BACKGROUND: In epidermolysis bullosa acquisita, it has been recognized that there exists heterogeneity in the clinical and serologic/immunopathologic features. OBJECTIVE: We examined patients with epidermolysis bullosa acquisita to see if there were any associated clinical and serological features which may predict disease activity or prognosis in the disease. METHODS: Clinical and some serologic features were compared. between 2 groups of patients with epidermolysis bullosa acquisita; one with complete remission of the symptoms and signs of the disease for more than 2 years and the other group with persistent disease activities of longer than 5 years.
Epidermolysis Bullosa Acquisita* ; Epidermolysis Bullosa* ; Humans ; Population Characteristics ; Prognosis

No abstract available.
Intracranial Aneurysm*

No abstract available.
Humans ; Pneumonectomy* ; Respiratory Function Tests*

No abstract available.
Arthroplasty, Replacement, Hip* ; Humans ; Passive Cutaneous Anaphylaxis*

Idiopathic ureteropelvic junction stricture is not an uncommon disorder with resultant hydronephrosis of affecting kidney, and most frequently encountered in infant and children. Multiple causes of stricture have been identified. Abnormal organization of smooth muscle bundles at the ureteropelvic junction has been reported, and electron microscopy has demonstrated excessive collagen deposition within the intramural stroma. However, the exact cause of obstruction of UPJ stricture is uncertain. We reviewed 23 cases with idiopathic hydronephrosis underwent dismembered pyeloplasty. Examination of strictured segment with light the normal interwoven pattern, were arranged into an abundant outer circular and an inner longitudinal layer in 21 of 23 cases. But muscle thickness was not changed, and collagen was normal in both amount and arrangement. This results suggested that the abnormal muscle arrangement at the ureteropelvic junction might be the cause of the idiopathic stricture.
Child ; Collagen ; Constriction, Pathologic* ; Humans ; Hydronephrosis ; Infant ; Kidney ; Microscopy, Electron ; Muscle, Smooth

No abstract available.
Gonadotropin-Releasing Hormone* ; Gonadotropins*

Through the clinicopathologic study of pathergy test sites of 16 patients with Behrets disease in the active or inactive stage, the following results were obtained; 1. In the active stage, six of 16 patients (37.5%) showed positive reactions in clinical pathergy tests, which are much higher than that in the inactive stage when only one patient showed a positive reaction. The severity of the ciniral pathergy reaction was directly related to the activity of the disease. 2. The characteristic histopathologic finding in the active stag was a dermal inflammatory cellular infiltration composed mainly of polymorphonuclear lukocytes and of lymphomononuclear cells accompanied by leukoctocylasia. Two of 16 patients showed true leukocytoclastic vasculitis. 3. Although the type of disease and the reactivity of the clinical pathergy test were related in terms of the severity of the histopathologic findings, there were some notible histopathologic changes even in the cases with negative clinical pathergy reactions. We concluded that the histopathologic findings of the pathergy test sites were more reliable for the diagnosis of Behcet's disease than the clinical findinigs.
Diagnosis ; Humans ; Vasculitis

No abstract available.
Prognosis* ; Stomach Neoplasms*

For parthenogenetic activation as a model system of nuclear transfer, microinjection and electroporation as activation treatments in bovine metaphase II oocytes were administered to each of three groups as follows: control group (treatments with Ca2+, Mg2+ -free PBS+100 micro M EGTA), IP3 group (control+25 micro M IP3) and IP3+ ryanodine group (control+25 micro M IP3+10 mM ryanodine). In experiments using microinjection, no significant differences were observed between any of the developmental stages of the electroporation experiment. For electroporation, cleavage rates were significantly higher in the IP3+ryanodine group than in the IP3 or control group (85.6% vs 73.7% or 67.6%, respectively). In the subsequent stages of embryonic development, such as morula and blastocyst formation, the IP3 and ryanodine group exhibited significantly higher rates of morula fomation than the IP3 or control groups (40.6% vs 24.2% or 16.7%, respectively). Similarly, the rate of blastocyst formation in the IP3+ryanodine group was significantly higher than the control group (16.3% vs 6.9%) but did not differ significantly from the IP3 group (16.3% vs 9.5%). In nuclear transfer, activation was performed at 30 hpm by microinjection and elecroporation with 25 micro M IP3+ 10 mM ryanodine followed by 6-DMAP treatment. No significant differences were observed at any stage of embryonic development and none of the embryos activated by electroporation reached either the morula or blastocyst stage. However, 3.8% and 1.9% of embryos activated by microinjection sucessfully developed to the morula and blastocyst stages, respectively. In conclusion, activation treatments using IP3 and ryanodine are able to support the development of bovine parthenogenetic and reconstructed embryos.
Adenine/administration & dosage/*analogs & derivatives/pharmacology ; Animals ; Cattle/*embryology/physiology ; Cell Fusion ; Electroporation/veterinary ; Embryonic and Fetal Development/*drug effects ; Enzyme Inhibitors/administration & dosage/pharmacology ; Female ; Inositol 1,4,5-Trisphosphate/administration & dosage/*pharmacology ; Microinjections/veterinary ; Nuclear Transfer Techniques ; Oocytes/drug effects/growth & development ; Parthenogenesis/*drug effects ; Protein Kinase Inhibitors ; Ryanodine/administration & dosage/*pharmacology ; Skin/cytology

This study was aimed to comprehend the pattern of renal response in bicarbonate reabsorption during various alterations in acid-base equilibrium in twelve dogs. In metabolic acidosis induced by infusion of hydrochloric acid, as the plasma bicarbonate and filtered load of bicarbonate decreased eminently, urinary excretion of bicarbonate was found to be negligible. which was attributable to almost complete reabsorption via the hydration of CO2. In metabolic alkalosis induced by infusion of sodium bicarbonate, along with an increment of plasma concentration of bicarbonate, all filtered bicarbonate was reabsorbed, with negligible amount of excretion until the plasma level attains the renal bicarbonate threshold. During the respiratory acidosis and alkalosis with higher or lower arterial Pco2, the bicarbonate reabsorption varied linearly with plasma Pco2. The linear relationship indicated that the hydration of CO, was an important source of hydrogen ion for the reabsorption of bicarbonate. In this regards, however, in metabolic alkalosis the renal bicarbonate threshold was found to be much higher than that of respiratory acidosis. The characteristics of renal bicarbonate reabsorption, during the mixed acid-base disturbances of metabolic and respiratory origin with no considerable alteration of plasma pH, induced by hydrochloric acid infusion with hyperventilation or sodium bicarbonate infusion with CO2 inhalation, were quite similar to those in metabolic acidosis and alkalosis caused by simple hydrochloric acid or sodium bicarbonate infusion, respectively.
Acid-Base Equilibrium ; Acidosis ; Acidosis, Respiratory ; Alkalosis ; Animals ; Dogs* ; Hydrochloric Acid ; Hydrogen-Ion Concentration* ; Hyperventilation ; Inhalation ; Plasma* ; Protons ; Sodium Bicarbonate