A case of progressive lipodystrophy affecting 19-year-old female, is reported. Two years ago, she accidentally discovered brownish pigmented, and depressed lesion on the periumbilical area. For one year after that, lipodystrophic process spread to the left lateral abdomen and chest wall in linear fashion and ceased spontaneously. Physically, she had no abnormalities on general conitions and fat distribution on whole body was also normal except the above mentioned area. Laboratory findings are with normal limits except incread ESR. Histopathologic findings showed abscence of subcutaneous adipose tissue.
Abdomen ; Female ; Humans ; Lipodystrophy* ; Subcutaneous Fat ; Thoracic Wall ; Young Adult

A case of solitary glomuys tumor affection 43 year-old woman, who has been suffered from bluish purple colored, smail, tener nodule on the left scapular area, was presented. Surgical excision of lesion was enough for relieving the whole subjective symptoms.
Adult ; Female ; Glomus Tumor* ; Humans

With recent progres ion in knowledge of immunology, the roles of eosinophils and basophils in immediate and delaye3 hypersnsitivity reatioons have been partly elucidated and generally they are known as marker cells in various allergic disorders. Changes in number of eosinophils and basophils in the infiltrates of the involved tissue or in circulating blood. in various allergic disordcrs have been reported by several investigators, however, there are only a fever ports about skin disorders, especially for basophils because staining and conting method of the basophils devcloped only recently by James and Moore. The present study has been performed to detect the alteration in absolute number of circulating eosinophils and basophils and to find out any correation between the changes of hoth cell numbers in various allergic dermatoses. A total of 84 pati,.nts with various allergic dermatoses and 50 healthy adults as control group were selected for this study at National Medical Center during the period of July to September 1976. The method of staining and counting of circulating eosinophils and basophils was essentially same with the originaI method of Randolph for eosinophils and James and Moore for basophils with only a minor modifications of both. All the blood specimens were taken between 9:00 and l2:00 a.m. and all the experiments were done within 6 hours after sampling. The results were as follows. 1. The mean value+1 S.D. for eosinophil, basophil and total leukocyte number in 50 normal control was 126.5+80.4, 31. 413.6, and 5,928.3+1,536.9, respectively. 2. In 20 cases of acute urticaria (duration of illness, less than 2 days), the mean value+1 S.D. for eosinophil, basophil, and total leukocyte number was 107.4+95.4, 9.3+7.3 and 9,620+3,240.5, respectively and the result showed a significant decrease of basophils(p<0.001). In 20 cases af chronic urticaria (duration of illness, more than 4 weeks and dermographism included), the mean value 1 S.D. for eosinophil, basophil and total leukocyte number was 237.3+202.9, 31.1+12.3 and 7,748.5+1,989,7, respect!vely and the result showed a significant increase of eosinophils(p<0.01). 4. In 15 cases of atopic dermatitis, the mean value+1 S.D. for eosinophil, basophil and total leukocyte number was 309.7+402.8, 28.8+16.5 and 7,694.5+3,221.9, respectively and the result showed a significant increase of eosinophils (p<0.01). 5. !n 10 cases of acute allergic contact dermatitis, the mean value+1 S.D. for eosinophil, basophil and total leukocyte number was 381.5+269.5, 53.6+34.0 and 7,979.4+1,126.0 respectively and the result showed a significant increase of eosinophils and basophils, respectively(p<0.001, p<0.0.1) 6. In 5 ceases of allergic drug eruption, the mcan value 1 S. D. for eosinophil, basophil and total leukocyte number was 520.0+367.5, 19.6+17.6 and 12,390+2,783.3, respectively and the result showed a significant in.rease of eosinophils (p<0. 001) and decrease of basophils. 7. In 10 cases of scabies, the mean value+1 S.D. for eosinophil, basophil and totai leukocyte number was 299.3+216.6, 30.4+11.5 and 8,081.6+3,304.4, respectively and the result showed a significant increase of eosinophils (p<0.01). 8. In 3 cases of tinea pedis with id eruption, the mean value+1 S.D. for eosinophil, basophil and total leukocyte number was 288.9+79.7, 29.6+5.2 and 8,916.7+2,739.2, respectively and the result shovred slight increase of eosinophils. 9. In order to observe the sequential changes in the number of circulating eosinophils and basophils, a patient with wart was sensitized and challenged with DNCB, and serial determinations were performed. During sensitization period the number of circulating eosinophils was not changed, but the basophils increased gradually, After spontaneous flare-up the number of eosinophils increased with the decrease toward normal of basophils. In the present study, we confirmed that the circulating eosinophils and basophils are definitely related to allergic dermatoses and found out the possibility that the difference in absolute number might be related to the causal agents and duration of disease.
Adult ; Allergy and Immunology ; Basophils* ; Cell Count ; Dermatitis, Allergic Contact ; Dermatitis, Atopic ; Dinitrochlorobenzene ; Drug Eruptions ; Eosinophils* ; Fever ; Humans ; Leukocyte Count ; Research Personnel ; Scabies ; Skin ; Skin Diseases* ; Tinea Pedis ; Urticaria ; Warts

