1.Nimodipine Treatment after Aneurysmal Subarachnoid Hemorrhage and Operation.
Dae Hee HAN ; Young Seob CHUNG ; Sun Ho LEE
Journal of Korean Neurosurgical Society 1991;20(1-3):28-35
Fifty-one consecutive 186 patients with aneurysmal subarachnoid hemorrhage were treated from the day of admission with nimodipine which was given first as an IV infusion at 30ug/kg/hr for 1 week and then orally in a dose of 360mg/day for 2 weeks and compared with 135 patients which were treated without nimodipine for the past 2 years. A comparision based on clinical and radiological variables influencing both the coruse and the outcome of the disease showed no significant difference between the nimodipine treated group and the control group except the delayed timing of surgery in the control group. There was no significant difference in the outcome between the nimodipine treated patients and the patients treated without nimodipine, however in Hung & Hess grade IV patients nimodipine treatment was associated with a significantly better outcome. Nimodipine treatment reduced the occurrence of delayed ischemic deficts(DID) in grade III, IV patients. Significant improvement in the outcome occurred in the nimodipine treated patients with subarachnoid hemorrhage of large amount(Fisher classification III).
Aneurysm*
;
Classification
;
Humans
;
Intracranial Aneurysm
;
Nimodipine*
;
Subarachnoid Hemorrhage*
2.The changes of CT number in various organs according to hematocrite level.
Jong Cheul CHOI ; Sung Seob CHOI ; Seoung Oh YANG ; Yung Il LEE ; Duck Hwan CHUNG
Journal of the Korean Radiological Society 1993;29(1):174-178
The computed tomography (CT) number is closely related to hematocrit level according to many of the previous reports. We measured the CT number in various organs, such as the frontal white matter, basal ganglia, occipital white matter, cerebrospinal fluid, liver, abdominal aorta, spleen, kidney, and psoas muscle. We correlated the CT numbers of the organs with hematocrit levels which were graded into 10% increments (20.0-29.9%, 30.0-39.9%, 40.0-49.9%). Thus the change of CT numbers in various organs according to the hematocrit level was analyzed. The increased CT numbers according to the 10% increment of hematocrit in the frontal white matter, basal ganglia, occipital white matter, liver, abdominal aorta, spleen, and psoas muscle were 1.3, 1.5, 1.6, 3.3, 5.3, 3.8, 2.4 respectively. Even though the CT numbers of the cerebrospinal fluid and kidney were not influenced by hematocrit level the CT numbers in most of the there organs postitively correlated with hematocrit level. Therefore, it was concluded that in the differential diagnosis using CT numbers, the hematocrit level of patient must be taken into consideration.
Aorta, Abdominal
;
Basal Ganglia
;
Cerebrospinal Fluid
;
Diagnosis, Differential
;
Hematocrit*
;
Humans
;
Kidney
;
Liver
;
Psoas Muscles
;
Spleen
;
White Matter
3.Effects of MK-801, CNQX, Cycloheximide and BAPTA-AM on Anoxic Injury of Hippocampal Organotypic Slice Culture.
Soo Hyeon MOON ; Taek Hyon KWON ; Youn Kwan PARK ; Heung Seob CHUNG ; Jung Keun SUH
Journal of Korean Neurosurgical Society 2000;29(8):1008-1018
No abstract available.
6-Cyano-7-nitroquinoxaline-2,3-dione*
;
Cycloheximide*
;
Dizocilpine Maleate*
4.Angiographic Hemorrhagic Risk Factors of Cerebral Arteriovenous Malformations.
O Ki KWON ; Dae Hee HAN ; Young Seob CHUNG ; Chang Wan OH ; Moon Hee HAN
Journal of Korean Neurosurgical Society 2000;29(8):995-1000
No abstract available.
Intracranial Arteriovenous Malformations*
;
Risk Factors*
5.The principles of tissue engineering and its recent advances and future prospects.
Journal of the Korean Medical Association 2014;57(2):145-154
The definition of tissue engineering by Langer is "an interdisciplinary field that applies the principles of engineering and the life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function." This technology has achieved remarkable growth in the past 20 years, provoked by its potential role in regenerating new tissues and naturally healing injured or diseased organs. Although stem cells are still in the research phase, their pluripotency and unlimited capacity for self-renewal may enable significant advances for reconstructive and cosmetic procedures with this engineering technology. This article aims at outlining the principles of tissue engineering and its recent advances and future prospects.
Biological Science Disciplines
;
Reconstructive Surgical Procedures
;
Regenerative Medicine
;
Stem Cells
;
Tissue Engineering*
;
Tissue Scaffolds
6.Experience in the Surgery of Acoustic Neurinoma.
