Humans ; Inflammation ; etiology ; Sepsis ; complications ; Signal Transduction

INTRODUCTIONNeonatal priapism is known to be associated with a wide range of aetiologies, but an association with spontaneous purulent cavernositis has not been reported in the paediatric literature. We report the first of such case.

CLINICAL PICTUREA 24-day-old neonate was brought with the history of persistent erection of penis since day 4 of life and swollen penis of 4 days' duration, which revealed frank pus on cavernosal aspiration bilaterally.

TREATMENTThe child was treated with closed aspiration drainage; cross-irrigation with antibiotic solution under systemic antibiotic cover helped in achieving complete detumescence.

OUTCOMEOn follow-up, child demonstrated normal full bladder tumescence and colour doppler revealed bilateral normal corporo-cavernosal appearance and blood flow, indicating good functional and anatomical recovery.

CONCLUSIONThis case report describes the presentation, successful management and excellent functional and anatomical outcome, on follow-up, of this rare association of neonatal priapism with spontaneous bilateral pyocavernositis. An attempt has been made to describe the underlying pathophysiology.

Algorithms ; Humans ; Infant, Newborn ; Inflammation ; complications ; Male ; Penile Diseases ; complications ; Priapism ; complications ; therapy ; Suppuration

Periodontal diseases are inflammatory diseases caused by oral pathogens around the periodontal supporting tissues, leading to systemic and chronic inflammatory conditions. The continuous chronic systemic inflammation may be a trigger of neuroinflammation, which is the prominent feature of a variety of neurological disorders. It implies that there may be a causal link between periodontal diseases and neurological disorders. This article presents epidemiological and biological evidences that periodontal diseases can induce or exacerbate neurological disorders, including Alzheimer's disease, Parkinson's disease, multiple sclerosis and major depressive disorder, and analyzes the possible mechanisms. The importance of maintaining oral health as well as preventing and treating periodontal diseases are emphasized. At the same time, this may provide novel approaches to study the relationship between periodontal diseases and neurological disorders in the prevention and treatment strategies of neurological disorders.
Alzheimer Disease ; Depressive Disorder, Major/complications* ; Humans ; Inflammation/complications* ; Periodontal Diseases/complications* ; Periodontium

The clinical results of 20 patients(20 eyes) who were operated due to perforated corneal laceration with traumatic cataract between March 5, 1991 and July 14, 1994 were analysed for the predictors of postoperative good visual outcome and compared simultaneous cataract surgery and implantation with secondary implantation. The most significant predictor of postoperative good visual outcome was the location of corneal laceration. Timing of lens implantation didn't influence significantly final visual acuity and postoperative inflammation. But postoperative complication were less frequent in patients where secondary IOL implantation was performed as opposed to those simultaneous IOL implantated.
Cataract* ; Humans ; Inflammation ; Lacerations* ; Postoperative Complications ; Visual Acuity

PURPOSE: To compare the clinical results of one-piece Acryl IOL C160 (Opthalmed(R), USA) with those of three-piece Acryl IOL AcrySof (MA60BM, Alcon(R), USA) in complicated cataracts. METHODS: In one eye of 30 patients with complicated cataracts, Acryl-C160 IOL was implanted and AcrySof IOL in the other eye. The degrees of anterior capsular fibrosis and posterior capsular opacification together with IOL decentration were evaluated for 12months prospectively. RESULTS: In 9 of 30 eyes with Acryl-C160 IOL, significant fibrosis of anterior capsule was seen as early as 1 month postoperatively. At 12 months, 15 eyes had more than grade 3 of capsular fibrosis. Five eyes had severe contraction of IOL haptic and one eye had significant IOL degradation to be exchanged. On the contrary, 2 of 30 eyes implanted with AcrySof IOL had moderate degree of capsular fibrosis. CONCLUSIONS: In complicated cataracts, Acryl-C160 IOL developed higher incidence of postoperative complications due to the inflammation and poor memory function of IOL haptic. The type and design of IOL haptic together with the function of IOL optic should be considered in selecting the IOLs best fitted in complicated cataracts.
Cataract* ; Fibrosis ; Humans ; Incidence ; Inflammation ; Memory ; Postoperative Complications ; Prospective Studies

Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data have shown that peroxisome proliferator activated receptor-alpha (PPAR-alpha) plays a pivotal role in the regulation of lipid homeostasis, fatty acid oxidation, cellular differentiation, and immune response such as inflammation or vascularization related to diabetic complication. This review will re-examine the metabolic role of PPAR-alpha, summarize data from clinical studies on the effect of PPAR-alpha agonist in diabetes, and will discuss the possible therapeutic role of PPAR-alpha activation.
Cardiovascular Diseases ; Diabetes Complications ; Fibric Acids ; Homeostasis ; Inflammation ; PPAR alpha*

Although glucose-lowering treatment shows some risk lowering effects in cardiovascular diseases, risks of macrovascular and microvascular complications have still remained, and development of new therapeutic strategies is needed. Recent data have shown that peroxisome proliferator activated receptor-alpha (PPAR-alpha) plays a pivotal role in the regulation of lipid homeostasis, fatty acid oxidation, cellular differentiation, and immune response such as inflammation or vascularization related to diabetic complication. This review will re-examine the metabolic role of PPAR-alpha, summarize data from clinical studies on the effect of PPAR-alpha agonist in diabetes, and will discuss the possible therapeutic role of PPAR-alpha activation.
Cardiovascular Diseases ; Diabetes Complications ; Fibric Acids ; Homeostasis ; Inflammation ; PPAR alpha*

Conjunctivodacryocystorhinostomy(CDCR) with Jones tube is indicated in the cases with upper and lower or common canaliculi obstruction or failed cases of dacryocystorhinostomy. We made a clinical evaluation of the 247 CDCR with Jones tube which had been performed from May of April of 1990. The results were as follows: 1. Canalicular obstruction occured mainly in economic age. 2. The most common cause of the canalicular obstruction was trauma involving canaliculi. 3. The overall success rate of CDCR with Jones tube was 96%. 4. The cases that needed reoperation were extrusion or loss of tube, tilting of tube anteriorly or superiorly, and being buried of Jones tube to nasal cavity in decending order of frequency. 5. Postoperative complications were obstruction of tube with mucoid discharge, granuloma formation, clogging of tube with conjungvtiva, and inflammation around the tube in decending order of frequency. 6. By the development of surgical technique, amount of intraoperative blood loss has been decreased and the duration operation time has become shortened.
Dacryocystorhinostomy ; Granuloma ; Inflammation ; Nasal Cavity ; Postoperative Complications ; Reoperation

Burns ; complications ; metabolism ; Humans ; Inflammation ; etiology ; metabolism ; prevention & control

Previous studies have shown that postoperative cognitive dysfunction (POCD) is related to multiple factors including age, postoperative trauma, inflammation, postoperative pain, and anesthesia, among which postoperative pain is thought to play an important role in the development of POCD. This review summarizes the recent findings in the study of the role of postoperative pain in the pathogenesis of POCD in light of nerve injuries, neural remodeling and stress, and the progress in the prevention and treatment of POCD in elderly patients. It is of vital important to assess the postoperative pain and formulate adequate analgesic regimens for effective prevention and management of POCD to protect the brain functions of elderly patients.
Aged ; Cognitive Dysfunction ; etiology ; Humans ; Inflammation ; Pain, Postoperative ; complications ; therapy ; Postoperative Complications