No abstract available.
Carcinoma, Basal Cell

No abstract available.
Bowen's Disease ; Vulva

This study is designed to determine the frequency of amblyopia and sensory fusional anomaly in intermittent exotropia and the relationship between amblyopia and sensory fusional anomaly. Ninety eight intermittent exotropic patients were selected and using full corrected visual acuity, the selected patients were divided into amblyopia group and non-amblyopia group. Then, refractive errors, Bagolini lens test, Worth 4 dot test and stereoacuity test were measured and these values were statistically analyzed. The frequency of amblyopia among intermittent exotropia group was 14 patients[14.3%]. Anisometropia among amblyopia group was 6 patients[43.9%] and among non-amblyopia group was 6 patients [7.1%]. Anisometropia was statistically meaningful in amblyopia group compared with non-amblyopia group[p<0.002]. Sensory fusional anomaly among amblyopia group showed 50%at near distance and 64.3%at far distance, among non-amblyopia group 10.7% at near distance and 20.2%at far distance in Worth 4 dot test. Therefore, it appeared to be statistically meaningful in amblyopia group compared with non-amblyopia group[p<0.001, p<0.002]. Sensory fusional anomaly among amblyopia group showed 35.7%and among non-amblyopia group 14.3%in Bagolini lens test, it appeared to be statistically not meaningful[p>0.064]. In stereoacuity, it decreased statistically meaningful when amblyopia[p<0.003] or sensory fusional anomaly[p<0.019]were present.
Amblyopia* ; Anisometropia ; Exotropia* ; Humans ; Refractive Errors ; Visual Acuity

Optic neuritis is one of the most important clinical manifestations of multiple sclerosis. We experienced 2 cases of retrobulbar optic neuritis associated with multiple sclerosis. One was a 14-year-old female patient who presented with decreased visual acuity and visual field defect in right eye followed by paralysis of both lower extremities and the other was a 39-year-old female patient who presented with repeated paresthesia and motor weakness of upper and lower extremities then rapid decrease in visual acuity in both eyes. Both patients had relative afferent pupillary defect, color perception abnormality, variable visual field defect and abnormality in VEP. In fundus exam and fluorescene angiography, there was no specific abnormal finding. T2 weighted MRI showed multiple high signals corresponding to plaques. These two patients were diagnosed as multiple sclerosis. We should keep in mind that retrobulbar optic neuritis could be associated with multiple sclerosis as a presenting sign or as a manifestation during its clinical course.
Adolescent ; Adult ; Angiography ; Color Perception ; Female ; Humans ; Lower Extremity ; Magnetic Resonance Imaging ; Multiple Sclerosis* ; Optic Neuritis* ; Paralysis ; Paresthesia ; Pupil Disorders ; Visual Acuity ; Visual Fields

Papular xanthoma is a rare normolipemic xanthomatous skin disease that primarily occurs in adults. While this rare disorder has been documented in children before, all but one case reported in the literature involved a normal lipid profile. The skin lesions of adult papular xanthoma appear to be persistent, whereas in children they generally self-heal within 1~5 years. Here, we describe a typical case of papular xanthoma in a 22-month-old boy who presented with numerous reddish-yellow papulonodules, 2~8 mm in diameter, mainly on the face, but also on the upper and lower extremities, and trunk, for 15 months. The lipid profile was normal, and histological studies showed a diffuse monomorphous infiltrate of foamy cells, with some Touton giant cells, in the dermis. The foamy cells stained positive for Cluster of Differentiation (CD) 68, and the Periodic Acid Schiff (PAS) stain was negative. These findings are consistent with the diagnosis of papular xanthoma.
Adult ; Child* ; Dermis ; Diagnosis ; Giant Cells ; Humans ; Infant ; Lower Extremity ; Male ; Periodic Acid ; Skin ; Skin Diseases ; Xanthomatosis*

No abstract available.
Esophageal Achalasia* ; Esophagogastric Junction*

Churg-Strauss syndrome (CSS) or allergic granulomatous angiitis is a rare systemic vasculitis with tissue and blood eosinophilia. A 37-year-old woman with a 2-year history of allergic rhinitis and asthma presented with polycyclic patches on both extremities and trunk. Laboratory studies revealed peripheral blood eosinophilia, hyper-IgE, and positivity for ANA (1:40, speckled pattern). Skin biopsy specimens showed endothelial cell swelling, perivascular and interstitial eosinophilic infiltration with nuclear dust in the dermis. She was treated with methylprednisolone and showed an improvement in symptoms. Two years later she developed a tingling sensation on her right hand and right lower extremity along with aggravation of skin lesions. The skin examination revealed erythematous papules and greenish patches on buttock and finger joints. On the histological examination of the patches on the buttock, prominent extravascular eosinophilic infiltration, endothelial cell swelling and degenerative collagen fibers were observed in the dermis.
Adult ; Asthma ; Biopsy ; Buttocks ; Churg-Strauss Syndrome ; Collagen ; Dermis ; Dust ; Endothelial Cells ; Eosinophilia ; Eosinophils ; Extremities ; Female ; Finger Joint ; Hand ; Humans ; Lower Extremity ; Methylprednisolone ; Rhinitis ; Rhinitis, Allergic, Perennial ; Sensation ; Skin ; Systemic Vasculitis ; Vasculitis

Disseminated superficial porokeratosis (DSP) is a keratinization disorder characterized by multiple small lesions with a slightly elevated, sharply defined ridge over the whole body. Inflammatory DSP has common clinical features, which involve a several-year history of asymptomatic DSP and the sudden appearance of intensively pruritic erythematous papules over the entire body. These lesions subside within several months, leaving a brownish atrophic lesion. We report on a 64-year-old man who displayed an atypical clinical feature of inflammatory DSP.
Humans ; Keratins ; Middle Aged ; Porokeratosis

BACKGROUND: Inflammatory labial lesions are quite common in dermatology. However, a few studies have been performed regarding the clinical and histopathological findings of inflammatory labial diseases. OBJECTIVE: The purpose of this study was to investigate the clinical and histopathological features of inflammatory labial diseases. METHODS: We retrospectively reviewed the data of 48 patients who underwent biopsy for inflammatory labial lesions between June 2005 and December 2012. Clinical features and histopathological findings of the lesions were investigated, and they were compared to each other for differential diagnosis. RESULTS: The most frequent inflammatory labial diseases were actinic cheilitis (25%), oral lichen planus (23%), plasma cell cheilitis (23%), oral lichenoid lesion (17%), and eczema (12%). Most of the labial lesions were located on the lower lip (87%). We found a broad overlap in the clinical features of lesions with each other, and in many cases, clinical impressions were inconsistent with their final diagnosis. Histopathologically, the degree of eosinophilic infiltrates in actinic cheilitis was comparable to those in eczema. Oral lichen planus showed orthokeratotic hyperkeratosis rather than parakeratosis, and oral lichenoid lesion displayed more frequent perivascular and deep inflammatory cell infiltrates than oral lichen planus. CONCLUSION: The diagnosis of inflammatory labial diseases may be challenging, because inflammatory labial diseases often show similar clinical features and have a broad overlap in histological features. Therefore, clinico-pathologic correlation is necessary to confirm the diagnosis and for proper management.
Actins ; Biopsy ; Cheilitis ; Dermatology ; Eczema ; Eosinophils ; Humans ; Lichen Planus ; Lichen Planus, Oral ; Lichens ; Lip ; Parakeratosis ; Plasma Cells ; Retrospective Studies

No abstract available.
Cranial Nerve Diseases ; Granuloma, Plasma Cell* ; Polychondritis, Relapsing*