Lichen planus with herpes zoster which showed generalized hyperpigmentation, plated papular eruption, fine scale and vesicular eruption on the right thigh were reported and the literatures of lichen planus were reviewed. The case was 41 years old man, who began to have itching, erythem and fine scale 6 years ago, but had no other symptom. Histopathologically, epidermis was hyperkeratotic, acanthotic and granular layer thickening and vesicular formation.
Adult ; Epidermis ; Herpes Zoster* ; Humans ; Hyperpigmentation ; Lichen Planus ; Pruritus ; Thigh

Author reported a case of Ritters disease,, 12 days old, male, who had visited with complaining generalized skin exfoliation. This patient was suffered from erythematous papules, vesicles and bullae on entire body from 7 days ago. He was treated with antibiotics and antibiotic ointment, and was discharged.
Anti-Bacterial Agents ; Humans ; Male ; Skin ; Staphylococcal Scalded Skin Syndrome*

A case report of a 6p-year-old man with crokeratosis verruciformis on the dorsa of hands & forearms is presented. This case is unusual in that the patient had late onset of the lesions and lack of a family history of the condition. Literatures are reviewed and possible linkage with Darier's disease is discussed.
Darier Disease* ; Forearm ; Hand ; Humans

INTRODUCTION: In 1910 phenylephrine hydrochloride was introduced first by Barger and Dale. Phenylephrine hydrochloride is a synthetic sympathomimetic compound structurally similar to epinephrine and ephedrine. Synthetic phenylephrine hydrochloride is clinically used as a nasal decongestant, vasopressor and mydriatic, etc.. The use of phenylephrine hydrochloride in ophthalmological practice is based on its action of vasoconstriction and mydriasis. Phenylephrine hyrdochloride has been introduced in U.S.A. as 10 % neosynephrine (U.S.P.) and in Japan as 5 % neosynesine. It's usefulness in therapy and examination is due to the following characteristics; (1) Rapid effect, (2) No influence on intraocular pressure nor on accommodation, (3) No undesirable side reaction. In many countries including U.S.A. and Japan. they reported experimentally and clinically in detail about the mydriatic action of phenylephrine hydrochloride but unfortunately there is no data concerning mydriatic action of phenylephrine hydrochloride in Koreans in spite of its wide use in ophthalmology. The study was performed for dilatation of the pupil, influence on intraocular pressure and accommodation, antagonistic action to pilocarpine, and side reaction after instillation of 10 % neosynephrine (U.S.P.) by the following method. METHOD AND MATERIAL: Material; 10 % Neosynephrine hydrochloride (U.S.P.), 2 % Pilocarpine. Subjects; 228 Korean normal eyes (6-84 yrs. old). METHOD: 1. Dilatation of the pupil (176 eyes). Group 1; One drop of 10 % neosynephrine instilled into 75 eyes. Over 60 yrs. old--10 eyes, 36-59 yrs. old--17 eyes, Under 35 yrs. old--48 eyes. Group 2; Two drops of 10 % neosynephrine instilled into 59 eyes. Over 60 yrs. old--2, eyes 39-59 yrs. old--17 eyes, Under 35 yrs, old--40 eyes. Group 3; Three drops of 10 % neosynephrine instilled into 42 eyes. Over 60 yrs. old--7 eyes, 36-59 yrs. old-14 eyes, Under 35 yrs. old-21 eyes. Interval between each instillation was two or three minutes. After instillation of 10 % neosynephrine into the eyes, the diameter of the pupils was measured frequently till maximum dilatation. 2. Influence on the intraocular pressure (25 eyes). After measurement of the intraocular pressure and diameter of the pupil in eacheyes, one drop of 10 % neosynephrine was instilled into 9 eyes and two drops into 10 eyes, and three drops into 6 eyes. After that measurement of intraocular pressure and diameter of the pupil was done every 10 minutes for 90 minutes and 2 and 3 hrs. later. 3. Influence on accommodation. The diameter of the pupil and distance of N.P.C. were measured before instillation of neosynephrine and every 10 minutes interval for 90 minutes and at 2 and 3 hrs. after instillation of 10 % neosynephrine into 23 eyes (one drop into 8 eyes, two drops into 10 eyes, three drops into 5 eyes). 4. Antagonistic action of 2 % pilocarpine to mydriatic action of 10 % neosynephrine. In two eyes of a 26 yrs. old man, diameter of the pupil was measured and compared in both eyes before instillation of one drop of 10 % neosynephrine and in 10 minutes interval to 90 minutes, at 2 and 3 hrs. after instillation of one drop of 10 % neosynephrine intoboth eyes. Then one drop of 2 % pilocarpine was instiIled into only the right eye at 50 minutes after first instillation of neosynephrine. One drop of 10 % neosynephrine was instilled into both eyes of a 23 yrs. old man, two drops into both eyes of a 20 yrs. old man. and three drops into both eyes of a man aged 22 yrs. One drop of 2 % pilocarpine was instilled into only the right eye of each person, respectively at 40 minutes (22 yrs. old eye), 50 minutes (20 yrs. old eye), and 60 minutes. (23 yrs. old eye) after first instillation of neosynephrine. The diameter of the pupil, the distance of N.P.c., and the intraocular pressure were measured and compared in both eyes of each person befere instillation and at 10 minutes intervals for 90 minutes. and at two and three hrs. after first instillation. RESULTS AND CONCLUSION: 1. In most of 176 eyes, the diameter of the pupils reached more than 7.5mm (maximum dilatation) and they took an average of 42 minutes to reach their maximum dilatation Among them, the shortest was 26 minutes and the longest 75 minutes. 2. The time the pupil takes to reach its maximum dilatation is a little differance between group 1 (one drop of neosynephrne instilled) and group 2 (two drops of neosynephrine instilled) but definetely shorter in group 3 (three drops of neosynepphrine instilled). 3. 10 % neosynephrine has little influence on intraocular pressure. 4. 10 % neosynephrine has slight influence on accommodation (slight paresis of accommodation) in about half of 26 eyes hut they have no disturbance at near work (Table 2 and 3). 5. 2 % pilocarpine constricts the dilated pupil more quickly than if not used (Table 4.). 6. Age has no effect on dilatation of the pupil due to instillation of 10 % neosynephrine. 7. No undesirable side reaction was noted.
Dilatation ; Ephedrine ; Epinephrine ; Humans ; Intraocular Pressure ; Japan ; Mydriasis ; Ophthalmology ; Paresis ; Phenylephrine* ; Pilocarpine ; Pupil ; Vasoconstriction