The mite fauna of the house-dust, collected from 39 houses of Seoul, were examined and the results are as follows. 1) Mites were present in 29 samples (74.3%) and the number of mites collected was 993 in total. 2) The families of the mites distinguished were Pyroglyphidae, Acaridae, Cheyletidae, Phytoseiidae and Smariidae, and the identified species were Dermatophagoides farinae, Deromatophagoides pteroassinus, Tyrophagus purtrecentiae, Landoglyphus konoi and Cheyletus malacensis. 3) D. farinae (53.6%) showed higher frequency rate of occurance than any other mites; C. malacensis (12.8%), T. putrecentiae (7.7%), D. pteronyssinus (5.0%) and I. konoi (2.7%).
Acaridae ; Dermatophagoides farinae ; Dust* ; Humans ; Mites* ; Pyroglyphidae ; Seoul

Neurilemmoma is usually a solitary nerve sheath tumor, most often seen in adults. Tl: neurilemmomas of the oral cavity have been reported to develop on the tongue, buccal m7; Cosa, palate, gingiva, floor of the mouth, and lower lip, in order of frequency. We describe 7-year-old boy witlf an asymptomatic, solitary neurilemmoma on his upper lip with a brit: review of the literature. Neurilemmoma should be considered as one of the tumors that ca develop on children's lips.
Adult ; Child ; Gingiva ; Humans ; Lip* ; Male ; Mouth ; Neurilemmoma* ; Palate ; Tongue

Itraconazole is the first orally active triazole antifungal agent. Authors performed multicenter trials to evaluate the therapeutic effect of itraconazole in dermatophytoses. During 6 months from September, 1988 to February, 1989, 246 patients with dermatophytoses were included in this study. 74 of these cases lost to follow-up and 3 cases developed drug eruption were excluded from analysis of therapeutic efficacy. Duration of therapy were 4 weeks in tinea pedis and tinea manus, and 2 weeks in tinea cruris and tinea corporis. The obtained results were as follows : 1. The everall cure rate of itraconazole in dermatophytoses were 81.3%, and the cure rate in each dermatophytosis were 80.3% in tinea pedis, 100.0% in tines manus, 85.3% in tinea cruris and 68.6% in tinea corporis. 2. The cure rate at two weeks after completion of the therapy(81.3%) was higher than that at the end of the therapy(74.3%). 3. Trichophyton rubrum(70.0%), Trichophyton mentagrophytes(81.3%), Microsporum canis(7.3%) and Epidermophyton floccosum(0.9%) were isolated from 110 cases among the enrolled patients. 4. Seven of the 190 patients experienced adverse effects of the treatment: abdominal discomfort(one); nusea(one); constipation(two); and drug eruption(three). Therefore we impressed that itraconazole is an effective and safe new oral therapeutic: agent for dermatophytoses.
Drug Eruptions ; Epidermophyton ; Humans ; Itraconazole* ; Lost to Follow-Up ; Microsporum ; Tinea Pedis ; Tinea* ; Trichophyton

