The clinical and statistical evaluations of 25 patients(29 eyes) with subluxated lenses which were extracted at St. Mary's hospital from October 1984 to June 1990. The results were as follows: 1. The average age was 41.3 years and the sex distribution was 23 males and 2 females. 2. The causes were divided by 17 eyes(58.6%) with trauma and 12 eyes(41.4%) without trauma. 3. The associated diseases were cataract(9 eyes; 31.0%), glaucoma(6 eyes; 20.7%), retinal detachment(4 eyes; 13.8%) and uveitis(2 eyes; 6.9%). 4. There were 9 eyes(31.0%) in superonasal, 4 eyes(13.8%) in inferotemporal direction of lens displacement. 5. The surgical procedures were intracapsular cataract extraction(22 eyes; 75.9% ), lens aspiration(3 eyes; 10.3% ), extracapsular cataract extraction(1 eye 3.5% ) and pars plana lensectomy with vitrectomy(3 eyes; 10.3%). 6. There were 9 eyes(28.0%) associated with vitreous protrusion and the vitrectomy were done in 20 eyes(62.5% ). 7. Postoperative corrected visual acuity improved fairly. It was the same as preoperative corrected visual acuity in 7 eyes(24.1%), improved in 21 eyes(72.4%) and worse in 1 eye(3.4%).
Cataract ; Female ; Humans ; Male ; Retinaldehyde ; Sex Distribution ; Visual Acuity ; Vitrectomy

To evaluate the character, management and clinical results of the posterior capsular rupture during cataract surgery, we retrospectively studied the cataract surgeries that were performed between May 1989 and Decemeber 1991. We discovered 64 eyes in which the posterior capsule was torn. The overall incidence of this complication was 4.4%. Our chart review of these surgical procedure revealed that the tear occurred most frequently during the nucleus removal(44%), occured more frequently at the periphery than the center and the extent was mostly below one-third of the whole posterior capsular surface(75%). We performed vitrectomy(58%) and peripheral iridectomy(14%). Posterior capsular lenses were implallted in 56 cases. The predicted power of lens calculated with SRK-II fomula and manufacturer's A-constant was approximately 0.46 diopter less than actual postoperative refraction. Final visual acuity of 20/40 or better was achieved in 73% of the 64 cases. Our results revealed that when properly managed, a torn posterior capsule is compatible with an excellent visual outcome.
Cataract* ; Incidence ; Retrospective Studies ; Rupture* ; Visual Acuity

Several kinds of non-contact tonometers have been used since the first non-contact tonometer was introduced in the 1970's in order to measure intraocular pressure with easiness and accuracy. However several problems were still remained because of:he inaccuracy of the non-contact tonometer in high and low range of intraocular pressure. A new non-contact tonometer (Model CT-20, Japan) was recently introduced by Topcon Company to evaluate the clinical efficacy of the non-ccntact tonometers. The authors measured the intraocular pressure with Topcon tonometer, AO tonometer and Pulsair non-contat tonometer and compared the results with those measured with Goldmann tonometer. The results were as follows: 1) The correlation coefficient between Goldmann and Topcon tonometer was 0.8452 (p=0.001), Goldmann and Pulsair tonometer was 0.7084 (p=O.OOl) and Goldmann and AO tonometer was 0.6048 (p=O.OOl) in the normal eyes. 2) The correlation coefficient between Goldmann and Topcon tonometer was 0.8651 (p=0.0001) in the ocular hypertensive or open angle glaucoma eyes. 3) The correlation coefficient between Goldmann and Topcon tonometer was 0.6987 (p=0.000l) in the low lOP eyes. 4) The correlation coefficient between Goldmann and Topcon tonometer was 0.6829 (p=0.0001) in the high myopic eyes. As above, a new-contact tonometer (Model CT-20, Japan) made by Topcon Company was relatively accurate in measuring not only the intraocular pressure of normal eyes but that of ocular hypertensive, low IOP and high myopic eyes.
Glaucoma, Open-Angle ; Intraocular Pressure

Malignant lymphoma is neoplastic transformation of cells that reside predominantly in lymphoid tissues. Malignant lymphoma involving the eye is a rare disease. Malignant lymphoma of the lid is extremely rare. The authors experienced a case of malignant lymphoma involving the lid in a 62 year-old male patient. At first visit, the patient complained of a palpable painless mass on the left upper eye lid. Later, the malignant lymphoma was confirmed by histopathologic examination. As for treatment, the lid mass excision was performed and 10 MeV electron beam 4000 rad radiotherapy was followed.
Eyelids* ; Humans ; Lymphoid Tissue ; Lymphoma* ; Male ; Middle Aged ; Radiotherapy ; Rare Diseases

