No abstract available
Gastritis* ; Stomach*

No abstract available.
Classification* ; Epilepsy*

This study was undertaken to obtain baseline data on electrolyte composition of bone marrow blood and compare it with those of simultaneously obtained peripheral blood in order to assess the clinical usefulness of bone marrow blood as an indicator of the early changes of bone mineral metabolism. The mineral salts deposited in the skeleton are not in chemical equilibrium with the circulating blood (Ramp and Neuman), and while the local concentration in bone lesions might thus be high, after dilution into the entire circulating volume, the total amount of enzyme might be too small to cause changes in the peripheral blood readings. And even when no tissue is obtained, the bone blood from the lesion may provide useful information(Woodard and Marcove). In the animal experimental group, electrolyte composition of femoral bone marrow blood was compared with a simultaneously obtained peripheral blood from the abdominal aorta of six week old Long Evans male rats with normal and calcium deficient diets. In the human group, 10 ml of bone marrow blood was obtained from the iliac donor site at the time of bone grafting for spondylolysis, spondylolisthesis and lumbar disc herniation and 10 ml of peripheral blood. was obtained from the cephalic vein immediately before the bone grafting. Electrolyte and enzyme composition of bone marrow blood from bone tumor sites was compared with peripheral blood and also with that obtained from the bone grafting(control) group. The results obtained are as follows.; 1. The concentration of total and ionized calcium in the bone marrow blood was significantly lower and inorganic phosphorus was significantly higher than values obtained from the peripheral blood of rats fed with normal and calcium deficient diets. 2. Similar differences were demonstrated in the human bone marrow blood and peripheral blood obtained from the bone grafting group. A modertae excess of alkaline phosphatase was found in the bone marrow blood. 3. A large excess of alkaline phosphatase was found in the bone marrow blood obtained from bone tumor.
Alkaline Phosphatase ; Animal Experimentation ; Animals ; Aorta, Abdominal ; Bone Marrow ; Bone Transplantation ; Calcium ; Chemistry ; Diet ; Humans ; Male ; Metabolism ; Miners ; Phosphorus ; Rats ; Reading ; Salts ; Skeleton ; Spondylolisthesis ; Spondylolysis ; Tissue Donors ; Veins

The mineral salts deposited in the skeleton are not in chemical equilibrium with the circulating blood (Ramp and Neuman), and while the local concentration in bone lesions might thus be high, after dilution into the entire circulating volume, the total amount of enzyme might be too small to cause changes in the peripheral blood readings. And even when no tissue is obtained, the bone blood from the lesion may p ovide useful information (Woodard and Marcove); This study was undertaken to assess the clinical usefulness of bone marrow blood as an indicator of the early findings of bone tumor. Ten ml. of bone marrow blood was obtained from the iliac donor site at the time of bone grafting for spondylolysis, spondylolisthesis and lumbar disc herniation and 10 ml. of peripheral blood was obtained from the cephalic vein immediately before the bone grafting. And electrolyte composition of bone marrow blood was compared with peripheral blood. Electrolyte and enzyme composition of bone marrow blood from bone tumor sites was compared with peripheral blood and also with that obtained from the bone grafting (control) group. The results obtained are as follows.; 1. The concentration of total calcium in the bone marrow blood was significantly lower and inorganic phosphorus was significantly higher than values obtained from the peripheral blood of obtained from the bone grafting group. A moderate excess of alkaline phosphatase was found in the bone marrow blood. 2 A large excess of alkaline phosphatase was found in the bone marrow blood obtained from bone tumor.
Alkaline Phosphatase ; Bone Marrow ; Bone Transplantation ; Calcium ; Chemistry ; Humans ; Miners ; Phosphorus ; Reading ; Salts ; Skeleton ; Spondylolisthesis ; Spondylolysis ; Tissue Donors ; Veins

