1.GSTM1 and GSTP1 Polymorphisms as Potential Factors for Modifying the Effect of Smoking on Inflammatory Response.
Jin Hee KIM ; Shin Goo PARK ; Kwan Hee LEE ; Ji Ho CHOI ; Eun Hee HA ; Seung Kwon MYUNG ; Yun Chul HONG
Journal of Korean Medical Science 2006;21(6):1021-1027
Inflammation has been known to be an important underlying condition for development of various diseases including cancer. The aims of this study were to investigate whether tobacco smoke exposure increases the level of inflammation biomarkers and the GSTM1 and GSTP1 gene polymorphisms are associated with inflam matory response due to tobacco smoke exposure. We measured urinary cotinine level in 300 healthy university students. Total serum TNF-alpha levels and blood WBC counts were determined to evaluate inflammatory response. Allelic loss of the GSTM1 and the GSTP1 (Ile105Val) polymorphism were determined by PCR and RFLP. Tobacco smoke exposure was found to be associated with increase of both TNF-alpha level and WBC count. Particularly, smokers with combination of GSTM1 null and GSTP1 AG or GG genotypes showed higher TNF-alpha level than those with the other genotype combinations (p=0.07). This result suggests that smoking may induce inflammation measured as TNF-alpha level or WBC count and combinations of the GSTM1 and GSTP1 polymorphisms may modify the effect of smoking on serum TNF-alpha level.
Tumor Necrosis Factor-alpha/blood
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Students
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Smoking/*epidemiology/*genetics/immunology
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Risk Factors
;
Risk Assessment/*methods
;
Prevalence
;
Polymorphism, Single Nucleotide/genetics
;
Male
;
Korea/epidemiology
;
Inflammation/*epidemiology/*genetics/immunology
;
Humans
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Glutathione Transferase/*genetics
;
Glutathione S-Transferase pi/*genetics
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Genetic Predisposition to Disease/epidemiology/genetics
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Female
;
Adult
2.GSTM1 and GSTP1 Polymorphisms as Potential Factors for Modifying the Effect of Smoking on Inflammatory Response.
Jin Hee KIM ; Shin Goo PARK ; Kwan Hee LEE ; Ji Ho CHOI ; Eun Hee HA ; Seung Kwon MYUNG ; Yun Chul HONG
Journal of Korean Medical Science 2006;21(6):1021-1027
Inflammation has been known to be an important underlying condition for development of various diseases including cancer. The aims of this study were to investigate whether tobacco smoke exposure increases the level of inflammation biomarkers and the GSTM1 and GSTP1 gene polymorphisms are associated with inflam matory response due to tobacco smoke exposure. We measured urinary cotinine level in 300 healthy university students. Total serum TNF-alpha levels and blood WBC counts were determined to evaluate inflammatory response. Allelic loss of the GSTM1 and the GSTP1 (Ile105Val) polymorphism were determined by PCR and RFLP. Tobacco smoke exposure was found to be associated with increase of both TNF-alpha level and WBC count. Particularly, smokers with combination of GSTM1 null and GSTP1 AG or GG genotypes showed higher TNF-alpha level than those with the other genotype combinations (p=0.07). This result suggests that smoking may induce inflammation measured as TNF-alpha level or WBC count and combinations of the GSTM1 and GSTP1 polymorphisms may modify the effect of smoking on serum TNF-alpha level.
Tumor Necrosis Factor-alpha/blood
;
Students
;
Smoking/*epidemiology/*genetics/immunology
;
Risk Factors
;
Risk Assessment/*methods
;
Prevalence
;
Polymorphism, Single Nucleotide/genetics
;
Male
;
Korea/epidemiology
;
Inflammation/*epidemiology/*genetics/immunology
;
Humans
;
Glutathione Transferase/*genetics
;
Glutathione S-Transferase pi/*genetics
;
Genetic Predisposition to Disease/epidemiology/genetics
;
Female
;
Adult
3.Association between Recent Acetaminophen Use and Asthma: Modification by Polymorphism at TLR4.
Seung Hwa LEE ; Mi Jin KANG ; Ho Sung YU ; Kyungmo HONG ; Young Ho JUNG ; Hyung Young KIM ; Ju Hee SEO ; Ji Won KWON ; Byoung Ju KIM ; Ha Jung KIM ; Young Joon KIM ; Hee Suk KIM ; Hyo Bin KIM ; Kang Seo PARK ; So Yeon LEE ; Soo Jong HONG
Journal of Korean Medical Science 2014;29(5):662-668
The risk of asthma has been increasing in parallel with use of acetaminophen, which is a potential source of oxidative stress. Toll-like receptor 4 (TLR4) plays a critical role not only in innate immunity, but also in mediating reactive oxygen species induced inflammation. Therefore, we investigated associations between acetaminophen usage and TLR4 polymorphism on asthma and bronchial hyperresponsiveness (BHR). The number of 2,428 elementary school children in Seoul and Jeongeup cities was recruited. Subjects who used acetaminophen with a family history of asthma had an increased risk of both asthma diagnosis ever and current asthma. Individuals with CT+TT genotypes at the TLR4 polymorphism, in combination with acetaminophen usage, also demonstrated an increased risk of asthma diagnosis ever (aOR, 2.08; 95% confidence interval [CI], 1.10-3.92). Family history of asthma and acetaminophen usage were risk factors for BHR. Although TLR4 was not an independent risk factor for BHR, individuals with CT+TT genotypes at the TLR4 polymorphism had an increased risk of BHR when combined with acetaminophen usage (aOR, 1.74; 95% CI, 1.03-2.94). In conclusion, acetaminophen usage may be associated with asthma and BHR in genetically susceptible subjects. This effect may be modified by polymorphism at TLR4.
Acetaminophen/*adverse effects/therapeutic use
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Adolescent
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Asthma/chemically induced/epidemiology/*genetics
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Bronchial Hyperreactivity/chemically induced/epidemiology/*genetics
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Child
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Cross-Sectional Studies
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Eosinophils/immunology
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Female
;
Genetic Predisposition to Disease
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Genotype
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Humans
;
Immunoglobulin E/blood/immunology
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Inflammation/immunology
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Male
;
Oxidative Stress/drug effects
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Polymorphism, Single Nucleotide
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Questionnaires
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Reactive Oxygen Species/immunology
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Risk
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Risk Factors
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Toll-Like Receptor 4/*genetics