When esotropia and diplopia is developed by Sixth nerve paralysis treatments including operation are delayed for 6 months; botulinum toxin injection to the medical rectus which is antagonist muscle, lateral rectus resection, medial rectus recession, transposition of the vertical recti to the horizontal plane and Jensen procedure. But there is little possibility of recovery of full rotation in the direction of action of the attacted muscle with classic recess-resect surgery. Transposition of the vertical recti to the horizontal plane has the problem that original actions of the transposed muscles are weakened, and vertical deviation may be introduced. We attampted the surgery with silicone band for the 42 year-old patient who was not improved sixth nerve paralysis for ten months for the purpose of regainning muscle force and reposioning esotropia. Silicone band was passed the medial half of superior and inferior rectus muscles and sutured beneath the lateral rectus muscle. We had the disappearance of diplopia and esotropia and improvement of lateral rectus muscle force from -4 to -2. We could predict that this method was good for sixth nerve paralysis.
Adult ; Botulinum Toxins ; Diplopia ; Esotropia ; Humans ; Muscles ; Paralysis* ; Silicones*

The majority of cardiac myxoma occur sporadically as isolated lesions in the left atrium of middle-aged women. However, a familial form and a syndrome form of this lesion have also been identified. The syndrome myxoma can present itself with pigmented skin lesions and peripheral or endocrine neoplasms. The familial and syndrome forms of cardiac myxomas can usually be distinguished from the sporadic form by their occurrences at younger ages, their unusual locations, the multicentricity of the lesions, and the presence of rare pathological conditions. In addition, a higher rate of recurrent lesions is usually associated with the familial and syndrome forms of this disease. We present a case of complex cardiac myxoma with pigmented skin lesions and breast myxoma and report it with a review of literature.
Breast ; Female ; Heart Atria ; Humans ; Myxoma* ; Nipples* ; Skin

PURPOSE: To evaluate segmentation reliability in diabetic macular edema (DME) estimates between a Cirrus™ HD-OCT image analysis algorithm and an Iowa reference algorithm, which are an automatic segmentation software. METHODS: Thirty eyes from 23 patients diagnosed with DME were included and underwent spectral-domain optical coherence scans (Cirrus™ HD-OCT). Central foveal thickness (CFT) and ganglion cell layer-inner plexiform layer segmentation data were compared with those produced by the Cirrus™ HD-OCT segmentation algorithm and Iowa reference algorithm. Measurement agreement was assessed using intraclass correlation (ICC) and segmentation errors were confirmed by 2 ophthalmologists. RESULTS: The mean CFT in the 1-mm central area determined by the manufacturer-supplied Cirrus software and Iowa reference algorithm was 512.07 ± 182.35 µm and 476.53 ± 32.36 µm, respectively (p < 0.05). The mean paired difference was 35.53 ± 92.46 µm (ICC, 0.929). Segmentation errors were demonstrated in eyes with a CFT less than 400 µm, specifically for 45% of scans obtained by the Cirrus algorithm and 9% from the Iowa algorithm; in eyes with a CFT equal to or higher than 400 µm, the error rates were 95% and 42%, respectively. CONCLUSIONS: CFT measurement in eyes with diabetic macular edema using the Cirrus algorithm and Iowa algorithm showed relatively high degrees of agreement and significant correlation. In eyes with a CFT equal to or higher than 400 µm, the Iowa algorithm showed higher reliability in retinal segmentation than the Cirrus algorithm.
Ganglion Cysts ; Humans ; Iowa ; Macular Edema* ; Retinaldehyde ; Tomography, Optical Coherence

In this study, we investigated the correlation between the expression of EGFR-mRNA in situ hybridization method and the clinical feature of the cataract. The results were as followed. Nineteen out of fourty six cases(41.3%) were showed the expression of EGFRmRNA in lens epithelium. No correlation between the age of the lenses and the expression of EGFR-mRNA could be demonstrated. The expression of EGFR-mRNA in lens epithelium correlated significantly (P<0.01) with the clinical stage of the cataract. No correlation between the diabetes mellitus and the expression of EGFRmRNA could be demonstated. These results suggest that the EGFR-mRNA status in lens epithelium could be important for the development of the cataract.
Cataract* ; Diabetes Mellitus ; Epidermal Growth Factor* ; Epithelium* ; In Situ Hybridization* ; Receptor, Epidermal Growth Factor*

