A 25 year old woman who presented a severely pruritic eruption of 1 month's duration on the lateral surface of her left shin is described. The histopathologic examination revealed dense cellularity consisting of hemosiderin laden macrophages and multinucleated giant cells of both the Touton type-like and the foreign body type, associated with many blood vessels, suggesting hemosiderotic histiocytoma. Given the additional finding of foamy cytoplasm, this case could be called xanthomatized hemosiderotic histiocytoma
Blood Vessels ; Cytoplasm ; Female ; Foreign Bodies ; Giant Cells ; Hemosiderin ; Histiocytoma* ; Histiocytoma, Benign Fibrous ; Humans ; Macrophages

BACKGROUND: The proliferating cell nuclear antigen(PCNA), one of the markers for proliferating cells, has been detected in solid human neoplasms. Psoriasis is a benign hyperproliferative disorder of the skin. OBJECTIVE: This study has been made to investigate if PCNA can be detected in the psoriatic epidermis. METHODS: Specimens from 10 patients with psoriasis were stained for PCNA using the one hour immunoalkaline phosphatase technique. RESULTS: The psoriatic epidermis showed positive nuclear staining in 20%-61% (mean, 45.7%) of keratinocytes. CONCLUSION: PCNA seems to be involved in the mechanism of increased epidermal cell proliferation in psoriatic lesions.
Cell Proliferation ; Epidermis* ; Humans ; Keratinocytes ; Proliferating Cell Nuclear Antigen* ; Psoriasis ; Skin

No abstract available.
Aneurysm* ; Carotid Artery, Internal* ; Epistaxis*

We herein described a female newborn baby who, on the day of birth, exhibited widespread discrete reddish purple colored, round and slightly hyperkeratotic papules measuring about 4 mm in size, the biopsy specimen of which showed the histologic findings of histiocytosis X. The skin lesions resolved spontaneously within a week. The following diseases were discussed as possible diagnoses; histiocytosis X, generalized eruptive histiocytoma, juvenile xanthogranuloma, congenital self-healing reticulohistiocytosis and xanthoma disseminaturn. Since the current case didn't fit well any of them, we proposed a new descriptive term for this : Histiocytoma Papulosa Benigna Congenita.
Biopsy ; Diagnosis ; Female ; Histiocytoma* ; Histiocytosis, Langerhans-Cell ; Humans ; Infant, Newborn ; Parturition ; Skin ; Xanthogranuloma, Juvenile ; Xanthomatosis

A genetic and clinical study was done on 20 index cases and their families who had lived in Chonnam province, visited Chonnam University Hospital from 1968 through 1983, and were diagnosed as peudoxanthoma elasticum based on clinical and histopathological findings. In Chonnam province, pseudoxanthoma elsticum occurred in a incidence of more thar, one per 125,000. The male to female ratio was 1: 1.25 (8: 10) with only the cases of familial occurrence although the sex ratio was 1: l. 85 (7: 13) among 20 index cases. Among 8 index cases showing familial occurrence, 6 showed autosomal recessive inheritance with 5 Type 1 and 1 Type 2 whereas 2 showed the autosomal dominant inheritance with both of thern Type 2 (Pope), pointing out the genetic heterogeneity in pseudoxanthorna elsticum. The age of patients ranged from 12 to 42 years old at the time of their first visit to our hospital, but the age that the patients first recognized the disease onset ranged from 9 to 22 years old. The duration of t he disease was also variable ranging from 11/2 to 30 years. The angioid streaks were observed in 38g of the cases whose disease duration ranged from 11/2 to 20 years. The sites of skin lesions were the neck, axillae and groin in the order of frequency.
Adult ; Angioid Streaks ; Axilla ; Classification ; Female ; Genetic Heterogeneity ; Groin ; Humans ; Incidence ; Jeollanam-do ; Male ; Neck ; Pseudoxanthoma Elasticum* ; Sex Ratio ; Skin ; Wills ; Young Adult

BACKGROUND: There have been many articles about the chemical peeling of Caucasian skin, but there have been few reports about postpeel results among Oriental people. OBJECTIVE: The purpose of this report is to evaluate the effects of chemical skin peeling on the facial skin of Korean individuals over a two year period and compare these results with those relating to Caucasian skin. METHOD: Using 15 to 50 per cent trichloroacetic acid (TCA), we have peeled 121 pationts with fine wrinking, irregular pigmentary deposits, superficial acne scars, and melasma, and observed them for 2 years. RESULTS: In contrast to melasma, fine wrinkling and irregular pigmentary deposits responded efficiently to TCA peeling. About 70 per cent of the patients showed satisfactory clinical results one year after treatment while 50 per cent of them did so two years after treatment. Postpeel hyperpigmentation and erythema lasted for 3.15 months and 6 weeks, respectively, on average. CONCLUSION: If we select a fair-skinned woman in her fifties, even though she is an Oriental. TCA peeling can treat the fine wrinkling or irregular pigmentary deposits to a satisfactory degree.
Acne Vulgaris ; Cicatrix ; Erythema ; Female ; Humans ; Hyperpigmentation ; Melanosis ; Methods ; Skin ; Trichloroacetic Acid*

