1.A Case of Congenital Mesoblastic Nephroma Detected by Prenatal Ultrasonography in Premature Infant.
Woo Jin KO ; Young Deuk CHOI ; Hee Won SONG ; Seung Kang CHOI ; Kook In PARK ; Kook LEE
Korean Journal of Urology 2000;41(2):341-344
No abstract available.
Humans
;
Infant, Newborn
;
Infant, Premature*
;
Nephroma, Mesoblastic*
;
Ultrasonography, Prenatal*
2.Small Hepatocellular Carcinoma: Pathologic Features of 39 Cases A Comparison with Large Hepatocellular Carcinoma.
Yong Il KIM ; Geon Kook LEE ; Sang Yong SONG
Korean Journal of Pathology 1992;26(2):103-116
With advance of diagnostic imaging technics, the detection rate of small hepatocellular carcinoma (HCC) has become much increased, but the questions whether the growth pattern and histologic nature of the HCC keep maintain the original gross and microscopic features with its advancement of tumor size remain still unclear. We reviewed 39 surgically resected hepatocellular carcinomas(HCCs) with a tumor size less than or equal to 3 cm in diameter(s-HCC), and their gross and microscopic features were compared with the HCCs bigger than 3 cm (i-HCC, 199 cases). Single nodular type(SN) was the most common gross type(60%) in s-HCCs, and was followed by single nodular type with perinodular extension(SNPE; 15.4%), multinodular-discrete type(10.3%) and multinodular-confluent type(5.1%). These figures contrasted to SNPE(42.2%) and SN(20.6%) in the i-HCCs. Of the 39 s-HCCs, 25 cases(64.1%) were encapsulated, and 14 cases(36%) demonstrated intratumoral fibrous septations, being contrasted to the i-HCCs in which fibrous septa formation was mord prominent but complete capsule formation was found only in 40.2% of the larger ones. Microscopically, the trabecular type was the most frequent one(53.9%), and increased with their size while the compact type transformed into trabecular one. Thirty three cases(84.6%) were associated with macronodular cirrhosis. Seropositivity for HBsAg was found in 26 cases(66.6%), and high serum alpha-fetoprotein level over 500 IU/L was found in 15 s-HCC cases(38.4%), while 53.3% in i-HCC. The above results suggest that HCCs change their pathologic features by increase of their size, and a comparison of the details with regard to the possible mechanisms involved is discussed.
Carcinoma, Hepatocellular
3.The Effect of Hypobaric Priming Solutions on Extracorporeal Circulation during Open Heart Surgery.
Sun Ok SONG ; Jung Kook SUH ; Heung Dae KIM
Yeungnam University Journal of Medicine 1984;1(1):101-106
Before beginning the extracorporeal circulation, perfusionists should supply oxygen into the oxygenator and establish blood flow through the blood line of the heart-lung machine. But these manipulation can induce severe hypocarbic state of priming solutions due to wash out of CO2 gas in the solution. This study was carried out to examine the relationship of blood gas changes between hypocarbic priming solutions and body circulation in 15 patients undergoing open heart surgery with extracorporeal circulation. PaCO₂, pH, buffer base and PaO2 were measured from priming solutions before and 15 minutes after the extracorporeal circulation. The results were as follows; 1) Before the extracorporeal circulation, mean PaCO₂ level was 12.1±7.8 mmHg in the priming solution. However, 15 minutes after extracorporeal circulation, the PaCO₂ level was maintained at 35.7±5.7 mmHg. 2) pH in the priming solution was variable from 6.93 to 7.99 (mean 7.45±0.29), but after 15 minutes it was ranged from 7.28 to 7.42 (mean 7.35±0.05). 3) Mean buffer base level in the priming solution was 7.9±3.5 mmol/l. but after 15 minutes, it was 19.6±1.2 mmol/l. 4) Mean PaO₂ level in the priming solution was 667.1±45.6 mmHg, but after 15 minutes, it was 280.7±131.7 mmHg.
Extracorporeal Circulation*
;
Heart*
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Heart-Lung Machine
;
Humans
;
Hydrogen-Ion Concentration
;
Oxygen
;
Oxygenators
;
Thoracic Surgery*
4.Electrodiagnostic and histologic changes of graded compression on cauda equina in dog.
In Kook SONG ; Nam Hyun KIM ; Ick Hwan YANG
The Journal of the Korean Orthopaedic Association 1992;27(6):1475-1487
No abstract available.
