PURPOSE: This study was to serve the sexual health education of the hysterectomy patients and to get the basic data of the nursing intervention on sexual health education. Sexual health education for the patients is an independent function as well as a professional responsibility of nurses. METHOD: The subjects were composed of 108 post-op patients who had undergone doing a hysterectomy 5 to 10 days previously and 101 nurses at OBGY hospitals. For data analysis, the study executed a frequency, mean, standard deviation, t-test, ANOVA, Duncan Multiple Range test and Spearman's rho correlation coefficient, in accordance with the purpose of the study using SPSS Win 10.0. RESULT: Mean score of the needs degree of sexual health education was 3.30 point. The need for education was highest in the sexual health promotion with education related to sexual interaction the lowest. Mean score of the nurses' teaching performance degree of sexual health education was 1.80 point. The nurses' teaching performance was highest in the sexual health promotion. There exist significant correlations between the degree of patients' educational needs and the degree of nurses' teaching performance on physiosexual (rho=-.667, p< .05), psychosexual (rho=.762, p< .05), sexual interaction (rho=.667, p< .05) respectively. There was no significant difference on sexual health promotion (rho=.359, p> .05). CONCLUSION: The degree of sexual health education needs of hysterectomy patients was very high. Therefore, continuous nursing education program should be developed and provided for the promotion of the performance of sexual health education as the nursing professional role.
Education* ; Education, Nursing ; Humans ; Hysterectomy* ; Nursing ; Professional Role ; Reproductive Health* ; Statistics as Topic

The purpose of this study was to examine the knowledge and practice of the Clean Inter mittent Self Catheterization (CIC) conducted by Spinal Cord Injury Patients (SPIC) or their significant others as an activity of daily living at their homes or working places. Forty-seven patients were participated in this study. Three questionnaires developed by researchers for this study were used to collect demographic data, knowledge and practice skill of CIC. Descriptive statistics and ANOVA were used to analyze the data. Nineteen (19) patients experienced Urinary Track Infection (UTI) during the last one years and two of them have had several times of UTI. Knowledge level of the participant was not high enough to perform correct CIC. Some evidences indicated that the knowledge did not apply to their practice. Systematic analysis and development of educational content based on this study results was recommended and the systematic instructional design before actual patient education was strongly recommended.
Catheterization ; Catheters ; Humans ; Patient Education as Topic ; Surveys and Questionnaires ; Spinal Cord Injuries* ; Spinal Cord*

No abstract available.
Risk Assessment*

BACKGROUND: Th2-like cells are thought to play a crucial role in the recruitment and activation of eosinophil in bronchial asthma. In contrast to Th2 cytokine, Thl cytokine IFN-y decreases eosinophil recruitment. Previous studies have shown that IL-12 promotes differentiation of Th0 into Thl and enhances production of Thl cytokine. IL-12 also prevents differentiation of Th0 into Th2 during primary immune response. Its effect on established Th2 cell, however, is well known. OBJECTIVE: The objective of aur study was focused on whether IL-12 prevents recruitment of eosinophil and expression of Th2 cytokine in murine model for bronchial asthma, and whether its effect differs according to timing of dosage. METHOD: Administration of IL-12 was tested in the 3 different time-frames; 1) allergic sensitization (early dosage) 2) allergic challenge (late doaage) or 3) both. The number of eosinophil in the bronchoalveolar lavage(BAL) fluid and tissue was examined for change of airway inflammation. The effect on cytokine expression was assessed by measuring cytokine in bronchoalveolar lavage fluid (ELISA) and mRNA in peribronchial lymph node (RT-PCR) RESULTS: Early dosage of IL-12, and the combination of early and late dosages, strikingly decreased the numbers of eosinophil in both BAL fluid and tissue(p<0.05). Late dosage of IL-12 decreased tissue eosinophilia, while the number of eosinophil in BAL fluid remained unchanged. IL-12 increased IL-4 and IL-5 levels, and decreased IL-2 and I~FN-r levels. There were no differences in Thl/Th2 cytokine regulation among the three dosage times. Early dosage of IL-12, and the combination of early and late dosages, increased IL-10 level, but late dosage had no effect on IL-10. CONCLUSION: These results demonstrate that depending upon whether IL-12 is administered during sensitization or during subsequent allergen exposure, Thl/Th2 cytokine regulation by IL -12 shows no difference because it seems that difference of inhibition of eosinophil recruitment by IL-12 might be related with the other factors, such as IL-10.
Animals ; Asthma* ; Bronchoalveolar Lavage Fluid ; Eosinophilia ; Eosinophils ; Inflammation* ; Interleukin-10 ; Interleukin-12* ; Interleukin-2 ; Interleukin-4 ; Interleukin-5 ; Lymph Nodes ; Mice* ; RNA, Messenger ; Th2 Cells

