; Inflammation ; etiology ; Liver Cirrhosis ; etiology ; Male
4.Concurrent Gastric and Pulmonary Mucosa-Associated Lymphoid Tissue Lymphomas with Pre-Existing Intrinsic Chronic Inflammation: A Case Report and a Review of the Literature.
Sooyeon OH ; Nayoung KIM ; Dong Hyun OH ; Soo Mee BANG ; Yoon Jin CHOI ; Ju Yub LEE ; Kyung Won LEE ; Ho Il YOON ; Hee Chul YANG ; Jin Ho PAIK ; Dong Ho LEE ; Hyun Chae JUNG
Gut and Liver 2015;9(3):424-429
Herein, we report a rare case of concurrent gastric and pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas. A 65-year-old man who had been diagnosed with Helicobacter pylori-positive gastric MALT lymphoma received eradication therapy and achieved complete remission. During follow-up, he developed de novo pulmonary MALT lymphoma as a sequela of pulmonary tuberculosis, accompanied by recurrent gastric MALT lymphoma. Polymerase chain reaction (PCR) products of the CDR3 region of the immunoglobulin heavy chain gene showed an overall polyclonal pattern with bands at 400 base pairs (bp) and 200 bp predominant in the pulmonary tissue, as well as two distinctive bands in the gastric tissue at 400 bp and 200 bp. This case suggests that multiorgan lymphomas are more likely to be independent from each other when they are far apart, involve different organ systems, and have independent precipitating factors.
Aged
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Gastric Mucosa/pathology
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Humans
;
Inflammation/pathology
;
Lung Neoplasms/etiology/*pathology
;
Lymphoma, B-Cell, Marginal Zone/etiology/*pathology
;
Male
;
Respiratory Mucosa/pathology
;
Stomach Neoplasms/etiology/*pathology
;
Tuberculosis, Pulmonary/complications
5.Concurrent Gastric and Pulmonary Mucosa-Associated Lymphoid Tissue Lymphomas with Pre-Existing Intrinsic Chronic Inflammation: A Case Report and a Review of the Literature.
Sooyeon OH ; Nayoung KIM ; Dong Hyun OH ; Soo Mee BANG ; Yoon Jin CHOI ; Ju Yub LEE ; Kyung Won LEE ; Ho Il YOON ; Hee Chul YANG ; Jin Ho PAIK ; Dong Ho LEE ; Hyun Chae JUNG
Gut and Liver 2015;9(3):424-429
Herein, we report a rare case of concurrent gastric and pulmonary mucosa-associated lymphoid tissue (MALT) lymphomas. A 65-year-old man who had been diagnosed with Helicobacter pylori-positive gastric MALT lymphoma received eradication therapy and achieved complete remission. During follow-up, he developed de novo pulmonary MALT lymphoma as a sequela of pulmonary tuberculosis, accompanied by recurrent gastric MALT lymphoma. Polymerase chain reaction (PCR) products of the CDR3 region of the immunoglobulin heavy chain gene showed an overall polyclonal pattern with bands at 400 base pairs (bp) and 200 bp predominant in the pulmonary tissue, as well as two distinctive bands in the gastric tissue at 400 bp and 200 bp. This case suggests that multiorgan lymphomas are more likely to be independent from each other when they are far apart, involve different organ systems, and have independent precipitating factors.
Aged
;
Gastric Mucosa/pathology
;
Humans
;
Inflammation/pathology
;
Lung Neoplasms/etiology/*pathology
;
Lymphoma, B-Cell, Marginal Zone/etiology/*pathology
;
Male
;
Respiratory Mucosa/pathology
;
Stomach Neoplasms/etiology/*pathology
;
Tuberculosis, Pulmonary/complications
6.Advances in bronchopulmonary dysplasia.
Chinese Journal of Pediatrics 2004;42(3):231-233
7.Clinical significance of inflammation factors in acute coronary syndrome from pathogenic toxin.