In pili torti, the affected Eair shaft is flattened and twisted through 180 degrees on its own axis. The involved hairs are dry, thin, brittle, and break off easily. Congenital pili torti may occur as an isolated phenomenon or may occur in association with other abnormalities. Acquired pili torti is usually associated with some sort of scarring process in the scalp itself. We present a case of congnital pili torti without any other abnormalities in a 14 year-old female. The pedigree of her fariiily was consistent with the inheritance of congenital pili torti as an autosomal dominant trait.
Adolescent ; Axis, Cervical Vertebra ; Cicatrix ; Female ; Hair ; Humans ; Pedigree ; Scalp ; Wills

BACKGROUND: The integrins comprise a family of transmembrane glycoproteins which mediate cell-cell and cell-matr ix intera ctions, and the bcl-2 oncogene is involved in tumorigenesis by blocking apoptosis. Typical acquired melanocytic nevi appear to follow a life cycle characterized by active growth, maturation, and progressive involution. In contrast, congenital rnelanocytic nevi have a different course and prcgnosis with potential for development of melanoma, and metastatic spread is very common in malignant melanoma. Objective . We investigated the expression of integrins (a2,a3,a) and bcl-2 in congenital and acquired rnelanocytic nevi, and malignant, melanomas by immunohistochemical technique. Methods . Formalin-fixed and paraffin-embedded tissues from 7 compound nevi, 7 intradermal nevi, 5 congenital melanocytic nevi, and 5 malignant melanomas were immunolabeled with monoclonal antibodies directed against a2, a3,and a integrin, and bcl-2 protein. RESULTS: All acquired and congenital melanocytic nevi showed a uniform staining for a2, a3, a and bcl-2. In 3 compound nevi which the nevus cells lie mainly within the upper dermis, the nevus cells in the papillary dermis showed weak to negative a expression. Within neurotized are as of intradermal nevus, bcl-2 and a expression became weaker and totally absent. All 5 malig- nant melanomas exhibited strong a2, a3, a, and bcl-2 expression. However, the tumor cells in the lower advancing border failed to express a integrin in 3 of 5 malignant, melanomas. In most malignant melanomas, there was variable intensity of staining for bcl-2 in different areas of the tumor. Conclusion . These findings suggest that the integrins and bcl-2 may be involved in active growth, maturation, and progressive involution of the melanocytic nevi, and seem to be related to metastasis and tumorigenesis of the malignant melanoma.
Antibodies, Monoclonal ; Apoptosis ; Carcinogenesis ; Dermis ; Glycoproteins ; Humans ; Integrins* ; Life Cycle Stages ; Melanoma* ; Neoplasm Metastasis ; Nevus ; Nevus, Intradermal ; Nevus, Pigmented* ; Oncogenes

No abstract available.

No abstract availalbe.
Severe Acute Respiratory Syndrome*

No abstract available.
Child* ; Humans

A case of familial cold urticaria is reported in a 29-year-old male who showed generalized erythematous macules and papules, finally an urticarial eruption shortly after cold exposure, particularly in cold windy weather with damp. Coincidentally, systemic symptoms such as headache, fever and chills, arthralgia, and conjunctival injection were acompanied. Autosomal dominant inheritance was found on examination of his pedigree in which 11 of 18 rnembers showed similar clinical manifestations. Routme laboratory findings were within normal limits except mild leukocytosis and elevated erythrocyte sedimentation rate. Biopsy specimen from a cold-evoked lesion revealed mild ederna and mild perivascular infiltrations composed of neutrophils, eosinophils and lymphocytes in the derms, Treatments included several widely-used antihistaminics, but turned out to be unsatisfactory.
Adult ; Arthralgia ; Biopsy ; Blood Sedimentation ; Chills ; Cryopyrin-Associated Periodic Syndromes* ; Eosinophils ; Fever ; Headache ; Humans ; Leukocytosis ; Lymphocytes ; Male ; Neutrophils ; Pedigree ; Weather ; Wills