Female ; Humans ; Infant, Newborn ; Mouth ; microbiology ; Pregnancy ; Premature Birth ; microbiology

OBJECTIVENeonatal listeriosis is a relatively rare but serious disease with a high mortality rate. This study was conducted to analyze the clinical features, treatment, and outcome of 6 cases with Listeria monocytogenes septicemia confirmed by positive blood cultures.

METHODSTotally 12,538 live births delivered in the hospital from January 1, 2004 to June 30, 2006 were investigated. Differences in the time of onset of the disease, clinical presentation, illness severity, laboratory data, management, and prognosis were compared between preterm and full-term infants.

RESULTSThe incidence of neonatal listeriosis was 4.8% in this study. All the cases with listeriosis were found to have early onset and the disease was transmitted from the mother to the fetus, 4 of the cases were delivered via cesarean section, 2 were born via normal spontaneous vaginal delivery. Maternal infection before parturition presented with fever in 4, diarrhea in 1; 5 had abnormal white blood cell counts and total neutrophil counts; 1 had positive result of Listeria monocytogenes in intrauterine contents culture. Three premature infants showed signs and symptoms of severe bacterial septicemia at birth, such as reduced activity, respiratory distress, poor skin color and poor peripheral perfusion; the enlarged liver was palpable 2 - 3 cm below the right costal margin and 5 cm below the xiphoid in one; congestive rashes over the body and muscular hypotonia. Abnormal results of laboratory tests included peripheral blood white cell count (21.6 - 33.8 x 10(9))/L, total neutrophil count 0.77 - 0.83; platelet count (102 - 59 x 10(9))/L; C-reactive protein (CRP) > (160 - 118) mg/L(24 - 72 h after birth). Three preterm infants who received intensive care, accompanied by pathological changes of lungs indicated by chest X ray required assisted mechanical ventilation and 2 of them survived without sequelae but the other one died at 51 h of life. The initial clinical signs of septicemia in 3 full-term infants appeared later than preterm newborn within 62 h, 63 h and 165 h, respectively after birth. They only had fever, T 38 - 39 degrees C, with lower activity in contrast to normal newborn and without other signs and symptoms of septicemia. Accurate diagnosis of listeriosis was established by positive bacterial blood cultures. Intravenous treatment of neonatal listeriosis with ampicillin or penicillins for 1 - 2 weeks was more effective, but cephalosporins were not effective.

CONCLUSIONSThere are sporadic cases with Listeria monocytogenes infection among pregnant women in this country, resulting in severe illness of their newborn infants. Early differential diagnosis, early detection of causative organisms, especially in newborn infants infected with Listeria monocytogenes, early treatment with sensitive antibiotics can decrease the mortality rate and improve neonatal outcome. It is necessary to enhance nationwide surveillance for listeriosis.

Female ; Humans ; Infant ; Infant, Newborn ; Infant, Newborn, Diseases ; diagnosis ; microbiology ; Listeria monocytogenes ; isolation & purification ; Listeriosis ; microbiology ; Male ; Sepsis ; diagnosis ; microbiology

Humans ; Infant, Newborn ; Male ; Sepsis ; diagnosis ; microbiology ; Urethral Stricture ; complications ; microbiology ; Urinary Tract Infections ; complications ; microbiology

Female ; Hemangioma ; microbiology ; therapy ; Humans ; Infant ; Infant, Newborn ; Male ; Microbial Sensitivity Tests ; Ulcer ; microbiology ; therapy

Humans ; Infant, Newborn ; Microbiological Techniques ; Sepsis ; blood ; microbiology

OBJECTIVETo study the efficiency of lactose-free formula feeding as an adjunctive therapy in infants with acute diarrhea.

METHODSA rigorous double-blind, randomized, controlled equivalence trial was performed. One hundred and twenty infants with acute diarrhea were randomly divided into two groups: lactose-free formula and conventional formula feeding. The two groups were given conventional medical treatment and oral rehydration therapy. The therapeutic effects were observed 1 week after treatment.

RESULTSThe cure rate and the total effective rate were 58.3% and 96.7% respectively in the lactose-free formula group, and they were 8.3% and 85.0% respectively in the conventional formula group. There were significant differences in the therapeutic effect between the two groups (p<0.05). The duration of diarrhea remission (3.17+/-1.04 days) in the lactose-free formula group was significantly shorter than that in the conventional formula group (5.25+/-1.58 days) (p<0.05). After treatment the incidence of fecal flora disturbance was lower in the lactose-free formula group than that in the conventional formula group (p<0.05). No aderverse events were observed in the two groups.

CONCLUSIONSLactose-free formula feeding together with conventional therapy can significantly shorten the disease course and improve the treatment outcome in infants with acute diarrhea.

Acute Disease ; Diarrhea, Infantile ; microbiology ; therapy ; Double-Blind Method ; Female ; Humans ; Infant ; Infant Formula ; Infant, Newborn ; Intestines ; microbiology ; Lactose ; Male

Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases ; microbiology ; prevention & control ; Mycoses ; prevention & control

Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases ; diagnosis ; microbiology ; prevention & control ; Mycoses ; diagnosis ; prevention & control

During the period from July to August 1987, the microbial flora in conjunctival sac of 93 newborns (186 eyes: normal vaginal delivery) and 19 newborns (38 eyes: cesarean section delivery) in nursery of Ewha Womans University Hospital were investigated for isolation and identification of bacteria on delivery day and on two days after birth. The results of the investigation are as follows: 1. Of 186 eyes (normal vaginal delivery), bacterial growth of one species was shown in 40 eyes (21.5%) on delivery day and in 64 eyes (34.4%) on two days after birth. Bacterial growth of two species shown in 10 eyes (5.4%) on delivery day and in 10 eyes (5.4%) on two days after birth. 2. Of 38 eyes (cesarean section delivery), bacterial growth of one species was shown in 2 eyes (5.3%) on delivery day and in 20 eyes (52.6%) on two days after birth. Bacterial growth of two species was shown 2 eyes (5.3%) on two days after birth. 3. Several kinds of bacterial species were isolated in normal vaginal delivery and cesarean section delivery. Staphylococcus epidermidis, Escherichia coli, Staphylococcus aureus were isolated.
Bacteria/*isolation & purification ; Cesarean Section ; Conjunctiva/*microbiology ; Female ; Humans ; Infant, Newborn/*microbiology ; Pregnancy

Endophthalmitis ; complications ; drug therapy ; microbiology ; Humans ; Infant, Newborn ; Meningoencephalitis ; complications ; drug therapy ; microbiology ; Suppuration ; complications