Young Seob CHUNG ; Kil Soo CHOI
Journal of Korean Neurosurgical Society 1985;14(1):131-138
The authors reviewed forty cases of acoustic neurinomas operated on from July 1974 to June 1984, analyzing our data obtained during 10 years in the following three periods: 1974 to 1978, 1978 to 1981, 1981 to 1984. A suboccipital approach was used for the removal of acoustic neurinomas in all cases. 1) A peak in the age distribution was seen at 40-50 years of age and no sexual difference was present. 2) The earliest symptoms were hearing loss(50%), headaches(25%), tinnitus(15%) in order of frequency. The time between onset of complaints and admission was mostly within 5 years(83%). 3) Most of the patients had large tumors(78%), greater than 3cm, of whom 4 patients were free of cerebellar and brain stem dysfunction. 4) Total removal was carried out in 27 out of 40 patients(67%) and particularly in 8 out of 14 patients(57%) with large tumors greater than 5cm. The total mortality was 7.5%. 5) In the last 3 years with the advance of microsurgical technique and CT scan, 25 patients were operated on only with a single death and total removal was carried out in 20 out of 25 patients. 6) In total removal, the total mortality was 7.4% and the mortality was 8% in patients with 3-5cm sized tumors and 13% in patients with tumors greater than 5cm, particularly 5% in the recent 3 years. 7) Preservation of the facial nerve following total removal was achieved in 59%. In the recent 3 years, the facial nerve was preserved in 65%. In the large tumors, 3-5cm sized and greater than 5cm, the rates of 75% and 37% were obtained.
Acoustics*
;
Age Distribution
;
Brain Stem
;
Facial Nerve
;
Hearing
;
Humans
;
Mortality
;
Neuroma, Acoustic*
;
Tomography, X-Ray Computed
7.Protein C and Protein S as a Risk Factor for Retinal Vein Occlusion.
Kyoung Seob LEE ; J K CHUNG ; Sung Jin LEE
Journal of the Korean Ophthalmological Society 2005;46(11):1796-1801
PURPOSE: The authors evaluated the possibility of protein C and protein S as risk factors for retinal vein occlusion (RVO). METHODS: We evaluated the medical histories and performed laboratory tests, including protein C and protein S, in patients who were diagnosed with RVO by fundus examination and fluorescein angiography. The same data were obtained from a healthy control group. We analyzed mean activity and the ratio of patients with decreased levels of protein C or protein S. RESULTS: Forty-seven patients with RVO in this study consisted of 14 with central retinal vein occlusion (CRVO) and 33 with branch retinal vein occlusion (BRVO). Sixteen normal subjects were also enrolled in this study as controls. There are no cases that presented decreased protein C activity. However, there was a statistically significant difference in the number of cases with protein S deficiency between the patients and the control group (p<0.05). CONCLUSIONS: Deficiency of anticoagulant proteins, especially protein S, may be a risk factor of retinal vein occlusion. Examination of the coagulation system may be useful in the systemic evaluation of RVO patients.
Fluorescein Angiography
;
Humans
;
Protein C*
;
Protein S Deficiency
;
Protein S*
;
Retinal Vein Occlusion*
;
Retinal Vein*
;
Retinaldehyde*
;
Risk Factors*
8.Renal cell carcinomas first detected by Tc-MDP bone scan.
Seoung Oh YANG ; Sun Seob CHOI ; Yung Il LEE ; Duck Hwan CHUNG
Korean Journal of Nuclear Medicine 1993;27(1):148-149
No abstract available.
Carcinoma, Renal Cell*
9.Combined use of carbamazepine and haloperidol in treatment-resistant schizophrenics: A double-blind, placebo-controlled study.
Chul Eung KIM ; Kyoo Seob HA ; Dae Yeob KANG ; Chung Han YOON ; Yong Sik KIM
Journal of Korean Neuropsychiatric Association 1993;32(3):400-406
No abstract available.
Carbamazepine*
;
Haloperidol*
10.A case of VATER syndrome.
Seong Jin HA ; Ki Hyun CHUNG ; Oh Kyung LEE ; Wan Seob KIM ; Kyung Hye LEE
Journal of the Korean Pediatric Society 1993;36(4):583-588
The VATER syndrome is a group of congenital anomalies with a nonrandom tendency for concurrence. Defects include vertebral, anorectal malformation, tracheoesophageal fisutla with esophageal atresia, radial-limb, vascular, and renal abnormalities. The critical period of organogenesis is at or before the sixth or seventh week of gestation. We experienced one case of VATER syndrome in a 1 day old male neonate having vertebral anomalies, esophageal atresia with tracheoesophageal fistula to the distal esophageal segment, imperforated anus, left renal dysplasia with hydronephrosis of the right kidney and both hydroureter, patent ductus arteriosus. We report a case of VATER syndrome with brief review of related literature.
Anal Canal
;
Critical Period (Psychology)
;
Ductus Arteriosus, Patent
;
Esophageal Atresia
;
Humans
;
Hydronephrosis
;
Infant, Newborn
;
Kidney
;
Male
;
Organogenesis
;
Pregnancy
;
Tracheoesophageal Fistula