No abstract available.
Hernia, Hiatal*

Pityriasis rotunda is an uncommon chronic dermatosis characterized by multiple, round or oval, hyperpigmented or hypopigmented patches that have a fine scale on the trunk and extremities. Most of the cases reported predominantly occurred in Oriental and black patients in association with internal disease. However, in Caucasians it has been documented in healthy persons usually as a familial tendency. We report a case of pityriasis rotunda which showed familial occurrence and had no underlying disease.
Extremities ; Humans ; Pityriasis* ; Skin Diseases

No abstract available.
Overbite*

No abstract available.
Focal Nodular Hyperplasia*

An extensive variety of methods has been used to detect antisperm antibodies in infertile individuals, and this reflects a concern about the immunological validity, interpretation and standardization of the tests. Comparisons of different methods using the same test materials have shown little correlation between results. The purpose of this Study is to compare the results of three methods. ELISA, gelatin agglutination test and sperm immobilization test-using the same test materials based on recommendations from WHO workshop. The results are as follows: 1. Ten normal controls showed negative reactions in all the 3 tests. Out of 34 patients, the positive sera were noted in 23 (67.6%) on ELISA test, 20 (58.8%) on gelatin agglutination test and 18 (52.9%) on sperm immobilization test. 2. Fifteen (44.1 %) out of 34 patients showed positive reactions in all the 3 tests, and 26 (76.5%) out of 34 patients showed positive reaction in one or more tests. 3. The titers of the antisperm antibodies were higher in the following orders; ELISA, gelatin agglutination test and sperm immobilization test. Therefore, it seems to be possible to increase the detectability of the antisperm antibodies, if more than one tests are impolyed.
Agglutination Tests* ; Agglutination* ; Antibodies ; Education ; Enzyme-Linked Immunosorbent Assay* ; Gelatin* ; Humans ; Immobilization* ; Infertility ; Male* ; Spermatozoa*

PURPOSE: Cholestasis is a common manifestation of biliary obstructive diseases. This study was designed to verify histopathologic manifestations of cholestatic liver injury after bile duct ligation in a murine model. METHODS: Eight-week-old female CB6 F1 mice underwent common bile duct ligation and sacrificed at various intervals after surgery. Serum samples were used for the levels of ALT, gamma-GT, total bilirubin. Liver tissues were used for H&E stain for histopathologic examination, Masson's trichrome to assess fibrosis, and reticulin for evaluation of hepatic lobular framework and cell loss. Data were analyzed using the Students' t-test. RESULTS: In mid-duct ligated animals, marked microvesicular fatty change was noted between 1 to 2 days, which completely subsided after 3 days. Scattered variable-sized foci of hepatic cell loss were noted also, beginning at 12 hours, but becoming more prominent at 1 to 3 days. Fibrosis in larger portal tracts near the hilum was first noted through day 3, and remained at days 7 and 28. This was accompanied by marked branching and/or epithelial proliferation in the large bile ducts. Peripheral hepatic fibrosis was evident at day 5 and continued postoperatively. Liver function tests on serums showed an obstructive jaundice pattern during the first week. These values normalized by week 4. Choledochoduodenal fistulae were formed in mice surviving 4 weeks after ligation. CONCLUSION: This study provides a temporally reproducible pattern of biochemical and histopathological changes in the liver, providing a useful model for studying the pathobiology of cholestatic liver diseases secondary to extrahepatic bile duct obstruction.
Animals ; Bile Ducts ; Bile Ducts, Extrahepatic ; Bilirubin ; Cholestasis ; Common Bile Duct* ; Female ; Fibrosis ; Fistula ; Hepatocytes ; Humans ; Jaundice, Obstructive ; Ligation* ; Liver Diseases ; Liver Function Tests ; Liver* ; Mice* ; Reticulin

No abstract available.
Asthma*

The wandering spleen is a rare condition, in which the spleen is located in other than the left upper quadrant of the abdomen. The clinical manifestation is variable from asymptomatic to abdominal catastrophy due to torsion of the splenic pedicle. We experienced a case of torsion of wandering spleen in 8-year-old girl who admitted with fever, vomiting, abdominal pain, palpable left abdominal mass. She was diagnosed preoperatively with the aid of abdominal sonography and C.T. scanning. A splenectomy was performed and she made uneventful recovery. The case report illustrates some of the diagnostic and therapeutic considerations pertaining to wandering spleen with a brief review of related literature.
Abdomen ; Abdominal Pain ; Child ; Female ; Fever ; Humans ; Spleen ; Splenectomy ; Vomiting ; Wandering Spleen*

PURPOSE: This project is designed to investigate the immune response of a rat transplantation model to donor specific allogeneic blood transfusion (DST) prior to kidney transplantation. It has been hypothesized that partial activation of the immune system due to allogeneic antigen presentation, followed by immune unresponsiveness. In addition, previous models have shown prolonged donor cell microchimerism can be established following organ transplantation. Mixed chimerism has been demonstrated in organ transplant recipients surviving over a long period. Attempts were made to assess the fate and movements of donor cells following organ transplantation. METHODS: Rat male-to-female renal transplantation and microchimerism was assessed by semiquantitative PCR. A PCR specific for the Y-chromosome (sex-determining region Y[Sry]) allowed the distinction of small amounts of male cells in a large excess of female cells. The study group was divided into four according to the donor specific transfusion (DST) and cyclosporin (CsA) Group 1 are recipients without DST or CsA administration, Group 2 are recipient with CsA, Group 3 with DSILT and Group 4 with full immunosuppresive agent (CsA & DSILT). The samples were obtained at thymus, lymph node, spleen and sternum following transplantation day 1, 7, 21. Donor cell microchimerism were detected by donor Y chromosome in female recipients using PCR RESULTS: The Y-chromosome was detected at high levels in group 4, 21 days after transplantation. The detection ratio in the lymph node was higher than in the other organs. CONCLUSION: The fate of donor cell were closely related to he additional supporting immunosuppressive agent.
Animals ; Antigen Presentation ; Blood Transfusion ; Chimerism ; Cyclosporine ; Female ; Humans ; Immune System ; Kidney Transplantation* ; Kidney* ; Leukocytes* ; Lymph Nodes ; Male ; Organ Transplantation ; Polymerase Chain Reaction ; Rats* ; Spleen ; Sternum ; Thymus Gland ; Tissue Donors ; Transplants ; Y Chromosome

No abstract available.
Humans ; Hypoplastic Left Heart Syndrome* ; Survivors*