1.Drug Interaction in Renal Excretion.
Journal of the Korean Medical Association 1997;40(1):19-23
No abstract available.
Drug Interactions*
2.A basic study for respiratory sybcytial virus detection using polymerase chain reaction.
Yong Kweon KIM ; Jong Duck KIM
Journal of the Korean Pediatric Society 1992;35(10):1402-1410
No abstract available.
Polymerase Chain Reaction*
;
Respiratory Syncytial Viruses
3.Multidrug resistance and cytotoxicity of anticancer drug by verapamil in cisplatin resistant human stomach cancer cell.
Seong Kweon SON ; Jung Hye KIM
Yeungnam University Journal of Medicine 1992;9(1):75-89
The development of multidrug-resistant tumor cell population is a major problem in the chemotherapy of human cancer. These cells are often cross resistant to unrelated drugs and the precise mechanisms of multidrug resistant phenotype of tumor cells has not been fully elucidated. Cisplatin resistant tumor cell (SNU-1/Cis₅) was induced from human stomach cancer cell line (SNU-1) in vitro. Growth profiles of survival cells were observed during 5 days by thiazolyl blue (MTT) assay. To investigate the cross resistance of various anticancer drugs in SNU-1 and SNU-1/Cis5, We compared the value of IC₅₀-drug concentration at 50% survival of control and gained relative resistances (RR). The RR for SNC-1/Cis₅ were as follows; vinblastine, > 43.0; epirubicin, 22.9; dactinomycin, 16.0; etoposide, 15.0; vincristine, 9.2; adriamycin, 5.7; aclarubicin, 5.3. But 5-fluorouracil, methotrexate, daunorubicin have not cross resistance with cisplatin. Resistant inhibition values of 10µM verapamil for SNU-1/Cis₅ were as follows; vincristine, 13.1; epirubicin, 10.0; etoposide, 6.3; vinblastine, 4.4; dactinomycin, 3.6; daunorubicin, 2.4. Membrane proteins of 51,400 and 81,300 daltons were identified by radioiodination with SDS-PAGE, which might represented the drug resistance.
Aclarubicin
;
Cell Line
;
Cisplatin*
;
Dactinomycin
;
Daunorubicin
;
Doxorubicin
;
Drug Resistance
;
Drug Resistance, Multiple*
;
Drug Therapy
;
Electrophoresis, Polyacrylamide Gel
;
Epirubicin
;
Etoposide
;
Fluorouracil
;
Humans*
;
In Vitro Techniques
;
Membrane Proteins
;
Methotrexate
;
P-Glycoprotein
;
Phenotype
;
Stomach Neoplasms*
;
Stomach*
;
Verapamil*
;
Vinblastine
;
Vincristine
4.A study on disclusion time of patient with temporomandibular dysfunction.
Hyeon Sin KWEON ; Chae Heon CHUNG
The Journal of Korean Academy of Prosthodontics 1993;31(1):63-76
No abstract available.
Humans
5.Newly-Designed Inferior Gluteus Maximus Myocutaneous Island Flap for Treatment of Ischial Sore.
Bong Kweon PARK ; Hee Chang AHN
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1999;26(5):984-990
The area overlying the ischium is the most frequent site for the development and recurrence of pressure sores in the paraplegic patient. This report describes a newly-designed inferior gluteus maximus myocutaneous island flap that is useful for the repair of ischial pressure sores in paraplegic patients. Sacral sore develops a wide and flat ulcer crater. However, ischial sore seems to develop large and deep bursa with relatively small openings. We have used a newly-designed gluteus maximus myocutaneous island flap according to the specific characteristics of ischial sore. The flap is designed in the fashion of a small skin island with a large muscle flap. This flap with its abundant and constant blood supply had proved very reliable in the surgical management of ischial pressure sore. There is also the possible advantage of cushioning with the bulk of muscle for greater long-term durability. Incision could be extended for a complete bursetomy and partial ischiectomy. The reliability, versatility and low morbidity of the inferior gluteus maximus island flap has been demonstrated by its use in our consecutive series of 7 patients with 8 ischial pressure sores. We conclude that this newly-designed inferior gluteus maximus myocutaneous island flap can be applied in deep, infected ischial sore according to the specific characteristics of ischial sore, and it is a very useful method in comparison to other flaps.
