1.Influence of food intake on the effect of intermediate action sulfonylurea.
Journal of the Korean Academy of Family Medicine 1997;18(7):688-696
BACKGROUND: Sulfonylurea is recommended to be taken before meal. But since premeal administration is against Koreans usual medication habit, it can be the cause of poor compliance. Such recommendation is based on the results of a few clinical trials about appropriate medication time. But most of the clinical studies had a limitation : observe only acute effects of medication, subjects were only healthy volunteer. So the chronic effect of sulfonylurea of each kind must be validated. METHODS: From 1996 May to 1996 July, data were collected from diabetic patients who visited an university hospitals for managing diabetes and used a intermediate-acting sulfonylurea. The subjects were randomized to two groups of premeal group and postmeal group, by chart number and were asked to take the previous medicine according to assignment. After 1 month medication, mixed meal tolerance test was done with 300Kcal carbohydrate, 400+/-50Kcal diet. The subjects were switched to the other group and 2nd mixed meal tolerance test was done 1 month later. The Area under curves was calculated in preand post-prandial glucose curve and was compared by paired t-test. RESULTS: During the study period, total 16 diabetic patients were enrolled. There was no significant statistical difference between pre-prandial group and post prandial group in AUC. CONCLUSIONS: Intermediate-acting sulfonylurea can be administered at any time in relation to meaL.
Area Under Curve
;
Compliance
;
Diet
;
Eating*
;
Glucose
;
Healthy Volunteers
;
Hospitals, University
;
Humans
;
Meals
2.Clinical observation on tuberous sclerosis.
Yong Seung HWANG ; Yong Soo YUN
Journal of the Korean Pediatric Society 1991;34(7):992-998
No abstract available.
Echocardiography
;
Tuberous Sclerosis*
3.Radiologic Analysis of Tuberculous Spondylitis.
Yeungnam University Journal of Medicine 1986;3(1):95-102
Among the skeletal tuberculous spondylitis is high incidence and curable disease, if early diagnosis and treatment are possible. We reviewed clinical manifestations and radiologic analysis of 30 cases tuberculous spondylitis from May 1983 to Sept. 1986, at Yeungnam medical center, Yeungnam University. The results were follows: 1. The frequent involve sites were thoracolumbar vertebra. 2. The continuous lesion is 86.7% of the all cases. 3. The most common type was intervertebral type, and lytic and sclerotic lesion were same incidence. 4. Paravertebral abscess, kyphosis and disc space narrowing were demonstrated more than 80.0% of the cases. 5. Computed tomography was more accurate diagnostic method rather than conventional plain study to evaluation of extent of lesion, involvement of spinal canal and cord, and size and location of paravertebral abscess. And CT guided abscess drainage procedure was helpful to diagnosis and treatment. 6. Ultrasonography was helpful to differential diagnosis between paravertebral abscess and other solid mass, and useful to follow up study of paravertebral abscess after treatment.
Abscess
;
Diagnosis
;
Diagnosis, Differential
;
Drainage
;
Early Diagnosis
;
Follow-Up Studies
;
Incidence
;
Kyphosis
;
Methods
;
Spinal Canal
;
Spine
;
Spondylitis*
;
Ultrasonography
4.Clinical study on spinal muscular atrophies.
Soo Ahn CHAE ; Yong Seung HWANG
Journal of the Korean Pediatric Society 1992;35(12):1728-1736
No abstract available.
Muscular Atrophy*
5.Surgical Complications and Its Management in Intracranial Aneurysm.
Journal of Korean Neurosurgical Society 2000;29(8):1113-1120
No abstract available.
Intracranial Aneurysm*
6.A comparative study on the agglutination inhibition activities to mouse red blood cells and adsorption activities to human red blood cells of phytagglutinin, caragana chamlagu.
Korean Journal of Legal Medicine 1992;16(1):47-51
No abstract available.
Adsorption*
;
Agglutination*
;
Animals
;
Caragana*
;
Erythrocytes*
;
Humans*
;
Mice*
7.Early Radiology Findings of Lung Cancer.
Kyung Soo LEE ; Jung Hwa HWANG
Journal of the Korean Medical Association 1999;42(2):211-214
No abstract available.
Lung Neoplasms*
;
Lung*
8.AllogeneicLymphocyte Stimulating Capacity of Contact Sensitized Epidermal Cells in Mouse.
