No abstract available.
Molecular Weight*

No abstract available.

No abstract available.

No abstract available.
Humans

No abstract available.

Local anesthetics produce pain during infiltration into skin. The relationship between local anesthetic-induced pain and pH of the local anesthetic solution has not been fully investigated. Commercial preparation of local anesthetics are prepared as acidic solutions of the salts to promote solubility and stability. And the acidity of local anesthetic solition may be related with the pain during infiltration of the solutione. So, we tried to neutralize the lidocaine hydrochloride solution which is one of the most frequently used local anesthetic agent. Sodium bicarbonate was used for neutralization. Sodium bicarbonate was mixed with lidocaine hydrochloride until the resulting pH of the solution become 7.4 which is identical to the acidity of body fluid. To identify the effect of neutralized lidocaine solution, we had a course of double blind test to 6 volunteers. Both forearm of each volunteer were injected with neutralized lidocaine and plain one and the degree of pain was estimated by each volunteers. According to subjective description by the volinteers, everyone felt neutralized lidocaine injection site was less painful than plain lidocaine. We concluded that we could reduce pain from infiltration of lidocaine hydrochloride by neutralization of the anesthetic solution with sodium bicarbonate.
Anesthetics, Local ; Body Fluids ; Forearm ; Hydrogen-Ion Concentration ; Lidocaine* ; Salts ; Skin ; Sodium Bicarbonate ; Solubility ; Volunteers

No Abstract Available.

No abstract available.
Korea*

Few morphometric data on the thickness and the inclination of vertebral lamina are found with its frequent involvement in many surgical procedures. The thickness in the middle of right vertebral lamina and the angle between the superior border of lamina and sagittal plane were measured in 90 dried vertebral columns. 1. The laminae of the cervical vertebrae were generally thin and they became gradually thicker down to the lumbar vertebrae. The lamina of the fifth lumbar vertebra was the thickest (9.4mm) and that of the fifth cervical was the thinnest (2.9mm). The thickest lamina appeared in second cervical, twelfth thoracic and fourth lumbar vertebrae in 71%, 44% and 36%, respectively. 2. The angles between superior border of long axes of the laminae and the sagittal plane were the widest in thoracic vertebrae, and narrower in lumbar, the narrowest in cervical vertebrae. The angle of eithth thoracic was the widest (59.8°) and that of the fifth lumbar was the narrowest (48.6°). Widest angle of lamina appeared in seventh cervical, sixth thoracic and fifh lumbar vertebra in 27%, 20% and 48%, respectively. 3. No significant differences were found in the thicknesses and the angles of inclination of vertebral laminae between males and females.
Adult* ; Cervical Vertebrae ; Female ; Humans ; Lumbar Vertebrae ; Male ; Spine ; Thoracic Vertebrae

No abstract available.
Hyperhidrosis* ; Iontophoresis*