Yan FENG ; Jing-chun ZHANG ; Rui-xi XI
Chinese journal of integrative medicine 2009;15(4):307-312
The inflammation factors and roles of them in acute coronary syndrome (ACS) were explored. The similarity between the theory of pathogenic toxin in Chinese Medicine and the inflammation response theory in ACS was discussed. The exploration of new inflammatory factors may be helpful for Chinese Medicine in the research of ACS.
Acute Coronary Syndrome
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complications
;
diagnosis
;
prevention & control
;
therapy
;
Humans
;
Inflammation
;
complications
;
etiology
;
pathology
;
therapy
;
Inflammation Mediators
;
physiology
;
Medicine, Chinese Traditional
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Prognosis
;
Toxins, Biological
;
adverse effects
8.Research progress on the role of epithelial-mesenchymal transition in pathogenesis of endometriosis.
Journal of Zhejiang University. Medical sciences 2016;45(4):439-445
Epithelial-mesenchymal transition plays an important role in the development and progression of endometriosis. Mesenchymal-epithelial transition is involved in forming localized lesions of endometriosis, while EMT is involved in the injury, repair and fibrosis induced by local inflammation of endometriosis and the process of cell invasion and metastasis. The studies of signal transduction pathway and related proteins of epithelial-mesenchymal transition in the process of endometriosis may provide new targets for diagnosis and treatment of endometriosis.
Endometriosis
;
complications
;
etiology
;
pathology
;
physiopathology
;
Epithelial-Mesenchymal Transition
;
physiology
;
Female
;
Fibrosis
;
complications
;
Humans
;
Inflammation
;
complications
;
Signal Transduction
;
physiology
9.Inflammation in hypertension: primary evidence.
Chinese Medical Journal 2006;119(14):1215-1221
10.Association of Hepatic Iron Deposition and Serum Iron Indices with Hepatic Inflammation and Fibrosis Stage in Nonalcoholic Fatty Liver Disease.
Joon Ho MOON ; Sang Hoon PARK ; Kil Chan OH ; Jae One JUNG ; Woon Geon SHIN ; Jong Pyo KIM ; Kyoung Oh KIM ; Cheol Hee PARK ; Taeho HAHN ; Kyo Sang YOO ; Jong Hyeok KIM ; Dong Jun KIM ; Myung Seok LEE ; Choong Kee PARK ; Sun Young JUN
The Korean Journal of Gastroenterology 2006;47(6):432-439
BACKGROUND/AIMS: Nonalcoholic steatohepatitis can develop from nonalcoholic fatty liver and progress to severe liver disease such as cirrhosis. The mechanism determining the progression from fatty liver to steatohepatitis is unknown. Iron is suspected to enhance hepatic damage associated with nonalcoholic fatty liver disease (NAFLD). The aims of this study were to evaluate the relationship of serum iron indices and hepatic iron deposition with hepatic fibrosis or inflammation, and to assess whether the increased hepatic iron deposition is an independent predictor of progression to liver injury. METHODS: The biochemical and histopathological data of thirty-nine patients with NAFLD were analyzed. Liver biopsy findings were graded according to the method described by Brunt, et al. Hepatic iron concentration was available in 29 of 39 patients. RESULTS: The mean hepatic iron concentration and hepatic iron indices were 1,349+/-1,188 microgram/g dry weight and 0.9+/-0.7 microgram/g/age. Serum ferritin and body mass indices were associated with hepatic inflammation (p=0.001, p=0.006) and fibrosis (p=0.005, p=0.013). Hepatic iron concentration and hepatic iron index were not associated with hepatic inflammation and fibrosis. Multivariate analysis did not identify serum ferritin or body mass index as an independent predictor of liver injury. CONCLUSIONS: Hepatic iron deposition shows no association with the degree of hepatic inflammation or fibrosis. Hepatic iron is not an independent predictor of hepatic injury in patients with NAFLD.
Adolescent
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Adult
;
Fatty Liver/complications/*metabolism
;
Female
;
Ferritins/blood
;
Humans
;
Inflammation
;
Iron/blood/*metabolism
;
Liver/*metabolism/pathology
;
Liver Cirrhosis/*etiology/metabolism/pathology
;
Male
;
Middle Aged