This study is an epidemiological investigation of the trends of leprosy of the last 10 years by age, sex, place of birth, present address, type of disease, onset age and duration of disease hetween the onset and the treatment. The study was conducted on 766(550males, 216females) out-patients who visited the Chronic Disease Laboratory from January, l965 to December, 1974. The importance of leprosy control in the urban area has been discussed. The conclusions are as follows; 1. Average monthly registered numbers of new patients are 5. 2 in A group of patients and 7. 6 in B group of patient. The ratio of male to female is 2. 7 and 2.4 respectively. By age groups, both male and female, the highest age group is 25~34 years. This age group comprised 41. 3% of the 1965~1969 group (A group) of patients, and 34. 7% of the 1970~1974 group (B group) of patients. In the former group of patients, a significantly higher number of patient were under 35 years and in the latter group of patients, the patients of 35 years or more showed a significant increase. It can be concluded that rate of patients of 35 years of age or more is on the increase. 2. By geographical locations of birth, the number of patients from the southern part of korea where leprosy is widely prevalent was the largest. These comprised 59. 3% in the A group of patients and 16. 0% in the B group of patients, followed by 23. 9% and 23. 7% from the middle part of Korea for those periods. The northern part of Korea showed only 10. 6% and 11. 7% respectively. Meanwhile, by present addresses, the number of patients residing in the northern part was dominantly large, and 80.3% of the A group of patients and 79.8% of the B group of patients were found to be living in the vicinity of Seoul. 3. Among the patients from the northern part, the increase of patients of L-type and B-group was remarkable. From this point of view, leprosy control policy for the neighbouring areas of large cities ia urgent. 4. The onset age shows highest in the age braeket of 15-19years with 24.5% in the A group of patients, 20.0% in the B group of patients. This is folIowed by the age bracket of 20~21 years of age comprising 16.8% in the A group of patients, 18. 4% in the B group of patients. A Comparative study of the peroid from the onset of the disease to the beginning of the treatment, showed that patients of less than 5 years amounted 69. 3% in the A group of patients and 64. 0% in the B group of patients. Those of more than 10 years were 9. 4% in the A group of patients and 14. 7%, in the B group of patients. 5. The results of bacteriological examination showed a tendency to increase in the positive rate with 14.2% in the A group of patients and 28.7% in the B group of patients. This is attributable to the increase of patients of L-type and B-group.
Age of Onset ; Chronic Disease* ; Female ; Humans ; Korea ; Leprosy* ; Male ; Outpatients ; Parturition ; Residence Characteristics ; Seoul

BACKGROUND: The pathogenic role of the hair follicle mite in rosacea is still a matter of debate. Although the hair follicle mite may induce a pathologic condition by dermal invasion or excessive number of mites, the number of mites necessary to induce a pathologic condition has not been established in Korea. OBJECTIVE: The purpose of our study was to know the causative role of the hair follicle mite in rosacea and the threshold value between 'normal' and 'abnormal' density of the hair follicle mite on Korean facial skin. METHODS: We applied skin surface biopsy to investigate the population density and distribution of hair follicle mites in the facial skin of 50 patients with rosacea (9 with episodic erythema, 29 with stage I, 12 with stage II), 7 patients with demodicidosis and 54 control subjects. The mites were counted in measured skin surface biopsy specimens obtained from three standard facial sites(2cm on cheek and chin, 1cm on nose) with cyanoacrylate glue. RESULTS: 1. The mean mite count per 5cm was 3.4+/-0.7 in control subjects and 10.7+/-1.9 in patients with rosacea(p<0.05) The density of Demodex(mite count/ 5cm) was significantly higher in patients with demodicidosis (115+/-14.2) than in the control (p<0.001) and rosacea patients(p<0.05). 2. The highest density of mites was found on the cheek in the control and diseased subjects. The incidence of hair follicle mites was higher on the nose than on the cheek in the control subjects and rosacea patients. In demodicidosis, the incidence of the hair follicle mites was higher on the cheek than on the nose. 3. The distribution of hair follicle mite was not significantly different among the three clinical stages of rosacea. The mite counts in stage II rosacea were higher than those of control subjects (p<0.05). 4. The distribution of the hair follicle mite in the control subjects was related to a increase of age but not related to sex. The distribution of the hair flooicle mites in rosacea patients was not related to age or sex. 5. Hair follicle mites were found in 33 out of 54 control subjects(61%) and in 40 out of 50 rosacea patients (80%). The mite counts of all control subjects and all rosacea patients were less than 5/cm and 10/cm, respectively. The mite counts of all demodicidosis patients were more than 10/cm. CONCLUSION: These results suggest that the increased nomber of mites play a part in the pathogenesis of rosacea and demodicidosis is a specifio disease entity differentiated from rosacea. When the density of the hair follicle mites is above 5 /cm2, a pathologic condition of the skin, such as rosacea and demodicidosis, would have to be considered. Demodicidosis should be suspected when the density of the hair follicle mites is above 10 /cm. In addition, skin surface biopsy is recommended as the most simple and useful clinical method in search of the distribution of the distrbution of the hair follicle mites.
Adhesives ; Biopsy* ; Cheek ; Chin ; Cyanoacrylates ; Erythema ; Hair Follicle* ; Hair* ; Humans ; Incidence ; Korea ; Mites* ; Nose ; Population Density ; Rosacea ; Skin*

