This study was designed to evaluate the therapeutic effect of H2 and H2 antihistaminics on dermographism. Twenty four patients with dermographism were allocated on a random to one of the following 3 treatment regimens. A) chlorphenirarnine and cimetidine (H1+H1) B) chlorpheniramine alone (H>) C) cimetidine alone (H) The patients cutaneous response to the dermographometer was assessed at weekly intervals for four weeks. The results were as follows: 1. The combinded treatment with chlorpheniramine and cimetidine was significantly more effective in inhibiting wheal and flare than the cimetidine alone (wheal p<0.01, flare p<0.02). 2. Following comparisions were not statistically significant: chlorpheniramine+ cimetidine vs chlorpheniramine (p>0. 05), chlorpbeniramine alone vs cimetidine alone(p>0.05). 3. Main side effects were drowsiness (3 cases) and mild gastric disturbance (2 cases) on hlorpheniramine alone.
Chlorpheniramine ; Cimetidine ; Histamine H2 Antagonists* ; Humans ; Sleep Stages

No abstract available.

No abstract available.
Forehead*

No abstract available.
Forehead*

A 47-years old korean farmer was first visited our department in Nov. 19, 1969 with complaining of proptosis, lateral deviation of eye ball and visual disturbance of 5 years duration. The onset was insidious. Past and family history were not contributory. On examination, right eye was within normal limit. The left eye was markedly proptotic (aoout 10 mm of exophthalmos) and displaced out-and downward. The vision of the left eye was L.P.. The ocular motility was slightly limited to all direction. Pupil was normal size and poorly reacted to light. Funduscopic examination revealed pale and slightly excavated in disc. X-ray of chest, skull and optic foramen showed normal. On Nov. 22. 1969 author adopted the Kronlein's approach and exceed well capsulated oval mass situated within the muscle cone, which attached to optic nerve. The tumor mass showed soft, dark reddish color of surface measuring 2 X 2 X 15 cm and its cut surface disclosed sponge like appearance. Histologically the section from tumorous mass showed many large cavernous spaces separated by connective tissue. The newly formed cavernouus space was for the most part lined by a single layer of endothelium and in part contained with red cell. We confirmed adiagnosis of cavernous hemangioma of the orbit in pathologic study. It was suggested that early loss of vision was caused by optic atrophy due to direct pressure of optic nerve by the tumor mass. A review of literature of recent years related to cavernous hemangioma of orbit was added.
Connective Tissue ; Endothelium ; Exophthalmos ; Hemangioma, Cavernous* ; Humans ; Middle Aged ; Optic Atrophy ; Optic Nerve ; Orbit* ; Porifera ; Pupil ; Skull ; Thorax

Syringocystadenoma papilliferum is a benign skin appendage tumor. The typical lesion occurs most frequently on the scalp or face. The lesion consists most commonly of flesh nodule or plaque that may have a papillary, hyperkeratotic surface. A number of hypotheses as to the origin of this disorder have been put forward by different authors, but its origin still remains obscure. We have recently experienced a case of 31 years old female who had a flesh colored, lobulated tumor mass of 3 * 10cm in the left flank area. The histopathological examination revealed rather typical findings of syringocystadenoma papilliferum.
Adult ; Female ; Humans ; Scalp ; Skin