Animals
;
Cauda Equina*
;
Dogs*
5.Papineau's Cancellous Bone Graft: 4 Cases report
Dae Yong HAN ; Eung Shick KANG ; In Kook SONG
The Journal of the Korean Orthopaedic Association 1984;19(1):185-188
No abstract available in English.
Transplants
6.Primary Necrotizing Granulomatous Vasculitis of the Stomach.
Myeong Cherl KOOK ; Sang Yong SONG ; Yong Il KIM ; In Sung SONG ; Keun Wook LEE
Korean Journal of Pathology 1997;31(1):68-74
A 55-year-old woman suffered from upper abdominal pain for two months and remained refractile against the anti-ulcer regimen. The palliative gastrectomy specimen revealed multiple shallow ulcerations on the thickened mucosal folds mainly in the antrum and body along the greater curvature where multiple, whitish nodules were found in the submucosa. Microscopically, individual submucosal nodules clearly corresponded to the necrotizing granulomatous vasculitis which were featured with diffuse fibrinoid necrosis of arterial walls accompanying granuloma formation and heavy infiltration of neutrophils, eosinophils, histiocytes and giant cells. Similar vasculitic lesions involved venules and arterioles. There were scattered vasculitic changes in the liver biopsy specimens and omentum. There were no clinical presentations or serological support of systemic involvement including systemic lupus erythematosus, Henoch-Schoenlein purpura, cryoglobulinemia or Churg-Strauss granulomatous vasculitis. We conclude that this is a hitherto undescribed primary necrotizing granulomatous vasculitis predominantly involving the stomach.
Abdominal Pain
;
Arterioles
;
Biopsy
;
Cryoglobulinemia
;
Eosinophils
;
Female
;
Gastrectomy
;
Giant Cells
;
Granuloma
;
Histiocytes
;
Humans
;
Liver
;
Lupus Erythematosus, Systemic
;
Middle Aged
;
Necrosis
;
Neutrophils
;
Omentum
;
Purpura, Schoenlein-Henoch
;
Stomach*
;
Ulcer
;
Vasculitis*
;
Venules
7.Psychosocial Factors and Psychiatric Disorder in Childhood Chronic Abdominal Pain.
Korean Journal of Pediatric Gastroenterology and Nutrition 2011;14(Suppl 1):S25-S33
Childhood chronic abdominal pain usually doesn't have an organic etiology. It may cause social impairment and emotional distress in children as well as their families. In view of cognitive and behavioral aspect, passive coping style, maladaptive social modeling, and reinforced secondary gain could contribute to the development and maintenance of pediatric somatization. Integrative etiological model includes biological factors due to the enteric sensitization process, psychosocial factors which encompass family influences, psychodevelomental vulnerability, and life event-related stress. These factors interact with each other and manifest as various psychosomatic symptoms. In the treatment of childhood chronic abdominal pain, multimodal treatment program, which includes cognitive behavioral therapeutic methods, emotional support, family education, selective serotonin reuptake inhibitor, and so on, is known to be most effective.
Abdominal Pain
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Biological Factors
;
Child
;
Combined Modality Therapy
;
Humans
;
Serotonin
8.Prenatal diagnosis of Duchenne muscular dystrophy using Polymerase Chain Reaction-restriction fragment length polymorphism(RFLP).
Dong Hyun CHA ; Kook LEE ; Jong Rak CHOI ; Kyung Soon SONG
Korean Journal of Obstetrics and Gynecology 2000;43(6):1080-1087
OBJECTIVE: Duchenne muscular dystrophy(DMD) is a X-linked recessive disease and results from mutation in the dystrophin gene. In this study, we evaluate the efficacy of polymerase chain reaction-restriction fragment length polymorphism in prenatal genetic diagnosis of DMD. METHODS: DNA was isolated from DMD family's blood and fetal amniocyte and used to perform PCR-RFLP. In DMD family(3 cases), linkage analysis was tried with 5 RFLP probes. RESULTS: DMDs of the family A had mutiple exon deletions(6, 8, 12, 13, 17). The mother was a heterozygote of pERT84;MaeIII. The male fetus had a same allele and also same exon deletions with the affected males. The pregnancy was terminated at IUP 18 gestational weeks. Pregnant woman of the family B was heterozygote of both pERT84;MaeIII and pERT87-15;BamHI, and pregnant woman of the family C was of pERT84;MaeIII. The both male fetuses , as compared with the affected male of each family, had a different allele. Thus, the fetuses were probably not affected with a confidence level of 95%. CONCLUSIONS: Prenatal diagnosis in prevention of DMD is most important. PCR-RFLP analysis in DMD family is rapid and useful diagnostic tool.
