1.Clinical Experiences of Testosterone Replacement Therapy in Frail Elderly Patients.
Eunju LEE ; Don LEE ; Young Soo LEE
Journal of the Korean Geriatrics Society 2003;7(4):288-294
PURPOSE: Frailty is a wasting syndrome common in old age and to confer high risk for morbidity and mortality. There is a growing consensus of the definition of frailty, but until now the diagnostic criteria is not clear yet. In the older male patients, almost of studies about testosterone replacement therapy performed to normal healthy population. And also only few studies were performed to the frail elderly patients. So we would like to investigate the effficacy of testosterone supplementation in the frail elderly. METHODS: Since May to Sep 2001, ambulatory elderly patients who were 65 years and over were recruited in the outpatient clinic of Asan Medical Center. All of them showed the typical characteristics of frailty symptom-weight loss, loss of muscle mass, weakness, fatigability, anorexia, inactivity. The patients who have sleep-apnea or previous history of prostate cancer were excluded. All patients were checked the serum PSA, total testosterone level, routine CBC, lipid, liver function test and evaluated prostate status with US or digital rectal examination, and treated with oral formula testosterone unde- canoate 80 mg daily. All patients were surveyed with ADL, IADL before the testosterone therapy and 3month later. RESULTS: A total of 6 male frail patients(mean age: 80+/-8.5) were enrolled. During 3 month Follow-up period, one was expired, 5 were finished the study. Before the testosterone replacement, mean total testos- terone level was 3.0+/-0.5 ng/ml and mean PSA was 1.3+/-0.7 ng/ml. After 3 months, blood hematocrit, cholesterol, total testosterone were not changed significantly and the body weight also showed insig- nificant increase. But after 3 months, all of them reported the increased well-being sensation, improved fatigability, weakness and improved ADL level. There were no significant adverse effects associated with testosterone replacement. CONCLUSION: In male frail elderly patients, the testosterone replacement therapy can be used safely, and can be improve the frailty associated symptom and ADL ability.
Activities of Daily Living
;
Aged
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Ambulatory Care Facilities
;
Anorexia
;
Body Weight
;
Cholesterol
;
Chungcheongnam-do
;
Consensus
;
Digital Rectal Examination
;
Follow-Up Studies
;
Frail Elderly*
;
Hematocrit
;
Humans
;
Liver Function Tests
;
Male
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Mortality
;
Prostate
;
Prostatic Neoplasms
;
Sensation
;
Testosterone*
;
Wasting Syndrome
2.Our Valuable Contributors: Reviewers of 2013.
Journal of Preventive Medicine and Public Health 2014;47(2):73-73
No abstract available.
3.Guidelines for the management of hypertension.
Korean Journal of Medicine 1999;57(6):1067-1069
No abstract available.
Hypertension*
4.Sepsis in Immunocompromised Patients: Current Status in Korea.
Korean Journal of Critical Care Medicine 2015;30(4):239-240
No abstract available.
Immunocompromised Host*
;
Korea*
;
Sepsis*
5.Basic Medical Science as a Medical Licensing Examination.
Korean Journal of Medical Education 1994;5(2):18-22
No abstract available.
Licensure*
6.Tuberculous Meningitis with Fever and Seizure.
Journal of the Korean Medical Association 1997;40(9):1235-1239
No abstract available.
Fever*
;
Seizures*
;
Tuberculosis, Meningeal*
7.Quantitative Evaluation of Liver Function with Hepatic Receptor Scintigraphy using Tc-99m Galactosylated Serum Albumin ( GSA ).
Korean Journal of Nuclear Medicine 1998;32(4):305-313
The reduction in the amount of asialoglycoprotein (ASGP) receptor, which resides exclusively on the plasma membrane of functioning mammalian hepatocytes, as a consequence of hepato-cellular damage has been demonstrated in various pathologic conditions of the liver. Galac tosylated human serum albumin (GSA) is a newly developed receptor-binding agent, specific for the ASGP receptor. Tc-99m GSA binds quantitatively to liver ASGP receptors and the rate of accumulation in the liver is dependent on hepatic function represented as the amount of receptor, as well as the amount of ligand injected, its affinity to the receptor and the hepatic blood flow. The findings of Tc-99m GSA scintigraphy were reported to reflect the hepatic function of the patients with large hepatic tumors, obstructive jauniice, acute and chronic liver disease. Tc-99m GSA scintigraphy is an easy and reliable test and has the clinical potentials to evaluate the liver function in the patients with hepatic disorders.
Asialoglycoprotein Receptor
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Cell Membrane
;
Evaluation Studies as Topic*
;
Hepatocytes
;
Humans
;
Liver Diseases
;
Liver*
;
Radionuclide Imaging*
;
Serum Albumin*
8.Pathophysiology of Type 2 Diabetes Mellitus.
Journal of Korean Society of Pediatric Endocrinology 2004;9(1):1-4
No abstract available.
Diabetes Mellitus, Type 2*
9.Neonatal Hyperbilirubinemia.
Journal of the Korean Pediatric Society 1986;29(5):1-5
No abstract available.
Hyperbilirubinemia, Neonatal*
10.A Study on Non-Organic Failure to Thrive Infants.
Journal of the Korean Pediatric Society 1994;37(4):464-471
Failure to thrive (FTT) is defined when the weight of a child is below 3rd percentile or when there is sudden weight loss in history. If organic cause of the weight loss is not found, it is called non-organic failure to thrive(NETT). Relatively little attention has been paid to NFTT in Korea for various reasons and the incidence is not known. 25 NFTT infants, aged 3 to 36 months, and 25 controls, matched by age and sex of the infants and age and education of the mothers, were studied through interviews, questionnaires and MMP1. None of the NFTT and control infants had signs of developmental delay on Korean DDST, but the NFTT babies had more negative attitudes toward foods and were viewed by their mothers as more 'difficult' compared to the controls. Screening of home situations were similar in both groups. There was no difference in reports of mothers' childhood, marital status, mental states or current relations with extended family members. Analysis of MMPI of mothers of NFTT babies showed lower T-scores in Hs (hypochondreiasis) and Hy (hysteria) and higher in Mf (masculinitty-feminity) scales than those of mothers of the controls. But most the scores of scores of MMPI of mothers were within normal limits. Conclusion:Multiple factors seem to play roles in the development of NFTT, the babies' attitudes toward food and temperament being the major ones. The relative improtance of any single factor varies according to each particular infant. Contrary to the findings of other Engligh reports, mothers' mental status was found to play negligible role in the development of NFTT in this study.
Child
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Education
;
Failure to Thrive*
;
Humans
;
Incidence
;
Infant*
;
Korea
;
Marital Status
;
Mass Screening
;
MMPI
;
Mothers
;
Surveys and Questionnaires
;
Temperament
;
Weight Loss
;
Weights and Measures