No abstract available.
Gallstones*

There had been no reports of trichophyton tonsurans infection in Korea yet. We have much chances to import the organism through international travels and exchanges. But we, Korean, have no experiences to observe T. tonsurans. Author tried mycological studies with T. tonsurans insolated in New Orleans, USA. The results are as follows: Gross findings of T. tonsurans showed that fine granular surface with light yellow hue or white color and grooving in the central area on the front side and mahogany brown color on the reverse side. On the urease test, various reddish discoloration was noted. Microscopic findings showed that septated hyphae, macroconidia, chlamydoconidia and microconidia. Macroconidia were 305 septated, smooth-surfaced, and were found more frequently in the whitish colony. Microconidia were characteristic in their arrangement and shape; round or oval shaped microconidia laterally to hyphae, some were match-head like terminal swelling. Hair perforation test showed positive results in 16 strains among 19 tested strains. All these findings are similar to T. rubrum and T. menatgrophytes, the most frequent isolates of dermatophytes in Korea, and we have to pay an attention to differentiate carefully.
Arthrodermataceae ; Hair ; Hyphae ; Korea ; Trichophyton* ; Urease

The study was made in order to investigate the present status of superficial dermatomycoses and incidence and frequency of the disease, sex distribution by the statistical survey and varieties of the causative organism by the mycological observation. The survey was made by out-patients of dermatology clinic of Seoul National University, and private clinic of Inchon, Jeonjoo, Kwangjoo, Pusan and Kyonggido provinces during 3 years, from 1972 to 1974. The results are as folIows: 1. Tinea(T.) cruris shows a increase and T. capitis shows a decrease in number as compared with those of during 1959. 2. Frequency of T. cruris shows more high in citizens than in a rustics, and more high in a rustics than citizens in those of T. capitis. 3. The strains were isolated by ordinary sabouraud's glucose agar media and obtained 4 species, 58 strains. A. Trichophyton rubrum was most common organism of superficial dermatomycoses (58.6%).b. Trichophyton ferrugineum was exclusive organism of T.capitis in or country.
Agar ; Busan ; Dermatology ; Dermatomycoses* ; Glucose ; Gyeonggi-do ; Humans ; Incheon ; Incidence ; Outpatients ; Seoul ; Sex Distribution ; Trichophyton

The study was made in order to investigate the present status of superficial dermatomycoses and incidence and frequency of the disease, sex distribution by the statistical survey and varieties of the causative organism by the mycological observation. The survey was made by out-patients of dermatology clinic of Seoul National University, and private clinic of Inchon, Jeonjoo, Kwangjoo, Pusan and Kyonggido provinces during 3 years, from 1972 to 1974. The results are as folIows: 1. Tinea(T.) cruris shows a increase and T. capitis shows a decrease in number as compared with those of during 1959. 2. Frequency of T. cruris shows more high in citizens than in a rustics, and more high in a rustics than citizens in those of T. capitis. 3. The strains were isolated by ordinary sabouraud's glucose agar media and obtained 4 species, 58 strains. A. Trichophyton rubrum was most common organism of superficial dermatomycoses (58.6%).b. Trichophyton ferrugineum was exclusive organism of T.capitis in or country.
Agar ; Busan ; Dermatology ; Dermatomycoses* ; Glucose ; Gyeonggi-do ; Humans ; Incheon ; Incidence ; Outpatients ; Seoul ; Sex Distribution ; Trichophyton

These studies were undertaken not only to evaluate the morphological change of topical vitamin A acid but also to compare the methodological difference in application, simple application and ODT, on mature mouse tail skin. All 18 animals were divided into 5 groups and serial biopsy was done after application of 0. 05% vitamine A achid and ointment base. I. 1 untreated control mouse. II. 2 mice treated with simple application of ointment base for 7 days. III. 3 mice treated with ODT of ointment base for 7 days. IV. 8 mice treated with sirnple application of 0. 05% vitamine A acid for 21 days. V. 4 mice treated with ODT of 0. 05% vitamin A acid for 7 days. The results are as follows: 1. Increase in epidermal thickness (60. 2 micron) was produced by simple applic- ation of 0. 05 % vitamin A acid for 21 days, but epidermal hypoplasia was noticert by ODT for 7 days. 2. Induction of granular layer was demonstrated by simple application of 0. 05 % vitamin A acid for 21 days. 3. There was a tendency of horny layer desquamation and epidermal darnage in application of vitamine A acid. Most severe desquamation and damage was produced by simple application of 0. 05% vitarnine A acid for 7 days. After that recovery was noticed in spite of continuous application for 21 days. 4. Epidermal hyperplasia, slight detachrnent of horny layer and epidermal damage were also produced by ODT of ointment base, probably due to nonspecific stimulation.
Animals ; Biopsy ; Hyperplasia ; Mice* ; Skin* ; Tail ; Tretinoin* ; Vitamin A* ; Vitamins*

No abstract available.