This experiment was performed to determine the stability of antiblotics in cured bone cement and the antibacterial effect with various the amount of antibiotics mixed in bone cement. Experimental animals were divided into control and antibioticimpregnated groups; 3 each for control, cloxacillin, celospor, kanamycln and panimycln groups. Antibiotic activities were measured by disk diffusion method using Staphylococcus aureus and Escherichla coli as standard organisms. The results were as follows: 1. Bone cement itself does not have antibacterial effect on the growth of Staphylococcus aureus and Escherlchia coli. Antlbiotlc impregnated acrylic bone cement showed antibacterial effects which was stable for 4 weeks. 2. In vitro test, the amount to antibiotics released In 24 hours perlod was proportional to the amount of antibiotlcs mixed in bone cement. 3. The duration of antibacterial effect was also roughly proportional to the amount of antiblotics mixed In bone cement. 4. No antibacterial effect could be measured in control groups. 4. In vivo test, the result was revealed similar patterns compared with the result of “In vitro test”, but the amounts of antibiotics released and durations of antibaterial effect was decreased. No antibacterial effect could be measured in control groups. As a result of this sutdy of this study, It is proved that the amount of antiblotics and the duratlon of antibacterial effect are proportional to the amount of antibiotics mixed in bone cemcnt. The impregnation of antiblotics in acrylic bone cement may be used to prevent and treat Infection in the orthopedic fleld.
Animals ; Anti-Bacterial Agents ; Cephacetrile ; Cloxacillin ; Diffusion ; In Vitro Techniques ; Methods ; Orthopedics ; Polymethyl Methacrylate ; Staphylococcus aureus

BACKGROUND: The laparoscopy requires carbon dioxide (CO2) insufflation and Trendelenburg position for operational convenience. However, the above circumstances affect the cardiopulmonary systems significantly and intraocular pressure (IOP) may be also influenced. METHODS: In 27 non-glaucoma patients right and left intraocular pressure (RIOP, LIOP) were measured 5 minutes after induction of general anesthesia (control value), 15 and 30 minutes after CO2 insufflation and endelenburg-lithotomy position. RESULTS: The control values of RIOP and LIOP were 11.3 4.7 mmHg and 11.5 4.7 mmHg respectively. At 15 minutes after CO2 insufflation and Trendelenburg-lithotomy position, they increased to 16.6 5.3 mmHg and 17.0 5.9 mmHg (p<0.05). At 30 minutes, 18.4 3.5 mmHg and 18.2 4.1 mmHg (p<0.05). CONCLUSION: CO2 insufflation and Trendelenburg-lithotomy position increase IOP significantly in non-glaucoma patients during laparoscopy.
Anesthesia, General ; Carbon Dioxide ; Head-Down Tilt ; Humans ; Insufflation* ; Intraocular Pressure* ; Laparoscopy*

In relief of postoperative pain, the value of epidural or subdural injection of opioids including morphine, methadone, petidine and fentanyl is now well established. The advantages of epidural or subdural over parenteral opioids is prolonged duration of analgesia, which last from several hours to several days, without sympathetic and motor blockade. But undesirable side effects include pruritus, urinary retention, delayed onset of somnolence, and cardiovascular and respiratory depression. To reduce postoperative pain, we evaluated the effects of caudal pentazocine 0.2-0.4 mg/kg with lidocaine 1.5% 400 mg for perianal surgery in 36 cases. The results were as follows: 1) There was no difference in analgesic onset between the Control Group (used lidocaine only) and Group A and B (mixed use of lidocaine and pentazocine: Group A, 0.2 mg/kg pentazocine; Group B, 0.4 mg/kg) 2) Mean duration of analgesia following caudal pentazocine and lidocaine injection was over 12 hours, but was less than 5 hours in the used lidocaine only. 3) Urinary retention was observed in all groups; 3 case in the Control group, and 4 cases in Group A and B. 4) In Group A and B, 6 cases had not used analgesics within 24 hours after caudal anesthesia. 5) No specific clinical changes were noted in the vital signs in all groups.
Analgesia ; Analgesics ; Analgesics, Opioid ; Anesthesia, Caudal ; Fentanyl ; Lidocaine ; Methadone ; Morphine ; Pain, Postoperative ; Pentazocine* ; Pruritus ; Respiratory Insufficiency ; Urinary Retention ; Vital Signs

BACKGROUND: Various kinds of methods had been tried to reduce pain on injection of propofol. In this study, the effect of lidocaine pretreatment and that of temperature controlled injections were compared and evaluated its clinical utility. METHODS: One hundred and twenty patients were randomly allocated into 4 groups after permission. Room temperature propofol was used as induction agent in group P,. In group C, cooling (4 degrees C) propofol was used and warming propofol (37 degrees C) in group H. And room temperature propofol following lidocaine (1 mg/kg) was used in group L. Injection dosage of propofol was 2 mg/kg and injection speed was 2 ml/sec in all groups. In each patients, pain score and visual analog scale were measured and tested by ANOVA or Kruskal-Wallis test. RESULTS: There were no statistical significant difference in pain score among the 4 groups. But in visual analog scale analysis, group L markedly reduced values than the other groups by statistically significant manner (in Duncan grouping). CONCLUSION: The alleviating effect of lidocaine pretreatment on painful injection was better than that of changing temperature of propofol itself. More over effectiveness, in view of simplicity, we recommend lidocaine pretreatment.
Humans ; Lidocaine ; Propofol* ; Visual Analog Scale

Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription coactivator (CRTC), is essential for controlling the expression of critical enzymes in the metabolic process, leading to more chronic changes in metabolic flux. Among the CRTC isoforms, CRTC2 is predominantly expressed in peripheral tissues and has been shown to be associated with various metabolic pathways in tissue-specific manners. While initial reports showed the physiological role of CRTC2 in regulating gluconeogenesis in the liver, recent studies have further delineated the role of this transcriptional coactivator in the regulation of glucose and lipid metabolism in various tissues, including the liver, pancreatic islets, endocrine tissues of the small intestines, and adipose tissues. In this review, we discuss recent studies that have utilized knockout mouse models to delineate the role of CRTC2 in the regulation of metabolic homeostasis.

No abstract available.
Intubation* ; Laryngeal Masks*

No abstract available.

No abstract available.
Extremities*

A tibial segment in 3cm length with vascular pedicle and periosteum (Living bone graft) and the segment without vascular pedicle and periosteum (Dead bone graft) was obtained from twenty four rabbits, being divided into two group respectively. Then it was replaced with the segmental bone in the initial osteomized defect. The grade of healing and the time factor required to accomplish the repair of resected segmental tibial transplant was determined at one week interval during one to eight weeks, aimed by the,comparative studies of microscopic (gross), radiological as well as histological observation during the healing process. The average time of callus formation in the living bone graft was approximately two weeks, as compared to four weeks of the dead bone graft. Radiographically the average time of bone union in the living bone graft was four weeks, compared with seven weeks for the dead bone graft. The living bone graft was permitted to the healing process of the simple fracture at the graft-recipient bone juncture, in the contrast with the dead bone graft it was united with replacement of the grafted bone by new bone, so called “creeping substitution”.
Bony Callus ; Periosteum ; Rabbits ; Tibia ; Time Factors ; Transplants

A case of hypertrophic interstitial neuropathy in a 32 years old man developed in the median nerve is reported. This is a rare disease characterized by thickened peripheral nerves which may be palpable and visible. This case was treated by excision of transverse carpal ligament and external and internal neurolysis.
Hereditary Sensory and Motor Neuropathy ; Ligaments ; Median Nerve ; Peripheral Nerves ; Rare Diseases