1.A case of syndrome of inappropriate secretion of antidiuretic hormone associated with paroxetine.
Hyo Jun AHN ; Hyung Wook KIM ; Young Soo KIM ; Young Ok KIM ; Sun Ae YOON ; Jae Ki CHOI
Korean Journal of Medicine 2010;79(6):710-713
Paroxetine is a well-known selective serotonin reuptake inhibitor, and has been reported to be advantageous for chronic pain control. Paroxetine is increasingly used for various types of chronic pain because of its safety; however, hyponatremia, or syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with paroxetine, has been reported. This complication is relatively rare, but some patients have presented with severe neurological symptoms. Here, we report the first case of SIADH associated with paroxetine in Korea.
Chronic Pain
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Humans
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Hyponatremia
;
Inappropriate ADH Syndrome
;
Korea
;
Paroxetine
;
Serotonin
2.Clinical Characteristics of Brucellosis Complicated by Syndrome of Inappropriate Secretion of Antidiuresis.
Xing Yu ZHAO ; Juan Hui ZHU ; Li An TONG ; Peng XIA ; Jie Lin WANG
Acta Academiae Medicinae Sinicae 2019;41(6):787-792
To summarize and analyze the causes of hyponatremia in patients with brucellosis and explore the clinical manifestations of syndrome of inappropriate antidiuresis(SIAD)in patients with brucellosis. The clinical data of 111 patients with acute brucellosis who were treated in Peking Union Medical College Hospital from September 2011 to December 2017 were retrospectively reviewed.Hyponatremia was defined by serum sodium level lower than 135 mmol/L.Clinical characteristics including medical histories,vital signs,and laboratory test findings were collected and analyzed. Hyponatremia was found in 14(12.6%)of 111 patients with brucellosis,among whom 3 patients were confirmed to be with SIAD,10 were suspected as SIAD,and 1 was diagnosis as hypopituitarism.Hypoalbuminemia,elevation of erythrocyte sedimentation rate,and high sensitivity C reactive protein were found in brucellosis patients with SIAD,along with severe complications such as infective endocarditis,septic shock,and anemia. Hyponatremia is not a rare condition in brucellosis patients and may be caused by SIAD.
Brucellosis
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Humans
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Hyponatremia
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Inappropriate ADH Syndrome
;
Retrospective Studies
3.Cerebral Salt Wasting Syndrome Associated with Pseudomonas Meningitis ccurred after Removal of Pituitary Adenoma: A Case Report.
Kwang Gik KO ; Jong Pil EUN ; Yong Seog KIM ; Soong Hee LEE ; Dong Gyu SHIN ; Chang Young KWON
Journal of Korean Neurosurgical Society 1999;28(5):726-
The authors report a case of cerebral salt wasting(CSW) syndrome followed by diabetes insipidus and meningitis after transsphenoidal approach for pituitary adenoma. Fluid and electrolyte imbalance occurs occasionally in neurosurgical patients due to DI or SIADH, however, CSW is different disease entity and the methods of treatment are different from those of DI or SIADH. A number of studies in recent years have shown that hyponatremia in many patients with intracranial disease might actually be caused by CSW in which a renal loss of sodium leads to hyponatremia and massive urinary water loss. CSW of this patient was resolved by fluid and salt replacement after 6 months.
Diabetes Insipidus
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Humans
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Hyponatremia
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Inappropriate ADH Syndrome
;
Meningitis*
;
Meningitis, Bacterial
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Pituitary Neoplasms*
;
Pseudomonas*
;
Sodium
;
Wasting Syndrome*
4.A Case of Cerebral Salt Wasting Syndrome in Neuromyelitis Optica Spectrum Disorder.
