Objective: In South Korea, there is a significant gap in systematic, evidence-based research on intensive case management (ICM) for individuals with severe mental illness (SMI). This study aims to evaluate the effectiveness of ICM through a randomized controlled trial (RCT) comparing ICM with standard case management (non-ICM). Methods: An RCT was conducted to assess the effectiveness of Seoul-intensive case management (S-ICM) vs. non-ICM in individuals with SMI in Seoul. A total of 78 participants were randomly assigned to either the S-ICM group (n=41) or the control group (n=37). Various clinical assessments, including the Brief Psychiatric Rating Scale (BPRS), Montgomery–Åsberg Depression Rating Scale, Health of the Nation Outcome Scale, and Clinical Global Impression-Improvement (CGI-I), along with quality-of-life measures such as the WHO Disability Assessment Schedule, WHO Quality of Life scale, and Multidimensional Scale of Perceived Social Support (MSPSS) were evaluated over a 3-month period. Statistical analyses, including analysis of covariance and logistic regression, were used to determine the effectiveness of S-ICM. Results: The S-ICM group had significantly lower odds of self-harm or suicidal attempts compared to the control group (adjusted odds ratio [aOR]=0.30, 95% confidence interval [CI]: 0.21–1.38). Psychiatric symptoms measured by the BPRS and perceived social support measured by the MSPSS significantly improved in the S-ICM group. The S-ICM group also had significantly higher odds of CGI-I compared to the control group (aOR=8.20, 95% CI: 2.66–25.32). Conclusion This study provides inaugural evidence on the effectiveness of S-ICM services, supporting their standardization and potential nationwide expansion.

Lung cancer remains a leading cause of cancer-related mortality worldwide. Low-dose computed tomography (LDCT) screening has demonstrated efficacy in reducing lung cancer mortality by enabling early detection. In several countries, including Korea, LDCT-based screening for high-risk populations has been incorporated into national healthcare policies. However, in regions with a high tuberculosis (TB) burden, the effectiveness of LDCT screening for lung cancer may be influenced by TB-related pulmonary changes. Studies indicate that the screen-positive rate in TB-endemic areas differs from that in low-TB prevalence regions. A critical challenge is the differentiation between lung cancer lesions and TB-related abnormalities, which can contribute to false-positive findings and increase the likelihood of unnecessary invasive procedures. Additionally, structural lung damage from prior TB infections can alter LDCT interpretation, potentially reducing diagnostic accuracy. Nontuberculous mycobacterial infections further complicate this issue, as their radiologic features frequently overlap with those of TB and lung cancer, necessitating additional microbiologic confirmation. Future research incorporating artificial intelligence and biomarkers may enhance diagnostic precision and facilitate a more personalized approach to lung cancer screening in TB-endemic settings.

Using the neutral zone concept can increase the stability of the prosthesis. In this case, bimaxillary denture were fabricated using the neutral zone in a patient who had alveolar ridge resorption and inwardly positioned lip. This condition was unfavorable for obtaining stability of the denture, so the force involved in denture had to be minimized. There were differences in the tooth arrangement and shape of the polished surface between the definitive denture made using the neutral zone impression technique and the provisional denture made without using it.

The loss of occlusal vertical dimension due to multiple tooth loss and wear can lead to a collapsed occlusion, resulting in both functional and aesthetic problems.This case report describes a patient exhibiting mandibular prognathism as a result of vertical dimension loss. A comprehensive oral rehabilitation involving an increase in vertical dimension was required. A minimal number of implants were placed, and implant-supported surveyed crowns were fabricated, allowing for the design of a stable and retentive implant-assisted removable partial denture. The treatment resulted in both functional and aesthetic improvements. The anterior rotational pattern of the mandible was alleviated, and the implant-assisted partial denture provided clinically high levels of patient satisfaction. This case report details the diagnostic and therapeutic processes involved in this treatment.

Crossbite refers to a condition where there are remaining teeth, but none of the teeth are in occlusal contact, resulting in the loss of vertical support. When posterior vertical stop is lost, it is important to appropriately restore this support and create a harmonious occlusal plane. In this case, the patient had lost posterior support but declined surgical intervention due to a history of osteoporosis and the associated risk of medication-related osteonecrosis of the jaw (MRONJ). To restore the vertical space required for prosthetic rehabilitation, the vertical dimension was increased. The missing posterior teeth were replaced using removable partial dentures. Cross-mounting was performed, and the metal copings of the surveyed crowns and the framework of the final removable partial denture were 3D printed. After the treatment was completed, the patient expressed satisfaction with both functions and aesthetics. Regular follow-ups were conducted to monitor oral hygiene and occlusal stability.

