We present a case of left ectopic ureteral orifice to the vagina with a hypoplastic kidney in a 15 year old girl and a case of ectopic ureteral orifice to the vaginal vestibule associated with bilateral complete double ureter in a 5 year old girl. They presented with urinary incontinence while normally secured voluntary voiding. Fifteen year old girl was treated with left nephrectomy and the other girl with heminephrectomy.
Adolescent ; Child, Preschool ; Female ; Humans ; Kidney ; Nephrectomy ; Ureter* ; Urinary Incontinence ; Vagina

Juvenile xanthogranuloma(JXG) is a a benign histiocytic proliferative disorder most frequently seen in infants. The usual course is self-limited, but it may be a manifestation of juvenile chronic myeloid leukemia(JCML). In addition to JXG, some patient with JCML may have multiple cafe-au-lait spots and a family history of neurofibromatosis(NF). The association of JXG and cafe-au-lait spots in patients with JCML is of interest in light of description of otherwise healthy children with JXG who also had cafe-au-lait spots. We report herein a case of JXG in 18-month-old boy who also had multiple cafe-au-alit spots, which predated the JCML.
Cafe-au-Lait Spots ; Child ; Humans ; Infant ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive* ; Male ; Neurofibromatoses* ; Xanthogranuloma, Juvenile*

The urinary flow rates of 917 children between 7 years and 15 years old were measures. The results were as follows . 1. Volume voided, average and maximum flow rate were higher according to increasement of age and sex. All values of female children were significantly higher than male children in same age and body Weight. 2. Voiding curves indicating the relationship between urinary flow and voided volume were obtained with logarithmic transformation. Voiding dates above 35kg were significantly higher than below 35kg and were similar to normal adults. 3. Fifth 10th, 15th, 20th and 25th percentiles nomograms were established with cumulative distribution.
Adolescent ; Adult ; Body Weight ; Child ; Female ; Humans ; Male ; Nomograms

Somatosensory evoked potentials(SEPs) has been an important part of electrodiagnosis and has been utilized as a clinical diagnostic technique in various neurological disease. The purpose of this study was to evaluate the utility of SEPs in the analysis of sensory deficit as an objective method. The test was performed on the two groups of patients with cerebrovascular disease associated with motor and sensory impairment (grouip A) and pure motor impairment (group B), and then the results are compared with that of normal age-matched group. The results are as follows: 1. There is no significant difference in the abnormalities of N9 and N14 component between group A and B (P>0.05). 2. There is no significant difference in the decreased amplitude of N20 component (P>0.05), but there is a significant difference in the delayed peak latency or absent wave of N20 component(P<0.01) between group A and B. 3. There is a significant difference in the increased central conduction time between group A and B (P<0.01). 4. Although the difference is not significant statistically, there are more abnormalities of N20 or central conduction time in the intact hemispheres in group A than group B after stimulation of the median nerves of the affected sides.
Electrodiagnosis ; Evoked Potentials, Somatosensory* ; Humans ; Median Nerve

No abstract available.
Osteomyelitis*

PURPOSE: To verify the expression of the mouse homolog of glucosamine-6-phosphate deaminase (GNPDA) in the testis and reproductive organs. MATERIALS AND METHODS: Expression of GNPDA was examined using a polyclonal antibody raised against a synthetic oliogopeptide of the N-terminus of the protein. RESULTS: In Western blots, an immunoreactive band of Mr 35 kDa was detected in the testis, ovary, and uterus extracts. Expression of GNPDA was greater in the adult than in the immature testis. With immunostaining, a positive signal was found in the cytoplasm of interstitial, Sertoli, and germ cells of adult testis. In the ovary, positive staining was found in the interstitial and luteal cells. Conclusion: The expression of GNPDA in many reproductive tissues suggests that the enzyme plays a housekeeping role in cell physiology and in the differentiation of the seminiferous tubules.
Adult ; Animals ; Blotting, Western ; Cell Physiological Phenomena ; Cytoplasm ; Female ; Germ Cells ; Housekeeping ; Humans ; Luteal Cells ; Mice* ; Ovary ; Seminiferous Tubules ; Testis ; Uterus

BACKGROUND: Idiopathic thromboycytopenic purpura(ITP) is one of the most common acquired bleeding disorders in childhood. The entity of chronic ITP is defined as the persistence of thrombocytopenia for more than 6 months from initial presentation. There are the controversies regarding the diagnosis and management of this disease. The aim of this study is to compare the responses to managements and clinical symptoms of children with chronic ITP. METHODS: We retrospectively analyzed patients with chronic ITP diagnosed and managed between Jan., 1992 and June, 1997. Data from 33 cases were collected. The length of follow-up ranged from 6 months to 5 years. Statistical analysis was done using Jandel Sigmastat software(version 2.0). RESULTS: 1) Mean age is 5.4+/-4.3 years. The ratio of female to male is 0.65. 2) Most common clinical symptoms at presentation were petechiae(81.8%) and mucosal bleeding(42.4%). The patients who presented only petechiae and purpurae were 18 cases(54.5%), both petechiae and mucosal bleeding were 9 cases(27.3%). 3) The platelet count was 43,015+/-39,912/mm3. Bone marrow examinations showed normal or increased megakaryocyte, no abnormal cells and normal cellularity. 4) The prolonged complete response lasting more than 6 months without maintenance therapy was attained in 15.2% of the patients. A continuous complete response was observed in 6.1% to prednisone and IV-gamma-globulin. A prolonged complete response to dexamethasone was in 23.8% and continuous complete response was in 14.3%. The splenectomy was underwent in 3 patients. All of them had a prolonged complete response. One of six patients who were treated with combination chemotherapy had a prolonged complete response. CONCLUSION: This analysis of chronic ITP patients suggests that splenectomy remains the most effective treatment and the next one is high dose dexamethasone therapy. But the number of patients was not enough, more attention should be given to the management of chronic idiopathic thrombocytopenic pupura(ITP).
Bone Marrow Examination ; Child ; Dexamethasone ; Diagnosis ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Hemorrhage ; Humans ; Male ; Megakaryocytes ; Platelet Count ; Prednisone ; Purpura ; Purpura, Thrombocytopenic, Idiopathic* ; Retrospective Studies ; Splenectomy ; Thrombocytopenia

