No abstract available.
Communicable Diseases*

No abstract available.
Rhinitis*

No abstract available.

The lactic dehydrogenase activities of Ascaris lumbricoides have been assayed according to the developmental course of the fertilized eggs compared with the unfertilized eggs. Experimental procedures were modified that of Wroblewski and La Due's method with use of diphosphopyridine nucleotide reduced form(DPNH). Sodium pyruvate and lactic dehydrogenase, the specific activities were expressed as DPNH unit per mg protein by method of Kornberg's. The experimental results are as follaws: Lactic dehydrogenase activity in fertilized eggs of Ascaris are significantly increased from morula stage and its optimal pH is in 3.4 degrees. While any activities were not observed in unicell stage of fertilized eggs and unfertilized eggs. Water soluble protein of fertilized eggs of Ascaris were varied in their amount during their developmental process. The amont of protein in tadpole stage eggs have increased to 1.3 times more than that of cleavage stage eggs. However the amounts of water soluble protein in unfertilized eggs are revealed to one-third less than that of fertlized eggs. The specific activity of lactic dehydrogenase in tadpole stage eggs are decreased to one third less than those of morula stage eggs during development, the stage is considered to be as a growth criteria in developmental process, as on this point the activity of aerobic cytochrome c oxidase and cyclophorase begin to increase respectively.
parasitology-helminth-nematoda ; lactic dehydrogenase ; cytochrome c oxidaes ; cyclophorase ; Ascaris lumbricoides ; biochemistry

No abstract available.
Fertilization*

No abstract available.
Epilepsy*

The McCune-Albright Syndrome is characterized by polyostotic fibrous dysplasia, cafe-au-lait colored patches of the skin and endocrinological abnormalities, including precocious puberty. Affected patients progress from GnRH-independent puberty to GnRH-dependent puberty. GnRH analogues are ineffective in GnRH-independent precocious puberty. Three year and 2 month old girl with breast development(SMR B3) and irregular vaginal bleeding were seen & diagnosed as incomplete sexual precocity. Decapeptyl treatment was started for the purpose of regression of breast development & vaginal bleeding with no effect. After 10 months, cafe-au-lait skin lesion & polyostotic fibrous dysplasia were noted and diagnosed as McCune-Albright syndrome. Breast development regressed to SMR B2 and vaginal bleeding was controlled with ketoconazole. As our experience, ketoconazole treatment might be effective to delay the progression of sexual development in patients with precocious puberty in McCune-Albright Syndrome.
Adolescent ; Breast ; Female ; Fibrous Dysplasia, Polyostotic* ; Gonadotropin-Releasing Hormone ; Humans ; Infant ; Ketoconazole* ; Puberty ; Puberty, Precocious ; Sexual Development ; Skin ; Triptorelin Pamoate ; Uterine Hemorrhage

This study was undertaken to obtain baseline data on electrolyte composition of bone marrow blood and compare it with those of simultaneously obtained peripheral blood in order to assess the clinical usefulness of bone marrow blood as an indicator of the early changes of bone mineral metabolism. The mineral salts deposited in the skeleton are not in chemical equilibrium with the circulating blood (Ramp and Neuman), and while the local concentration in bone lesions might thus be high, after dilution into the entire circulating volume, the total amount of enzyme might be too small to cause changes in the peripheral blood readings. And even when no tissue is obtained, the bone blood from the lesion may provide useful information(Woodard and Marcove). In the animal experimental group, electrolyte composition of femoral bone marrow blood was compared with a simultaneously obtained peripheral blood from the abdominal aorta of six week old Long Evans male rats with normal and calcium deficient diets. In the human group, 10 ml of bone marrow blood was obtained from the iliac donor site at the time of bone grafting for spondylolysis, spondylolisthesis and lumbar disc herniation and 10 ml of peripheral blood. was obtained from the cephalic vein immediately before the bone grafting. Electrolyte and enzyme composition of bone marrow blood from bone tumor sites was compared with peripheral blood and also with that obtained from the bone grafting(control) group. The results obtained are as follows.; 1. The concentration of total and ionized calcium in the bone marrow blood was significantly lower and inorganic phosphorus was significantly higher than values obtained from the peripheral blood of rats fed with normal and calcium deficient diets. 2. Similar differences were demonstrated in the human bone marrow blood and peripheral blood obtained from the bone grafting group. A modertae excess of alkaline phosphatase was found in the bone marrow blood. 3. A large excess of alkaline phosphatase was found in the bone marrow blood obtained from bone tumor.
Alkaline Phosphatase ; Animal Experimentation ; Animals ; Aorta, Abdominal ; Bone Marrow ; Bone Transplantation ; Calcium ; Chemistry ; Diet ; Humans ; Male ; Metabolism ; Miners ; Phosphorus ; Rats ; Reading ; Salts ; Skeleton ; Spondylolisthesis ; Spondylolysis ; Tissue Donors ; Veins

