1.Indomethacin therapy in polyhydramnios : a case report.
Soon Ha YANG ; Ji Hee LEE ; Mee Lee LEE ; Eun Hwan JEONG ; Bo Hyun YOON ; Hee Chul SYN ; Syng Wook KIM
Korean Journal of Perinatology 1993;4(3):422-427
No abstract available.
Indomethacin*
;
Polyhydramnios*
2.Modulation of development of 7,12-dimethylbenzanthracene-12-0-tetra decanoyl phorbol-13-acetate induced mouse vulvar, uterine cervical tumors by indomethacin.
Hae Suk KIM ; Wan Young KIM ; Soon Beom KANG ; Hyo Pyo LEE
Korean Journal of Obstetrics and Gynecology 1992;35(1):46-50
No abstract available.
Animals
;
Indomethacin*
;
Mice*
3.The Effect of IFN- and PGE2 in the Production of TNF- by Human PBMC Stimulated with LPS.
Journal of the Korean Pediatric Society 1996;39(2):255-264
PURPOSE: The purpose of this study was to observe the effect of IFN- and PGE2 on TNF- production by human peripheral mononuclear cells(PBMC) that were stimulated with LPS. METHODS: PBMC were separated by Ficoll-Hypaque gradient centrifugation from human peripheral venous blood and were incubated for 72 hours with or without LPS, IFN- , PGE2, and indomethacin according to various conditions. TNF- activity of PBMC culture supernatants was assayed by determining the cytotoxicity against L929 cells. RESULTS: 1) The production of TNF- by PBMC in response to LPS reached the highest level between 8-24 hours and returned to control level by 72 hours. 2) When IFN- was added together with LPS, LPS-induced TNF- production was enhanced and prolonged, which was more remarkable when IFN- was added at higher concentration or earlier than LPS. 3) When PGE2 was added together with LPS, LPS-induced TNF- production was suppressed. 4) The addition of IFN-gamma reduced the suppressive effect of PGE2 on LPS-induced TNF- production. 5) Enough amount of indomethacin enhanced production of TNF- by LPS. CONCLUSIONS: IFN-gamma increased and PGE2 decreased the production of TNF- by PBMC which were stimulated with LPS. And PBMC which were pretreated with IFN-gamma were resistent to the suppressive effect of PGE2.
Centrifugation
;
Dinoprostone*
;
Humans*
;
Indomethacin
4.A case of Bartter's syndrome.
Kyu Young LEE ; Byoung Soo CHO ; Hah Young LEE ; Jay BERNSTEIN
Journal of the Korean Pediatric Society 1991;34(6):849-856
No abstract available.
Bartter Syndrome*
;
Indomethacin
5.Effects of Antenatal Indomethacin on Neonate.
Ja Ye KIM ; Seung Joo LEE ; Keun LEE
Journal of the Korean Pediatric Society 1985;28(11):1066-1072
No abstract available.
Humans
;
Indomethacin*
;
Infant, Newborn*
6.Histological Study of Ductus Arteriosus Affected by Indomethacin in the Fetal Rates.
Young Sook JANG ; Chang Yeoul JEON ; Heon Sook LEE ; Jung Soo KIM ; Moo Sam LEE
Journal of the Korean Pediatric Society 1983;26(8):770-777
No abstract available.
Ductus Arteriosus*
;
Indomethacin*
7.Study on preparation of indomethacin pellets with released action by push back method of forming spheroids
Pharmaceutical Journal 2005;353(9):16-20
Optimum formula of indomethacin sustained release pellets prepared by extrusion and spheronization method was obtained by using an artificial neural network. In the pellets, Avicel PH 101 was used as a matrix excipient for sustained release and HPMC E15, PVP K30, polysorbat 80 was used to enhance the solubility of indomethacin from the matrix. The capsules containing prepared indomethacin sustained release pellets showed an in vitro drug release similar to that of CHRONO-INDOCID capsules which were used as a reference product. The studied products were stable during 6 months when preserving in urgent aged condition
Indomethacin
;
Pharmaceutical Preparations
8.Study on manufacture of indomethacin tablets with released action
Pharmaceutical Journal 2003;0(6):23-25
The factors affect to the drug release of sustained release indomethacin tablets were investigated in the laboratory. The results showed that amount of Xanthan gum, dicalcium phosphate, talc-magnesium stearate and sodium laurylsulphate involved in the tablets had influenced on the drug release. The suitable formulation of tablets was chosen and some of its criteria were established
Indomethacin
;
Pharmaceutical Preparations
;
Tablets
9.Study on manufacture of indomethacine Pellet LR by method of strengthening gradually
Pharmaceutical Journal 2004;44(6):21-23
The goal: Pellet was introduced into sustained release product containing indometacin to promote the advantage of this drug form. The material: Indometacin (China), avicel pH 101 (Taiwan), lactose (Holland), polyvinylpyrolidon (Holland), hydroxypropyl methylcellulose (England)… The method: Pellet indometacin was prepared by layering method. The result: the optimal formulary to prepare sustained release pellet indometacin using layering method was selected. Coated pellet may be filled into the capsules shell or compressed into tablet having sustained release effect by oral (up to 12h)
Indomethacin
;
Pharmaceutical Preparations
;
Capsules
10.Comparison of ketorolac and indomethacin for the closure of patent ductus arteriosus among preterm infants born at the Philippine General Hospital: A randomized controlled crossover design.
Maria Esterlita T. Villanueva-Uy-UY ; Carmen R. Briones ; Edgardo M. Ortiz
Acta Medica Philippina 2022;56(9):84-88
Background. Indomethacin has been the gold standard for the closure of patent ductus arteriosus (PDA). Still, the availability of the intravenous (IV) form has been a big issue precluding its use in the Philippines. IV ketorolac is another non-steroidal anti-inflammatory drug (NSAID) that is cheaper and more available in our country and used for post-cardiac surgery pain management among neonates.
Objectives. To compare the efficacy of ketorolac versus indomethacin in the closure of patent ductus arteriosus among preterm infants.
Methods. We conducted a randomized controlled, double-blind, crossover design, non-inferiority trial on the use of iindomethacin versus ketorolac among preterm infants with PDA. We enrolled preterm infants at 5-12 days postnatal life, diagnosed with PDA by echocardiography at the Philippine General Hospital (PGH). We excluded infants with upper gastrointestinal bleeding, renal failure, birthweight < 500 grams, septic shock, and lethal anomalies. Patients were randomly allocated between two treatment groups (indomethacin versus ketorolac). The primary outcome measure was PDA closure measured after the treatment course. Adverse events like oliguria and bleeding were recorded.
Results. A total of 27 preterm infants were randomly assigned to the indomethacin (0.2 mg/kg/dose) and ketorolac (0.6 mg/kg/dose) group. Ketorolac has a 60% success rate for PDA closure (9/15) compared to indomethacin 41.67% (5/12) (p=0.154). No renal insufficiency and bleeding diathesis were noted. Five patients died in the study, four in the group initially allocated in ketorolac and one in indomethacin. Causes of death were late-onset sepsis, bronchopulmonary dysplasia, and congenital adrenal hyperplasia.
Conclusion. The success rate of PDA closure between IV ketorolac and IV indomethacin was not significantly different. There was neither oliguria nor bleeding observed in both groups.
Ductus Arteriosus, Patent ; Ketorolac ; Indomethacin