In this study, the authors attempted to investigate distribution of the house dust mites in Korea on a nationwide scale. Mites were isolated and classified from 211 house dust samples which were collected from 7 urban areas and 3 rural areas. The result were as follows: 1) Nineteen species of mites were identified in this study including 4 new species which were not recorded in Korea. 2) The most frequent house dust mites were Pyroglyphid mites. Among then, Derntatophagoides farinae was found to be dominant species in Korea since this species was more widely distributed and more frequently found than D. pteronyssinus, 3) The occurence rates of Dermatophagoides sp. in the urban areas were higher than that in the rural areas, but vice versa in the occurence rates of other mites accidently found in the dust samples.
Dust* ; Korea ; Mites ; Pyroglyphidae*

The detection of renal disorders now involves a series of complicated diagnostic procedure such as radiologic pyelography, function studies in laboratory and others These add up to a painful, expensive, and time consuming experience for the patient, others may be spared the discomfort of unnecessary. Consequently, the development of methods for preliminary screening of patients is significant both with regard to the diagnostic information obtained and to the selection of those patients requiring complete urologic work up. In particular, a reliable screening test is important in establishing or ruling out renal pathology as an underlying factor in hypertension the finding of a disorder of one kidney in the hypertensive patient may be at indication for nephrectomy or other surgical measures of renal artery. A positive preliminary investigation warrants precise diagnosis by aortography and confirmation by individual renal clearance tests. Finally the primary objective of the screening test is the restriction of more exacting procedures such as aortography with its inherent risk of serious complications to the preoperative evaluation of a demonstrated lesions. The visualization of an internal structure by determining the spatial distribution of a gamma radiation-emitting isotope was started in 1950 when Cassen and his associates utilized newly developed scintillation counters to print mechanically the spatial distribution of radioactive iodine in the thyroid gland. Visual and functional informations referable to each kidney separately may be obtained by radioisotopes and tracer or by scanning techniques rapidly and without trauma. The renogram or tracing of the renal uptake and excretion of a labeled contrast medium is a clinically useful measure of renal vascularity, tubular cell function, and the patency of the upper urinary passage, and especially valuable as a screening test for the hypertensive patient with suspected unilateral disease of the kidney. Similarly, scanning images are achieving an important place in medical diagnosis of irregularities effecting the kidneys and other specific organs. Radioactive contrast media, such as I131 labeled diodrast, miokon, Urokon, or hippuran have been widely used for renal function studies. They are entirety unsatisfactory, however, for renal scintillation scanning because they are rapidly excreted by the kidneys without retention in the renal parenchyma in contrast but mercurial diuretics labeled with radioactive mercury are concentrated to a high degree in the renal tubular cells, chiefly in the cortex, prior to their appearance in the urine (Borghgraef 1956.MaAfee and Wagner 1960). Following the report of these letter writers, scintillation scanning of the kidney after the intravenous injection of Hg Neohydrin have been widely used in urological clinics for preliminary screening method of renal disease such as delineating the parenchyma of the kidney and space-occupying lesions by Krevitz, Berk, and