The anatomical variations of 112 hypophysis and diaphragma sellae in Korean adult cadavers and coronal CT were studied. 1) The hypophysis was classified 4 types based on superior view. 2) The superior surface of the hypophysis was concave(65.9%) in cadavers and flat(55.3%) in CT. 3) The neural lobe was placed on the center of the posterior surface of the anterior lobe(72.3%). 4) The hypophysis was compressed by the internal carotid artery in 9.6%. 5) The mean A-P length, width and height of the hypophysis were 10.4mm, 14.2mm and 4.8mm in cadavers, respectively. The mean width and height in CT were 13.2mm and 5.0mm, respectively. 6) The width of the hypophysis was significantly different between man and woman. 7) The diaphragma sellae was concave or flat. 8) The diaphragmatic line was average 13.9mm in man and 14.6mm in woman. 9) The diaphragmatic foraman was circular or oval and the A-P diameter was greater than transverse one. 10) Type IIb that diaphragma sellae and hypophysis were concave according to Busch(1951) was 40.4%. 11) The empty sella was found in 14.4%.
Adult* ; Cadaver* ; Carotid Artery, Internal ; Female ; Humans ; Pituitary Gland* ; Pituitary Gland, Posterior

OBJECTIVE: The objective of this study is to assess whether genetic functional variants of disintegrin and metalloprotease 33 (ADAM33) are associated with susceptibility to systemic lupus erythematosus (SLE) in a Korean population. METHODS: We previously identified 48 single nucleotide polymorphisms (SNPs) in ADAM33. Six SNPs were selected with regard to the linkage disequilibrium pattern. An association study of ADAM33 was conducted in 190 patients with SLE and 469 control subjects. SNPs were genotyped using the TaqMan Real-time polymerase chain reaction method, and haplotype analyses of related variants were performed. RESULTS: All SNPs were in Hardy-Weinberg equilibrium. Significant associations were found between the ADAM33 polymorphisms and SLE at rs2787094 (adjusted odds ratio [OR] 1.88, 95% confidence interval [CI] 1.00 to 3.54; p<0.0001). The rs554743 polymorphism was associated with the presence of the immunoglobulin M anti-cardiolipin antibody (adjusted OR 0.29, 95% CI 0.10 to 0.83; p=0.021). CONCLUSION: ADAM33 polymorphisms were associated with susceptibility to SLE and development of clinical disease manifestations in a Korean population. Further study is warranted to clarify the role of ADAM33 in SLE pathogenesis.
Haplotypes ; Humans ; Immunoglobulin M ; Linkage Disequilibrium ; Lupus Erythematosus, Systemic* ; Odds Ratio ; Polymorphism, Single Nucleotide ; Real-Time Polymerase Chain Reaction