1.A case of poorly differentiated malignant lymphoma in the early childhood.
Yong Ji RHO ; Kyu Suk LEE ; Joon Young SONG
Korean Journal of Dermatology 1992;30(3):422-427
A 19-month old male patient developed mutiple, firm, plum-colored, finger tip to chestnut sized nodules on the left cheek, right preauricular area, both elbow joints, and right wrist. On physical examination, a right cervical lymph node was palpable. Histology from one of the nodules revealed a diffuse infiltration of atypical, hyperchromatic, polymorphous lymphocytes in the dermis and subrutaneous fat. Bone marow aspiration, chest X-ray, ultrasonogram, and computerized tomogram were performed revealing bone marrow and lymph node involvement. The patient was treated with a POG @8617 schedule. Skin lesions markedly improved after one cycle regimen. We present a case of diffuse, ponrly differentiated, malignant lymphocytic lymphoma in the early childhood.
Appointments and Schedules
;
Bone Marrow
;
Cheek
;
Dermis
;
Elbow Joint
;
Fingers
;
Humans
;
Infant
;
Leukemia, Lymphocytic, Chronic, B-Cell
;
Lymph Nodes
;
Lymphocytes
;
Lymphoma*
;
Male
;
Physical Examination
;
Skin
;
Thorax
;
Ultrasonography
;
Wrist
;
Prunus domestica
2.Laminin B1 mRNA expression in squamous cell carcinoma of the skin.
Kyu Suk LEE ; Youn Ji RHO ; Joo Young SONG
Korean Journal of Dermatology 1993;31(2):157-162
BACKGROUND: Laminin, which is present in all basement membrane, is a multifunctional glycoprotein with diverse biological activities. Like fibronectin, it can influence cell adhesion, growth, morphology, differentiation, and migration as well as the assembly of the extracellular matrix. Laminin primarily affects cells of epithelial origin, and response varies depending on the cells. OBJECTIVE: Studies about the relationship of laminin and the pathogenesis or metastasis of squamous cell carcinoma(SCC). MEHTODS: In this study, we have examined the laminin B1 mRNA expression and localizing pattern of laminin in SCC, using Northern and slot-blot hybridization, in situ hybridization and immunoperoxidase stain. RESULTS: In Northern blot hybridization, 5.6Kb mRNA transcript was detected in control and SCC specimens. Slot-blot hybridization indicated theat amounts of laminin B1 mRNA expression in SCC was 677.0+/-268.5 densitometer absorbance unit, in control was 228.0+/-16.37 unit respectively. There is a 3-fold increase in SCC compared to control. In in situ hybridization, 35S-labeled laminin B1 cDNA-mRNA hybrid granules were detected along the basement membrane and adjacent cells of SCC. In immunoperoxidase stain, laminin has stained strongly and continuously along the basement membrane of the tumor nest in well differentiated SCC, and weakly and interrupted in poorly differentiated SCC. CONCLUSION: These results suggested that laminin might be related to the pathogenesisand metastasis of squamous cell carcinomas.
Basement Membrane
;
Blotting, Northern
;
Carcinoma, Squamous Cell*
;
Cell Adhesion
;
Extracellular Matrix
;
Fibronectins
;
Glycoproteins
;
In Situ Hybridization
;
Laminin*
;
Neoplasm Metastasis
;
RNA, Messenger*
;
Skin*
3.TGF-beta mRNA expression in cultured fibroblasts.
