No abstract available.
Aged* ; Humans ; Osteoarthritis*

No abstract available.
Aged* ; Antioxidants ; Blood Pressure* ; Humans ; Hypertension* ; Minerals* ; Vitamins*

Some of chronic benign recurrent dermatoses are markedly recalcitrant to the ordinary dermatological treatments. The author studied the therapeutic effect of beta ray on those of 30 patients including 6 cases of psoriasis, 3 of lichen simplex chronicus, 9 of nummular eczema, 8 of pustulosis palmaris et plantaris, and 4 of chronic eczema of the finger. All of the above were promptly recurred with ordinary treatments. Strontium 90 applicator was used as the source of beta ray and the total irradiation doses to each sites were ranged from 600 to 1500 rads in divided doses(usually weekly) over 2 to 3 weeks. The results were as follows, 1. In psoriasis patients with papular type were cleared by strontium 90, however, with chronic localized plaque type were poorly responded. The relapses of the cleared papular type were noticed between 13 to 24 days intervals, and it appeared that the larger doses did not influence significantly the clinical results. 2. Almost all of the chronic eczematous dermatoses including lichen simplex chronicus, nummular eczema, pustulosis Palmaris et plantaris, and chronic eczema of the finger, which were irradiated by beta rays following clearance with preliminary corticosteroid therapy, were recurred between 2 to 4 weeks intervals. However, larger doses resulted in prolonged recurrence intervals in a few patients. 3. No noticeable eariy hazards of irradiation were detected except for the mild hyperpigmentation on the irradiated skin.
Beta Particles ; Eczema ; Fingers ; Humans ; Hyperpigmentation ; Neurodermatitis ; Psoriasis ; Recurrence ; Skin ; Skin Diseases* ; Strontium*

PURPOSE: This study was to evaluate the nutritional status of low-income elders in urban areas and factors affecting their nutritional risk. METHODS: A cross-sectional analysis was conducted. The subjects were 300 elders selected from home visiting clients of DongJack Public Health Center. Data were collected using a questionnaire containing questions on socio-demographic characteristics. health behavior and disease. dietary pattern. Nutritional Screening Initiative. Geriatric Depression Scale and Barthel Index for ADL. Collected data were analyzed through descriptive statistics. chi2-test and multiple regression analysis using SPSS. RESULTS: Of the subjects, 63% had high nutritional risk, 21.3% moderate nutritional risk, and 15.7% good nutritional risk. NSI score was significantly different according to economic status, subjective health condition, medication, dental health, depression. regularity of diet and meal with family. Multiple regression analysis revealed that depression, subjective health condition, dental health and regularity of diet and meal with family explain 38.1% of nutritional risk. CONCLUSION: It is necessary to evaluate nutrition status and to control nutritional risk factors such as depression, dental health, regularity of diet and meal with family for improving the health of the low-income elderly.
Activities of Daily Living ; Aged* ; Cross-Sectional Studies ; Depression ; Diet ; Health Behavior ; House Calls ; Humans ; Mass Screening ; Meals ; Nutritional Status ; Public Health ; Risk Factors ; Surveys and Questionnaires

Impetigo herpetiformis is a rare disease which has not been cleary defined in the European or American literature and is currently not fully appreciated or accepted as a clinical entity. According to Baker & Ryan, Impetigo herpetiformis was reffered to as the Exanthematous type of generalized pustular psoriasis. Impetigo herpetiformis starts suddenly without any preceding lesions of psoriasis as an extensive eruption of pustules on an erythematous base, and may. occur repeatedly during successive pregancies but may occur also without any known cause. A case of Impetigo herpetiformis affecting 30 year old 8 month pregnent woman, who has been suffering from generalized coaIesced pustular eruption with slight itching & buming sensation with fever & chill. 15days before, The Eruption began as an erythematous macule which developed pustules along the margin. There was extension by the development of fresh peripheral pustules and coalescence of these patches and central clearing. Diagnasis was confirmed by histopathologic finding and treated with cortico.teroid and Antibiotics, But improvement was not noted.
Adult ; Anti-Bacterial Agents ; Female ; Fever ; Humans ; Impetigo ; Pruritus ; Psoriasis ; Rare Diseases ; Sensation

A case of Klippel-Trenaunay-Weber syndrome described originally by Klippel and Trenaunay on 1900, was presented with a brief review of literatures. The patient, 30 year-old male, said that he had noticed a reddish plaque in his right leg at the age of about 10 and had felt the asymmetricity of the limbs about 5 years later. On physical examination, he had an ulcerated sclerosing hemangioma on his right limb which is extending from medial aspect of upper one third of the lower leg to the foot. It was also associated with the varicosities just above the hemangioma, edema and hypertrophy around the right ankle, and a visible elongation of the right limb. A plane X-ray revealed osteohypertrophy of tibia and fibula without any periosteal reaction, and a soft tissue hypertrophy was also noticed around the right ankle. Histological findings of the hemangioma revealed moderate fibrosis around the proliferated vascular tissue and two of the remarkable thrombosis in the median sized vessels.
Adult ; Ankle ; Edema ; Extremities ; Fibrosis ; Fibula ; Foot ; Hemangioma ; Histiocytoma, Benign Fibrous ; Humans ; Hypertrophy ; Klippel-Trenaunay-Weber Syndrome* ; Leg ; Male ; Physical Examination ; Thrombosis ; Tibia ; Ulcer

