In order to understand the pathogenesis and progression of some synaptic loss related neuropsychiatric diseases. We attempted to develop a computer model in this study. We made a simple autoassociative memory network remembering numbers, transformed it into a disease model by pruning synapses, and measured its memory performance as a function of synaptic deletion. Decline in performance was measured as amount of synaptic loss increases and its mode of declines is sudden or gradual according to the mode of synaptic pruning. The developed computer model demonstrated how synaptic loss could cause memory impairment through a series of computer simulations, and suggested a new way of research in neuropsychiatry.
Computer Simulation* ; Dementia ; Memory ; Neuropsychiatry ; Schizophrenia ; Synapses

No abstract available.

No abstract available.
Humans ; Infant* ; Parturition*

The purpose of this study was to aid in the use of the digital images by edge-detect interpolation for direct digital periapical images using edge-deted interpolation. This study was performed by image processing of 20 digital periapical images; pixel replication, linear non-interpolation, linear interpolation, and edge-sensitive interpolation. The obtained results were as follows ; 1. Pixel replication showed blocking artifact and serious image distortion. 2. Linear interpolation showed smoothing effect on the edge. 3. Edge-sensitive interpolation overcame the smoothing effect on the edge and showed better image.
Artifacts

PURPOSE: To investigate the regional characteristics and the factors that influence final visual acuity in corneal laceration and use the results for prevention and treatment of corneal laceration. METHODS: Sixty-eight patients who visited the Chosun University Medical Center from January 1, 2006 to December 31, 2010 were retrospectively surveyed. The incidence of corneal laceration, sex, age, monthly and seasonal distribution, cause, site and length of corneal laceration, secondary operation, complications, and ocular trauma score were reviewed statistically. In additional, the factors influencing visual prognosis were investigated. RESULTS: The incidence was more common in males (94.1%) and in the 6th-decade of life (29.4%). The corneal laceration was more common in the summer (38.2%) and in September (26.5%) and the most common cause was stone (39.7%) and metal (35.3%), respectively. The corneal laceration tended to occur at the corneal center. The most common first operation was primary closure (81.9%), and the secondary operation was most often performed due to a traumatic cataract (32.1%). The factors that significantly influenced the final visual acuity were initial visual acuity, length and site of laceration, and secondary operation. CONCLUSIONS: The present survey investigated the regional characteristics and important factors influencing final visual acuity. Results show initial visual acuity, the length and site of laceration, and the secondary operation significantly influenced final visual acuity.
Academic Medical Centers ; Cataract ; Humans ; Incidence ; Lacerations ; Male ; Prognosis ; Retrospective Studies ; Seasons ; Visual Acuity

BACKGROUND: Centrotemporal spikes (CTS) are the hallmark of the syndrome of benign childhood epilepsy with centrotemporal spikes or Rolandic seizures. However, they also can be encountered in other symptomatic epilepsies or may incidentally be found in non-epileptic children with or without neurological symptoms. We investigated clinical and electroencephalographic characteristics of children with CTS on EEG. METHODS: A 7 year material of children with CTS on EEG were reviewed. Sixty-eight children were found. RESULTS: Among them, 55 patients exhibited recurrent rolandic seizures of benign course (so-called benign rolandic epilepsy ; BRE), 9 children suffered from chronic headache without clinical seizure, three patients showed multiple types of seizures or rolandic seizures with some degree of mental retardation, and one child was asymptomatic. In 55 BRE cases, seven children (13%) had a preceding history of febrile convulsions, and a positive family history of epilepsy was found in 9 patients. Generalized spike and wave discharges were observed in 9 patients (16.7%), but none of them experienced clinical absence seizure. In 25 of 29 BRE patients who showed overt lateralized ictal manifestations on history, symptoms were correlated with the main foci of spike discharges. Of the nine children, found to have CTS during evaluation of chronic intermittent or daily headache, the headache was successfully controlled by antiepileptic drugs in two cases. CONCLUSION: Most children with CTS were compatible to the BRE without any causative lesional factor. However, nonepileptic cases were not uncommon and, though rare, atypical cases were also present in children with CTS on EEG.
Anticonvulsants ; Child* ; Electroencephalography* ; Epilepsy ; Epilepsy, Absence ; Epilepsy, Rolandic ; Headache ; Headache Disorders ; Humans ; Intellectual Disability ; Seizures ; Seizures, Febrile

No abstract available.
Child* ; Humans

The purpose of this study was to compare E-speed film, CDR, and modified CDR images by means of observing some artificial defects of alveolar bone wall in the sound human dried mandibles. High diagnostic accuracy was shown in 1 wall and 4 wall defects by all 5 observers (2 Radiologists, 2 Periodontists, 1 General practitioner), but the diagnosis in 2 wall and 3 wall defects was inaccurate. Modified CDR images had the more diagnostic accuracy than E-speed film and CDR images, but there was no statistical difference among them. Finally, radiologist used modified CDR images more than others and used equalization effect more than the change in contrast and/or brightness.
Diagnosis ; Humans ; Mandible ; Radiographic Image Enhancement*

The purpose of the present study was focused the anthropometric charateristics of normal Korean eyes, including inclination, height, width, epicanthus and upper eyelid crease. The author measured normal eyes and investigated incidence of epicanthal fold and upper eyelid crease in 774 males and 658 females with photographs. The epicanthus were classified by three types and the upper eyelid crease were classified by four types. The angle of inclination of eyes was larger in females than males and in young ages than old ages. Incidence of the slanting eye over 10 degree was 34.1 % in males and 41.0% in females. Incidence of the epicanthal fold was 57.0%, and there was no difference between males and females. The most common type of the epicanthal fold was type I. Incidence of the upper eyelid crease was 30.9% in males, 47.2% in females. The most common type of the upper eyelid crease was parallel (or floating) type. In conclusion, the anthropometric characteristics of normal Korean or oriental eyes are apart each other and slanting eyes in addition to puffy eyelid, narrow palpebral fissure, presence of epicanthal fold and absence of upper eyelid crease.
Eyelids ; Female ; Humans ; Incidence ; Male

The melanotic neuroectodermal tumor of infancy is a rare neoplasm arising in the first year of life. A 33-day-old female infant had an enlarged alveolar ridge on the right anterior maxilla. Intraoral examination revealed a nonulcerative swelling at the site. An intraoral radiograph showed an ill-defined radiolucency on the right anterior maxilla and displacement of primary incisors from their alveolar sockets. CT scans revealed an expansion of the surrounding bone and partial destruction of the anterior wall of the premaxilla. Histopathologic examination showed the cytoplasm of neuroblastic cells and eosinophilic, epithelioid cells frequently contained a dark brown granular pigment that stained positively to vimentin and HMB45, focally positive to NSE and cytokeratin. Four weeks after the operation, CT scans showed a rapidly growing soft tissue mass occupying right maxillary sinus encroaching to the orbit and nasal cavity. The final diagnosis was made as a malignant melanotic neuroectodermal tumor of infancy.
Alveolar Process ; Cytoplasm ; Diagnosis ; Eosinophils ; Epithelioid Cells ; Female ; Humans ; Incisor ; Infant ; Keratins ; Maxilla ; Maxillary Sinus ; Nasal Cavity ; Neuroectodermal Tumor, Melanotic* ; Neuroectodermal Tumors ; Orbit ; Tomography, X-Ray Computed ; Vimentin