Conflicting results have been reported, as to whether or not wound repair is influenced following treatment with low doses of prednisolone, insulin, or thyrotrophic hormone. The present studies were undertaken to evaluate and compare the influence of above hormones on the wound repair process and their target organs in rats at different times after operation. The influence of the above hormones were observed as measurement of the tensile strength of healing skin incisions and the histologic finding of the wound sites and the target organs staining with H-E, PAS, and Masson's trichrome method. Saline 0. 1 ml were injected daily intramusculary in control group: prednisolone acetate 0. 2ml (4mg/kg/day) in prednisolone treated group: regular zinc insulin 0.1 ml(1.5IU/kg/day) in insulin treated group; thyrotrophin 0.1 ml (0.4IU/kg/day) in TSH trcated group. The observation period wer at 4th day, 7th day, 14th day and 21st day of post-operation. The results were as follows: 1. Prednisolone treated group: (1) The tensile strength were decreased at 4th and 7th day than control groups, but there were no statistically significant difference at 14th and 21st day from control group. (2) In histologic findings of the wound sites at 4th and 7th day, the repair processes were suppressed, but at 14th and 21st day, there were no difference from control group. (3) In histologic finding of adrenal cortex, the atrophic changes was observed from early stage. 2. Insulin treated group: (1) There were no statistical difference from control group in tensile strength at each observation period. (2) In histologic findings of the wound sites, the pictures of the repair processes were similar with control group at each observation period. (3) Atrophic change of islets of Langerhans in pancreas was observed at each observation period. 3. TSH treated group: (1) The tensile strength were increased at 4th, 7th, and 14th day than control group, but there was no statistical difference at 21st day frorn control group. (2) In histologic findings of the wound sites, the repair processes were aecelerated at 4th and 7th day than control group, but there were no defferences at 14th and 21st day from control group. (3) Hyperplastic change of acini in thyroid gland was observed through entire observation period.
Adrenal Cortex ; Animals ; Insulin ; Islets of Langerhans ; Pancreas ; Prednisolone ; Rats ; Skin ; Tensile Strength ; Thyroid Gland ; Thyrotrophs ; Thyrotropin ; Wounds and Injuries* ; Zinc

No abstract available.
Thinking*

BACKGROUND: The renin-angiotensin system (RAS) plays a crucial role in pathophysiology of congestive heart failure and ventricular remodeling after myocardial infarction (MI). There are two components, systemic and local, in RAS. There has not been a study to analyze differentially the sequential changes of systemic and local RAS after MI. The aim of this study was to analyze the sequential change of the expression of angiotensinogen mRNA, the first component of the renin-angiotensin system, in liver and non-infarcted myocardium in rats after myocardial infarction. METHOD: Female Sprague-Dawley rats (body weight 200-250 g) were subjected either to left coronary artery occlusion or to sham operation. And the rats were sacrificed at 1, 4, 18, 24 hours, 3 days, 2, 3 weeks. Hemodynamic measurement was performed and RNA was extracted from various tissues including liver and ventricle for the analysis of the expression of the angiotensinogen mRNA by northern blot analysis or RT-PCR. RESULTS: Coronary artery ligation resulted in comparable infarct sizes among rats at 3 weeks after MI and was accompanied by significant increases of LVEDP (preMI 11+/-2 vs postMI 21+/-3 mmHg, n=4). Systolic arterial pressure was reduced in animals with infarction (preMI 130+/-15 vs postMI 90+/-10 mmHgn n=4). The liver angiotensinogen mRNA levels increased at 4, 18, 24 hours after myocardial infarction and decreased at 3rd day to control values (Angiotensinogen/GAPDH;preMI 1.35+/-0.20 vs postMI 5.97+/-0.25, max 4-fold, n=3). After sham operation, the liver angiotensinogen mRNA levels increased also at 4, 18, 24 hours, but in a less degree (Angiotensinogen/GAPDH;preop. 2.15+/-1.17 vs postop. 3.41+/-1.76, max 1.5-fold, n=3). In contrast to the liver, small amounts of angiotensinogen mRNA were detectable in normal left ventricle of rat with RT-PCR. The myocardial angiotensinogen mRNA levels decreased transiently in acute phase after MI, and recovered at 3-day after MI and increased further afterwards upto 3rd month after MI. CONCLUSION: The angiotensinogen in liver was activated early during acute phase after MI and decreased toward normal as the stable state was achieved. In contrast to the circulating RAS that was activated in acute phase after MI, the local RAS in heart was activated in chronic phase after MI.
Angiotensinogen* ; Animals ; Arterial Pressure ; Blotting, Northern ; Coronary Vessels ; Female ; Gene Expression ; Heart ; Heart Failure ; Heart Ventricles ; Hemodynamics ; Humans ; Infarction ; Ligation ; Liver* ; Myocardial Infarction* ; Myocardium* ; Rats* ; Rats, Sprague-Dawley ; Renin-Angiotensin System ; RNA ; RNA, Messenger* ; Ventricular Remodeling

The hemodynamic aspects of cerebral arteriovenous malformations(AVM) are currently the subject of increasing interest. Recently developed methods such as Doppler sonography, Xenon-enhanced Computed tomography Cerebral blood flow(CT CBF), single photon emission computed tomography(SPECT), and position emission tomography(PET) have promoted a more dynamic diagnostic and therapeutic approach to the complicated problem related to surgery of AVM. In this article, the literatures concerning the hemodynamics of cerebral AVM were reviewed.
Arteriovenous Malformations ; Hemodynamics* ; Intracranial Arteriovenous Malformations*

No abstract available.

No abstract available.
Lymphocytes* ; T-Lymphocyte Subsets* ; Thyroid Gland*

No abstract available.
Aged* ; Humans

No abstract available.
Early Detection of Cancer*

The purpose of the study was to investigate the effects of social support on loneliness and life satisfaction in elderly Korean Immigrants living in the U.S.A. The sample consisted of 174 community-dwelling elderly Korean Immigrants who lived in a large Midwestern city area. Telephone interviews were used to collect the data using translated Korean version of the Social Support Questionnaire 6, Revised UCLA Loneliness Scale, and the Life Satisfaction Index-Z. A descriptive level correlational design was used in this study. Results indicated that the subjects had on the average of two to three emotional supporters. The mean score of social support satisfaction was between fairly and a little satisfaction on the scale. The mean score of loneliness was 42.60, indicating that the subjects were moderately lonely. the mean score of life satisfaction was 12.94, indicating that the subjects were moderately satisfied with their life. In this study, social support variables( network size and satisfaction ) had both a direct effect on life satisfaction and an indirect effect through loneliness. Elderly Korean immigrants who had the large number of people in their network were less lonely and thus more satisfied with their life than those who had the small number of people in their network. also, elderly Koreans who were more satisfied with social support were less lonely and thus more satisfied with their life than those who were less satisfied with social support. Social support satisfaction was a better predictor for loneliness and life satisfaction than social network size.
Aged* ; Emigrants and Immigrants* ; Humans ; Interviews as Topic ; Loneliness* ; Surveys and Questionnaires

No abstract available.
Humans ; T-Lymphocyte Subsets* ; Thyroid Gland*