Statisticsl observation was made on 404 patients who had been referred for consultation to the Department of Dermatology during their admission in Seoul National University Children's Hospital from October 1985 to March 1987. The results were as follows : 1. The consulted pstients were 404 among 126,622 inpatients(0.32%). 2. The most frequent age group was below 1 year(25.0%). 3. Pediatrics was the most importnat department in the number, as well as in the rate of consulted patients to inpatients. 4. The most common 10 dermatoses were contact dermatitis, atopic dermatitis, drug eruption, fungal infection, viral infection, infantile eczema, benign tumor, miliaria, urticaria, and skin manifestation of systemic diseases in order of frequency. 5. The frequent causes of consultation were as follows ; the dermatologic diseases or conditions 67.6%, the diseases related to the trestment 13.4%, the skin lesions of systemic diseases 10.8%, the dermatologic tests 3.6%, and admitted to other departments with dermatologic diseases 1.2% respectively.
Dermatitis, Atopic ; Dermatitis, Contact ; Dermatology* ; Drug Eruptions ; Humans ; Inpatients* ; Miliaria ; Pediatrics ; Seoul ; Skin ; Skin Diseases ; Skin Manifestations ; Urticaria

No abstract available.
Child* ; Humans

Nevus flammeus is benign but cosmetically devastating congenital vascular malformation whose past treaments have been marred by unacceptable complication or by unacceptable ineffectiveness. Argon laser is a therapeutic device which has been newly applied to this condition with fairly good result. However, all lesions do not show good response and it depends on the clinical and histopathological types. Therefore, it is very important to select patients who will show good response to argon laser therapy. Histological pattern was indicated as the most important prognostic factor. However, it is not always possible to get the histological data. This study was undertaken to evaluate whether it is possible to anticipate histologic patterns of nevus flammeus from color and clinical morphology of the lesions when biopsy is difficult to be taken. Color and clinical morphology of the lesions were recorded, and 4-mm punch biopsies were performed in 74 patients who visited the Laser Clinic in our dermatologic department during past 2 years, The study results were as follows. Eleven pink cases were all patch form morphologically but 8 cases(72, 7%) were constricted type and 8 cases(27 Q%) were intermediate type histopathologically. In 28 red cases, 27 cases(96 4gp) were patch form and only 1 case was smooth elevated form morphologically. And 2p cases(74, l%) were dilated or intermediate type and 7 cases(25 9%) were constricted or deep located type histologically.
Argon ; Biopsy ; Humans ; Laser Therapy ; Nevus* ; Port-Wine Stain* ; Vascular Malformations

No abstract available.

Atopic dermatitis is characterized by many signs of immunodeficiency. We have performed this experiment to know whether there are reduced respiratoty burst of neutrophils in patients with atopic dermatitis in response to stimulants such as zymosan activated serum(ZAS), phorbol myristate cetate(PMA) and for- mylmethionylleucylphenylalanine(FMLP). The atopic derrqatitis group consisted of 27 patients(5 are severe, 22 are mild) and the control group consisted of 10 persons. Superoxide anion generation of neutrophils in response to stimulants was measured as nmol of reriuced cytochrome C by spectrophotometer(at 550nm, molar extinction coefficient of cytochrome C=21.lmM 1cm ). We compared the superoxide anion generation according to the severity of atopie dermatitis, total serum IgE level and eosinophil count. Results were as follows. 1. After stimulation by PMA and FMLP, superoxide anion generation in severe atopic dermatitis group decreased compared with the control and mild atopic dermatitis group. After stimulation by ZAS there was a decreasing tendency in severe atopic dermatitis group, however it was not statistically significant. 2. Superoxide anion generation had no correlation with the total serum IgE level. 3. Superoxide anion generation had no correlation with the eosinophil count. Our data suggested that some physiologic stimulants of respiratory hurst may be generated during the course of atopic dermatitis. Possible physiologic stimulants include C5a, bacterial chemotactic factors, certain arachidonate metabolites such as leukotriene B4, as well as phagocytosis. We think that these physiologic stimulants can desensitize neutrophils of atopic dermatitis in vivo specifically or onspecifically so that superoxide anion generation may be reduced in response tostimulants in vitro.
Chemotactic Factors ; Cytochromes ; Cytochromes c ; Dermatitis ; Dermatitis, Atopic* ; Eosinophils ; Humans ; Immunoglobulin E ; Leukotriene B4 ; Molar ; Myristic Acid ; Neutrophils* ; Phagocytosis ; Superoxides* ; Zymosan

No abstract available.

