PURPOSE: Frailty is a wasting syndrome common in old age and to confer high risk for morbidity and mortality. There is a growing consensus of the definition of frailty, but until now the diagnostic criteria is not clear yet. In the older male patients, almost of studies about testosterone replacement therapy performed to normal healthy population. And also only few studies were performed to the frail elderly patients. So we would like to investigate the effficacy of testosterone supplementation in the frail elderly. METHODS: Since May to Sep 2001, ambulatory elderly patients who were 65 years and over were recruited in the outpatient clinic of Asan Medical Center. All of them showed the typical characteristics of frailty symptom-weight loss, loss of muscle mass, weakness, fatigability, anorexia, inactivity. The patients who have sleep-apnea or previous history of prostate cancer were excluded. All patients were checked the serum PSA, total testosterone level, routine CBC, lipid, liver function test and evaluated prostate status with US or digital rectal examination, and treated with oral formula testosterone unde- canoate 80 mg daily. All patients were surveyed with ADL, IADL before the testosterone therapy and 3month later. RESULTS: A total of 6 male frail patients(mean age: 80+/-8.5) were enrolled. During 3 month Follow-up period, one was expired, 5 were finished the study. Before the testosterone replacement, mean total testos- terone level was 3.0+/-0.5 ng/ml and mean PSA was 1.3+/-0.7 ng/ml. After 3 months, blood hematocrit, cholesterol, total testosterone were not changed significantly and the body weight also showed insig- nificant increase. But after 3 months, all of them reported the increased well-being sensation, improved fatigability, weakness and improved ADL level. There were no significant adverse effects associated with testosterone replacement. CONCLUSION: In male frail elderly patients, the testosterone replacement therapy can be used safely, and can be improve the frailty associated symptom and ADL ability.
Activities of Daily Living ; Aged ; Ambulatory Care Facilities ; Anorexia ; Body Weight ; Cholesterol ; Chungcheongnam-do ; Consensus ; Digital Rectal Examination ; Follow-Up Studies ; Frail Elderly* ; Hematocrit ; Humans ; Liver Function Tests ; Male ; Mortality ; Prostate ; Prostatic Neoplasms ; Sensation ; Testosterone* ; Wasting Syndrome

No abstract available.
Peripheral Arterial Disease*

No abstract available.
Hypertension*

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Child* ; Humans

No abstract available.

The glomus tumor or glomangioma is an uncommon benign tumor that arises from the modified smooth muscle cells of the glomus body, a neuromyoarterial receptor sensitive to temperature, that regulates arterial flow. It is most commonly found in the skin particularly in the nailbeds or fingertips, but approximately 70 cases described in the stomach. The author experienced a glomus tumor of the stomach was found in a 43 year old female patient who had discomfort in upper abdomen for 40 days. Clinically, this uncommon gastric tumor mimics most of the benign and malignant lesions of the stomach and the most important aspect of this tumor is its histologic identification and differentiation from the more common gastric lesion. Microscopically the tumor was composed of cellular lobules of various sizes separately by irregular fibrous and muscular trabeculae. Ultrastructural study showed basal lamina, pinocytotic vesicles and numerous subplaomalemmal plaque.
Female ; Humans

No abstract available.

No abstract available.

No abstract available.
Epilepsy*

No abstract available.
Hypoxia-Ischemia, Brain ; Language Development* ; Mass Screening*