1.Treatment of Progressive Hemifacial Atropht (Romberg's Desease) with Microvascuar Free Flap.
Rong Min BAEK ; Doo Seong JEONG ; Se Min BAEK
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1999;26(5):933-937
Romberg's disease is an uncommon condition manifested by progressive hemifacial atrophy of the skin, soft tissue and bone. Facial asymmetry with soft tissue deficiency in Romberg's disease causes a significant disability affecting the social life and can bring about many psychological problems. The aim of surgical treatment is cosmetic amelioration of the defect. Several conventional reconstructive procedures have been used for correcting facial asymmetry. They include fat injections, dermal fat grafts, silicone injections, cartilage and bone grafts, pedicled flaps and free flaps. We report our experience with 6 patients involving 6 free flaps with a minimun of 1 year follow-up who were treated from October 1989 to March 1998. All patients were classified as having moderate to severe atrophy. The average age of disease onset was 4.5 years. The average duration of atrophy was 5.2 years. No patient was operated on with a quiescent interval of less than 1 year. The average age at operation was 14.1 years, ranging from 10 to 24 years. Follow-up ranged from 1 to 9 years. Reconstruction was performed using 2 groin dermofat free flaps and 4 latissimus dorsi muscular free flaps. To achieve the finest symmetrical and aesthetic results, several ancillary procedures were performed in 4 patients. These procedures included Le-Fore 1 1/2 leveling osteotomy, sagittal split ramus osteotomy, reduction malarplasty and angleplasty, rib and calvarial bone graft, correction of alopecia and additional dermofat graft. All patients were satisfied with the results. We believe that free flap is one of the best choices for contoured restoration of facial asymmetry in Romberg's disease.
Alopecia
;
Atrophy
;
Cartilage
;
Facial Asymmetry
;
Facial Hemiatrophy
;
Follow-Up Studies
;
Free Tissue Flaps*
;
Groin
;
Humans
;
Osteotomy
;
Osteotomy, Sagittal Split Ramus
;
Ribs
;
Silicones
;
Skin
;
Superficial Back Muscles
;
Surgical Flaps
;
Transplants
2.ANALYSIS OF DONOR SITE OF THE COSTOCHONDRAL GRAFT AFTER TOTAL EAR RECONSTRUCTION.
Seong Jun BAEK ; Jae Ho LIM ; Rong Min BAEK ; Kap Sung OH ; Se Min BAEK
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1997;24(5):1214-1216
No abstract available.
Ear*
;
Humans
;
Tissue Donors*
;
Transplants*
4.Luque Instrumentation
Se Il SUK ; Goo Hyun BAEK ; Choon Seong LEE
The Journal of the Korean Orthopaedic Association 1984;19(5):893-898
Luque introduced new posterior spinal instrumentation by segmental sublaminar wiring for spinal deformity in 1976. This system initially developed for the treatment of paralytic scoliosis, but now its application was extended to treatment of other types of scolisis, spinal fractures and spondylolysthesis. Advantages of this system in scoliosis are better correction force and secure internal fixation enabling early ambulation without external support. Disadvantages include longer operation time, possibilities of epidural bleeding and dural laceration. Luque instrumentation in thoracic and lumbar spine fracture is an effective means of obtaining following goals: provide reduction, maintenance of alignment, restoration of stability, prevention of deformity, low pseudarthrosis rate and early mobilization without external support. Luque instrumentation were carried out in 5 cases at Dept. of O.S. at SNUH from Oct. 1983 to Feb. 1984 with excellent results. The average follow-up period was 7.4 months and there was no complication. Two cases of unstable thoracic and lumbar spine fractures were treated with Luque instrumentation with fusion. The use of double sublaminar wiring with Luque rods, two levels above and two levels below on area of fracture provided early stabilization to allow rehabilitation without external immobilization. Three cases of paralytic scoliosis underwent Luque instrumentation by a modification of the Galveston technique with fusion. Average preoperative curve was 110°(ranged from 101° to 126°). Immediate postoperative correction was 58.7°(46.6%) and average 7 months-following result was 56.3°(48.3%). Operation time averaged 6hr 7min and blood loss was averaged 12 pints. Those patients required instrumentation from the pelvis to middorsal segment, in an effort to control the curve and associated pelvic tilting. In early follow-up the author obtained remarkable correction in paralytic curves, and the pelvic obliquity were well corrected with a pelvis and provid ing with better sitting balance.