Young Min PAEK ; Jae Jung LEE ; Pamela SONG ; Hee Kyung PARK ; Joong Yang CHO
Soonchunhyang Medical Science 2017;23(2):115-117
Neuromyelitis optica spectrum disorder (NMOSD) may present with area postrema syndrome, which is characterized by intractable vomiting and hiccups. Hyponatremia is common in NMOSD and is mostly associated with the syndrome of inappropriate antidiuretic hormone secretion (SIADH). In contrast to SIADH, cerebral salt wasting syndrome (CSWS) causes hyponatremia, which is associated with severe natriuresis and extracellular volume depletion in patients with cerebral disease. To our knowledge, hyponatremia associated with CSWS has not been reported in a patient with NMOSD. Here, we describe a NMOSD presenting with hyponatremia, which may be caused by CSWS following area postrema syndrome.
Area Postrema
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Hiccup
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Humans
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Hyponatremia
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Inappropriate ADH Syndrome
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Natriuresis
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Neuromyelitis Optica*
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Vomiting
;
Wasting Syndrome*
5.SIADH Associated with Guillain-Barre Syndrome.
Youn Kyoung LEE ; Seong Kwon MA ; Sang Hun KIM ; Yoon Chul LEE ; Min Seok CHO ; Soo Wan KIM ; Nam Ho KIM ; Ki Chul CHOI
Korean Journal of Nephrology 2004;23(4):630-632
The most common cause of hyponatremia in hospitalized patients is syndrome of inappropriate antidiuretic hormone secretion (SIADH) characterized by water retention leading to decreased serum sodium concentration and osmolality. Since the report of Schwartz and his co-workers1), this syndrome has been described in various clinical settings. There are some reports on SIADH associated with Guillain-Barre syndrome in the literature2-6). However, to our knowledge, there was only one reported case of SIADH associated with Guillain-Barre syndrome in Korea
Guillain-Barre Syndrome*
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Humans
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Hyponatremia
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Inappropriate ADH Syndrome*
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Korea
;
Osmolar Concentration
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Sodium
;
Water
6.Evaluating and Managing Hyponatremia.
Minwook YOO ; Ozan AKCA ; Evelyn BEDIAKO
The Korean Journal of Critical Care Medicine 2008;23(2):67-74
Although hyponatremia is a common electrolyte disorder, its evaluation and management are not well defined. When diagnosed, hyponatremia should be categorized based on four criteria: volume status, urinary Na+, serum K+, and acid-base balance. This approach helps to determine what the cause of hyponatremia is and how it should be treated. Initially, hypovolemic hyponatremia, including cerebral salt wasting syndrome (CSWS), is treated by volume resuscitation and salt supplementation. Euvolemic hyponatremia, including the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), is treated by fluid restriction and salt supplementation, and hypervolemic hyponatremia is treated by fluid restriction and salt restriction. Hyponatremia can be managed well using these primary treatments and medications.
Acid-Base Equilibrium
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Hyponatremia
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Hypovolemia
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Inappropriate ADH Syndrome
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Resuscitation
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Wasting Syndrome
7.A case of SIADH in small cell lung cancer.
Kyu Chang WON ; Jong Sik LIM ; Chan Woo LEE ; Hyoung Woo LEE ; Choong Ki LEE ; Jin Hong CHUNG ; Myoung Soo HYUN ; Bong Sup SHIM ; Hyun Woo LEE
Yeungnam University Journal of Medicine 1991;8(2):227-234
The syndrome of inappropriate ADH secretion is a disorder characterized by hyponatremia which results from water retention attributable to ADH release. The hallmark of SIADH is hyponatremia due to water retention, in the presence of urinary osmolality above plasma osmolality. The SIADH was initially described by Schwartz et al (1957). This syndrome, first recognized in patients with bronchogenic carcinoma, has now been observed in a variety of other illnesses. Recently, we encountered a 59 year-old female with small cell lung cancer, also she had SIADH. Thus, we present a case and review the literature on the subject.
Carcinoma, Bronchogenic
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Female
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Humans
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Hyponatremia
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Inappropriate ADH Syndrome*
;
Osmolar Concentration
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Plasma
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Small Cell Lung Carcinoma*
;
Water
8.The Study on Administration of High-Dose Methotrexate in Children with Osteosarcoma.
