No abstract available.
Cardioplegic Solutions* ; Heart* ; Thoracic Surgery*

No abstract available.
Epithelium* ; Humans* ; Insulin*

The orbicularis oculi muscle transpositions with horizontal shortening procedures were performed for involutional entropion of the fourteen lower eyelids in twelve patients. The age ranged from 51 to 84 years (average 66.9 years). One patient was man and eleven patients were women. All patients were satisfactory with good cosmesis and improvement of tearing, discharge and ocular pain etc. after the follow-up period of 6 to 26 months. But mild subcutaneous hematoma of the eyelid was noticed in 3 cases with good absorption.
Absorption ; Entropion* ; Eyelids ; Female ; Follow-Up Studies ; Hematoma ; Humans

The renal scan was performed of 18 cases of acute pyelonephritis. 2 cases were normal and 16 cases were abnormal uptake findings in renal scan. Among these cases, 11 cases were mottled, 4 cases were decreased, 1 case was defect uptake finding. Conclusively, we believe that renal scan is a more sensitive index than the pyelogram for renal parenchymal lesions in the acute pyelonephritis.
Pyelonephritis*

No abstract available.
Hyperlipidemias* ; Tarsal Tunnel Syndrome*

The success of radioation therapy depends on exact treatment of the tumor with significant high dose for maximizing local control and excluding the normal tissues for minimizing unwanted complications. To achieve these goals, correct estimation of target volume in three dimension, exact dose distribution in tumor and normal critical structures and correction of tissue inhomogeneity are required. The effect of therapy oriented CT (planning CT) were compared with conventional simulation method in necessity of planning change, set dose, and proper distribution of tumor dose. Of 365 new patients examined, planning CT was performed in 104 patients (28%). Treatment planning was changed in 47% of head and neck tumor, 79% of intrathoracic tumor and 63% of abdmonial tumor. In breast cancer and musculoskeletal tumors, planning CT was recommended for selection of adequate energy and calculation of exact dose to critical structures such as kidney or spinal cord. The average difference of tumor doses between CT planning and conventional simulation was 10% in intrathoracic and intra-abdominal tumors but 20% in head and neck tumors which suggested that tumor dose may be overestimated in conventional simulation. Although some limitations and disadvantages including the cost and irradiation during CT are still criticizing, our study showed that CT planning is very helpful in radiotherapy planning.
Breast Neoplasms ; Head ; Humans ; Kidney ; Neck ; Radiotherapy ; Spinal Cord

Animal models have long been developed for cardiovascular research. These animal models have been helpful in understanding disease, discovering potential therapeutics, and predicting efficacy. Despite many efforts, however, translational study has been underestimated. Recently, investigations have identified stem cell treatment as a potentially promising cell therapy for regenerative medicine, largely because of the stem cell's ability to differentiate into many functional cell types. Stem cells promise a new era of cell-based therapy for salvaging the heart. However, stem cells have the potential risk of tumor formation. These properties of stem cells are considered a major concern over the efficacy of cell therapy. The translational/preclinical study of stem cells is essential but only at the beginning stages. What types of heart disease are indicated for stem cell therapy, what type of stem cell, what type of animal model, how do we deliver stem cells, and how do we improve heart function? These may be the key issues that the settlement of which would facilitate the transition of stem cell research from bench to bedside. In this review article, we discuss state-of-the-art technology in stem cell therapies for cardiovascular diseases.
Animals ; Cardiovascular Diseases ; Heart ; Heart Diseases ; Models, Animal ; Regenerative Medicine ; Stem Cell Research ; Stem Cells ; Tissue Therapy ; Translational Medical Research

Radiation effect on mammals, especially on hematologic changes, has been studied since discovery of x-ay. Various experimental animals were tried for radiobiological studies. 72 hybrid mice with conventional ffaction (5X/week), large abdominal field (2 x3cm, from symphysis pubic to xyphoid process) were used. Body weight was declined gradually by increasing irradiation doses, nadir was about 29.7% in male ; 30.4% in female at 6000 rad irradiation group. Hemoglobin value was nearly normal throughout entire treatment. Significant dropping of WBC count was noted to 40-0% of pretreatment values by only 1000 rad irradiation. Change of differential count was interesting; lymphocyte proportion showed gradual reduction, instead of gradual increasing of segmented neutrophil. Those proportion were reversed after 6000 rad irradiation. Urinary protein tests showed + - +++, showing no correlation with dosage. Application. of our study in clinical combination therapy (radiation + chemotherapy) was discussed.
Animals ; Body Weight* ; Female ; Humans ; Lymphocytes ; Male ; Mammals ; Mice* ; Neutrophils ; Radiation Effects*