Alleles
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Diagnosis
;
DNA
;
Dystrophin
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Exons
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Female
;
Fetus
;
Heterozygote
;
Humans
;
Male
;
Mothers
;
Muscular Dystrophy, Duchenne*
;
Polymerase Chain Reaction
;
Polymorphism, Restriction Fragment Length
;
Pregnancy
;
Pregnant Women
;
Prenatal Diagnosis*
9.Proliferative Activity of Thyroid Lesions Evaluated by Mitotic Count and Proliferating Cell Nuclear Antigen (PCNA).
Hwa Sook JEONG ; Geon Kook LEE ; Hyung Geun SONG ; Ro hyun SUNG
Korean Journal of Pathology 1997;31(12):1297-1307
To evaluate the clinical and histopathological significance of the proliferative activity in neoplastic and non-neoplastic thyroid lesions, we analyzed the mitotic count and the proliferating cell nuclear antigen labeling index (PCNA-LI) by immunohistochemistry as the proliferation- related markers. In this study included were surgically removed normal thyroid tissue (27 cases), adenomatous goiter (15 cases), Hashimoto's thyroiditis (5 cases), follicular adenoma (13 cases), follicular carcinoma (7 cases), papillary carcinoma (44 cases), poorly differentiated carcinoma (2 cases) and undifferentiated carcinoma (3 cases). The median PCNA-LI was 0 in normal thyroid tissue, 0.5 in adenomatous goiter, 6.2 in Hashimoto's thyroiditis, 1.2 in follicular adenoma, 4.8 in follicular carcinoma, 8.5 in papillary carcinoma, 60.8 in poorly differentiated carcinoma, and 55.2 in undifferentiated carcinoma (p=0.0001). Although PCNA-LI was exceptionally high in Hashimoto's thyroiditis, it was suggested that PCNA-LI could be used as a marker differentiating benign lesions from malignant neoplasm. Also, it could differentiate follicular adenoma from follicular carcinoma. Except clinical stage (p=0.0397), PCNA-LI was not related with sex, size, histologic subtype, and lymph node metastasis in papillary carcinoma. The presence of mitosis differentiated the neoplastic thyroid lesions from the non-neoplastic lesions (p<0.05), however, it could not divide benign and malignant neoplasm. These results suggest that an evaluation of the proliferative activity can help to differentiate the thyroid lesions. In addition, there was no significant correlation between the value of PCNA-LI and the presence of mitosis. It can be recommended to evaluate both the mitotic count and the PCNA-LI for determining the proliferative activity of the thyroid lesions.
Adenoma
;
Carcinoma
;
Carcinoma, Papillary
;
Goiter
;
Immunohistochemistry
;
Lymph Nodes
;
Mitosis
;
Neoplasm Metastasis
;
Proliferating Cell Nuclear Antigen*
;
Thyroid Gland*
;
Thyroiditis
10.Pathological Analysis of the Basal Cell Carcinoma.
Kye Yong SONG ; Young Hwa CHOI ; Mi Kyung KIM ; Kenn Kook LEE ; Eui Kenn HAM
Korean Journal of Pathology 1994;28(2):160-167
Though basal cell carcinoma is the most frequent and increasing malignant tumor of the skin in Korea, its pathological analysis has been done only on the small numbers. So, we did a comprehensive pathologic study on the 283 patients with basal cell carcinoma diagnosed in the Department of Pathology, Seoul National(233cases) and Chung-Ang(50cases) University Hospital during 1975-1992. The age distribution was ranged from 15 to 84 years with highest incidence rate in the age group of 5th-8th decades and 83.7% of all patients were over 40 years of age. Sex difference was not noted. The most common site was face occuring in 235 out of 283cases(83.0%) especially in the eyelid(25.5%), nose(17.9%) and cheek(16.6%). The most frequent histopathologic type was solid type(54.0%) followed by mixed(23.9%), adenoid(7.5%), and metatypical(4.7%). Among 51 mixed type, all showed solid components with adenoid(51.0%) followed by morphea(25.5%) and metatypical type(13.7%). And among 14 recurrent cases, solid type is found in 50% of cases. The characteristic clinicopathological findings are solid arrangement of tumor cells with various histological pattern and predominant occurence on the face.
Incidence