It is well known that early diagnosis and early treatment is very important for the patient with congenital dislocation of the hip joint to have favorable function in the whole life. The goal of treatment is to replace the hip restored in containment with anatomical position. There have been various treatments in both conservative and surgical methods. In the past, conservative treatment has been prevalled, and since Salter has advocated innominate osteotomy, this surgical method could be successively replaced the treatment of congenital dislocation of the hip in the older age group. We have experienced 40 congenital dislocation of the hips out of 35 patients at the Department of Orthopaedic Surgery in National Medical Center. Clinical analysis has been performed, with average 3 years and 9 months follow-up study and the resuits are as follows. 1. Majority of the case was treated primarily at age between 12-24 months. 2. The preponderence of girl to boys was 33:2. 3. The affection ratio of left to right side was nearly equal as 16:14. Five out of 35 cases were involved at both sides. 4. The chief complaints were almost limping and limb shortening. 5. In 40 hips from 35 patients, 12 hips were treated by closed reduction, 3 hips by open reduction and 18 hips by Salters innominate osteotomy in the age group under 7 years old. By Seddon's classification, we obtained 11 excellent and good results out of 12 cases treated by closed reduction, 2 out of 3 hips by open reduction and 15 out of 18 hips by Saiters innominate osteotomy. 6. We performed femoral derotation osteotomy in 2 cases, 9 and 11-year-old patients. Steels operation with femoral shortening in 9-year-old girl and bilateral THR on 2 hips in 44-year-old patient. Result of derotation osteotomy belonged to clinical failure and THR belonged to excellent group by Seddons classification. 7. We experienced one case of avascular necrosis transiently, but finally healed delaying weight bearing.
Adult ; Child ; Classification ; Containment of Biohazards ; Dislocations ; Early Diagnosis ; Extremities ; Female ; Follow-Up Studies ; Hip Joint ; Hip ; Humans ; Methods ; Necrosis ; Osteotomy ; Steel ; Weight-Bearing

The effectiveness of alternate flexion and extension splint(splint group) in restoring the range of motion(ROM) following total knee arthroplasty(TKA) was evaluated, comparing with the continuous passive motion(CPM) group. One hundred and twenty knees of 87 patients(21–80 years old:12 males & 75 females) who were followed for 2.7 years(ranging from 1.2 to 5.3 years) were involved in this study. The ROM of following groups were compared each other and the results were analyzed statistically with Wilcoxon rank sum test and the differences between each prosthesis were compared with Kruskal-Wallis test. 1) Splint(51 knees, 42.5%) v.s CPM group(69 knees, 57.5%) 2) RA(43 knees, 35.8%) v.s. OA(77 knees, 64.2%) 3) Various types of prosthesis(PSCK, PCA, Tricon-M, M/G, Oxford Knee, PFC) The results were as follws:1. The ROM of splint group(average 132.2°, ranging from 85–145°) was significantly greater than that of CPM group(average 110.5°, ranging from 50–140°)(p<0.01). 2. The ROM of osteoarthritic knees(average 122.2°) was slightly greater than that of rheumatoid knees(average 115.8°) without statistical significance(p) 0.05). 3. There was statistically significant difference between ROM of the various types of implant(p < 0.01). However this difference seemed due to different methods of rehabilitation rather than different types of prosthesis. From this result it is suggested that the alternate flexion and extension splint following TKA is a useful method in restoring ROM, comparing to gradual ROM exercise with CPM.
Arthroplasty, Replacement, Knee ; Humans ; Knee ; Male ; Methods ; Passive Cutaneous Anaphylaxis ; Prostheses and Implants ; Rehabilitation ; Splints