Chronic obstructive pulmonary disease (COPD) was the 3rd leading cause of death in 2012 worldwide. It is particularly severe in the elderly, who are at risk of death by coughing, mucous hypersecretion, and finally breathlessness. Recently, anti-COPD drug development has increased, and many animal screening systems have been studied. Tobacco smoke animal models are the best known animal screening system, but have several preparation requirements, such as a tobacco smoke generator and a separate facility to prevent smoke release. Accordingly, we evaluated the properties of a lipopolysaccharide (LPS) murine model for COPD screening and the effect of the time elapsed from 0 to 72 hr after LPS intranasal instillation on various biomarkers of COPD severity, such as WBC and neutrophils in bronchoalveolar fluid (BALF), IgE in serum, histopathology in the lung, and cytokines (IL-8, TNF-α, IFN-γ, and TGF-β) and chemokines (CCL-2, CXCL1, CXCL9, CXCL10, and CXCL11) in the respiratory system. Although from 48 hr after LPS treatment several factors which could be evaluated as biomarkers for COPD establishment such as WBC and neutrophil in BALF, IgE in serum, cytokines (IL-8, TNF-α, and IFN-γ), and chemokines (CCL-2, CXCL1, CXCL9, CXCL10, and CXCL11) increased at 72 hr the increment of important factors for COPD establishment such as IgE, fibrosis in the lung, and cytokines (IL-8, TNF-α, and IFN-γ) was more clear. Based on our results, we concluded that the optimal time after LPS intranasal instillation is 72 hr.
Aged ; Animals ; Biomarkers ; Cause of Death ; Chemokines ; Cough ; Cytokines ; Dyspnea ; Fibrosis ; Humans ; Immunoglobulin E ; Lung ; Mass Screening ; Mice* ; Models, Animal ; Neutrophils ; Pulmonary Disease, Chronic Obstructive* ; Respiratory System ; Smoke ; Tobacco

PURPOSE: In the past 30 years, the chemotherapeutic approach to advanced colorectal cancer has remained major challenge. Fluorinated pyrimidine has been the main active drugs, and cisplatin was introduced under clinical conditions. Because of the renal and hematologic toxicity of cisplatin, oxaliplatin was developed. The purpose of this study was to assess the clinical response to and the side effects of oxaliplatin chemotherapy. METHODS: From January 1999, 11 patients who received oxaliplatin chemotherapy entered this study. There were 9 males and 2 females, and their ages varied from 40 to 71 years old. The mean ECOG scale was 1. According to TNM staging, 2 was stage 2 at diagnosis, 5 at stage 3, and 4 at stage 4. Totally, we performed 57 cycles of oxaliplatin chemotherapy. Labaratory data and toxicity were assessed for each cycle according to the WHO scale. Ten (10) patients have received follow-up CT since treatment. RESULTS: Grade 1 anemia occurred in 68% of the cycles, grade 2 in 20%, and grade 3 in 12%. Grade 1 thrombocytopenia occurred in 35% of the cycles and grade 2 in 14%. Grade 1 leukopenia and neutropenia occurred in 27% and 25% of the cycles, respectively. Grade 1 stomatitis occurred in 12% of the cycles and grade 2 in 2%. Grade 1 nausea occurred in 44% of the cycles. Grade 1 vomiting occurred in 14% of the cycles and grade 2 in 4%. Grade 1 diarrhea occurred in 10% of the cycles and grade 2 in 4%. Nephrotoxicity was absent, and typical oxaliplatin neurotoxicity was reported as grade 1 in 2% of the cycles. No complete response was observed, and oxaliplatin che motherapy induced one partial remission. CONCLUSION: There was a mild hematologic and alimentary side effect. There were no renal and few neurologic side effects, but the response to oxaliplatin was poor.
Aged ; Anemia ; Cisplatin ; Colorectal Neoplasms* ; Diagnosis ; Diarrhea ; Drug Therapy* ; Female ; Follow-Up Studies ; Humans ; Leukopenia ; Male ; Nausea ; Neoplasm Staging ; Neutropenia ; Stomatitis ; Thrombocytopenia ; Vomiting