Congenital Abnormalities
;
Early Ambulation
;
Follow-Up Studies
;
Hemorrhage
;
Humans
;
Immobilization
;
Lacerations
;
Pelvis
;
Pseudarthrosis
;
Rehabilitation
;
Scoliosis
;
Spinal Fractures
;
Spine
5.Status of Nosocomial Urinary Tract Infections in the ICU: Molecular Epidemiology of Imipenem Resistant P. aeruginosa.
Seong Mi YU ; Seong Sook JEON ; In Soon KANG ; Hye Gyung AN
Journal of Korean Academy of Nursing 2006;36(7):1204-1214
PURPOSE: This retrospective study was done to evaluate the status of nosocomial urinary tract infections and to determine the risk factors andtransmission route of causal IRPA through molecular epidemiology. METHOD: Two hundred ninety-nine of 423 patients admitted to the internal medicine and surgery ICU at a university hospital incity B had a positiveurine culture. Twelve of the 299 patients who had a urinary tract infection had IRPA strains. The data was collected from November 1, 2004 to January 31, 2005. The following results were obtained after the data was analyzed using percentile and UPGMA. RESULT: The rate of nosocomial urinary tract infections in the ICU was 10.8%. Therewere 16.8 cases of infection based on the period of hospitalization. There were 16.9 cases of infection based on the use of a foley catheter. The rate of nosocomial urinary tract infection in the ICU and urinary tract infections related to IRPA were higher in patients with the following characteristics: men, old age, admission through the emergency room, longer than seven days admission, severity of admitting causes, disturbance of consciousness, hydration less than 300cc in 24hours, a long course of antibiotics, a long period of foley catheterization and perineal care. Most of the microorganisms that caused the urinary tract infection were gram negative bacilli, among which P. aeruginosa was found in 70 patients (18.5%) and IRPA in 12 (4.0%). Among the 12 IRPA strains that were tested with PFGE, eight showed a dice coefficient higher than 80%, suggesting a genetic relationship. They were related with the period of hospitalization in the same ICU. These patients all received direct care for a urinary tract infection. CONCLUSION: Through these results, IRPA can be consideredas a contributing factors to urinary tract infections thus, active preventative measures are needed by the medical staff.
Adult
;
Aged
;
Aged, 80 and over
;
Anti-Bacterial Agents/*pharmacology
;
Cross Infection/*epidemiology/etiology/microbiology
;
Drug Resistance, Bacterial
;
Female
;
Humans
;
Imipenem/*pharmacology
;
Intensive Care Units
;
Male
;
Middle Aged
;
Pseudomonas Infections/drug therapy/*epidemiology
;
Pseudomonas aeruginosa/classification/drug effects/*genetics
;
Retrospective Studies
;
Risk Factors
;
Urinary Catheterization
;
Urinary Tract Infections/*epidemiology/etiology/microbiology
6.Effect of Retrovirus and p53 Tumor Suppressor Gene in Gene Therapy of Cancer Cells.
Seong Il SUH ; Min Ho SUH ; Won Ki BAEK ; Jae We CHO
Journal of the Korean Society for Microbiology 1998;33(2):227-235
Cancer is considered to occur through abnormal growth and differentiation processes, in which oncogenes and tumor suppressor genes are deeply related. Cellular responses to DNA-damaging agents are believed to be critical determinants of human tumorigenesis. Cell cycle arrests and DNA repair following DNA damage require the coordination of multiple gene products that, as a whole, serve to maintain the integrity of the genome. Within the cell cycle, both G1-S and G2-M phase transitions are under constant surveillance by checkpoint genes for the protection of cells from either exogenous or endogenous DNA-damaging agents. p53 tumor suppressor gene mediates cell cycle perturbations in response to DNA damage, and play a role in cell death, genetic stability, and cancer susceptibility. Recently, gene therapy with p53 tumor suppressor gene is expected as a new effective therapeutic strategy in many kinds of cancer. By using retroviral vector system, we transduced p53 tumor suppressor gene into human osteosarcoma cells, and analysed its growth suppression and apoptosis inducing effects. Combined effects of p53 gene therapy with chemotherapeutic agent or radiation were also analysed. Titer of ecotrophic p53 retrovirus was 5.0x10/ml, and that of amphotrophic p53 retrovirus was 2.0x10/ml when NIH3T3 cells were used as target cells. Human osteosarcoma cells infected with amphotrophic p53 retroviruses showed increased p21waf1 gene expression, which acts as a major cyclin-dependent kinase inhibitor in DNA damage responses. In normal DMEM media, human skin fibroblasts infected with amphotrophic p53wt retroviruses showed very slow growing (1.7 fold increase in doubling time) and very low saturation density (50% decrease in cell density). In media containing chemotherapeutic agent, human osteosarcoma cells infected with p53wt retroviruses died rapidly; 75% of them died within 4 days and all of them died within 10 days of incubation with chemotherapeutic agent. Their DNAs were extracted and electrophoresed in agarose gel, and we identified DNA ladders characteristic of apoptotic cell death. When human osteosarcoma cells infected with p53 retroviruses were irradiated with ultraviolet light, more than 95% of cancer cells died within 1 day; whereas mock infected cells showed only less than 5% of cell death. These findings suggest that retroviral vector mediated p53 tumor suppressor gene transfer into cancer cells can suppress tumor cell growth and decrease tumor cell density effectively. These findings also suggest that effective induction of tumor cell apoptosis can be obtained when p53 gene therapy is used in combination with chemotherapy or radiotherapy.