The Purpose of this study is to explore the effects of Craniosacral therapy(CST) on the chronic headache patients, and the research was used the one-group pretest-posttest design. The subjects were 31 chronic headache patients, who received Craniosacral therapy by once per week for 6 weeks. The data were collected from July 1, 2003 to August 28, 2003. In order toevaluate the effects of craniosacral therapy, Visual Analogue Scale(VAS) for headach intensity, blood pressure, pulse rate, respiration rate, craniosacral rhythm rate, depression and stress perception were measured before and after treatment. The results are as follows : 1) The mean score of intensity of headache (VAS) significantly decreased after each session of Craniosacral therapy(F=86.14, p<.001). 2) The mean score of systolic blood pressure significantly decreased after each session of craniosacral therapy(F=6.99, p<.001), and the mean score of diastolic blood pressure significantly decreased after 3rd session of Craniosacral therapy(t=5.710, p<.001). The means of pulse(F=6.19, p<.001), respiration(F=7.93, p<.001) and craniosacral impulse rate(F=22.84, p<.001) significantly decreased after each session of Craniosacral therapy. 3) The means score of depression significantly decreased after Craniosacral therapy(t=6.627, p<.001) and stress also significantly decreased after Craniosacral therapy(t=5.987, p<.001). Therefore, these results of this study suggest that Craniosacral therapy could be an effective nursing intervention to reduce the intensity of headache.
Blood Pressure ; Depression ; Headache ; Headache Disorders* ; Heart Rate ; Humans ; Nursing ; Respiratory Rate

The purposes of this study was to determine the effect of exercise in stroke patients and to define to strategy to promote their activity of daily living. decrease to their depression. The experiemental design was designed nonequivalent control group non-synchronized design. The study method had been done by investigating the experimental group and control group through the questionaire on 60 patients who had been in patient department in D University hospital and K University hospital in Busan from November 5th. 2000 to the end of February 28th. 2001. Exercise was conducted by the researcher and was carried out experimental group once per day for 20 minutes for daily fourteen days. ADL check List tool by Kang and Center of Epideilogic Studies-Depression (CES-D) were used for measurement in this study. The data was analyzed by means of freqency, percentage, mean+/-SD, t-test. chi-square test and ANOVA with SPSS/PC. The results were summarized as follow; 1. The experimental group which received exercise should be higher in activity of daily living than the control group was supported (t=2.70. P=.009) 2. The experimental group which received exercise should be lower in depression than the control group was not support(t = -1.120, P= .267) but experimental group post-pre depression score support(t = 7 .247, P= .000), 3. Factors influencing the activity of daily living measured are payer of medical expenses (F=3.98, P=.018) and complications(t=3.97. P= .056) 4. Factors influencing the depression measured are economic status(F=5.71. P= .009) and caregivers(F=3.09, P= .045). In conclusion, the exercise incresed the activity of daily living and effect on depression of stroke patiens. Based upon these results. it is recommended that the nurses who take care of stroke patients such as exercise.
Activities of Daily Living ; Busan ; Depression* ; Humans ; Stroke*

The purpose of study was to identify relationship between body image and depression of diabetes mellitus patients. The subjects of study were 120 diabetes mellitus patients who were B hospital in Pusan. Data were collected from 15th April to 20th August, 1998. The instrument used for this study were Osgood's body image scale and Zung's depression scale. The collected data were analyzed frequency, percentage, mean, standard deviation, t-test, ANOVA, Scheffe test, Pearson's correlation coefficients. The results were as follows: 1. The mean score of body image was 68.91+/-8.04, and the mean score of depression was 56, 18+/-1.58. 2. The score of body image according to marital status(t=-2.434, p = ,016). economic status (F=6.252, p=.001), reason of different regular hospital visiting(F=3.017, p=.014), treatment method of diabetes mellitus (F=3.048, p=.013) were significantly difference. ere significantly difference. The score of depression according to sex(t= 2.353, p= .020). occupational status (F=4.657, p=.002), marital status(t=-2.325, p=.022), economic status(F=5.536, p=.001), regular hospital visiting(t=2.081. p=.040), reason of different regular hospital visiting(F=3.352, p=.007), treatment method of diabetes mellitus(F=3.102. p=.012), paticipation of diabetes mellitus(t=3.726, p = .000), paticipation of diabetes mellitus visiting(F=4,819. p=.003) were significantly difference. 5. Body image and depression was a significant negative correlation(r=-.679. p=.000).
Body Image* ; Busan ; Depression* ; Diabetes Mellitus* ; Employment ; Humans

