Fifty-one consecutive 186 patients with aneurysmal subarachnoid hemorrhage were treated from the day of admission with nimodipine which was given first as an IV infusion at 30ug/kg/hr for 1 week and then orally in a dose of 360mg/day for 2 weeks and compared with 135 patients which were treated without nimodipine for the past 2 years. A comparision based on clinical and radiological variables influencing both the coruse and the outcome of the disease showed no significant difference between the nimodipine treated group and the control group except the delayed timing of surgery in the control group. There was no significant difference in the outcome between the nimodipine treated patients and the patients treated without nimodipine, however in Hung & Hess grade IV patients nimodipine treatment was associated with a significantly better outcome. Nimodipine treatment reduced the occurrence of delayed ischemic deficts(DID) in grade III, IV patients. Significant improvement in the outcome occurred in the nimodipine treated patients with subarachnoid hemorrhage of large amount(Fisher classification III).
Aneurysm* ; Classification ; Humans ; Intracranial Aneurysm ; Nimodipine* ; Subarachnoid Hemorrhage*

No abstract available.
Carcinoma, Renal Cell*

No abstract available.
Carbamazepine* ; Haloperidol*

Although many experiments of renal infection in animals have been studied, its pathway, regional pathogenesis and the healing process are yet to be cleared exactly. Especially in human. we have infrequent opportunities to study the pathologic changes of the acute pyelonephritis by renal biopsy, because ot accompanying general symptoms such as fever and bacteremia. This study underwent to define these changes exactly. A strain of Escherichia coli No.018 :K77 was inoculated to rabbit bladder to produce retrograde pyelonephritis. The histopalho1ogical changes at the early stage of acute pyelonephritis, the pathways of bacterial invasion, distribution in the infected kidneys and healing process were studied by using light and electron microscope. The histopathological changes were characterized by degeneration and destruction of renal pelvis and tubular epithelial cells, and a massive infiltration of polymorphonuclear leukocytes. The inflammatory changes were initially found at renal fornix and progressed to medullar after 7 hours of bacterial inoculation. These changes extended to basement membrane accompanying with discrete chronic inflammatory changes after 9 hours. The inflammatory changes extended to cortex with bacilli within blood vessels after 12 hours and sustained until the end of first week. The chronic inflammatory. changes subsided as a whole of renal parenchyma until eighth weeks. Therefore we concluded that the retrograde pyelonephritis in rabbit extends rapidly from forniceal mucosa to capsule through tubule, interstitium and blood vessels, and the natural healing process occurs diffusery for longer period.
Animals ; Bacteremia ; Basement Membrane ; Biopsy ; Blood Vessels ; Epithelial Cells ; Escherichia coli ; Fever ; Humans ; Kidney ; Kidney Pelvis ; Mucous Membrane ; Neutrophils ; Pyelonephritis* ; Urinary Bladder

No abstract available.
6-Cyano-7-nitroquinoxaline-2,3-dione* ; Cycloheximide* ; Dizocilpine Maleate*

No abstract available.
Intracranial Arteriovenous Malformations* ; Risk Factors*

The definition of tissue engineering by Langer is "an interdisciplinary field that applies the principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function." This technology has achieved remarkable growth in the past 20 years, provoked by its potential role in regenerating new tissues and naturally healing injured or diseased organs. Although stem cells are still in the research phase, their pluripotency and unlimited capacity for self-renewal may enable significant advances for reconstructive and cosmetic procedures with this engineering technology. This article aims at outlining the principles of tissue engineering and its recent advances and future prospects.
Biological Science Disciplines ; Reconstructive Surgical Procedures ; Regenerative Medicine ; Stem Cells ; Tissue Engineering* ; Tissue Scaffolds

The VATER syndrome is a group of congenital anomalies with a nonrandom tendency for concurrence. Defects include vertebral, anorectal malformation, tracheoesophageal fisutla with esophageal atresia, radial-limb, vascular, and renal abnormalities. The critical period of organogenesis is at or before the sixth or seventh week of gestation. We experienced one case of VATER syndrome in a 1 day old male neonate having vertebral anomalies, esophageal atresia with tracheoesophageal fistula to the distal esophageal segment, imperforated anus, left renal dysplasia with hydronephrosis of the right kidney and both hydroureter, patent ductus arteriosus. We report a case of VATER syndrome with brief review of related literature.
Anal Canal ; Critical Period (Psychology) ; Ductus Arteriosus, Patent ; Esophageal Atresia ; Humans ; Hydronephrosis ; Infant, Newborn ; Kidney ; Male ; Organogenesis ; Pregnancy ; Tracheoesophageal Fistula

PURPOSE: The authors evaluated the possibility of protein C and protein S as risk factors for retinal vein occlusion (RVO). METHODS: We evaluated the medical histories and performed laboratory tests, including protein C and protein S, in patients who were diagnosed with RVO by fundus examination and fluorescein angiography. The same data were obtained from a healthy control group. We analyzed mean activity and the ratio of patients with decreased levels of protein C or protein S. RESULTS: Forty-seven patients with RVO in this study consisted of 14 with central retinal vein occlusion (CRVO) and 33 with branch retinal vein occlusion (BRVO). Sixteen normal subjects were also enrolled in this study as controls. There are no cases that presented decreased protein C activity. However, there was a statistically significant difference in the number of cases with protein S deficiency between the patients and the control group (p<0.05). CONCLUSIONS: Deficiency of anticoagulant proteins, especially protein S, may be a risk factor of retinal vein occlusion. Examination of the coagulation system may be useful in the systemic evaluation of RVO patients.
Fluorescein Angiography ; Humans ; Protein C* ; Protein S Deficiency ; Protein S* ; Retinal Vein Occlusion* ; Retinal Vein* ; Retinaldehyde* ; Risk Factors*

Previous successful results of neocartilage formation using tissue engineering technique in immunocompromised nude mouse xenograft model were reported. For clinical application, autogenous cell is preferrable to allogenic or xenogenic cell for circumvention of immune rejection. This study evaluates the feasibility of producing a engineered cartilage using autogenous chondrocytes. Chondrocytes were isolated from the auricular cartilage of New Zealand White rabbit and seeded onto PGA polymer coated with polylactic acid in round pattern(diameter 0.7 cm, thickness 0.1 cm) at a concentration 7 x 10(7) chondrocytes per cm3. Each Autogenous Cell-polymer constructs were implanted subcutaneously into the left side of dorsum of twelve rabbits. Polymer templates not containg cells were implanted into the right side as a control. Twelve rabbits were sacrificed at the following intervals: 5 rabbits at nine weeks, 7 rabbits at twelve weeks New autogenous cartilage formation which retained the approximate dimensions of original round polymer template in 11 of 12 cell seeded implants. Histological examination using hematoxyline and eosin stain revealed vast majority of implants developed into mature cartilage. This study opens up the possibility of autologus cell transplant to construct autogenous cartilge.
Animals ; Cartilage* ; Chondrocytes* ; Ear Cartilage ; Eosine Yellowish-(YS) ; Hematoxylin ; Heterografts ; Mice ; Mice, Nude ; New Zealand ; Polymers ; Rabbits ; Tissue Engineering ; Transplants