Yong Ji RHO ; Kyu Suk LEE ; Joon Young SONG
Korean Journal of Dermatology 1992;30(6):824-829
Transforming growth factor beta(TGF-p), initially identified in vlatelet extracts by virtue of its ability to confer anchorage of independent growth and a necplastic phenotype on mesenchymal cells, has subsequently been identified as a potent inh bit or of proliferation in most cells of epithelial origin. The family of TGF-p peptides is currenly onsisted of four subtypes (TGF-pl, p2, p3, p4). Tkiey are initially translated very larged are urssors of approximately 390 amino acids and produced by a wide variety of cell type. iricluding normal cells and tumor cells. TGF-ps promote deposition of extracellular matrix compcineits, facilitate remodeling events during embryonic development, and suppress immune ce 1 fimetion during the inflammatory process. Several nutaneous diseases are characterized typxcessive and progressive fibrosis of the dermis anil subcutaneous tissues. Prominent amon these disorders are progressive systemic sclerosi(PSS) and generalized morphea(GM), is well as the recently described syndrome of diffuse fasciitis eosinophilia(DF), also known; Shulmans syndrome. The hallmark of the pathologic alteration in these disorders is the excessive deposition of collagen and other connenctive iissues. Macromoleculse in the aerriis and/or the subcutaneous and fascial strutures often accompanied by variable degress of hronic inflammatory cell infiltrates. Now we have examined the expression of TGF-b1 mRNA using of northern blot hybridization with specific sequenced cDNA probe in the normal curltured fibroblasts, placental tissues, and fibrosarcorna derived tumor cell line(HT1080). We found that the size of TGF-b mRNA of each specimen was 2.5kb and theres no alteration of its quality.
Amino Acids
;
Blotting, Northern
;
Collagen
;
Dermis
;
DNA, Complementary
;
Embryonic Development
;
Extracellular Matrix
;
Fasciitis
;
Female
;
Fibroblasts*
;
Fibrosis
;
Humans
;
Peptides
;
Phenotype
;
Pregnancy
;
RNA, Messenger*
;
Subcutaneous Tissue
;
Transforming Growth Factor beta*
;
Transforming Growth Factors
;
Virtues
4.A Clinical Study of Small Incision Trabeculectomy.
Suk Han KIM ; Dong Won PARK ; Sae Heun RHO
Journal of the Korean Ophthalmological Society 2000;41(12):2603-2610
No Abstract Available.
Trabeculectomy*
5.Cystic Diseases of the Kidney in Chidren.
Pyung Kil KIM ; Ji Suk LEE ; Ji Hong KIM ; Jae Seung LEE ; Kwang Sik RHO
Journal of the Korean Society of Pediatric Nephrology 1997;1(2):144-150
A case of metastatic adenoid cystic carcinoma of the lung, originated from the trachea, was diagnosed by fine needle aspiration. Although the cytologic features of adenoid cystic carcinoma have been well described, it is easy to confuse adenoid cystic carcinoma with more common primary small cell neoplasms of the lung, i.e., small cell carcinoma, well differentiated adenocarcinoma, and carcinoid tumor of the lung. The features distinguishing adenoid cystic carcinoma from these neoplasms include 1) tight, globular, honeycomb pattern of cells, 2) acelluair basement membrane material in the lumen, and 3) cells lacking true nuclear molding and having bland chromatin pattern. The mcrphologic feature of metastatic adenoid cystic carcinoma in this case was so distinctive as to permit a definite diagnosis by aspiration cytology.
Adenocarcinoma
;
Basement Membrane
;
Biopsy, Fine-Needle
;
Carcinoid Tumor
;
Carcinoma, Adenoid Cystic
;
Carcinoma, Small Cell
;
Chromatin
;
Diagnosis
;
Fungi
;
Kidney*
;
Lung
;
Trachea
6.Epidemiologic study of epidermolysis bullosa in Korea.
Yong Ji RHO ; Yoon Ae CHOI ; Kyu Suk LEE ; Joon Young SONG
Korean Journal of Dermatology 1993;31(6):931-936
BACKGROUND: Epidermolysis bullosa is a group of inherited disorcier characterized by blistering of the skin as a result of minor trauma. OBJECTIVE: There exist very little epidemiologic data for most of the major and minor subsets of inherited epidermolysis bullosa in Korea. We look forward to obtaining basic data for the pathogenesis and treatment of epidermolysis bullosa. METHOD: We performed 1st and 2nd trial of survey with the help of 28 dermatologic Departments snd 28 pediatric departments of medical colleges and 14 dermatologic dipartments of general hospitals. RESULTS: 68 cases were collected and classified by disease type, sex distribution, age distribution, and regional distribution. In disease type, 42 cases of EB simplex(62%), 8 cases of junctional type(12%), 10 cases of dominant dystrophic type(15%), 8 cases of recessive dytrcphic type(12%) were reported. In most cases males predominnted, but in dominant dystrophic type both sexes were equivalent. EB simplex, junctional type, RDEB were mostly developed in the 1st decade of life, dominant dystrophic type in the 2nd decade of life. In regional distribution, the number of pi tients was outstanding in large cities such as Seoul, Pusan, Taegu, Kwanju. CONCLUSION: Due to many limitations and shortage of techniques, this epidemiologic study may be notgood enough for the total estimated number of epidermolysis bullos. patients, prevalence rate, and therapeutic modalities. Furthe evaluation should be necessary next time.
