3.Acute Myocardial Infarction Induced by Anaphylaxis.
Chinese Medical Journal 2018;131(10):1251-1252
6.Establishment of a new rabbit model of ischemic cerebral infarction by autologous clot embolism.
Yan LIN ; Pei-Gang YANG ; Qi YU ; Chun-Fang ZHANG ; Hong ZHU ; Peng-Hui YANG ; En-Qi LIU
Journal of Southern Medical University 2009;29(11):2291-2294
OBJECTIVETo establish a convenient method for preparing rabbit models of ischemic cerebral infarction using autologous clot embolism.
METHODSIschemic cerebral infarction was induced in rabbits by embolizing the middle cerebral artery using autologous clot emboli. Clinical and histological observations were carried out to evaluate the validity of the animal model.
RESULTSHemiplegia of different severities was observed in the rabbits after the operation. TTC and HE staining of the brain sections confirmed ischemic cerebral infarction 6 h after obstructing the middle cerebral artery with the autologous clot emboli.
CONCLUSIONEmbolizing the middle cerebral artery using the autologous emboli is convenient to induce focal ischemic cerebral infarction in rabbits. This model has practical value in the study on the mechanism of ischemic cerebrovascular disease and in developing new strategies for prevention and treatment of the relevant diseases in human.
Animals ; Cerebral Infarction ; etiology ; Disease Models, Animal ; Infarction, Middle Cerebral Artery ; etiology ; Male ; Rabbits ; Random Allocation
8.Lectin-like oxidized low-density lipoprotein receptor-1: protein, ligands, expression and pathophysiological significance.
Chinese Medical Journal 2007;120(5):421-426
OBJECTIVETo review the recent research progress in lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) including its protein, ligands, expression and pathophysiological significance. Data sources Information included in this article was identified by searching of PUBMED (1997 - 2006) online resources using the key term LOX-1.
STUDY SELECTIONMainly original milestone articles and critical reviews written by major pioneer investigators of the field were selected.
RESULTSThe key issues related to the LOX-1 protein as well as ligands for LOX-1. Factors regulating the expression of LOX-1 were summarized. The pathophysiological functions of LOX-1 in several diseases were discussed.
CONCLUSIONSIdentification of LOX-1 and a definition of its biological role in pathophysiologic states provide deeper insight into the pathogenesis of some cardiovascular diseases especially in atherosclerosis and provide a potential selective therapeutic approach. LOX-1 is unlocking and drugs targeting LOX-1 might be a promising direction to explore.
Animals ; Arthritis, Rheumatoid ; etiology ; Atherosclerosis ; etiology ; Humans ; Ligands ; Myocardial Infarction ; etiology ; Osteoarthritis ; etiology ; Scavenger Receptors, Class E ; chemistry ; genetics ; physiology
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