Based on a study of 140 caaes of spondyloses with chronic backache, the sites and types of spurs and underlying congenital anomalies were analized. The following results were obtained. The most common sites of spurs were expected to be between L5 & S1 but contrary to the expectation, these were found most commonly between L4 & L5 and between L3 & L4. The reason for the preponderance of the spurs between L4 & L5 and L3 & L4 were not immediately available. All spurs represent claw type except in 4 cases which resemble traction spurs of McNab but without segamental instability. There were 39 cases of congenital anomalies. 28 of them were of tropism. Thus we conclude that the most common congenital anomaly associated with spondylosis is tropism.
Animals ; Back Pain ; Hoof and Claw ; Spine ; Spondylosis ; Traction ; Tropism

Programmed cell death (PCD), or apoptosis, plays an important role in embryonic development, metamorphsis, hormone-dependent atrophy and tumor growth, as a physiological event regulating the cell number or eliminating damaged cells. Currently hybridoma cell production, resulting from the fusion of myeloma cells with antibody producing spleen cells, is widely used in various fields of life science. This technique requires a hypoxanthine guanine phosphoribosyl transferase (HGPRT) deficient mutant myeloma cell line as a fusion partner. When these rnutant cells are treated with aminopterin plus hypoxanthine-thymidine (HAT) after the cell fusion they are selectively and efficiently eliminated so that one could get only fused hybridoma cells. But there hasn't been any report regarding this selective elimination mechanism of HGPRT mutant myeloma cell. By using HGPRT myeloma V653 as a model system this study demonstrated that PCD was induced by aminopterin treatment of this V653 cell. And this PCD was further characterized by cotreatement of cycloheximide, actinomycin-D, and calcium ionophore A23187 together with aminopterin. The apoptotic endonuclease involved in this PCD process was also detected and characterized. When V653 cells were incubated for the various periods of time in the presence of 0.4 uM aminopterin, the viability was continued to decrease until 48 hours of aminopterin treatment and there was no viable cell affer 36 hours of incubation. DNA fragmentation was detectable 3 hours of incubation and peaked between 12 and 18 hours of aminopterin treatment. The induction of cell death and DNA fragmentation of V653 cells by aminopterin were inhibited by protein synthesis inhibitor, cycloheximide, and RNA synthesis inhibitor, actinomycin-D and maximal inhibitory effects on cell death were seen at concentrations of 2 ug/ml and 0.5 uM, respectively. Ca2+ ionophore A23187 promoted aminopterin-induced cell death of V653. When the cells were coincubated with A23187 in the presence of aminopterin, cell viability was remarkably decreased at concentrations of more than 2 uM and DNA fragmentation was increased at concentrations of more than 0.2 uM. A23187 also induced cell death when the cells were treated with A23187 alone. When endogenous endonuclease activities of nuclei isolated from intact healthy cells and aminopterin-treated cells were compared for four different conditions, there were notable increases in the Ca2+/Mg2+ -independent and the Mg2+ -dependent endonuclease activity after incubation with aminopterin for 12 hours. In northern blot analysis, induction of c-myc gene was observed in aminopterin-treated V653 cell reached peak at 2 hours and thern decreased drastically.
Aminopterin* ; Animals ; Apoptosis* ; Atrophy ; Biological Science Disciplines ; Blotting, Northern ; Calcimycin ; Calcium ; Cell Count ; Cell Death ; Cell Fusion ; Cell Line ; Cell Survival ; Cycloheximide ; DNA Fragmentation ; Embryonic Development ; Female ; Genes, myc ; Guanine ; Hybridomas ; Hypoxanthine ; Hypoxanthine Phosphoribosyltransferase ; Mice* ; Pregnancy ; RNA ; Spleen ; Transferases

Familial Renign Chronic Femphigus(FRCP) is rare, persistent and vesicobullous genodermatoai. Three casee of FRCP with typical clinical and histapathological findings are reported. The first case of FBCP was 27-year-oId man who had recurrent episodes of grou vesicles and rust with miId pruritue at the posterior neck, in both axillae and in inguinal area for 10 years. The second case was 49-year-old woman with skin lesions of recurrent persistent. vesicles, pustules on the erythematous skin, crust and lichenification on the flexural area of extrimeties, axillae, ingumal and neck area for 10 yeara. The third case was 49-year-old male patient who had recurrent pruritic grouped vesicles with crust on the neck and axillary area. In all three patients, skin eruptions usually began and or aggravated in the spring or summer and tend to heal spontaneously in the autumn and winter and showed positive Nikolsky sign. The only one case of the reported three casea had familiaI history of skin lesions similar to FRCP. Histopat,holag;ic finding of biopsy specimens from the vesicular eruption showed auprabasal vesiculation with acantholysis, lacunae and villi formation in all 3 cases.
Acantholysis ; Axilla ; Biopsy ; Female ; Humans ; Male ; Middle Aged ; Neck ; Pemphigus, Benign Familial* ; Skin