There are rare reports of vascular complications in patients with cardiac myxoma, including both central and peripheral arterial thrombosis. We report on a patient with cerebral infarctions affecting multiple territories, which may have been related to cardiac myxoma. The patient also exhibited cyanosis of the hand. A diagnosis was made of peripheral artery occlusion with myxomatous emboli. A careful physical examination with suspicion of concomitant peripheral embolism is needed in patients with acute embolic stroke induced by cardiac myxoma.
Arteries ; Cerebral Infarction* ; Cyanosis ; Diagnosis ; Embolism* ; Hand ; Humans ; Myxoma* ; Physical Examination ; Stroke ; Thrombosis

PURPOSE: The development of fever in neutropenic cancer patients is frequently a sign of infection. Infection remains the major cause of death in the patient with cancer, primarily as a consequence of the profound alterations of normal host defences which result from the malignancy, its treatment or both. Fever in the patient with neutropenia is generally recognized as an indication of the need for prompt initiation of antibiotic therapy, but in spite of intensive efforts to identify infections in these patients and to institute appropriate antibiotic therapy, high mortality rate have continued to occur. This study was performed to identify the current etiologic agents, differences in frequency and/or type of infection in patients with hematologic malignacy as compared to those with solid tumor and to assess the period of neutropenia and treatment. METHODS: Between May 1994, and Feburuary 1994, we retrospectively evaluated 84 febrile episodes occurring in 46 patients with neoplastic diseases which were identified at Korea university hospital. Neutropenic fever has been defined as three episode of elevation of temperature above 38degrees C or a single elevation above 38.5degrees C in neutropenic patient (granulocyte<500/mm3) RESULTS: 1) Eighty-four episodes of fever and neutropenia were identified in 47 patients whose mean age was 6.6 years. 2) Thirty-three patients had leukemia or lymphma, representing 70.2% of the episodes of fever and neutropenia. 3) Microbiologically documented infection, clinically documented infection and unexplained fever accounted for 13%, 23%, 64% of the febrile episodes respectively. 4) Gastroenteritis and pharyngitis were the most common type of infection. 5) The common organism were Escherichia coli, Klebsiella pneumoniae, Staphyrococci aureus were common in decreasing order. 6) The mean duration of febrile neutropenia was 11.9 days in hematologic malignacy and 6.5 days in solid tumor. 7) The mean duration of receiving G-CSF was 13.1 days in hematologic malignancy and 5.8 days in solid tumor. 8) There was no significant difference in duration of neutropenia, times of receiving treatment and ANC level at fever in patients with MDI compared to CDI or UF. CONCLUSIONS: Gram negative bacilli are dominant pathogens of neutropenic fever in Korea university hospital.
Cause of Death ; Drug Therapy* ; Escherichia coli ; Febrile Neutropenia* ; Fever ; Gastroenteritis ; Granulocyte Colony-Stimulating Factor ; Hematologic Neoplasms ; Humans ; Klebsiella pneumoniae ; Korea ; Leukemia ; Mortality ; Neutropenia ; Pharyngitis ; Retrospective Studies

OBJECTIVES: We carried out tests for neurobehavior by using WHO-NCTB (neurobehavioral core test battery) and Perdue pegboard score test to identify differences between lacunar infarction cases and controls. METHODS: Among the subjects who underwent MRI between February 2001 and March 2002 in a university hospital located in Seoul and who were diagnosed only as lacunar infarction without any intracranial disease, 46 patients were selected as cases (male: 21, female: 25). Controls were selected who had no cerebrovascular disease on MRI by matching age (5 years), gender, and education (2 years) in a ratio of 1: 1. Among WHO-NCTB, the following 5 tests and Perdue pegboard score test were used to categorize the study subjects: digit and symbol matching, simple reaction time, Benton visual retention, digit span, and Pursuit aiming test. RESULTS: Among the above 6 tests of neurobehavior, lacunar infarction cases showed lower score than controls except for the simple reaction time test. As the controlling variables of multivariate analysis in the stepwise regression analysis, the followings were selected due to their significant association: age, education, BMI, gender, drinking, exercise, and systolic blood pressure. From multivariate regression analysis, there was significant difference (p< 0.05) between lacunar infarction cases and controls in digit and symbol matching, Benton visual retention, digit span, pursuit aiming, and Perdue pegboard score test, but not in the score of simple reaction time test. CONCLUSIONS: We suggest that the above 5 tests for neurobehavior, with the exception of the simple reaction time test, might be used as the basis for recommendation of further treatment and other neurological tests by the earlier detection for neurological abnormality in lacunar infarction.
Blood Pressure ; Case-Control Studies* ; Cerebrovascular Disorders ; Drinking ; Education ; Female ; Humans ; Magnetic Resonance Imaging ; Multivariate Analysis ; Reaction Time ; Seoul ; Stroke, Lacunar*