Extraosseous tuberculosis of the extremities is relatively rare even in the wide spread incidence of bone and joint tuberculosis. And few reports about extraosseous tuberculosis of the extremities have been published in the literatures. Eight cases of the extraosseous tuberculosis of the extremities were experienced at the Department of Orthopaedic Surgery, National Medical Center, from 1975 to Sep. 1979. Five out of 8 extraosseous tuberculosis were tenosynovitis and the others were bursitis in location. All cases were surgically excised and combined with antituberculous chemotherapy, and primarily cured.
Bursitis ; Drug Therapy ; Extremities ; Incidence ; Tenosynovitis ; Tuberculosis ; Tuberculosis, Osteoarticular

No abstract available.
Hepatitis* ; Immunoglobulins* ; Plasmapheresis*

The results of allelic frequency of polymorphic loci in the short arm of chromosome 3 in normal Koreans are shown using a polymerase chain reaction (PCR) based restriction fragment length polymorphism analysis on blood samples of 20 males and 20 females without any tumor or hereditary diseases. The allelic frequency of two loci, D3S2 (MspI) and D3F15S2 (Hind III ) was quite different between renal cell carcinoma in Koreans and Caucasians, but THRB (MspI) locus was similar This suggests the importance of determining specific loci to Koreans. The study of tumor suppressor gene on these genetic loci due to D3S2 (MspI) and THRB (EcoRI) loci showed high constitutional heterozygosity, contrast to D3F15S2 (Hind III), THRB (BamHI) and THRB (MspI) loci where low constitutional heterozygosity were seen. Therefore, the study of tumor suppressor gene should be directed to investigate. This study showed the allelic distribution of Koreans differing from Caucasians and the genetic locus with the high frequency of heterozygosity among the polymorphic loci comparable to Koreans were due to the difference of heterozygosity frequency according to genetic loci. Therefore, the author thinks that the need for the detection of specific genetic loci for Koreans to study the correlation among many cases for classifying the tumorigenesis and active research should be initiated to find other genetic locus related to multi-step tumorigenesis.
Arm* ; Carcinogenesis ; Carcinoma, Renal Cell ; Chromosomes, Human, Pair 3* ; Female ; Genes, Tumor Suppressor ; Genetic Diseases, Inborn ; Genetic Loci ; Humans ; Male ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length

No abstract available.
Osteomalacia*

Listeria monocytogenes is a gram-positive rod which can be isolated from soil, vegetation, and many animal reservoirs. Human disease due to Listeria monocytogenes is uncommon but occurs most frequently in the neonatal period, during pregnancy and in elderly or immuno-suppressed patients. Listeriosis in pregnant women may cause spontaneous abortion, fetal distress, preterm labor, fetal death, or neonatal septicemia/meningitis. Maternal infection alone may occur without infection of the infant, especially at the end of pregnancy. One case of septicemia with Listeria monocytogenes in pregnant women at the 35th weeks of pregnancy with fetal distress is presented.
Abortion, Spontaneous ; Aged ; Animals ; Female ; Fetal Death ; Fetal Distress* ; Humans ; Infant ; Listeria monocytogenes ; Listeriosis ; Obstetric Labor, Premature ; Pregnancy ; Pregnancy Trimester, Third* ; Pregnant Women ; Sepsis ; Soil

