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This study was designed to assess the effects of compound madecassol(madecassic acid with neomycin sulfate and hydrocortisone acetate) on the wound healing. Madecassol is a titrated extract of centella asiatica and the clinical effects of madecassol are stated to the enhancement of wound healing and the prevention and relief of excessive scar formation. Compound madecassol is composed of madecassol and neomycin sulfate and hydrocortisone acetate. Neomycin sulfate has antibiotic effect and hydrocortisone acetate has antiinflammatory and antiallergic effects. So, compound madecassol has a synergistic effect of madecassol as well as neomycin sulfate and hydrocortisone acetate. Using 54 rats, we compared the effect of compound madecassol on wound healing at 3rd, 7th, 14th, and 21th postoperative days. This study examined the histologic findings and the gross findings which were wound size, epithelization and quality of granulation tissue. In this study, compound madecassol showed lower degree of inflammatory infiltration, shorter inflammatory phases and less wound contraction. The number of the myofibroblast in the group of compound madecassol were fewer than other groups. Granulation tissue of the compound madecassol was relatively healthier than others. There were no significant difference of re-epithelization between compound madecassol and other groups. In conclusion, compound madecassol can reduce excessive wound contraction and promotes wound healing process.
Animals ; Centella ; Cicatrix ; Granulation Tissue ; Hydrocortisone ; Myofibroblasts ; Neomycin ; Rats ; Wound Healing* ; Wounds and Injuries*

3.Occult papillary carcinoma of the thyroid.

Seung Keun OH ; Hwan Young YOO

Journal of the Korean Cancer Association 1993;25(5):651-657

4.A Clinical Observation on 112 Cases of Hypospadias.

Jong Keun YOO ; Kun Weon CHOO

Korean Journal of Urology 1982;23(8):1143-1147

A clinical observation was made on 112 cases of hypospadias which were treated at the Department of Urology, Seoul National University Hospital during the period June 1977 through May 1982. The results were as follows: 1. The ages were distributed from 7 months to 31 years and most of the cases (64.3%) was treated in the age group of less than 7 years. 2. Most of the types of hypospadias was penoscrotal type (43.8%). 3. Cryptorchism was the most frequent associated anomalies with 21 cases (18.8%). 4. The complication rate of other anomalies was greatest in the perineal type (81.8%). 5. Success rate of one-stage urethroplasty was 52.9%. 6. In two-stage operation, the first stage operation of 97 cases was successful except one of incomplete chordee release and the success rate of Thiersch-Duplay and Johanson second stage urethroplasty was 44.4% and 66.7% respectively. 7. As the urethral stent was used in the urethroplasty, the success rate of use of silastic tube was better than red rubber and feeding tube.
Cryptorchidism ; Female ; Humans ; Hypospadias* ; Male ; Rubber ; Seoul ; Stents ; Urology