Although port-wine stains present as macular patches generally, some patients show considerable overgrowth of angiomatous tissue and show different results of laser therapy according to their histologic patterns. We observed 337 port-wine stain patients clinically, and tried to classify clinical morphology of port-wine stains and analyze with other features such as color, age and size. The results were as follows: Most of the lesions were located on the face, followed by neck, upper extremity, lower extremity and trunk in order. 2, On the face, the left lower part was the most frequent area of the lesions. The difference of the distribution between right and left side was not found, but the lesions were significantly more frequent on the lower part than the upper one. 3. The morphology was classified into patch, hypertrophic, cavernous and papular form according to therapeutic purpose. 4 When the color is darker, the others than the patch form appeared. 5, In old patients the color was darker and the papular form increased. 6. When the size enlarged, the hypertrophic form. increased. 7. Among ten patients who got the lesions at both the upper and lower eyelids, two showed ocular problems.
Coloring Agents* ; Eyelids ; Humans ; Laser Therapy ; Lower Extremity ; Neck ; Port-Wine Stain ; Upper Extremity ; Wine*

No abstract available.
Humans

This study was undertaken to elucidate any quantitative abnormalities of T cells and T subsets(helper/inducer T cell: T cell and suppressor/cytotoxic. T cell; Tsc cell) in the peripheral blood and cutaneous lesion in patients with atopic dermatitis by using monoclonal antibodies, and to ascertain whether there are any relations bctwcen such immunologic abnormalities and the severity of the disease. Thirty seven patints(19 male, 18 female) were entered in this study, who vistited the Departement of Dermatology of Seoul National University Hospital frnrn February 1985 to November 1985. The control group comprised fifteen healthy children (8 male, 7 female). The peripheral blood samples of 30 patients and the skin biopsy specirnens of 29 patients were examinecl. Both were examined in 22 patients. The results showed that there was a quantitative abnormality in pcripheral blood Tsc cells in patients with atopic dermatitis and it could be related to the severity of the disease. The predominance of T cells seemed to be relatecl to the pathogenesis of atopic dematitis.
Antibodies, Monoclonal ; Biopsy ; Child ; Dermatitis, Atopic* ; Dermatology ; Humans ; Male ; Seoul ; Skin ; T-Lymphocytes*

The purpose of this study was to evaluate the effect of proportional thickness of various reline materials on the transverse strength of denture base. The denture base resin used in this study was Vertex RS (Dentimex Zeist., Holland). The reline resins used were Tokuso rebase normal set (Tokuyama Corp., Japan), Rebaron (GC Corp., Japan), KoolinerTM(GC INC., U.S.A). New trulinerTM(Harry J. Bosworth Co., U.S.A). The bulk specimens with 2.5mm thickness of denture base were prepared as the control group. Group 1 was fabricated with 2.0mm thickness of denture base and 0.5mm reline material, group 2 with 1.5:1.0mm. group 3 with 1.0:1.5mm, group 4 with 0.5:2.0mm composition. Measurements of transverse strength were taken for each specimens. The results were as follows: 1. Regardless of the reline resin type, the transverse strength of denture base was decreased after reline procedure. 2. The transverse strength according to the reline resin type was decreased in the following order : Rebaron, Tokuso rebase, Kooliner, and then New truliner and there was a significant difference among the reline materials (P<0.05). 3. The strength of the relined denture base generally decreased as the proportional thickness of the denture reline material increased. These results suggest that increasing the proportional thickness of the reline material progressively decreased the strength of the relined denture base. Thus, the denture base should not be unnecessarily altered during the reline procedure.
Denture Bases* ; Dentures*