Parathyroid hormone(PTH), a major bone hormone, inhihits DNA and collagen syntheses in osteohlast-like cells in vitro, but increase the proliferation of osteoblast in vivo as secn in hyperparathyroidism. On the other hand, insulin is known to increase DNA and collagen syntheses and modify the effects of PTH in osteoblast-like cells. We have examined the effects of PTH and insulin in rat osteosarcoma UMR-l06-01 cells and whether PTH plays a role in the insulin-mediated bone formation. When 1 nM PTH and 10 nM insulin were administered to VMR-l06-01 ceils, the rates of DNA synthesis were 124% and 136% of the untreated control, respectively. When the two hormones were administered serially by exposing to 1 nM PTH for 7 days followed by 10 nM insulin lor 24h, the largest increase was observed. The protein synthesis was also increased remarkahly when the two hormones were aclministered serially: the[3H]-leucine incorporation rates, compared to the control group, were 75% and l62% with PTH ancl insulin administration, respectively, but the rate was 297% with the serial administration of the two. The collaeen synthesis, as measured by the (3H)-proline incorporation rates were 60% and l64% with PTH and insulin administration, respectively, but 351% with serial administration, again showing a dramatic effect. These results showed that 1 nM PTH decreased DNA and collagen syntheses in UMR-l06-01 cells after both a 24h and a more prolonged exposure. Similar exposures to insulin tended to increase the syntheses. The comhination of PTH and insulin tended to increase the syntheses. hut not beyond the effect of insulin alone. However, the sequential administration of PTH and insulin markedly increases ihose rales relative to the simultaneous adminstration of these two hormones. Thus, it is possihle that sequential stimulation of PTH and insulin in hone matrix exerts an synergistic effect on hone formation in vivo.
Animals ; Collagen ; DNA ; Hand ; Hyperparathyroidism ; Insulin* ; Osteoblasts ; Osteogenesis ; Osteosarcoma* ; Parathyroid Hormone* ; Rats ; Respiratory Sounds

PURPOSE: To investigate the effects of varying the time of Mitomycin-C (MMC) subconjunctival injection before, during and after operation. METHOD: We divided rabbits into 3 groups according to injection time. Subconjunctival injections of 0.01% MMC 0.05 ml were given to the preoperative group at 6, 12 and 24 hours before operation, and to the postoperative group at 6, 12 and 24 hours after operation. The control group was given the injections during operation. Bleb formation and histologic analyses were studied for 4 weeks after operation. RESULTS For gross findings, the blebs of the preoperative and control groups were seen on the fourth day and completely formed at one week after operation, and were larger than those of the postoperative group. On the other hand, the blebs of the postoperative group were seen to have poor formation, displaying hypervascularity on the fourth day and disappearing one week after operation. For histologic findings, the proliferation of collagen fibers and the undifferentiation of fibroblasts observed in the preoperative and control groups were almost identical. But, the proliferation of collagen fibers and well-differentiated fibroblasts were seen to increase in the postoperative group, so aqueous flow was obstructed at week 3. CONCLUSIONS: Subconjunctival injections within 24 hours before or during glaucoma filtration surgery were better for bleb formation and preservation than those administerd after surgery.
Blister ; Collagen ; Fibroblasts ; Filtering Surgery* ; Filtration* ; Glaucoma* ; Hand ; Mitomycin* ; Rabbits*

PURPOSE: To investigate the effects of varying the time of Mitomycin-C (MMC) subconjunctival injection before, during and after operation. METHOD: We divided rabbits into 3 groups according to injection time. Subconjunctival injections of 0.01% MMC 0.05 ml were given to the preoperative group at 6, 12 and 24 hours before operation, and to the postoperative group at 6, 12 and 24 hours after operation. The control group was given the injections during operation. Bleb formation and histologic analyses were studied for 4 weeks after operation. RESULTS For gross findings, the blebs of the preoperative and control groups were seen on the fourth day and completely formed at one week after operation, and were larger than those of the postoperative group. On the other hand, the blebs of the postoperative group were seen to have poor formation, displaying hypervascularity on the fourth day and disappearing one week after operation. For histologic findings, the proliferation of collagen fibers and the undifferentiation of fibroblasts observed in the preoperative and control groups were almost identical. But, the proliferation of collagen fibers and well-differentiated fibroblasts were seen to increase in the postoperative group, so aqueous flow was obstructed at week 3. CONCLUSIONS: Subconjunctival injections within 24 hours before or during glaucoma filtration surgery were better for bleb formation and preservation than those administerd after surgery.
Blister ; Collagen ; Fibroblasts ; Filtering Surgery* ; Filtration* ; Glaucoma* ; Hand ; Mitomycin* ; Rabbits*