No abstract available.
Splints

Since Duhamel (1739), numerous experimental studies on the longitudinal growth of growing long bone have been reported. In Hales(1747) experience, growing long bone showed overgrowth after drilling in the tibia of chickens. David(1924) observed the fact that various degrees of shortening disappeared within 15 months after fracture of the femur in children and he concluded that fractures in children should be treated with the caution that the growing long bone has a tendency to increase in length after injury. Bisgard(1936) concluded that shortening from overriding of fragments in fractured extremities of children will frequently, but not invariablly, become partially or totally eliminated by the acceleration of growth which incidentaIly results from the inflammatory process, incited by trauma and fracture repair. Hass(1926) reported that interstitial proliferation of osseous tissue plays no part in the elongation of a growing bone, either in the mature bone or the young osteoid tissue bordering on the epiphyseal cartilage plate, and length growth of bone is entirely dependant on the purposeful multiplication of cartilage cells of the epiphyseal cartilage plate. Ham(1952) reported that the growth of long bone depends upon the interstitial growth of cartilage. This study was initiated to investigate the effects of fractures in the longitudinal bone growth of growing bone. Artificial fractures were made at two different sites in the diaphysis of the tibia in young rabbits. The operation for artificial fracture was performed under general anesthesia with ether. The type of fracture was an incomplete one, leaving a part of the posterior cortex of the tibia, in order to prevent the displacement of fractured fragments. In all of the cases, no cast immobilization was applied. After the fractures, follow up observations were made weekly till the 4th week, and thereafter at two week intervals, with roentgenographic, lethal measurement and histological examination. The results were as follows; 1) Longitudinal bone growth was increased from fracture of the diaphysis of growing long bone. 2) Compared with the control limb, tendency to overgrowth of growing bone was noted from the first week after the operation. 3) In follow up measurements, no growth inhibition was observed till the 10th week after the operation, but, thereafter, a tendency to reduce the proliferation of cartilage cells was noted. 4) In cases of fracture of the mid 1/3, the gorwing activity in the epiphyseal plate was increased more than from proximal 1/3 fractures. 5) The bony growth, accelerated by fractures in diaphysis of growing long bone without displacement was transient, and the prolonged overgrowth was compensated by the reduction of growing activity and premature closure of the epiphysis.
Acceleration ; Anesthesia, General ; Bone Development ; Cartilage ; Chickens ; Child ; Diaphyses ; Epiphyses ; Ether ; Extremities ; Femur ; Follow-Up Studies ; Growth Plate ; Humans ; Immobilization ; Rabbits ; Tibia

An appreciation of the range of normal variation and normal values for the pelvis and hip remains a continuing problem for the orthopedic surgeon in Korea. To help overcome this problem and to provide a comprehensive single source for this information, I have undertaken a study of 1037 unselected Korean subjects (605 normal males and 432 females) who varied in age from newborn to 86 years. The present study is concerned with normal angles and distances of the pelvis and hip, examined roentgenographically for statistical survey from January 1965 to August 1971 at Severance Hospital in Korea. The results of this study are as follows: 1. The value of the C-E angle, distance h, and distance d is increased according to increment of age but the value of the femoral neck shaft angle, acetabular angle, iliac index and interval of symphysis pubis is decreased with age. 2. The acetabular index in all age groups, iliac angle in the 1–3 months group, C-E angle in the 6–10 months group and the adult group over 18, interval of the symphysis pubis in the 4–22 year group, distance h in the 3–6 months group and the 4–8 year group, and distance d in the 1–3 months group show a difference between males and females. 3. There are differences between normal females and pregnant women in the interval of the symphysis pubis. Also the degree of relaxation of joints of the pelvis is higher in primigravida than multigravida. 4. The value for the femoral neck shaft angle is higher in Koreans than Europeans.
Acetabulum ; Adult ; Female ; Femur Neck ; Hip ; Humans ; Infant, Newborn ; Joints ; Korea ; Male ; Orthopedics ; Pelvis ; Pregnant Women ; Pubic Bone ; Reference Values ; Relaxation

The purpose of the present placebo-controlled double-blind study was to investigate the preventive effect of 5mg dexamethasone on swelling, trismus, and pain after removal of impacted mandibular third molars with bone reduction. The participants were consisted of 20 healthy individuals(9 male, 11 female) with bilaterally symmetrical impacted mandibular third molars. Each patient served as his own control. Immediately after removal of impacted teeth, either 5mg dexamethasone or normal saline was injected intramuscularly. On the first day, 2nd day, and 7th day after operation, facial swelling, trismus, and pain were evaluated. On the first day, the difference in the volumetric change of facial swelling was 45% (p<0.05) as measured by Holland's nine pointers facebow. The trismus was reduced by 28% (p<0.01) in test froup. Pain assessed with Visualanaloguescale(VAS) was reduced by 33% (p<0.001) by dexamethasone. It can be concluded that sterokd treatment is recommended in third molar surgery when pronounced postoperative swelling, trismus, and pain are expected.
Dexamethasone* ; Double-Blind Method ; Humans ; Male ; Molar, Third* ; Tooth, Impacted ; Trismus

Darier's disease is a congenital dyskeratosis and is as an autosomal dominant reait but a case with a family history is relatively rare and only 2 such cases have been reported in Korea. We present typical Darier's disease occuring in a mother and her 2 daughters. A 45 year-old female has shown muitiple, confluent, dirty verrucous keratotic papules on the seborrheic area and whitish papules on the sotf palate since the age of 7 year-ole. Histologically there, are corps ronds, grains and suprabssal lacunae in the epidermis.
Edible Grain ; Darier Disease* ; Epidermis ; Female ; Humans ; Korea ; Middle Aged ; Mothers ; Nuclear Family ; Palate

No abstract available.
Denture, Partial, Fixed* ; Finite Element Analysis*

No abstract available.
Adhesives* ; Intestinal Obstruction*