Placenta previa is a common grave complication of late pregnancy, usually manifestated clinically by painless antenatal vaginal bleeding. Digital and rectal examinations are dangerous, due to the possibility that profuse hemorrhage from the vagina may result. Various radiological examinations have been performed in placenta previa for diagnosis and localization. However radioisotopic methods are superior due to safety, simplicity and a lower radiation dose, both fetal and maternal, compared to plain radiography. Among radiopharmaceuticals, In113m (transferrin for blood pool scan) is useful, giving more satisfactory results without any complications or untoward reactions. In our series of 88 cases from March 1971 to April 1975, In113m placental scan was performed and analysed in 62 cases which were confirmed by clinical follow up and the results are as follows: 1) Maternal age pattern. Mothers 31~35 years were 20/62 or 30.6%. 2) Maternal gravida pattern. All were multipara except 8 cases of primipara. 3) Gestational maturity on scan. 40/62 or 64% were before 36weeks or less in maturity. 4) On scan analysis Placenta previa was confirmed in 36/62 cases or 58%. 5) Fetal maturity. On delivery most were full term, 42/62 or 67.7%. 6) Vaginal delivery was done on cases where placenta was localized in the upper uterine segment, except for three who had fetal malpresentation and congenital anomaly of the maternal pelvis. All patients of placenta previa had cesarian section, except 5 cases with a minor degree of placenta previa. 7) Two cases showed false negative, which suggests 97% accuracy in the screening test of placenta previa by scan, wich is a similar result to other reports. Only 4 cases of false positive discrepancy were noted.
Adult ; Female ; Human ; Indium/diagnostic use* ; Middle Age ; Placenta* ; Placenta Praevia/diagnosis* ; Pregnancy ; Radioisotopes ; Radionuclide Imaging*

Placenta previa is a common grave complication of late pregnancy, usually manifestated clinically by painless antenatal vaginal bleeding. Digital and rectal examinations are dangerous, due to the possibility that profuse hemorrhage from the vagina may result. Various radiological examinations have been performed in placenta previa for diagnosis and localization. However radioisotopic methods are superior due to safety, simplicity and a lower radiation dose, both fetal and maternal, compared to plain radiography. Among radiopharmaceuticals, In113m (transferrin for blood pool scan) is useful, giving more satisfactory results without any complications or untoward reactions. In our series of 88 cases from March 1971 to April 1975, In113m placental scan was performed and analysed in 62 cases which were confirmed by clinical follow up and the results are as follows: 1) Maternal age pattern. Mothers 31~35 years were 20/62 or 30.6%. 2) Maternal gravida pattern. All were multipara except 8 cases of primipara. 3) Gestational maturity on scan. 40/62 or 64% were before 36weeks or less in maturity. 4) On scan analysis Placenta previa was confirmed in 36/62 cases or 58%. 5) Fetal maturity. On delivery most were full term, 42/62 or 67.7%. 6) Vaginal delivery was done on cases where placenta was localized in the upper uterine segment, except for three who had fetal malpresentation and congenital anomaly of the maternal pelvis. All patients of placenta previa had cesarian section, except 5 cases with a minor degree of placenta previa. 7) Two cases showed false negative, which suggests 97% accuracy in the screening test of placenta previa by scan, wich is a similar result to other reports. Only 4 cases of false positive discrepancy were noted.
Adult ; Female ; Human ; Indium/diagnostic use* ; Middle Age ; Placenta* ; Placenta Praevia/diagnosis* ; Pregnancy ; Radioisotopes ; Radionuclide Imaging*

OBJECTIVETo evaluate the effect of 90Y-DOTATOC and 131I-MIBG in treatment of metastatic medullary thyroid carcinoma (MTC).

METHODSTwelve histologically confirmed patients with metastatic MTC were included. All patients underwent both 111In-DTPA-octreotide imaging and 131I/ 123I-meta-iodobenzylguanidine (MIBG) imaging. According to the results of the combined imaging, positive patients were selected to be treated with 90Y-DOTA-D-Phe1-Tyr3-octreotide (90Y-DOTATOC) or 131I-MIBG, respectively. The therapeutic procedures of targeted internal radiation were performed with 3.33 GBq 90Y-DOTATOC at 6-week intervals, or 11.1 GBq 131I-MIBG with a minimum interval of three months.

RESULTSThe imaging procedure was positive in all 12 patients: 111In-DTPA-octreotide imaging in eight patients, 131I/ 123I-MIBG imaging in six patients. According to the results of combined imaging, we identified four patients to be treated with 90Y-DOTATOC, and five patients with 131 I-MIBG. After three to five sessions of treatment, three patients with partial remission and six with stable disease were observed. The effective rate was 3/9 (33.3%) and the overall tumor response rate was 9/9 (100%). No relevant toxicity was observed.

CONCLUSIONThe combined imaging technique can be used to identify patients for effective radionuclide treatment. The treatment with 90Y-DOTATOC or 131I-MIBG is well tolerated and may improve the fate of patients with metastatic MTC.

3-Iodobenzylguanidine ; therapeutic use ; Adult ; Aged ; Antineoplastic Agents ; therapeutic use ; Carcinoma, Medullary ; metabolism ; radiotherapy ; secondary ; Female ; Follow-Up Studies ; Humans ; Indium Radioisotopes ; Male ; Middle Aged ; Octreotide ; analogs & derivatives ; therapeutic use ; Pentetic Acid ; analogs & derivatives ; Positron-Emission Tomography ; Remission Induction ; Thyroid Gland ; diagnostic imaging ; pathology ; radiation effects ; Thyroid Hormones ; metabolism ; Thyroid Neoplasms ; metabolism ; pathology ; radiotherapy ; Treatment Outcome ; Yttrium Radioisotopes ; therapeutic use