No abstract available.
Sleep Initiation and Maintenance Disorders*

No abstract available.
Biological Clocks* ; Periodicity*

No abstract available.

No abstract available.

BACKGROUND: The histopathological findings of acute cutaneous graft-versus-host reaction are similar to that of erythema multiforme. OBJECTIVE: The objective of this study was to compare the histopathological findings of acute cutaneous graft-versus-host reactions with that of erythema multiforme. METHODS: Histopathological setions of 9 patients with grade 2 acute cutaneous graft-versus- host. reactions and of 13 patient,, with erythema multiforme were reviewed. RESULTS: Parakeratosis, the degree of the exocytosis and the endothelial cell swelling were not useful in the differential diagnosis between acute cutaneous graft-versus-host reactions and ery- thema multiforme. Rete ridge effacement and relative hyperkeratosis were characteristic in many cases of acute cutaneous graft-versus-host reactions but absent in erythema multiforme. Spongiosis, vacuolar degeneration of the basal cells, perivascular lymphocytic infiltration and erythrocyte extravasation were usually more prominent in erythema multiforme than in acute cutaneous graft-versus-host reactions. The number of dyskeratotic cells per epidermal linear mm was usually higher in erythema multiforme but not in acute cutaneous graft-versus-host reactions. An eosinophilic infiltrate was observed occasionally in erythema multiforme but not in acute cutaneous graft-versus-host reactions. CONCLUSION: The histopathological findings show the same pattern of interface dermatitis and are different only in degree beween acute cutaneous graft-versus-host reactions and eryt,hema multiforrne. Rete ridge effacement and relative hyperkeratosis speaks for a diagnosis of acute cutaneous graft-versus-host reactions, and an eosinophilic infiltrate for a diagnosis of erythema multiforme.
Dermatitis ; Diagnosis ; Diagnosis, Differential ; Endothelial Cells ; Eosinophils ; Erythema Multiforme* ; Erythema* ; Erythrocytes ; Exocytosis ; Humans ; Parakeratosis ; Transplants*

Graft-versus-host disease occurs after the administration of foreign immunologically competent cells to an individual who is immunologically compromised. It is a clinical syndrome characterized by cutaneous changes, gastrointestinal dysfunction and liver dysfunction. Cutaneous graft-versus-host reaction is usually the earliest and certainly the most common form of the disease. The diagnosis of graft-versus-host disease is a complex clinicopathologic skill requiring considerable experience. There as yet appears to be no pathognomonic single clinical or histologic feature in the acute phase. In this review article, the definition, immunological aspects and. clinical features of graft-versus-host disease, diagnostic criteria of acute cutaneous graft-versus-host reaction and graft-versus-tumor effect are discussed.
Diagnosis ; Graft vs Host Disease ; Liver Diseases

No abstract available.

No abstract available.
Lymphangioma* ; Nipples*

No abstract available.
Darier Disease* ; Lichens* ; Neurodermatitis*

No abstract available.
Nevus, Blue*