[Objective]To study the regulation effects of Oridonin on pulmonary artery pressure in pulmonary hypertension rats with hypoxia-hypercapnia and its mechanism.[Methods]SD rats were divided in to three groups randomly: the normal control group(NC),the hypoxia-hpercapnia group(HH),and the hypoxia-hpercapnia plus Oridonin group(O).The time of hypoxia-hypercapnia was 4 weeks.The mean pulmonary artery pressure(mPAP),right ventricular rate(RV/(LV+S)),percentage of thickness of pulmonary artery wall in vascular external diameter(WT%),percentage of pulmonary artery wall area in total vascular area(WA%),vitality of caspase3 and caspase9,expression cyt-c of each group were observed.[Results]The mPAP,RV/(LV+S),WT%,WA% in group HH were significantly higher than those in group NC(P

Renal scarring can cause hypertension, proteinuria, chronic kidney disease, and even end stage renal disease. To understand the risk factors of renal scarring in children is helpful for its early detection, diagnosis, prevention, and treatment. High grade vesicoureteric reflux, recurrent urinary tract infection, and delayed treatment are risk factors for kidney scarring. However, there are still some controversies about the relationship between renal scarring and the some factors such as gender, age, and congenital factors. Recent studies have found that noninvasive urine indicators such as urine neutrophil gelatinase associated lipid delivery protein, urinary endothelin-1, and risk prediction models can predict the formation of renal scar. However, prophylactic use of antibiotics can reduce occurance of urinary tract infections, but do not reduce the risk of renal scarring. This article reviews the possible risk factors and predictors of renal scarring in children, providing a basis for early detection, timely intervention, and effective prevention of it in clinic, so as to reduce the formation and progression of renal scarring.

Administration, Topical ; Humans ; Immunosuppressive Agents ; administration & dosage ; adverse effects ; therapeutic use ; Lichen Planus, Oral ; complications ; drug therapy ; pathology ; Oral Ulcer ; drug therapy ; etiology ; Tacrolimus ; administration & dosage ; adverse effects ; therapeutic use ; Treatment Outcome

Objective:To study the feasibility and reliability of using phosphorylated H2AX(?H2AX)as a predictor for sensitivity of hepatic carcinoma cell HepG2.215 to chemotherapy agents: etoposide, doxorubicin, mitomycin, and cisplatin. Methods: HepG2.215 cells were exposed to etoposide, doxorubicin, mitomycin or cisplatin of 1, 2, 4 and 20 concentration index (CI). Untreated HepG2.215 cells were taken as control. The proportion of HepG2.215 cells expressing ?H2AX was measured by flow cytometry, the number of ?H2AX foci in HepG2.215 cells was measured by immunocytochemistry, and cell proliferation was measured by MTT. The correlation between the number of ?H2AX foci and the percentage of HepG2.215 cells expressing ?H2AX in HepG2.215 cells was analyzed; the correlation of CI with the percentage of HepG2.215 cells expressing ?H2AX or ?H2AX foci and inhibitory rate of cell proliferation was analyzed; and the correlation of inhibitory rate of cell praliferation with the percentage of HepG2.215 cells expressing ?H2AX or ?H2AX foci was also analyzed. Results: There was a positive correlation between the number of ?H2AX foci and the percentage of HepG2.215 cells expressing ?H2AX in HepG2.215 cells after treatment with the above 4 agents (all P

This article presents a new digital haemoglobin meter.This device adopts HICN method recommended by WHO.Its unique designing of automate proofread zero circuit and automatic controlling in determination provids high accuracy and stability,handy and reliable,It can be widely used in the hospital chemical ex- amination laboratory,commue hospital,health station and related laboratory.

Purpose: To study the influences of immune suspression by oral administration of type Ⅱ collagen on the pathogenesis of collagen induced arthritis(CIA) and traumatic oseoarthritis(OA) in rats; Methods: Rat knee traumatic osteoarthritis model made by excision of medial collateral ligament and medial meniscetomy and CIA model were applied for the observation of the changes on hisological and histochemical staining and the inhibition of T cells after oral administration of type Ⅱ collagen. Results: In OA, although the T cells were suspressed by oral administration of type Ⅱ collagen, however, the the pathogenesis was not hindered comparing with RA. It indicated that for OA, machanical factor is more important than the immunological factor, oral administration of type Ⅱ collagen has little effect on decreasing the speed of development of OA. It is not adequate to take the remedy of oral administation of type Ⅱ collagen for the treatment of OA.

This article discussed the ancient and modern meaning of security of intense drugs for pregnant woman. And emphatically studied the meaning of the ‘gu’, pointing out that ‘gu’had three connotations, one referred to disease, second mean the original disease, with the ‘new’disease relative, the third referred to reasons. In addition, the article expounded how can be safe for the pregnant woman to use drugs with extremely intense action. In this paper, its purpose was to examine how to achieve security under circumstance of sick and fi nally achieve balance and harmony.

The arterial supply of the human sacrum and coccyx was studied on 56 fresh. cadavers of different ages by dissection, clearing, casting and radiography.All sacrums receive their blood supply from the lateral sacral arteries, the median sacral artery, the iliolumbar arteries and the fifth lumbar arteries. The median sacral artery, the lateral sacral arteries and their branches anastomose with each other and form the lattice anastomosis on the ventral surface of the sacrum.The anterior spinal canal branch bifurcates into an ascending and a descending branches. The former passes upwards to join the descending branch from the anterior spinal canal branch above it, they also anastomose with their contralateral counterparts, thus forming a rhombic system notable for its regularity.The posterior spinal canal branch also divides into an ascending and a descending branches and they join each other to dispose in a ladder anastomosis on the ventral surface of the laminae.The dorsal branch gives off three main sets of branches: the lateral, the medial and the muscular. The medial and the lateral branches both subdivide into an ascending and a descending branches and they anastomose with each other on the dorsal aspect of the sacrum.On the ventral surface, the coccyx obtains arterial supply from the median sacral artery and the lateral sacral arteries, while its dorsal surface mainly receives blood supply of the lateral sacral artery. Anastomosis has been found scarce on the ventral and dorsal surfaces of the coccyx.

The arterial supply of the human sacrum and coccyx was studied in 68 fresh cadavers of different ages by dissection, clearing, casting and radiography.The nutrient arteries of the sacral vertebrae penetrate the body from the dorsal, ventral and lateral surfaces of the body. The central branches are the main nutrient arteries of the body. Their numbers are constant and do not increase with the advancement of age. The peripheral branches are variable and supply only the outer collar of the body. According to the distribution of nutrient artery within the body of the sacrum, they can be classified into three types 1. predominant ventral nutrient artery pattern, 2. predominant dorsal nutrient artery pattern and 3. balanced nutrient artery pattern. It is found that in S_4 and S_5, type 1 occurs more frequently while type 2 occurs usually in S_1 to S_3. Type 1 is relatively common in adults but type 2 is prevailing in fetuses. There is few balanced pattern in different age groups. Both ventral and dorsal nutrient arteries are distributed in the central zone of the body and the lateral nutrient arteries supply that portion near the intervertebral foramen in the adults. The nutrient arteries within body anastomose with each other to form a dense arterial network.The nutrient arteries of the lateral part of the sacrum enter the bone through its ventral, dorsal and medial aspects. Among the dorsal nutrient arteries, there is a main artery that supplies the lateral mass.The arterial supply to the coccyx is scarce. It enters the coccyx mainly through the ventral surface.