Humans
;
Ischium
;
Pressure Ulcer
;
Recurrence
;
Skin
;
Ulcer
6.Evaluation of the serum erythropoietin levels in neonates.
Soo Young KWEON ; Gyoung Hee KIM
Journal of the Korean Pediatric Society 1993;36(1):67-72
Erythropoietin is the major hormonal regulator of erythropoiesis. It is controlled by many factors inducing hypoxia in tissue. The serum erythropoietin levels of neonates have shown gradual dccrease until 1 month of age, which they are reactivated in the period of physiologic anemia. This change is exaggerated if the meonates are born prematurely, and the levels of erythropoietin respond to lower hemoglobin are lower than those of term neonates and adults. The purpose of this study was to assess the values of erythropoietin levels to compare hemoglobin on the preterm and term neonates until 1 month of age. The results were as follows: 1) At birth mean erythropoietin values of preterm and term neonates were 16.5+/-1.4mU/ml, 16.5+/-1.7mU/ml respectively, there was no significant difference. Also erythropoietin values in preterm and term neonates were 23.6+/-13.3mU/ml, 10.9+/-1.5mU/ml respectively. Resticulocyte counts in preterm and term neonates were 10.7+/-3.3%, 5.7+/-2.9% respectively, so they were significantly higher in preterm than in term neonates. 2) The changes of mean hemoglobin, reticulocyte counts and erythropoietin according to postnatal ages were that those of reticulocyte counts and erythropoietin were significantly increased about 1 month of age. 3) At the 1 month of age, mean erythropoietin values in preterm neonates were lower than those of term neonates and adults, despite of the lowest hemoblobin. This results showed that erythropoietin values in preterm neonates during the physilolgic anemia were lower values than those of term neonates and adults in spite of the lowest hemoglobin.
Adult
;
Anemia
;
Anoxia
;
Erythropoiesis
;
Erythropoietin*
;
Humans
;
Infant, Newborn*
;
Parturition
;
Reticulocyte Count
7.Caudal epidural steroid injections for treatment of chronic lower back pain.
Byung Gwon PARK ; Kweon Yeong KIM
Journal of the Korean Academy of Rehabilitation Medicine 1993;17(4):642-648
No abstract available.
Low Back Pain*
8.A case of neuroma cutis.
Hyuk Jin KWEON ; Jee Kyung PARK ; Gun Yeon NA
Korean Journal of Dermatology 1991;29(4):549-552
No abstract available.
Neuroma*
9.Coniparision of Clinical Results Between Keratomileusis In Situ and Laser Assisted In Situ Keratomileusis for High Myopia from -15 Diopter to -23 Diopter.
Soo Jin LIM ; Eung Kweon KIM ; Jae Bum LEE
Journal of the Korean Ophthalmological Society 1998;39(5):872-878
Photorefractive keratectomy (PRK), Keratomileusis In Situ (KM), Laser Assisted In Situ Keratomileusis (LASIK), and clear lens extraction have been performed for high myopic patients. Among the above surgical procedures KM and LASIK are applied to young patients in general. However, comparison of clinical results of these two procedures was not reported yet in Korea. To evaluate the clinical results of KM (n=16) and LASIK (n=11) for high myopic patients between -15 diopter (D) and -23 diopter (D), spherical equivalent (S.E) and uncorrected visual acuity were studied for more than ten months, retrospectively. The mean S.E. was changed from -17.36 D before operation to -3.70 D ten months after operation in KM, whereas it was from -17.41 D to -0.31 D in LASIK. At ten months after operation, uncorrected visual acuity equal or better than best corrected visual acuity before operation was 43. 8% in KM and 63. 6% in LASIK. This results show that the clinical result of LASIK were superior to that of KM for high myopia.
Humans
;
Keratomileusis, Laser In Situ
;
Korea
;
Myopia*
;
Photorefractive Keratectomy
;
Retrospective Studies
;
Visual Acuity
10.A case of incontinentia pigmenti.
Soo Young KWEON ; Hyun Joo CHOI ; Gyung Hee KIM
Journal of the Korean Pediatric Society 1992;35(3):417-421
No abstract available.
Incontinentia Pigmenti*