PURPOSE: Telomerase is known to play a role of adding repetitive parts to chromosomal ending and to be involved in carcinogenic process through cell immortalization. The purpose of this study is to evaluate that restraining of telomerase activation can have killing effect on cancer cell and enhance susceptibility of cancer cells to anticancer substance. METHODS: The killing effect on melanoma cells was studied by using recombinant adenovirus that makes it possible to inhibit telomerase from getting activated, with such targets as two types of melanoma cell lines. This recombinant adenovirus was used combined with cisplatin, one of the most representative anticancer medicine to evaluate enhancement in susceptibility of cancer cells to anticancer substance. RESULTS: From the result of cytotoxic assay, it is found that melanoma cells have much resistance to cisplatin on the whole. In the case of using Ad-OA of recombinant virus alone, killing effect on melanoma cells was insignificant. On the other hand, when Ad-OA was used in combination with cisplatin, susceptibility of melanoma cell lines to cisplatin was enhanced. CONCLUSIONS: Ad-OA, recombinant adenovirus, could be used as a supplementary medicine in the targeted cancer gene therapy against cancer cell lines resistant to cisplatin.
Adenoviridae* ; Cell Line* ; Cisplatin* ; Genes, Neoplasm ; Hand ; Homicide ; Melanoma* ; Telomerase

BACKGROUND: Recently technetium-99m sestamibi (99mTc MIBI), which dose not require withdrawal of thyroid hormone, has been used for imaging of thyroid carcinoma. The aim of this study was to determine the clinical usefulness of Tc MIBI scintigraphy after total thyroidectomy for thyroid carcinoma. The results were compared with those of standard 131I scintigraphy. METHODS: One hundred twelve patients with a median age of 44 years (range, 14-76 years) were included in the study. After optimal endogenous thyroid stimulating hormone stimulation (>50 mIU/mL), whole body scintigraphy using 4 mCi of 'I and 20 mCi of Tc sestamibi were done simultaneously. Concomitantly serum thyroglobulin and anti-thyroglobulin antibody levels were checked. If abnormal findings on any of the scintigraphic methods or high levels of thyroglobulin (> 10ng/mL) were detected, diagnostic imaging studies were done to confirm the existence of the disease. And high dose (150-200 mCi) 'I was administered as therapy and then whole body scans were performed again after the therapy. The presence or absence of thyroid cancer was established by pathologic, radiologic, and/or high dose I scan findings. RESULTS: In 11 patients, Tc MIBI scan revealed positive accumulations which were not found on 131I scan, of whom 6 had elevated thyroglobulin levels. In these cases, 5 cases were interpreted to have normal thyroid remnant and 6 cases showed pathologic findings (2 lung, 1 lymph node, 1 lung and lymph node, 1 local recurrent cancer, and 1 false positive accumulation of 99mTc MIBI). Metastasis or residual cancer were confirmed histologically in 1 and radiologically in 4 cases. Negative 99mTc MIBI scans, despite of positive I scans, occurred in 9 patients, of whom 2 had abnormal thyroglobulin levels. Seven cases were interpreted to have thyroid remnant, 2 cases were confirmed to have lung metastasis, and another one was misinterpreted due to breast shadow. CONCLUSION: In conclusion, these results suggest that 99mTc MIBI scan may have similar sensitivity and specificity for the detection of residual or metastatic differentiated thyroid carcinoma. The 99mTc MIBI scan, especially in cases of negative 131I scan despite of abnormal thyroglobulin levels, can be used as a very useful complementary diagnostic tool.
Breast ; Diagnostic Imaging ; Follow-Up Studies* ; Humans ; Lung ; Lymph Nodes ; Neoplasm Metastasis ; Neoplasm, Residual ; Radionuclide Imaging* ; Sensitivity and Specificity ; Technetium Tc 99m Sestamibi ; Thyroglobulin ; Thyroid Gland* ; Thyroid Neoplasms* ; Thyroidectomy ; Thyrotropin ; Whole Body Imaging

Psoriasis is characterized by disregulation of keratinocyte growth with profound epidermal hyperplasia. Keratinocyte hyperplasia in psoriasis may be expained in part by overproduction of growth factor, and by altered metabolism of the epidemal growth factor receptors (EGFR) in affected skin. The expression of epidermal growth f ictor receptor was investigated by Northern blot and slot-blot analysis of total RNA extrated from biopsies of normal skin and psoriatic lesions. In Northern blot analysis, EGFR-specific mRNA transcripts from psoriatic tissues demonstrated the specificity of hybridizarion with a EGFR mDNA probe. The size of EGFR mRNA transcript was 6.7kb in psoriasis lesions which showed no change of quality. In slot-blot analysis, the levels of EGFR mRNA in poriasis revealed a 1.2 fold to 4.1 fold elevation when compared to normal skin. EGFR were present in all epidermal layers by immunoperoxidase staining, whereas in normal skin they were primarily present in the stratum basalis. These results indicate that the increased expresion of the EGFR gene may be, in part, responsible for the hyperproliferation of the epider nis and that retained EGFR may reflect incomplet; abnormal differentiation in active porasis. This altered process of EGFR metabolism may be involved in the pathogenesis of psoriasis.
Biopsy ; Blotting, Northern ; Epidermal Growth Factor* ; Genes, erbB-1 ; Hyperplasia ; Keratinocytes ; Metabolism ; Psoriasis* ; Receptor, Epidermal Growth Factor* ; Receptors, Growth Factor ; RNA ; RNA, Messenger ; Sensitivity and Specificity ; Skin