No abstract available.
Drug Interactions*

Erythropoietin is the major hormonal regulator of erythropoiesis. It is controlled by many factors inducing hypoxia in tissue. The serum erythropoietin levels of neonates have shown gradual dccrease until 1 month of age, which they are reactivated in the period of physiologic anemia. This change is exaggerated if the meonates are born prematurely, and the levels of erythropoietin respond to lower hemoglobin are lower than those of term neonates and adults. The purpose of this study was to assess the values of erythropoietin levels to compare hemoglobin on the preterm and term neonates until 1 month of age. The results were as follows: 1) At birth mean erythropoietin values of preterm and term neonates were 16.5+/-1.4mU/ml, 16.5+/-1.7mU/ml respectively, there was no significant difference. Also erythropoietin values in preterm and term neonates were 23.6+/-13.3mU/ml, 10.9+/-1.5mU/ml respectively. Resticulocyte counts in preterm and term neonates were 10.7+/-3.3%, 5.7+/-2.9% respectively, so they were significantly higher in preterm than in term neonates. 2) The changes of mean hemoglobin, reticulocyte counts and erythropoietin according to postnatal ages were that those of reticulocyte counts and erythropoietin were significantly increased about 1 month of age. 3) At the 1 month of age, mean erythropoietin values in preterm neonates were lower than those of term neonates and adults, despite of the lowest hemoblobin. This results showed that erythropoietin values in preterm neonates during the physilolgic anemia were lower values than those of term neonates and adults in spite of the lowest hemoglobin.
Adult ; Anemia ; Anoxia ; Erythropoiesis ; Erythropoietin* ; Humans ; Infant, Newborn* ; Parturition ; Reticulocyte Count

The area overlying the ischium is the most frequent site for the development and recurrence of pressure sores in the paraplegic patient. This report describes a newly-designed inferior gluteus maximus myocutaneous island flap that is useful for the repair of ischial pressure sores in paraplegic patients. Sacral sore develops a wide and flat ulcer crater. However, ischial sore seems to develop large and deep bursa with relatively small openings. We have used a newly-designed gluteus maximus myocutaneous island flap according to the specific characteristics of ischial sore. The flap is designed in the fashion of a small skin island with a large muscle flap. This flap with its abundant and constant blood supply had proved very reliable in the surgical management of ischial pressure sore. There is also the possible advantage of cushioning with the bulk of muscle for greater long-term durability. Incision could be extended for a complete bursetomy and partial ischiectomy. The reliability, versatility and low morbidity of the inferior gluteus maximus island flap has been demonstrated by its use in our consecutive series of 7 patients with 8 ischial pressure sores. We conclude that this newly-designed inferior gluteus maximus myocutaneous island flap can be applied in deep, infected ischial sore according to the specific characteristics of ischial sore, and it is a very useful method in comparison to other flaps.
Humans ; Ischium ; Pressure Ulcer ; Recurrence ; Skin ; Ulcer

No abstract available.
Humans

The development of multidrug-resistant tumor cell population is a major problem in the chemotherapy of human cancer. These cells are often cross resistant to unrelated drugs and the precise mechanisms of multidrug resistant phenotype of tumor cells has not been fully elucidated. Cisplatin resistant tumor cell (SNU-1/Cis₅) was induced from human stomach cancer cell line (SNU-1) in vitro. Growth profiles of survival cells were observed during 5 days by thiazolyl blue (MTT) assay. To investigate the cross resistance of various anticancer drugs in SNU-1 and SNU-1/Cis5, We compared the value of IC₅₀-drug concentration at 50% survival of control and gained relative resistances (RR). The RR for SNC-1/Cis₅ were as follows; vinblastine, > 43.0; epirubicin, 22.9; dactinomycin, 16.0; etoposide, 15.0; vincristine, 9.2; adriamycin, 5.7; aclarubicin, 5.3. But 5-fluorouracil, methotrexate, daunorubicin have not cross resistance with cisplatin. Resistant inhibition values of 10µM verapamil for SNU-1/Cis₅ were as follows; vincristine, 13.1; epirubicin, 10.0; etoposide, 6.3; vinblastine, 4.4; dactinomycin, 3.6; daunorubicin, 2.4. Membrane proteins of 51,400 and 81,300 daltons were identified by radioiodination with SDS-PAGE, which might represented the drug resistance.
Aclarubicin ; Cell Line ; Cisplatin* ; Dactinomycin ; Daunorubicin ; Doxorubicin ; Drug Resistance ; Drug Resistance, Multiple* ; Drug Therapy ; Electrophoresis, Polyacrylamide Gel ; Epirubicin ; Etoposide ; Fluorouracil ; Humans* ; In Vitro Techniques ; Membrane Proteins ; Methotrexate ; P-Glycoprotein ; Phenotype ; Stomach Neoplasms* ; Stomach* ; Verapamil* ; Vinblastine ; Vincristine

No abstract available.
Polymerase Chain Reaction* ; Respiratory Syncytial Viruses

No abstract available.
Low Back Pain*

The purpose of this study was to compare the corrosion characteristics between implant fixture and two types of abutment screw; gold screw, titanium screw. The anodic polarization behavior, the galvanic corrosion behavior, and the crevice corrosion behavior of prepared samples were investigated using potentiostat and scanning electron microscope. The results were as follows : 1. Anodic polarization behavior of samples: The primary passivation potential of implant fixture was -420mV, implant abutment was -560mV, titanium screw was -370mV and gold screw was -230mV. All samples were shown to have a high corrosion potential and good formation of passive film. The critical passive current density of gold screw was higher than of other samples and the sample of gold screw showed a unstable passive film formation at passive region. 2. Galvanic corrosion behavior of samples: Contact current density between implant fixture and titanium screw showed 8.023x 10-5C/cm2. Contact current density between implant fixture and gold screw showed 5.142x 10-5C/cm2. 3. Crevice corrosion behavior of samples : The crevice corrosion resistance of sample using titanium screw was higher than that of sample using gold screw, and a severe corrosion morphologies were observed at the fixture-screw interface by the scanning electron microscope.
Corrosion* ; Titanium

No Abstract Available.
Adenoma*

Malassezia intertrigo is a very rare clinical entity in which the clinical lesions occur in intertroginous areas as erythematous scaling macules and direct microscopic examinatons of scales reveal only large numbers of yeast forms of Malassezia organism. A 59-year-old man, developed brown, finely scaling macular lesions on the inguinal areas. Direct microscopy and culture of the scalings taken from the lesional areas of the patient revealed only oval forms of Malassezia organism.
Humans ; Intertrigo* ; Malassezia* ; Microscopy ; Middle Aged ; Weights and Measures ; Yeasts