Soo Chan KIM ; Seon Young HWANG
Korean Journal of Dermatology 1989;27(6):641-649
Allergic contact dermatitis is a prototype of delayed hypersensitivity reaction. Langerhans cells, keratinocytes and T lyrnphocytes play major roles in the pathogenesis of allergic contact dermatitis. We observed Langerhans cells and keratinocytes in contact sensitized epidermal sheets of mice and performed mixed epidermal cell lymphocytes reaction with normal epidermal cells and contact sensitized epidermal cells to determine the lymphocyte stimulating capacity of contact sensitized epidermal cell. We obtained following results : 1. The Langerhans cells were decreased in number and morphologically damaged in contact sensitized epidermis. 2. Ia antigen expression on keratinocytes was detected in almost all contact sensitized epidermal sheets. 3. The allogeneic lymphocyte stimulating capacity of contact sensitized epidermal cells was greater than that of normal epidermal cells. 4. The allogeneic lymphocyte stimulating capacity of contact sensitized epiderrnal cells was lost after treatment of epidermal cells with anti Ia antibody and complement. From these results, it is conceivable that the contact sensitized epidermal cells can amplify the immune reactions by stimulating the lynphocytes which are infiltrated in contact sensitized epidermis.
Animals
;
Complement System Proteins
;
Dermatitis, Allergic Contact
;
Epidermis
;
Histocompatibility Antigens Class II
;
Hypersensitivity, Delayed
;
Keratinocytes
;
Langerhans Cells
;
Lymphocytes
;
Mice*
9.Clinical Observation of the Arthodesis of the Hip: Review of 42 Cases
Chung Soo HWANG ; Moon Sik HAHN
The Journal of the Korean Orthopaedic Association 1973;8(4):369-374
Various types of arthroplasty has been performed to obtain mobile joint in the treatment of the hip disease. In the view of stabilization and painlessness of the hip joint arthrodesis has been the treatment of choice in many hip problems, especially in unilateral tuberculosis of the hip. There are many kinds of techniques to gain arthrodesed hip: intra-articular only, extra-articular and combined method. The author reviewed the 42 cases of the arthrodesis of the hip performed at Dept. of Orthopedic surgery, SNUH during the period of 1964 to 1972 with following results. 1. Among 42 patients, there were 29 males and 12 females. Age group of predominence was 2 nd and 3rd decade (66.7%). 2. Thberculosis was the most common causative disease (61.9%) and remainders were fracturedislocation and avscular necrosis of femoral head. Average duration of illness was 3.8 years 3. The operative techniques were 21 Ghomley method (50%) and 11 Davis (26.2%). Satisfactory fusion was gained in 25 cases(92.6%) among 27 cases which follow-up study were possibe for more than 6 months. 4. There was no definite difference in fusion rate between Ghomley and Davis techniques. 5. Satisfactory fusion was gained with Davis technique in avascular necrosis of femoral head. 6. The fusion rate was superior in less than 39 years age group (95%).
Arthrodesis
;
Arthroplasty
;
Female
;
Follow-Up Studies
;
Head
;
Hip Joint
;
Hip
;
Humans
;
Joints
;
Male
;
Methods
;
Necrosis
;
Orthopedics
;
Tuberculosis
10.Study of Ferritin Concentration in Synovial Fluid and Serum of Rheumatoid Arthritis
Kwang Jin RHEE ; Deuk Soo HWANG ; Sang Soo DO
The Journal of the Korean Orthopaedic Association 1984;19(3):447-453
Rheumatoid arthritis is a chronic inflammatory systemic disease of young or middle aged adults, characterized by destructive and proliferative changes in synovial membrane, periarticular structure, skeletal muscle and perineural sheaths. Eventually, joints are destroied, ankylosed and deformed. Moderate anemia is occured frequently in rheumatoid arthritis patients, and these patients show abnormalities of iron metabolism such as lower serum iron concentration and occurance and distribution of iron in the synovial membrane. It has been suggested that the mechanism of iron deposits in rheumatoid arthritis is continuous oozing of blood from vascular granulation tissue into the synovial cavity and this lead the patient to anemia. We collected samples from serum and knee joint fluid in 21 cases of rheumatoid arthritis for chemical estimation of the ferritin concentration by radioimmunoassay, and compared with that of osteoarthritis. The following results were obtained: 1. The mean hemoglobin concentration(11.4gm %) in rheumatoid arthritis was lower than osteoarthritis(13.4gm %). 2. The mean serum ferritin concentration(118. 4ng/ml) in rheumatoid arthritis was lower than osteoarthritis(135. 6ng/ml), on the contrary in synovial fluid rheumatoid arthritis(279.8ng/ml) showed higher than osteoarthritis(190. 4ng/ml). 3. The mean ratio of synovial fluid ferritin on serum ferritin was 2. 36 in rheumatoid arthritis, in contrast with l. 4 in osteoarthritis. There was significant correlation between the ferritin concentration in synovial fluid and serum. 4. Serial check of ferritin concentration in synovial fluid during treatment would be thought meaningful criteria for determination of progress.and effectiveness of treatment.
Adult
;
Anemia
;
Arthritis, Rheumatoid
;
Ferritins
;
Granulation Tissue
;
Humans
;
Iron
;
Joints
;
Knee Joint
;
Metabolism
;
Middle Aged
;
Muscle, Skeletal
;
Osteoarthritis
;
Radioimmunoassay
;
Synovial Fluid
;
Synovial Membrane