The mineral salts deposited in the skeleton are not in chemical equilibrium with the circulating blood (Ramp and Neuman), and while the local concentration in bone lesions might thus be high, after dilution into the entire circulating volume, the total amount of enzyme might be too small to cause changes in the peripheral blood readings. And even when no tissue is obtained, the bone blood from the lesion may p ovide useful information (Woodard and Marcove); This study was undertaken to assess the clinical usefulness of bone marrow blood as an indicator of the early findings of bone tumor. Ten ml. of bone marrow blood was obtained from the iliac donor site at the time of bone grafting for spondylolysis, spondylolisthesis and lumbar disc herniation and 10 ml. of peripheral blood was obtained from the cephalic vein immediately before the bone grafting. And electrolyte composition of bone marrow blood was compared with peripheral blood. Electrolyte and enzyme composition of bone marrow blood from bone tumor sites was compared with peripheral blood and also with that obtained from the bone grafting (control) group. The results obtained are as follows.; 1. The concentration of total calcium in the bone marrow blood was significantly lower and inorganic phosphorus was significantly higher than values obtained from the peripheral blood of obtained from the bone grafting group. A moderate excess of alkaline phosphatase was found in the bone marrow blood. 2 A large excess of alkaline phosphatase was found in the bone marrow blood obtained from bone tumor.
Alkaline Phosphatase ; Bone Marrow ; Bone Transplantation ; Calcium ; Chemistry ; Humans ; Miners ; Phosphorus ; Reading ; Salts ; Skeleton ; Spondylolisthesis ; Spondylolysis ; Tissue Donors ; Veins

Since Duhamel (1739), numerous experimental studies on the longitudinal growth of growing long bone have been reported. In Hales(1747) experience, growing long bone showed overgrowth after drilling in the tibia of chickens. David(1924) observed the fact that various degrees of shortening disappeared within 15 months after fracture of the femur in children and he concluded that fractures in children should be treated with the caution that the growing long bone has a tendency to increase in length after injury. Bisgard(1936) concluded that shortening from overriding of fragments in fractured extremities of children will frequently, but not invariablly, become partially or totally eliminated by the acceleration of growth which incidentaIly results from the inflammatory process, incited by trauma and fracture repair. Hass(1926) reported that interstitial proliferation of osseous tissue plays no part in the elongation of a growing bone, either in the mature bone or the young osteoid tissue bordering on the epiphyseal cartilage plate, and length growth of bone is entirely dependant on the purposeful multiplication of cartilage cells of the epiphyseal cartilage plate. Ham(1952) reported that the growth of long bone depends upon the interstitial growth of cartilage. This study was initiated to investigate the effects of fractures in the longitudinal bone growth of growing bone. Artificial fractures were made at two different sites in the diaphysis of the tibia in young rabbits. The operation for artificial fracture was performed under general anesthesia with ether. The type of fracture was an incomplete one, leaving a part of the posterior cortex of the tibia, in order to prevent the displacement of fractured fragments. In all of the cases, no cast immobilization was applied. After the fractures, follow up observations were made weekly till the 4th week, and thereafter at two week intervals, with roentgenographic, lethal measurement and histological examination. The results were as follows; 1) Longitudinal bone growth was increased from fracture of the diaphysis of growing long bone. 2) Compared with the control limb, tendency to overgrowth of growing bone was noted from the first week after the operation. 3) In follow up measurements, no growth inhibition was observed till the 10th week after the operation, but, thereafter, a tendency to reduce the proliferation of cartilage cells was noted. 4) In cases of fracture of the mid 1/3, the gorwing activity in the epiphyseal plate was increased more than from proximal 1/3 fractures. 5) The bony growth, accelerated by fractures in diaphysis of growing long bone without displacement was transient, and the prolonged overgrowth was compensated by the reduction of growing activity and premature closure of the epiphysis.
Acceleration ; Anesthesia, General ; Bone Development ; Cartilage ; Chickens ; Child ; Diaphyses ; Epiphyses ; Ether ; Extremities ; Femur ; Follow-Up Studies ; Growth Plate ; Humans ; Immobilization ; Rabbits ; Tibia