A 12 years old Korean girl was seen on 10 Oct. 1969 with chief complaint of a large fleshy mass extruded out of the orbit associated with ocular pain of mild degree for several months. Her parents were first noticed that the girl's right eye had a peculiar reflex from the pupillary zone in 2 years of her age. She was advised by a local clinician to correct surgicaIly someday later in her childhood. At the age of four, the pupillary margin of the affected eye had become distorted and they became aware of the eyeball was a little protruded and the grade of protrusion had slowly advanced as she had grown up. About a year ago the patient suffered from sudden attack of severe ocular pain associated with vomiting. Having experienced the recurrences of similar attack several times, she at last in Sept. 1969 met a spontaneous outburst of the extruded mass from which the purulent and bloody contents flowed out. It was to be regretted that the history could not reveal when and how the globe had been disorganized as completely as such that no trace of configuration of the anterior segment could be recognized. Familial and past history were not contributory except measle with good recovery at 2 years of age. On examination, the left eye had good vision and no structural changes, wherease the right side showed a marked extrurusion of fleshy mass out of the lid aperture. The mass had a relatively smooth and congested coverage of the conjunctiva except it had the fistulae through which a small amount of the purulent and bloody discharge flowed out under the digital pressure. It was felt somewhat elastic and movable with a broad base into the orbit. On its surface no trace of the cornea or the other global structures could be found. Physical examinations of the whole body including regional lymphnodes revealed normal X-ray Was of chest, skuIl and optic foramina were normal. On 14 Oct. 1969 under general anesthesia an orbital exentration was undertaken because of either probability of a malignant tumor or a long standing intraocular inflammation. In the way of procedure necrotic contents bursted out by mechanical pressure through the weak point, i.e. the fistulae, and correspondingly the tumorous mass became softened. Confirming no hard mass palpable into the orbit, the operating procedure shifted to do partial exentration. The extirpated mass was subjected to the histological study. Grossly, the dissected area revealed that it contained a well preserved structure of sclera on the one side and completly necrotised material on the other, but it did not contain any remnants of the ordinary global structures such as cornea, iris, lens, vitreous and choroid. The hollowed space partially surrounded by scleral structure was filled with the dark and gelatinous materia. The mass was as a whole rather soft Histological examination showed numerous gland like proliferations composed of poorly differentiated and unpigment columner cells having relatively large nuclei, some of which showed a mitotic figure. These were conceivable to be of an embryonic retina. The lumina of the gland like structures with the various sizes and shapes were filled with a pink staining coagulum and an extremly delicate and regularly arranged fibrillar structure. In some parts the tumor consisted of solid cellular conglomeration with rosett like arrangement and in the other necrotic masses containing tumor cells in all stages of degeneration. For the most part and the surrounding structure of the tumor cells, the picture showed likely to be a diffuse inflammation with an infiltration of polymorphonuclear cells, partly vessels being mostly of capillaries and recent hemorrhages, but the cartilage was not found.
Anesthesia, General ; Capillaries ; Cartilage ; Child ; Choroid ; Conjunctiva ; Cornea ; Estrogens, Conjugated (USP) ; Female ; Fistula ; Gelatin ; Hemorrhage ; Humans ; Inflammation ; Iris ; Orbit ; Parents ; Physical Examination ; Recurrence ; Reflex ; Retina ; Sclera ; Thorax ; Vomiting

The authors reviewed the clinical findings and treatment results of 12 cases of spinal meningeal cysts which were detected in MRI of low back patients. In these lesions, large cysts without CSF communication can compressed the nerve roots within spinal canal and it is difficult to confirm the cause of symptom whether it is originated from cysts or from associated spinal disorders. The terms and classifications of spinal meningeal cysts were very confusing. Among 12 cases, we excised 3 cases of large cysts with gluteal and perianal pains that were caused by compressed sacral nerve roots. All three cases were type 2 cyst (classified by Nabors) and located in sacral canal. In one case associated with isthmic spondylolisthesis, posterolateral fusion and pedicle screw fixations were combined with cyst excision. In other two cases, there were not any spinal pathologic findings that compressed sacral nerve roots except mild degenerative changes and intervertebral disc herniation in lower lumbar and sacral levels All 3 excised cases showed good prognosis in more than one year follow up. The other cases were treated conservatively for the associated spinal disorders.
Classification ; Follow-Up Studies ; Humans ; Intervertebral Disc ; Magnetic Resonance Imaging ; Prognosis ; Radiculopathy ; Spinal Canal ; Spondylolisthesis

No abstract available.

Folliculosebaceous cystic hamartoma is a rare, benign condition. The histological criteria of folliculosebaceous cystic hamartoma have been well established by Kimura et al. We report two cases of folliculosebaceous cystic hamartoma which showed typical histological findings. As far as we know, it has not yet been reported in Korean dermatological literature. The first case is a 23-year-old man who had a pedunculated nodule on the scalp. The second one is a 46-year-old man who had a bean sized pedunculated nodule on the left cheek.
Cheek ; Hamartoma ; Humans ; Middle Aged ; Scalp ; Young Adult