The development of inexpensive high throughput methods to identify individual DNA sequences is important to the future growth of medical genetics. This has become increasingly apparent as psychiatric geneticists focus more attention on the molecular basis of complex multifactorial diseases at which most of psychiatric disease is estimated. Furthermore, candidate gene approaches used in identifying disease associated genes necessitate screening large sequence blocks for changes tracking with the disease state. Even after such genes are isolated, large scale mutational analysis will often be needed for risk assessment studies to define the likely medical consequences of carrying a mutated gene. This review provide basic knowledge of up-to-date technology, cDNA microarray which enables above mentioned various research themes.
Base Sequence ; DNA, Complementary* ; Genetics, Medical ; Mass Screening ; Oligonucleotide Array Sequence Analysis* ; Risk Assessment

PURPOSE: This study was conducted to examine the effects of solution-focused group counseling on the general stress, stress response and coping in the delinquent juveniles. METHOD: The subjects consisted of a convenience samlple of 60 delinquent juveniles who had been placed under probation in Kwang-ju, and recruited from Oct., 2000 to Dec., 2000. Solution-focused group counseling was conducted for the experimental group once a week for 120 to 180 minutes for 6 week. The control group received no group session. For both groups the level of general stress, stress response and coping were measured before and after the experiment. RESULT: General stress significantly decreased in the experimental group and increased in the control group, but showed no significant difference between the two groups. Stress response decreased significantly in the experimental group and increased in the control group, but showed no significant difference between the two groups. The problem-focused coping significantly increased in the experimental group and decreased in the control group, and showed a significant difference between the two groups. The emotion-focused coping significantly decreased in the experimental group and increased in the control group, and showed no significant difference between the two groups. CONCLUSION: This study showed that solution-focused group-counselling has a positive effect on variables like the general stress, stress response, emotion-focused coping and problem-focused coping. Further study needs to be conducted to verify results.

OBJECTIVE: Bacteroides fragilis, normal colonic inhabitant, is the most frequently isolated anaerobes in infected tissues, particularly in intraabdominal abscesses. In the acute infection model with abscesses, the response to B. fragilis infection is characterized by infiltration of neutrophils and macrophages. This study was designed to determine whether proinflammatory cytokines could be upregulated in peritoneal tissue of B. fragilis-infected mouse model. METHODS: After C57BL/6 mice were infected with abscess-inducing encapsulated B. fragilis, RNA was extracted from the intraperitoneal tissues. Cellular RNA was also extracted from mouse peritoneal macrophages (MPM) and human peripheral blood mononuclear cells (PBMC) after infection with B. fragilis. Expression of various cytokine mRNA was assessed using RT-PCR and standard RNA. Each cytokine protein was also measured by ELISA. RESULTS: B. fragilis-infected intraperitoneal tissues showed upregulated expression of IL-1u, IL-6 and TNFu mRNA. Expression of IL-1u and TNFu mRNA and protein was significantly higher in MPM or PBMC infected with B. fragilis than in those without infection. However, expression of IL-6 mRNA and protein was not increased in MPM or PBMC infected with B. fragilis compared with those without infection. CONCLUSION: These results suggest that the cytokines can be involved in immunopathologic reactions of the peritoneal tissue infected with B. jragilis.
Abscess ; Animals ; Bacteroides fragilis* ; Bacteroides* ; Colon ; Cytokines ; Enzyme-Linked Immunosorbent Assay ; Humans ; Interleukin-6 ; Macrophages ; Macrophages, Peritoneal ; Mice* ; Neutrophils ; RNA ; RNA, Messenger

Invasion of enteric bacteria, such as Salmonella and invasive E. coli, into intestinal epithelial cells induces proinflammatory gene responses and finally epithelial cell apoptosis. In this study, we asked whether invasive bacterial infection of human intestinal epithelial cells could upregulate cyclooxygenase-2 (COX-2) gene expression and whether increased COX-2 expression could influence intestinal epithelial cell apoptosis. Expression of COX-2 mRNA and prostaglandin (PG) E production were upregulated in HT-29 colon epithelial cells which were infected with S. dublin or invasive E. coli, as examined by quantitative RT-PCR and radioimmunoassay. Inhibition of COX-2 expression and PGE2 production using NS-398, a specific COX-2 inhibitor, showed a significant increase af epithelial cell apoptosis and caspase-3 activation in HT-29 cells infected with invasive bacteria. However, the addition of valerylsalicylate, a specific COX-1 inhibitor, did not change apoptosis in S. dublin-infected HT-29 cells. These results suggest that upregulated COX-2 expression and PGE2 production in response to invasive bacterial infection could contribute to host defense by inhibiting apoptosis of intestinal epithelial cells.
Apoptosis* ; Bacteria ; Bacterial Infections* ; Caspase 3 ; Colon ; Cyclooxygenase 2 ; Dinoprostone ; Enterobacteriaceae ; Epithelial Cells* ; Gene Expression ; HT29 Cells ; Humans ; Prostaglandin-Endoperoxide Synthases* ; Radioimmunoassay ; RNA, Messenger ; Salmonella