Age Distribution
;
Blister
;
Busan
;
Daegu
;
Epidemiologic Studies*
;
Epidermolysis Bullosa*
;
Gwangju
;
Hospitals, General
;
Humans
;
Korea*
;
Male
;
Prevalence
;
Seoul
;
Sex Distribution
;
Skin
7.Two cases of Klippel-Treaunay-Weber Syndrome.
Chang Suk SEO ; Jae In RHO ; Young Su KWON ; Man Chul HA ; Jin Young JUNG
Journal of the Korean Pediatric Society 1990;33(4):553-558
No abstract available.
8.A Case of Eosinophilic Pustular Folliculitis (Ofuji's Disease) in a Newborn.
Eil Soo LEE ; Nark Kyoung RHO ; Suk Jin CHOI ; Joo Heung LEE ; Eil Soo LEE
Annals of Dermatology 2002;14(2):117-120
We describe a case of eosinophilic pustular folliculitis in a 1-month-old Korean male infant. The patient was suffering from erythematous papules and pustules affecting the scalp, trunk, and extremities, detected at birth. The flare was accompanied by leukocytosis and eosinophila. Histopathology revealed folliculitis with a predominant eosinophilic infiltrate. Lesions showed partial response to topical steroid and disappeared in four weeks. Three months after the resolution of the lesions, he presented a similar clinical picture as the previous episode.
Eosinophils*
;
Extremities
;
Folliculitis*
;
Humans
;
Infant
;
Infant, Newborn*
;
Leukocytosis
;
Male
;
Parturition
;
Scalp
9.Clinical Efficacy of Trabeculecto my Combined with Aminiotic Membrane Transplantation.
Suk Han KIM ; Dae Wook KIM ; Woo Chan PARK ; Sae Heun RHO
Journal of the Korean Ophthalmological Society 2000;41(7):1569-1576
We analyzed the clinical result of trabeculectomy with amniotic membrane transplantation which has antifibrotic and antiinflammatory action in risky glaucoma patients. Subjects were included four eyes of four patients with neovascular glaucoma, one eye of one patient with primary open angle glaucoma and four eyes of three patients with congenital glaucoma. After limbal based scleral flap was made in triangular shape with 5x4 mm sized, amniotic membrane, sized by 6x6 mm with epithelial side up, was placed on the scleral flap and then sutured to medial and lateral portion at 3 mm superior to base of scleral flap base with 10-0 nylon(2 points). The state of bleb, intraocular pressure and complications were observed at postoperative 1st, 3rd, 6th and 9th week. The IOP was reduced from 33.6+/-11.1 mmHg, to 15.5+/-6.5 mmHg at postoperative one week, 17.0+/-8.3 mmHg at three weeks, 16.9+/-8.1 mmHg at six weeks, 17.1+/-6.4 mmHg at nine weeks. 6 eyes(77.7%)had controlled IOP under 21 mmHg without antiglaucomatous agents at last follow up. Avascular blebs were observed throughout postoperative period in all subjects. Postoperative complications were shallow anterior chamber in one eye at 1st week and low intraocular pressue in one eye at 1st, 3rd week, that resolved at six weeks. Trabeculectomy with amniotic membrane transplantation on the scleral flap appeared to be effective as an augment therapy for filtering surgery in risky glaucoma.
Amnion
;
Anterior Chamber
;
Blister
;
Filtering Surgery
;
Follow-Up Studies
;
Glaucoma
;
Glaucoma, Neovascular
;
Glaucoma, Open-Angle
;
Humans
;
Intraocular Pressure
;
Membranes*
;
Postoperative Complications
;
Postoperative Period
;
Trabeculectomy
10.Right coronary artery-right ventricular fistula: report of one case.
Hee Jun KIM ; Sung Lin YANG ; Suk Yol LEE ; Choong Hee NAM ; Kihl Rho LEE
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(5):491-497
No abstract available.
Fistula*