It is well known that leprosy bacilli have a special affinity for peripheral nerves, especially Schwann cells but also including perineurial cells and endothelial cells of endoneurial blood vessels. The Schwann cells, after invasion by and saturation with multiplied M. leprae, are destroyed and segmental demyelination and Wallerian degeneration follow. This condition, then is known to be the main neural pathogenosis in early leprosy. It is rarely observed that the progressive paralysis occurs in arrested leprosy patients under adequate treatment. Therefore, the authors performed a histopathologic study of 80 peripheral nerves obtained from the autopsies of 10 old lepromatous leprosy patients including two active cases whose disease durations ranged from 6 to 49 years. The authors arbitrarily divided all the histopathologic findings into 5 grades on the basis of 1) difference in pathological findings in relation to disease duration and bacterial index, and 2) the coexistence of various lesions within the same nerve trunk. As the disease progresses the destroyed nerve fibers are replaced by fibrous and granulation tissue while the perineurial reaction increases. The cellular reaction is minimal in the low grades. There is a slightly early increased vasculature probably due to M. leprae and later a more pronounced increase with large vessels indicating the presence of the granulation process. There is minimum to moderate interfascicular reaction throughout every grade, ie. increased cellularity, vessel wall thickening and increased numbers of vessels with fibrosis. Acid-fast bacilli were demonstrated only in the active cases. The coexistence of different fascicular lesions within the same nerve trunk of peripheral nerve and of femoral nerves mear the spinal cord indicates the presence of some perineurial inhibitory effect which, while promoting the centripetal spread of, prevents the transfascicular spread of M. leprae for some time.
Autopsy ; Blood Vessels ; Demyelinating Diseases ; Endothelial Cells ; Femoral Nerve ; Fibrosis ; Granulation Tissue ; Humans ; Leprosy* ; Leprosy, Lepromatous ; Nerve Fibers ; Paralysis ; Peripheral Nerves* ; Schwann Cells ; Spinal Cord ; Wallerian Degeneration

Among the skeletal tuberculous spondylitis is high incidence and curable disease, if early diagnosis and treatment are possible. We reviewed clinical manifestations and radiologic analysis of 30 cases tuberculous spondylitis from May 1983 to Sept. 1986, at Yeungnam medical center, Yeungnam University. The results were follows: 1. The frequent involve sites were thoracolumbar vertebra. 2. The continuous lesion is 86.7% of the all cases. 3. The most common type was intervertebral type, and lytic and sclerotic lesion were same incidence. 4. Paravertebral abscess, kyphosis and disc space narrowing were demonstrated more than 80.0% of the cases. 5. Computed tomography was more accurate diagnostic method rather than conventional plain study to evaluation of extent of lesion, involvement of spinal canal and cord, and size and location of paravertebral abscess. And CT guided abscess drainage procedure was helpful to diagnosis and treatment. 6. Ultrasonography was helpful to differential diagnosis between paravertebral abscess and other solid mass, and useful to follow up study of paravertebral abscess after treatment.
Abscess ; Diagnosis ; Diagnosis, Differential ; Drainage ; Early Diagnosis ; Follow-Up Studies ; Incidence ; Kyphosis ; Methods ; Spinal Canal ; Spine ; Spondylitis* ; Ultrasonography

BACKGROUND: The purpose of this study was to identify predictive factors for preventive behaviors of falls in elderly inpatients. METHODS: Data on 200 elderly inpatients at one university hospital were collected. Descriptive analysis, independent t-test, analysis of variance, and stepwise multiple regression analysis were done to analyze the data. RESULTS: The high risk group, scoring higher than 5.0 in the degree of self-awareness of fall risk, scored low in knowledge about falls while subjects with activity limitations and not using hearing aids scored significantly high in the same area. Subjects with no training regarding falls and the high risk group scored low in fall efficacy while subjects with activity limitations and using hearing aids scored significantly high in the same area. The degree of self-awareness of fall risk, knowledge about falls, and fall efficacy were significant factors affecting fall prevention activities. CONCLUSIONS: These findings suggest that self-awareness of the risk of falls, knowledge about falls, and fall efficacy are significant factors in preventing falls. These factors should be considered when developing nursing assessment tools and intervention programs for elderly inpatients.
Accidental Falls ; Aged ; Hearing Aids ; Humans ; Inpatients ; Nursing Assessment

Zoophiilc dermatophytes are basically animal pathogens, but all can cause dermatophytoses in man. Accordingly animals with dermatophytes are an important source of human dermatophytoses, since zoophilic dermatophytes are frequently transmitted directly or indirectly from domestic or wild animals to man through the use of the se animal as pets, or through contact in rural araes. With the recent increased incidence of zoophilic dermatophytoses worldwide,it is consided to be an important public health problem in view of its epidemiologie aspect i.e. its simultaneous occurence in families or groups. To this time, Microsporum canis in cats has only been sporadically reported throughout the country in the late 1970s and very little is additionally known of the zoopbilic species in animal populations and reservoir or host animals in Korea. Therefore, the authors performed a mycological study by culturing hair and skin lesions of 100 dornestic and 64 zoo animals fortnightly for the purgose of isolating zoophilic derrnatophytes and thereby recognizing the reservoir animals. We also performed an experimental derrnatophyte inoculation in human, mice and rabbits by using Microsporum canis, Trichopyton mentagrophyte vagranulare and Microsporum gypseum isolated from animals and patients lesions from Jan. l980 through Jun. 1981, for the comparison of pathogenicity of these dermatophytes species on human and animals and also for the comparison of pathogenicity of strains isolated from patients lesions and animals and thereby considered different from each other. Microsporum canis was isolated from 11 cats. Trichophyton mentagrophyte var granulare from 3 cats, and Microsporum gypseum from 2 Korean racoon dogs.
Animals ; Animals, Wild ; Animals, Zoo ; Arthrodermataceae* ; Cats ; Dogs ; Hair ; Humans ; Incidence ; Korea ; Mice ; Microsporum ; Public Health ; Rabbits ; Skin ; Tinea ; Trichophyton ; Virulence*