This issue features six papers in aerospace medicine and safety, including four original articles and two reviews, focusing on pilot health, safety management, aerospace education, cardiovascular research in space, and artificial intelligence (AI) guidelines in aviation safety. Two studies analyze aviation medical examinations, highlighting rising pilot disqualification rates primarily due to neurological, cancer-related, and mental health disorders, emphasizing the need for targeted health management strategies. Another paper proposes enhancing the Line Operations Safety Audit methodology to systematically capture positive crew behaviors, competencies, and proactive threat management. A research article explores relationships between selfefficacy, team-member exchange, and academic performance in aviation service students, recommending customized training programs. Additionally, a review discusses cardiovascular therapeutics using microgravity and cosmic radiation environments, revealing potential terrestrial applications for cardiac regeneration and drug development. Finally, guidelines for AI development in aviation safety stress reliable governance, ethics, and transparency. Future research expanding practical implementation and deepening interdisciplinary collaboration in aerospace medicine and safety is anticipated.

Purpose: The physical and mental fitness of pilots is important for aviation safety. This study analyzes the causes of disqualification among class 1 pilots who underwent aviation medical examinations in South Korea from 2022 to 2024. Methods: A retrospective analysis was conducted using data from class 1 pilots who underwent disqualification between 2022 and 2024. The disqualifying conditions were categorized into major groups (e.g., neurological, cancer, mental health, car diovascular). Results: Among the 26 disqualified pilots, 92.3% (n=24) were men, and the mean age was 49.4 years old (standard deviation, ±6.9). Neurological conditions were the leading cause (27.0%), followed by cancer-related conditions (23.1%) and mental health disorders (15.4%). Cardiovascular diseases accounted for 11.5%, while falsification of medical records, ophthalmologic issues, musculoskeletal problems, and hearing impairments made up the remaining cases. Conclusion These findings emphasize the importance of rigorous medical standards, robust follow-up protocols, and effective management of both chronic and emergent medical conditions in aviation.

Purpose: Over the past 25 years, aviation medical examinations have become esse ntial for pilot health and safety, paralleling industry advancements. As the number of new and aging pilots increases, the demand for systematic health assessments has also grown. However, comprehensive analyses of pilots’ health behaviors and qualifications, particularly their lifestyle habits, remain scarce. Methods: This study analyzed data from the Airmen Medical Certificate Management System (2000–2024), covering age, sex, license type, affiliation, diagnoses, and screening outcomes. Results: Aviation medical examinations increased from 2,366 in 2000 to over 10,000 by 2016, peaking at 14,652 in 2019. Disqualification rates rose from 0.2%–0.4% to 0.5%–1.0% post-2016. Commercial pilot certificates issuance surged over threefold since 2011, peaking at 1,688 in 2019. Male’s disqualification rates remained around 1%, while female’s rates increased to over 3% by 2023. The highest disqualification rate was in the 50–59 age group (0.48%). Obesity rates increased (33% to 39%), smoking rates remained stable (20%), and alcohol consumption stayed high (around 60%). Conclusion The study highlights the growing demand for aviation medical examinations and rising disqualification rates, particularly among older pilots and female. Targeted health management strategies addressing obesity, smoking, and alcohol consumption are essential to maintain the health and safety of aviation professionals and ensure industry growth and safety.

Background/Aims: Gastroesophageal reflux disease (GERD) is a chronic and recurrent condition requiring constant dietary management and medication. This study evaluated the efficacy and safety of HIP1601, a dual delayed-release formulation of esomeprazole, in patients with GERD in a clinical setting. Methods: This prospective, multicenter, observational study was conducted at 309 medical institutions in Korea between June 2021 and March 2023. HIP1601 was administered at daily doses of 40 mg or 20 mg to 5,407 patients requiring treatment or prevention of erosive esophagitis. The primary outcome was the improvement rate of GERD symptoms at four weeks. GERD-related symptoms and treatment-emergent adverse events were also analyzed. Results: This study included 5,282 patients in the safety analysis set and 5,232 in the full analysis set. At four weeks, the improvement rate of GERD symptoms was 92.1% (95% confidence interval [CI]: 91.3–92.8%). By eight weeks, the improvement rate increased to 94.6% (95% CI: 94.0–95.3%). After HIP1601 administration, the severity scores for all four GERD symptoms decreased to less than 1, with statistically significant changes in the scores (p<0.001). HIP1601 was well-tolerated, with minimal adverse events reported (0.17%), and the treatment-emergent adverse events were mild to moderate in severity. Conclusions HIP1601 showed strong efficacy and safety in managing GERD symptoms, with high rates of symptom relief at four and eight weeks. Its extended action and improved symptom control make it a promising therapeutic option for GERD patients.