Dysplastic nodule (DN), which is nodular hepatocellular proliferation of at least 1mm in diameter, is detected most often through radiological and pathological observations in chronic advanced liver diseases. DNs characteristically contain portal tracts and they can be classified into low grade for mild atypia and high grade for at least moderate atypia that is insufficient for the diagnosis of malignancy. DNs are supplied portal venous blood and arterial blood supply. In unpaired arteries, new angiogenesis, shows stepwise increases in the following order of DN low grade, DN high grade, early hepatocellular carcinoma and hepatocellular carcinoma. There are convincing clinicopathological data to support the premise that DNs are considered to be precancerous lesions and early stages of multistep processes of hepatocellular carcinogenesis. Extensive clinicopathological and molecular study can provide a better understanding of the characteristics of DNs and new therapeutic approaches to DNs.
Arteries ; Carcinogenesis ; Carcinoma, Hepatocellular ; Diagnosis ; Liver Diseases ; Liver*

No abstract available.
Humans ; Myocardial Infarction* ; Young Adult*

No abstract available.

No Abstract available.
Infant, Newborn ; Infection Control* ; Intensive Care Units, Neonatal* ; Intensive Care, Neonatal*

No abstract available.
Precursor Cell Lymphoblastic Leukemia-Lymphoma*

No abstract available.
Joints*

1. We have reported here a case of left marked hydronephrosis due to left aberrant renal vessel, which was treated by ablative procedure. 2. Aberrant renal vessel is a rare disease, but is a relatively common cause of uretero-pelvic obstruction with intrinsic ureteropelvic stenosis. Clinically it is important that this disease may he easily complicated with the conditions such as obstruction, hydronephrosis and infection, and also, the surgeon may inadvertently lacerate the structure with resultant profuse hemorrhage during the operation.
Constriction, Pathologic ; Hemorrhage ; Hydronephrosis* ; Rare Diseases

A clinical study was made on 85 cases' of urinary lithiasis among the number of 3795 out-patients, during 5 years and 8 months from January 1964 to August 1969, and 80 cases were analyzed by a chemical method. (70 cases were safely reserved stone, 10 cases were by litholapaxy.) The results were as following: 1. The incidence of urinary calculi was 2.2%, male to female ratio being approximately 3.7: l. 2 83 cases of urinary calculi were found in the Chonnam district and 2 cases were found in the Chonbuk district 3. The age of the patients ranged from 20~40 years in approximately 65.6%. 4 The location of the urinary calculi was in ureter in 47%, kidney (29.4%), bladder(14.2%) and urethra (9.4%). 5. The most favored predilection of ureteral stone was lower third of ureter in approximately 47% of all cases 6. In a number of urinary calculi in each location 83.5% (71 cases) was single. The most common sire, was below 0.5cm in its diameter, and weight, below 0.5Gm on 41 cases (51.25%). 7. The clinical symptoms of upper urinary tract lithiasis showed flank pain in 81.5%, hematuria in 35. 4%, and suprapubic discomfort in 30. 8%, ,but in lower urinary tract, painful urination was in 85%, urgency in 60%, stoppage of urinary stream in 65% and hematuria in 40%. 8. The microscopic hematuria showed 87.1%, which incidence was higher in lower urinary tract calculi, and pyuria was revealed in 39. 9%. 9. The most frequent surgical intervention was ureterolithotomy in 38.5% (35 cases). 10. The results of chemical analysis of 80 urinary calculi showed the mixed type of calcium-phosphate and calcium oxalate in 40% (32 cases), calcium oxalate in 12. 5% (10 cases), calcium phosphate in 12.5% (10 cases), the mixed type of calcium-phosphate and ammonium-phosphate in 10% (8 cases), calcium-carbonate in 10% (8 cases) and urate in 3.75% (3 cases). 11. Cases of bilateral urinary calculi were revealed in 13.8%.
Calcium ; Calcium Oxalate ; Calculi ; Female ; Flank Pain ; Hematuria ; Humans ; Incidence ; Jeollabuk-do ; Jeollanam-do ; Kidney ; Lithiasis ; Male ; Outpatients ; Pyuria ; Rivers ; Ureter ; Urethra ; Uric Acid ; Urinary Calculi ; Urinary Tract ; Urination ; Urolithiasis*

Extracapsular cataract extraction with posterior chamber intraocular lens in 24 eyes of 24 diabetics. With and without diabetic retinopathy, were followed up postoperatively for an average of 14 months to determine the incidence of diabetic retinopathy, the final visual acuity and factors predictive of progression of retinopathy and final visual acuity. Overall, retinopathy progressed in 52% of operated-on eyes. Cataract extraction was highly associated with progression of diabetic retinopathy. Women had a significantly increased risk of progression of retinopathy in the operated-on eye compared to men. Visual acuity improved in 22 of 24 orerated-on eyes : however, only 11 eyes achieved a visual acuity of 0.5 or better and only 7 eyes achieved a visual acuity of 0.7 or better. Patients treated with oral hypoglycemic agents had a worse visual prognosis than those treated with insulin. The prognosis of patients with diabetic retinopathy about to undergo cataract surgery, even extracapsular cataract extraction with placement of a posterior chamber lens, is guarded.
Cataract Extraction ; Cataract* ; Clinical Study* ; Diabetic Retinopathy* ; Female ; Humans ; Hypoglycemic Agents ; Incidence ; Insulin ; Lenses, Intraocular ; Male ; Prognosis ; Visual Acuity

Sleep-related eating disorder (SRED) is a newly recognized parasomnia that describes a clinical condition of compulsive eating under an altered level of consciousness during sleep. Recently, it is increasingly recognized in clinical practice. The exact etiology of SRED is unclear, but it is assumed that SRED might share features of both sleepwalking and eating disorder. There have been also accumulating reports of SRED related to the administration of various psychotropic drugs, such as zolpidem, triazolam, olanzapine, and combinations of psychotropics. Especially, zolpidem in patients with underlying sleep disorders that cause frequent arousals, may cause or augment sleep related eating behavior. A thorough sleep history is essential to recognition and diagnosis of SRED. The timing, frequency, and description of food ingested during eating episodes should be elicited, and a history of concurrent psychiatric, medical, sleep disorders must also be sought and evaluated. Interestingly, dopaminergic agents as monotherapy were effective in some trials. Success with combinations of dopaminergic and opioid drugs, with the addition of sedatives, has also been reported in some case reports.
Arousal ; Benzodiazepines ; Consciousness Disorders ; Dopamine Agents ; Eating ; Feeding and Eating Disorders ; Feeding Behavior ; Humans ; Hypnotics and Sedatives ; Parasomnias ; Psychotropic Drugs ; Pyridines ; Sleep Wake Disorders ; Somnambulism ; Triazolam