Eun A KIM ; Ho Joon IM ; Hahng LEE
Korean Journal of Pediatric Hematology-Oncology 1998;5(2):314-321
PURPOSE: We investigated serum levels of MTX and accompanying organic toxicities after administration of High-Dose Methotrexate (HDMTX). METHODS: We reviewed a total of 42 courses of HDMTX administration in 6 patients who were diagnosed with osteosarcoma in Hanyang University Hospital from 1993 to 1997. The HDMTX was infused at the doses of 8~12 g/m2, and serum levels were assessed. Leucovorin administration was started 20 hours from the beginning of MTX infusion, and continued until the serum MTX level is below 1x10-7 mol/L and toxicities are not detectable. RESULTS: Of 6 patients (4 males and 2 females), mean age at diagnosis was 11.6 years (8.5~15.6 years). Sites of origin included distal femur in 3, proximal tibia in 1, proximal fibula in 1 and proximal humerus in 1. Serum MTX levels were 1.87+/-0.69x10-4 mol/L at 12~23 hours, and 5.10+/-3.22x10-8 mol/L at 120 hrs after HDMTX infusion. Of 42 courses, hematologic toxicity greater than grade III was observed in 19(45.2%) resulting reduction of dose in 2 patients, and hepatic toxicity greater than grade III in 28(67%). The mean ALT levels was 680+/-563 U in 1st day, and mostly normalized in 10th day. Stomatitis was generally mild, except 1 patient with grade III toxicity. No renal or neurologic toxicity was observed, except 1 seizure episode due to SIADH. CONCLUSION: HDMTX with leucovorin in osteosarcoma was well tolerated, and in majority of courses, serum MTX levels returned to non-toxic level after 120 hours and leucovorin will be desirable to administer during at least 5 days.
Child*
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Diagnosis
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Femur
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Fibula
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Humans
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Humerus
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Inappropriate ADH Syndrome
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Leucovorin
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Male
;
Methotrexate*
;
Osteosarcoma*
;
Seizures
;
Stomatitis
;
Tibia
9.Inappropriate Secretion of Antidiuretic Hormone in a Patient with Systemic Lupus Erythematosus.
Ju Ock NA ; Bin YOO ; Young OK JUNG ; Seong Ho KIM ; You Sook CHO ; Mi Kyoung LIM ; Chan KIM ; Soo Gyl PARK ; Hee Bom MOON
Korean Journal of Medicine 1998;55(5):977-981
The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) has been reported in a great variety of diseases and disorders of central nervous system (CNS). However, there has been only 7 cases of SLE reports in association with SIADH and correlation of SIADH and SLE has not been clearly demonstrated. Previous cases showed improvement of SIADH as lupus activity resolved during treatment. We report a case of SLE in association with SIADH which showed improvement during treatment with prednisolone and cyclophosphamide.
Central Nervous System
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Cyclophosphamide
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Humans
;
Inappropriate ADH Syndrome
;
Lupus Erythematosus, Systemic*
;
Prednisolone
10.A Case with the Syndrome of Inappropriate Antidiuretic Hormone Associated with Sertraline.
Korean Journal of Psychopharmacology 1999;10(1):95-98
Authors report a case of syndrome of inappropriate antidiuretic hormone(SIADH) associated with sertraline. A 77 years-old male patient showed decreased serum & urine osmolality with symptoms of nausea and anorexia after the ingestion of sertraline, 50 mg for four days, which led to the diagnosis of SIADH. The symptoms of nausea and anorexia improved as serum osmolality improved in several days after discontinuation of sertraline. It is recommended to check serum Na level routinely at the initial treatment when patients on SRRI aggrevate in symptom, have a past history of hyponatremia, or are old.
Aged
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Anorexia
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Diagnosis
;
Eating
;
Humans
;
Hyponatremia
;
Inappropriate ADH Syndrome
;
Male
;
Nausea
;
Osmolar Concentration
;
Sertraline*