In this study I assesed the efficacy and tolerance of cyclosporin A (CyA) in the treatment of steroid-dependent MCNS (minimal change nephrotic syndrome) and steroid resistant FSGS (focal segmental glomerulosclerosis). The results showed, that 1) CyA was effective in sustaining a remission in steroid-dependent MCNS without prednisone treatment, and, therefore, could be an alternative therapeutic choice. 2) After discontinuation of CyA, relapses reoccurred as frequently as before, and the children remained steroid responsive. 3) In steroid resistant FSGS the CyA treatment was followed by a partial remission (normalization of serum albumin) in 2 out of 7 Patients, and proteinuria was diminished in most cases. However, no complete remission with loss of proteinuria was observed. 4) CyA treatment was well tolerated, especially signs of definitive nephrotoxicity were not observed. It was remarkable, the the well being of all patients improved markedly under CyA treatment and that a normal growth was achieved.
Child ; Cyclosporine* ; Equidae ; Glomerulosclerosis, Focal Segmental* ; Humans ; Nephrosis, Lipoid* ; Prednisone ; Proteinuria ; Recurrence

No abstract available.
Lipoma*

No abstract available.

Eleven nonathletes and eleven athletes wore exorcised on a otandardised Harvard step test, and the average rate of chance in QRS amplitude in lead III of the electocadiogram associated with heart rotation and the average change in rate of heart beat were observed. 1. After the Harvard step exercise, the average rate of change in QRS amplitude in lead III of both groups increased. This was due to the clockwise rotation of the heart and was associated with respiratory movement. The diaphragm was inferred to remain for a while in a relatively more insapiratory position. 2. After the Harved step exercise, a high correlation between the recovery of the average rate of change in QRS amplitude in lead III and the average change in rate of heart beat was observed in the athletic group. 3. In the nonathletic group there was no significant correlation between the average rate of QRS amplitude change and the average rate of change of heart beat. 4. Athletes were assumed to be trained to ventilate quickly at their maximum ability, using deep descending movements of the diaphragm and other respiratory musclature. Consequently, the average in rate of heat beat also recovered quickly. 5. Nonath1etes were inferred not to have been trained to adjust quickly to ventilate so efficiently with their diaphragm movement and other respiratory, musculature, and are characterised by their longer time to complete recovery.
Athletes ; Axis, Cervical Vertebra* ; Diaphragm ; Exercise Test ; Heart* ; Hot Temperature ; Humans ; Sports

Eleven nonathletes and eleven athletes wore exorcised on a otandardised Harvard step test, and the average rate of chance in QRS amplitude in lead III of the electocadiogram associated with heart rotation and the average change in rate of heart beat were observed. 1. After the Harvard step exercise, the average rate of change in QRS amplitude in lead III of both groups increased. This was due to the clockwise rotation of the heart and was associated with respiratory movement. The diaphragm was inferred to remain for a while in a relatively more insapiratory position. 2. After the Harved step exercise, a high correlation between the recovery of the average rate of change in QRS amplitude in lead III and the average change in rate of heart beat was observed in the athletic group. 3. In the nonathletic group there was no significant correlation between the average rate of QRS amplitude change and the average rate of change of heart beat. 4. Athletes were assumed to be trained to ventilate quickly at their maximum ability, using deep descending movements of the diaphragm and other respiratory musclature. Consequently, the average in rate of heat beat also recovered quickly. 5. Nonath1etes were inferred not to have been trained to adjust quickly to ventilate so efficiently with their diaphragm movement and other respiratory, musculature, and are characterised by their longer time to complete recovery.
Athletes ; Axis, Cervical Vertebra* ; Diaphragm ; Exercise Test ; Heart* ; Hot Temperature ; Humans ; Sports

No abstract available.
Child* ; Humans ; Kidney Diseases* ; Kidney*

No abstract available.

SUMMARY Diagnosis of mitochondrial disorders has been difficult due to the clinical and genetic heterogeneity, as well as unique features of mitochondrial genetics. Definitive diagnosis requires the identification of molecular defects in either the mitochondrial or the nuclear genome. We describe the clinical and molecular characteristic of some common mitochondrial syndromes and molecular methodologies available for the detection of mitochondrial DNA mutations. This review provides overview of current molecular diagnosis of mitochondrial DNA disorders that is useful in patient care and genetic counseling.

Numerous drugs are known to cause seizures with therapeutic use or overdose. However, the relative frequency of such complications has rarely been studied, and little is known about the relationship of drug-induced seizures to eventual medical outcome. This study was performed to determine the causes and consequences of seizure associated with poisoning and drug intoxication. We analyzed about 786 cases of drug intoxication visited to Chung-Ang Gil hospital during recent 4 years from Jan. 1993 to Dec. 1996. The results were summarized as follows: 1. The total number of cases of drug intoxication was 786 and the most common drug of intoxication was antihistamines(291 cases, 36.3%); insecticides(113 cases, 14.7%); caustics(90 cases, 11.8%); herbicides(47 cases, 6.1%); NSAID(38 cases, 4.9%); rodenticides(36 cases, 4.6%); acetaminophens(34 cases, 4.4%); anticonvulsants(18 cses, 2.3%); neuroleptics(13 cases, 1.6%); hydrocarbons(9 cases, 1.2%); sympathomimetics(8 cases, 1.0%). 2. The leading causes of seizures were antihistamines(12 cases, 42.8%); insecticides(7 cases, 25.0%); sympathomimetics(3cases, 10.7%); neuroleptics(2 cases, 7.2%); others(4 cases, 14.3%). 3. Seizures associated with antihistamines were generally brief(11 cases, 92.0%) and uncomplicated(3 cases, 25.0%). 4. Seizures incidence by drug intoxication was relatively high in sympathomimetics(3 cases, 35.7%); and neuroleptics(2 cases, 15.4%). 5. Poisoning associated with seizure had relatively high risk compared with non seizure poisoning for medical complication.
Drug Overdose* ; Histamine Antagonists ; Incidence ; Poisoning* ; Seizures*

Scleredema is a rare skin disease of unknown cause involving the face, neck, upper portion of the trunk, and proximal upper extremities. The clinical features of it are nonpitting, solid emema or stiffness of the neck, which may be sudden or insidious onset. Preceeding upper respiratory infection or diabetes mellitus have been frequently discribed to be associated with the disease. A monoclonal gammopathy has been frequently observed in patients with scleredema. We present a case of scleredema developed the face, upper portion of the back and shoulder in 16-year-old girl who had a preceeding upper respiratory infection.
Adolescent ; Diabetes Mellitus ; Female ; Humans ; Neck ; Paraproteinemias ; Scleredema Adultorum* ; Shoulder ; Skin Diseases ; Upper Extremity