No abstract available.

No abstract available.
Hyperbilirubinemia, Neonatal*

No abstract available.

The serotonin reuptake inhibitors(SRIs) and the serotonin selective reuptake inhibitors(SSRIs) are considered the first choice agents for pharmacologic treatment of obsessive-compulsive disordr(OCD). However, many patients with OCD experience little or no improvement in their symptoms when treated with SRIs or SSRIs. Patients who have experienced a partial or no response to an SRI/SSRI at 10 to 12 weeks are often considered for augmentation strategies. Nearly every class of psychotropic medications has been tried in an open fashion, though augmentation strategies have been somewhat disappointing.
Humans ; Obsessive-Compulsive Disorder* ; Serotonin

No abstract available.
Craniocerebral Trauma* ; Head* ; Mental Disorders*

No abstract available.
Leukocytes*

BACKGROUND: Thyroid Transcription Factor-1(TTF-1) acts as a tissue specific transcription factor in the regulation of lung specific gene expression and as morphogenic protein during lung organogenesis. Currently, there is very little information on the cis-acting sequences and transcription and transcription factors that direct the TTF-1 gene expression. DNAse 1 hypersensitive (DH) sites represent a marker for active or potentially active chromatin and are likely to be especially important in gene regulation, being associated with many DNA sequences that regulate gene expression. It is clear that DH regions correlate with genetic regulatory loci and binding for sequence-specific DNA-binding proteins. METHODS: We have used DH site assays to identify putative distal regulatory elements in H441 lung adenocarcinoma cells, which express the TTF-1 gene and HeLa cells. RESULTS: There are four DH sites 5' of the TTF-1 gene. These sites are located at base pair approximately +150, -450, -800, and -1500 from the start of transcription. CONCLUSION: These data suggest that there may be at least one intragenic site and regulatory region 5' prime to the promotor region.
Adenocarcinoma ; Base Pairing ; Base Sequence ; Chromatin ; Deoxyribonuclease I* ; Deoxyribonucleases* ; DNA-Binding Proteins ; Gene Expression ; HeLa Cells ; Humans ; Lung* ; Organogenesis ; Promoter Regions, Genetic ; Regulatory Sequences, Nucleic Acid ; Thyroid Gland ; Transcription Factors*

Side effects of iohexol myelography are known to largely depend on the leakage amount of cerebrospinal fluid at the puncture site of the dura. To evaluate the relationship between side effect incidence and spinal needle size and to assess the possibility of performing myelography in outpatients, iohexol myelography was performed in 100 patients(58 inpatients and 42 outpatients) using variable sized needles. A questionaire including presence or absence, duration and degree of various side effect was used for evaluation of side effect. The overall side effect included headache (15%), back pain (14%). Dizziness (9%), and nausea(4%), etc. The incidences of side effects were 28.0% in total, and 16.7%, 23.5%, 26.3%, 46.4%, in patients using 25G, 23G, 22G, 21G spinal needles, retrospectively. The difference of side effect incidence was not significant between male and female. In conclusion, the use of fine spinal needles(25-26G) is recommended to decrease the side effect incidences in myelgraphy. Our findings support the use of fine needle myelography as a safe, less side-effect procedure, not only for in patients but also for out patients.
Back Pain ; Cerebrospinal Fluid ; Dizziness ; Female ; Headache ; Humans ; Incidence* ; Inpatients ; Iohexol* ; Male ; Myelography* ; Needles* ; Outpatients ; Punctures ; Retrospective Studies

No abstract available.
Endocrine System Diseases* ; Nuclear Medicine*

No abstract available.
Adenoma*