others(Reley, Blahd, Mins, Morgan, Kuhl, Bender, Simmons, Blau, Kim) and remained several problems which is anticipated to improvements in resolution for further using of renal scan. The main purposes of this experimental study were: 1) to learn at which period of time it is best to visualize the renal parenchyma following the intravenous administration of Hg Neohydrin, 2) to learn the minimal detectable size of space-occupying lesion within the kidney phantom, and 3) to compare the renal scan with aortography and pyelography on various period of hydronephrosis for visualization of renal parenchyma, 4) to compare the renal scan with aortography on various degree of narrowing of the renal artery for visualization of renal parenchyma. MATERIALS AND METHODS: These experiments have been performed on 17 normal adult mongrel dogs anesthetized with intravenous injection of sodium amycal. Ofthese 3 dogs were used for determining the optimal time of visualization of the renal parenchyma. 8 dogs for the visualization of the parenchyma of hydronephrotic kidneys as created by partial ligation of the left ureter for the period of 1. 2. 3 and 4 weeks as devided in 4 groups, and 6 dogs were used for the visualization of the narrowed renal artery produced by partial obstruction to various degrees. A wax phantom of the kidney was utilized for the study of detectable minimal size of the intrarenal space occupying lesion, the phantom measures 12.5 X 6.2 X 3.5cm. All animals underwent renal scintiacan received 80 microcuri of Hg neohydrin intravenously, they were placed in a prone position and the study was carried out using a Nuclear-Chicago dual scanner with a 62-hole coarse focusing collimator containing a 3x3 inch sodium iodide crystal, the collimator was passed back and forth over the target are at a rate of 12-15cm, per minute. The scan usually required 30 minutes for complete of scan. The pyelography was performed in retrograde way with 30% diodrast injected through ureteral catheter and the amount of dye injected was adjusted to replace the urine from renal pelvis. The aortography was performed by transfemoral arterial catheterization technique as described by Seldinge. RESULTS: 1. The optimal opacification period of renal parenchyma after injection of Hg 203 neohydrin was found to range from 1 to 6 hours 2. By kidney phantom study it was demonstrated that the space-occupying lesion measuring 2cm. in diameter can not be detected on scan. While the lesion measuring 3cm, or more can be successfully visualized. 3. The effect of partial obstruction of the ureter upon the renal scintiscan for visualization of renal parenchyma was not. dependable, the renal scintiscan continued to appear up to at least the 2 weeks after partial obstruction of ureter whereas the retrogredepyelography and aortography showed the definite picture of hydronephrosis to various degree. 4. The renal scan is inconsistent in many instances of renal artery stenosis, the scan showed a diminished concentration of mercury in the kidney with stenotic main renal artery and complete failure of visualization of the renal substance in cases with completely obstructed renal artery. 5. It is possible to demonstrate the value and usefulness of renal scan of Hg neohydrin as a routine preliminary screening test for renal pathology, the alteration of the concentration of the mercury can might be expected to give additional information.
Administration, Intravenous ; Adult ; Animals ; Aortography ; Catheterization ; Catheters ; Contrast Media ; Diagnosis ; Diuretics ; Dogs* ; Humans ; Hydronephrosis ; Hypertension ; Injections, Intravenous ; Iodine ; Iodopyracet ; Kidney ; Kidney Pelvis ; Ligation ; Mass Screening ; Nephrectomy ; Pathology ; Prone Position ; Radioisotopes ; Renal Artery ; Renal Artery Obstruction ; Scintillation Counting ; Sodium ; Sodium Iodide ; Thyroid Gland ; Ureter ; Urinary Catheters ; Urography