1.The adaptor protein LAD/TSAd mediates laminin-dependent T cell migration via association with the 67 kDa laminin binding protein.
Eunkyung PARK ; Youngbong CHOI ; Eunseon AHN ; Inyoung PARK ; Yungdae YUN
Experimental & Molecular Medicine 2009;41(10):728-736
The adaptor protein, LAD/TSAd, plays essential roles in T cell activation. To further understand the functions of this protein, we performed yeast two-hybrid screening using TSAd as bait and identified 67 kDa laminin binding protein (LBP) as the interacting partner. Subsequently, TSAd-LBP interaction was confirmed in D1.1 T cell line. Upon costimulation by T cell receptor (TCR) plus laminin crosslinking or TCR plus integrin alpha6 crosslinking, LBP was coimmunoprecipitated with TSAd. Moreover, TCR plus laminin costimulation-dependent T cell migration was enhanced in D1.1 T cells overexpressing TSAd but was disrupted in D1.1 cells overexpressing dominant negative form of TSAd or TSAd shRNA. These data show that, upon TCR plus integrin costimulation, TSAd associates with LBP and mediates T lymphocyte migration.
Adaptor Proteins, Signal Transducing/genetics/*metabolism
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Amino Acids, Diamino/metabolism
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Carrier Proteins/*metabolism
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*Cell Movement
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Humans
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Integrin alpha6/metabolism
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Jurkat Cells
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Mutation
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Protein Binding
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RNA, Small Interfering/genetics
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*Receptor Cross-Talk
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Receptors, Antigen, T-Cell/metabolism
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T-Lymphocytes/*metabolism
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Transgenes
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Two-Hybrid System Techniques
2.Risk Factors for Depression of Patients with Tuberculosis in Tuberculosis Specialty Hospital.
Jung Hyun WANG ; Chul Soo PARK ; Bong Jo KIM ; Cheol Soon LEE ; Boseok CHA ; So Jin LEE ; Dongyun LEE ; Ji Yeong SEO ; InYoung AHN ; Baek Jong CHUL ; Hyung Seok KANG ; Sung Ho MOON
Korean Journal of Psychosomatic Medicine 2015;23(2):114-120
OBJECTIVES: This study aimed to investigate the risk factors of depression for patients with tuberculosis(TB). METHODS: A total of 57 patients with TB were recruited. All participants completed the Becks Depression Inventory-II for evaluating depressive symptoms. The risk factor for depression was analyzed by binary logistic regression analysis. Nomogram was performed for probability of depression. RESULTS: Low body mass index(BMI, OR 0.801, 95% CI 0.65, 0.98), interruption of treatment for TB(OR 5.908, 95% CI 1.19, 29.41), past history of depression(OR 24.653, 95% CI 1.99, 308.44) were associated with increased risk for depression. The calibration curve for predicting probability of survival showed a good agreement between the nomogram and actual observation(Original C-index=0.789, bias corrected C-index=0.754). CONCLUSIONS: The result of the present study indicate that low BMI, interruption of treatment for TB, and past history of depression were risk factors for depression in patients with TB. The psychiatric intervention may be needed to prevent depression if the patients with TB have risk factor during treatment for TB.
Bias (Epidemiology)
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Calibration
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Depression*
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Humans
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Logistic Models
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Nomograms
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Risk Factors*
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Tuberculosis*
3.Core Needle Biopsy of the Thyroid: 2016 Consensus Statement and Recommendations from Korean Society of Thyroid Radiology.
Dong Gyu NA ; Jung Hwan BAEK ; So Lyung JUNG ; Ji hoon KIM ; Jin Yong SUNG ; Kyu Sun KIM ; Jeong Hyun LEE ; Jung Hee SHIN ; Yoon Jung CHOI ; Eun Ju HA ; Hyun Kyung LIM ; Soo Jin KIM ; Soo Yeon HAHN ; Kwang Hwi LEE ; Young Jun CHOI ; Inyoung YOUN ; Young Joong KIM ; Hye Shin AHN ; Ji Hwa RYU ; Seon Mi BAEK ; Jung Suk SIM ; Chan Kwon JUNG ; Joon Hyung LEE
Korean Journal of Radiology 2017;18(1):217-237
Core needle biopsy (CNB) has been suggested as a complementary diagnostic method to fine-needle aspiration in patients with thyroid nodules. Many recent CNB studies have suggested a more advanced role for CNB, but there are still no guidelines on its use. Therefore, the Task Force Committee of the Korean Society of Thyroid Radiology has developed the present consensus statement and recommendations for the role of CNB in the diagnosis of thyroid nodules. These recommendations are based on evidence from the current literature and expert consensus.
Advisory Committees
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Biopsy, Fine-Needle
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Biopsy, Large-Core Needle*
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Consensus*
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Diagnosis
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Humans
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Methods
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Thyroid Gland*
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Thyroid Neoplasms
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Thyroid Nodule
4.2017 Thyroid Radiofrequency Ablation Guideline: Korean Society of Thyroid Radiology.
Ji hoon KIM ; Jung Hwan BAEK ; Hyun Kyung LIM ; Hye Shin AHN ; Seon Mi BAEK ; Yoon Jung CHOI ; Young Jun CHOI ; Sae Rom CHUNG ; Eun Ju HA ; Soo Yeon HAHN ; So Lyung JUNG ; Dae Sik KIM ; Soo Jin KIM ; Yeo Koon KIM ; Chang Yoon LEE ; Jeong Hyun LEE ; Kwang Hwi LEE ; Young Hen LEE ; Jeong Seon PARK ; Hyesun PARK ; Jung Hee SHIN ; Chong Hyun SUH ; Jin Yong SUNG ; Jung Suk SIM ; Inyoung YOUN ; Miyoung CHOI ; Dong Gyu NA
Korean Journal of Radiology 2018;19(4):632-655
Thermal ablation using radiofrequency is a new, minimally invasive modality employed as an alternative to surgery in patients with benign thyroid nodules and recurrent thyroid cancers. The Task Force Committee of the Korean Society of Thyroid Radiology (KSThR) developed recommendations for the optimal use of radiofrequency ablation for thyroid tumors in 2012. As new meaningful evidences have accumulated, KSThR decided to revise the guidelines. The revised guideline is based on a comprehensive analysis of the current literature and expert consensus.
Advisory Committees
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Catheter Ablation*
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Consensus
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Humans
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Thyroid Gland*
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Thyroid Neoplasms
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Thyroid Nodule
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Ultrasonography