Various studies have documented a variability of hyoid bone position in relation to changed mandibular position or head position. The aim of this study was to evaluate the hyoid bone position and inclination on the lateral cephalometric radoigraphs of two group of patients exhibiting Class I normal occlusion and Class III maloccluslon, so to verify the relatlonships between hyoid bone position, pharyngeal airway and relative mandibular position In the class I group, there were 16 femailes, while the Class III group consisted of males and females. The results were as follows 1. By the length of A-Aph, N-APH, and GoP-PPH, the hyoid of Class IIIgroup was more anteriorly and inferiorly positioned than Class I group 2. On the analysis of soft tissue airway, the measurement(PNS-ad) of Class III group were smaller than Class I group 3. In the comparison of the variances betwwen male and female, hyoid bone was inferiority positioned and showed sinificantly more lager pharyngetal with of haled tissue in the Class I male and In the Class III male, same tendancy about hyoid position and pharyngeal wldth was seen and more anteriorly positioned 4. There was no statiscally significances between pharyngeal airway measurements and relative mandidular position, but statistical significance between wits appraisal and hyold bone position was seen. 5. The S-N-Pog which shows relative mandibular protrusion inverse ratio in the in the analysis with A-APH , N-APH and Facial ratio with LAH-Mp also showed Inverse ratio.
Female ; Head ; Humans ; Hyoid Bone* ; Male

Substance P is one of the neuropeptide which presents highly in tension site of periodontal ligament during the orthodontic tooth movement. It has been also known as one of the neuropeptides which cause neurogenic inflammation in various tissues and organs. However, there is no report about the effect of substance P on major extracellular matrix protein, collagen production. The purpose of this study was to evaluate the collagen production by substance P in human periodontal ligament cell. The collagenase-digestion method was used to evaluate collagen production and also used Northern blot hybridization for the evaluation of collagen mRNA level. This study also included in terms of prostanglandins and gelatinase production with respect to collagen production. For the collagen degradation, zymography was used to estimate denatured collagen degradation. Dose-dependent effect of substance P on noncollagen protein, collagen, and percent collagen was that substance P increased noncollagen protein synthesis, but decreased collagen sytnsis, So the percent collagen, which determined by relative collagen production against total protein production, was decreased from 7% to 3.6%. This inhibitory effect of substance P on collagen production was disappeared when cells were treated concomitantly with indomethacin. It means that substance P-induced inhibitory effect on collagen production was due at least in part to the production of prostaglandins. To evaluate whether substance P-induced inhibitory effect on collagen production is correspond to the steady-state levels of procollagen mRNA, Northern blot hybridization was performed and it showed that substance P has no effect on the steady-state level of alpha1(I) procollagen mRNA. It means that the inhibitory effect of substance P on collagen production was due to the change of a certain mechanism after posttranscription. In this context, gelatinase production by substance P in periodontal ligament cells was evaluated by zymography. Zyrmogram showed that substance P has no effect on gelatinase production in periodontal ligament cells. To explore whether substance P-induced inhibitory effect on collagen production is selective in periodontal ligament cells or not, MC3T3-E1 cells which originated from mouse calvaria was used. It showed that substance P has no effect on collagen production in MC3T3-E1 cells. Taken together, substance P inhibits collagen production in human periodontal ligament cells. This effect was not due to the change of the steady-state level of procollagen mRNA and gelatinase production, but due at least in part to the change of prostaglandins production.
Animals ; Blotting, Northern ; Collagen* ; Extracellular Matrix ; Gelatinases ; Humans* ; Indomethacin ; Mice ; Neurogenic Inflammation ; Neuropeptides ; Periodontal Ligament* ; Procollagen ; Prostaglandins ; RNA, Messenger ; Skull ; Substance P* ; Tooth Movement