Apoptosis
;
Carcinogenesis
;
Cell Count
;
Cell Cycle
;
Cell Cycle Checkpoints
;
Cell Death
;
DNA
;
DNA Damage
;
DNA Repair
;
Drug Therapy
;
Fibroblasts
;
Gene Expression
;
Genes, p53
;
Genes, Tumor Suppressor*
;
Genetic Therapy*
;
Genome
;
Humans
;
Oncogenes
;
Osteosarcoma
;
Phase Transition
;
Phosphotransferases
;
Radiotherapy
;
Retroviridae*
;
Sepharose
;
Skin
;
Ultraviolet Rays
;
Zidovudine
7.Antimicrobial resistance of escherichia coli isolated from clinical specimens.
Sung Duck PAIK ; Won Ki BAEK ; Seong Il SUH ; Jong Wook PARK ; Min Ho SUH
Journal of the Korean Society for Microbiology 1993;28(4):261-267
No abstract available.
Escherichia coli*
;
Escherichia*
8.A Case of Angiomyolipoma of the Colon Manifested by Intussusception.
Korean Journal of Gastrointestinal Endoscopy 2006;33(6):377-380
Angiomyolipomas are a form of mesenchymal hamartoma that consists of blood vessels, smooth muscle cells, and mature fat cells. The vast majority of these tumors occur in the kidney. Extrarenal angiomyolipomas are extremely rare and have been reported in the liver, nasal cavity, vagina, spermatic cord, skin, and mediastinum. We report a case of symptomatic angiomyolipoma manifestated caused by colonic intussusception. A 67-year-old male was admitted because of lower abdominal pain that began 10 days prior. Abdominal computed tomography showed intussusception, and colonofiberscopic finding showed a lumen filled with a smooth surfaced pedunculated mass in the left side colon. The patient underwent a partial segmental resection of the sigmoid colon. I report a case of angiomyolipoma that was confirmed by the pathology findings.
Abdominal Pain
;
Adipocytes
;
Aged
;
Angiomyolipoma*
;
Blood Vessels
;
Colon*
;
Colon, Sigmoid
;
Hamartoma
;
Humans
;
Intussusception*
;
Kidney
;
Liver
;
Male
;
Mediastinum
;
Myocytes, Smooth Muscle
;
Nasal Cavity
;
Pathology
;
Skin
;
Spermatic Cord
;
Vagina
9.Consideration of Birth Weight by Gestational Age.
Mi Keong BAEK ; Hyun Il AHN ; Youn Hee HWANG ; Seong Sook SEO
Korean Journal of Obstetrics and Gynecology 1998;41(7):1882-1888
This study was undertaken to make current fetal growth curve throughout later part of pregnancy. 5,110 normal singleton deliveries at Il Shin Christian Hospital were included. The 10th, 25th, 50th, 75th, 90th percentiles of birth weight were calculated from 21 to 42 weeks' gestation and the 10th, 50th, 90th percentiles of birth weight compared by fetal sex, maternal parity and height were graphed to know the potency of factors. There was a linear growth pattern between 28 and 38 weeks' gestation. During last month of prgnancy, three factors have significant effect on median birth weight but no significant differences in 10th percentiles. Maternal height & parity significantly affeect on 90th percentiles. So, these factors must be considered when diagnosing large for date.
Birth Weight*
;
Female
;
Fetal Development
;
Gestational Age*
;
Parity
;
Parturition*
;
Pregnancy
10.Characterization of R plasmid and antimicrobial drug resistance of kelbsiella pneumoniae isolated from clinical specimens.
Kyung Ran LEE ; Won Ki BAEK ; Seong Il SUH ; Jong Wook PARK ; Min Ho SUH
Journal of the Korean Society for Microbiology 1991;26(1):25-35
No abstract available.
Drug Resistance, Microbial*
;
Plasmids*
;
Pneumonia*