No abstract available.
Licensure*

No abstract available.
Breast Neoplasms* ; Breast*

It is still not well documented what the basic roles for the regulation of renin secretion from the kidney take place. Since the early study on the renal ischemia for the production of hypertension was introduced, the renin-angiotensin system has been regarded as the possible pathogenetic mechanism for the renovascular hypertension. The renin-angiotensin system, however, could be activated by various stimuli, such as, the changes of intrarenal perfusion pressure, the load or concentriation of sodium at the sites of macular densa, the changes of the sympathetic nervous activity and the changes of potassium balance. To investigate the renin-angiotensin system and the influence of sympathetic nervous system on the regulation of renin secretion, the renovascular hypertension was induced in the dogs by constriction of unilateral renal artery, and the plasma renin activity was measured. The sodium load at the sites of macula densa was attained by furosemide, and then the activity of sympathetic nervous system was depressed by reserpine. The plasma renin activity was assayed by the method of Helmer and Cohn. By this bio-assay method, the plasma renin activity equivalent to 1 nanogram angiotensin-II can be measurable and the prepared plasma was found to have still vasopressor activity. The results observed in this experimental work are summarized as follows. 1. The blood pressure reached maximum on the 3rd postoperative day, and declined gradually to the level of preoperative day on the day of from the 6th to 12th day following constriction of renal artery. 3. The plasma renin activity was found to be well correlated with the increase of blood pressure, and then declined to its preoperative level with the reduction of blood pressure. It appears, therefore, that the renin-angiotensin system plays an important role in the pathogenesis of renovascular hypertension. 4. The urine flow rate in normal and reserpinized dogs was the same before administration of furosemide, but its rate was significantly increased in both groups after furosemide. The urine flow rate of reserpinized dogs, however, was significantly lower than that of the normal dogs during the first 5 minutes. 5. The urinary sodium excretion in normal and reserpinized dogs was significantly increased in both groups after administration of furosemide and there were no difference between the two groups. 6. The plasma renin activity of renal venous blood was significantly higher than that of femoral arterial blood in both groups before and after administration of furosemide. 7. The plasma renin activity of reserpinized dogs was significantly lower than that of normal dogs before administration of furosemide. After furosemide, however, the plasma renin activity was significantly increased in 30 minutes in both groups. This increase of plasma renin activity was less prominent in resepinized dogs than in normal. This results would suggest that the intrarenal mechanism regulating renin secretion also requires an intact sympathetic nervous system.
Animals ; Blood Pressure ; Constriction ; Dogs ; Furosemide ; Hypertension ; Hypertension, Renovascular ; Ischemia ; Kidney ; Perfusion ; Plasma ; Potassium ; Renal Artery ; Renin* ; Renin-Angiotensin System ; Reserpine ; Sodium ; Sympathetic Nervous System

Milk allergy can be caused by milk protein components or extrinsic allergens such a.s penicillin. The author have experienced a young female patient with drug eruption like skin lesions. Her skin lesions recurred after reingestion of milk. Intradermal test with rnilk as is and provocation test with oral penicillin are considered to be positive. Therefore her skin eruption seemed to be caused by penicillin in milk.
Allergens ; Drug Eruptions* ; Female ; Humans ; Intradermal Tests ; Milk Hypersensitivity ; Milk Proteins ; Milk* ; Penicillins* ; Skin

No abstract available.
Korea* ; Liver Transplantation* ; Liver*

Treatment of peptic ulceration by suppression of gastric aeid, secretion with the histamine H,-receptor antagonist, cimetidine is now well established. Prior to the availability of ranitidine, cimetidine was the only histamine H2-receptor antagonist available for treatment of duodenal and gastric ulceration. The aim of this study was to compare the efficacy of ranitidine and cimetidine in accelerating the healing of duodenal ulcer. The therapeutic trials comparing ranitidine with cimetidine in a total of 44. out-patients with endoscopically diagnosed duodenal ulcer ivere entered into the study. 28 patients were treated with ranitidine 150mg twiee daily, and 16 patients with cimetidine 200 mg 4 times daily for 4 weeks. Overall endoscopic healing rates were 75%, on ranitidine and 64.3% on cimetidine, and so ranitidine appears to be slightly more effective than cimetidine although too small numbers af patients were studied to detcet any difference between drugs. Aa ranitidine is effective with administration twice daily, patient compliance may be better than with the 4 times daily treatment regimen adopted with cimetidine, though has not yet to be adequately demonstrated. There were no significant side-effects, either ranitidine or cimetidine, to the administration of the drug, except a case of dyspepsia on cimetidine regimen.
Cimetidine ; Duodenal Ulcer ; Dyspepsia ; Histamine ; Humans ; Outpatients ; Patient Compliance ; Peptic Ulcer* ; Ranitidine ; Stomach Ulcer

To clarify the physiological thermoregulatory response of the human body, the local heating and hunting reaction experiments were performaed. The subjects were 10 healthy women from 19 to 22 years of age. For the local heating experiment, oral temperature, skin temperature, deep skin temperature and thermal sensations were measured every 5 min during the 40 min experiment. Heated areas were neck, shoulder, abdomen, hands and feet. These five areas were heated with the hot pack of 50℃. For the hunting reaction experiment, oral temperature, thermal sensation of the whole body and cold pain sensation of the finger were measured every 5 min during and after immersion of the left middle finger in 5℃ ice water for 40 min. The skin temperature of the finger tip was measured with a copperconstantan thermocouple every each min during and after immersion. Cold tolerance index was made on the basis of following items ; the skin temperature at the first rise(T.F.R), time for the first skin temperature rise (T.T.R), mean skin temperature during immersion(M.S.t). Conclusions : 1. Skin temperature and deep skin temperature have been much influenced by the abdomen heating. 2. The correlation between the whole body thermal sensation and the upper trunk thermal sensation was singnificantly recognized. 3. T.F.R. and M.S.T. of the hunting reaction with abdomen heating is significantly higher at the 0.01 level by T-test than that of the hunting reaction without abdomen heating. T.T.R is also significantly shorter for the hunting reaction with abdomen heating than that for the hunting reaction without abdomen heating.
Abdomen ; Female ; Fingers ; Foot ; Hand ; Heating* ; Hot Temperature* ; Human Body ; Humans ; Ice ; Immersion ; Neck ; Sensation ; Shoulder ; Skin Temperature ; Water

Three point scoring systems for the diagnosis of left ventricular hypertrophy were studied referring to positivity as well as false positivity in 100 cases of clinically proven LVH and 100 cases of healthy persons. 1) By Estes' scoring system 98% of LVH cases were diagnosed as LVH. There was 14% of false positive rate in healthy person. 2) By Romhilt and Estes' scoring system, 58% of LVH cases were diagnosed as LVH. There was 1% of false positive rate in healthy person. 3) By Skjaggested and Kierulf scoring system, 81% of LVH were diagnosed as LVH. There was 17% of false positive rate in healthy person. 4) Point scoring systems were more accurate in electrocardiographic diagnosis for LVH than any other conventional criteria. Among the reported scoring systems, Estes scoring system was considered the most useful as well as accurate one.
Diagnosis* ; Electrocardiography* ; Humans ; Hypertrophy, Left Ventricular*

No abstract available.
Diagnosis* ; Gout*

No abstract availalble.