1.A Proposal for Health Insurance Policy to the New Administration.
Journal of the Korean Medical Association 2003;46(2):84-86
No abstract available.
Insurance, Health*
2.What Makes Geriatric Medicine/Longevity Medicine Different from Conventional Medicine?.
Journal of the Korean Medical Association 2001;44(8):860-865
No abstract available.
3.Ambulatory Blood Pressure Mornitoring.
Korean Circulation Journal 1997;27(11):1218-1218
No abstract available.
Blood Pressure*
4.Estrogen Therapy in Syndrome X.
Korean Circulation Journal 1999;29(3):249-250
No abstract available.
Estrogens*
5.The Relationship between Quality of Life and Comorbid Depression or Anxiety in Patients with Chronic Obstructive Pulmonary Disease.
Korean Journal of Health Promotion 2011;11(4):184-190
BACKGROUND: It is well known that patients with chronic obstructive pulmonary disease (COPD) show symptoms of depression and anxiety more often than patients with other chronic illnesses or the general population. This study was designed to evaluate the effects of depression and anxiety on quality of life in patients with COPD. METHODS: Quality of life was assessed using the Short Form-36 (SF-36) questionnaire and depression and anxiety symptoms were assessed using the Primary Care Evaluation of Mental Disorder Patient Health Questionnaire (PRIME-MD PHQ) in 129 patients with COPD visiting an outpatient clinic. We examined the correlations between the SF-36 scores and clinico-demographic features by Pearson's correlation analysis and the influence of depression and anxiety symptoms on the SF-36 scores by multiple regression analysis. RESULTS: Of the 129 patients, 48.8% were diagnosed as having major depressive syndrome, 18.6% other depressive syndromes, 23.3% panic syndrome, and 30.3% other anxiety syndrome by the PRIME-MD PHQ. The physical component summary was affected the most by depressive symptoms followed by dyspnea (P<0.05). The mental component summary was only affected by depressive symptoms (P<0.05). CONCLUSIONS: The prevalence of depression and anxiety symptoms in COPD patients is markedly increased, and depressive symptoms decrease the quality of life in these patients. Thus, there is a need for physicians to assess for and recognize such symptoms and promptly administer appropriate interventions.
Ambulatory Care Facilities
;
Anxiety
;
Chronic Disease
;
Depression
;
Depressive Disorder
;
Dyspnea
;
Humans
;
Mental Disorders
;
Panic
;
Prevalence
;
Primary Health Care
;
Pulmonary Disease, Chronic Obstructive
;
Quality of Life
;
Surveys and Questionnaires
6.Prospects of Geriatric Research.
Journal of the Korean Geriatrics Society 1998;2(2):1-6
No abstract available.
7.Geriatrics.
Journal of the Korean Medical Association 1997;40(10):1313-1318
No abstract available.
Geriatrics*
8.A study on the expression of type I and type II collagen genes and proteins in the developing human mandible.
Yoon Ah KOOK ; Sang Cheol KIM ; Eun Cheol KIM
Korean Journal of Orthodontics 1995;25(6):723-731
Type I and type II collagens are considered the major collagens of bone and cartilage respectively. Monitoring the patterns of those gene and protein expressions during development will provide a basis for the understanding of the normal and abnormal growths. This study was undertaken to investigate the expression of collagen genes and proteins involved in the developing human mandible. Fifty embryos and fetuses were studied with Alcian blue-PAS, Masson's Trichrome, reverse transcription polymerase chain reaction (RT-PCR), Western blot analysis, and Southern blot analysis. Our results showed that pro-alpha1(II) collagen gene expression begins in the 5th week. Type II collagen is synthesized in mesenchymal cells in advance of overt chondrogenesis. The gene expression for type II collagen was highest during the appearance of Meckel's cartilage. There was a switch in collagen protein expression from type I to type II during the appearance stage of Meckel's cartilage. The distribution of the mRNA for type II collagen corresponded well with the pattern of type II collagen protein. The endochondral ossification was observed where there was direct replacement of cartilage by bone.
Blotting, Southern
;
Blotting, Western
;
Cartilage
;
Chondrogenesis
;
Collagen
;
Collagen Type II*
;
Embryonic Structures
;
Fetus
;
Gene Expression
;
Humans*
;
Mandible*
;
Polymerase Chain Reaction
;
Reverse Transcription
;
RNA, Messenger
9.A study on chondrogenic potential in mandibular and limb bud mesenchymal cells of human embryos : A possible role of protein kinase C.
Yoon Ah KOOK ; Eun Cheol KIM ; Sang Cheol KIM
Korean Journal of Orthodontics 1996;26(6):667-676
We have examined the in vitro stage-related chondrogenic potential of human mandibular and limb bud mesenchyme cells using micromass culture, Our results indicate that limb bud mesenchyme cells as early as stage 16 by Carnegie system (37 days), well before the initiation of in vivo chondrogenesis, have chondrogenic potential which is expressed in micromass culture, These results are correlated with stage-related chondrogenic potential of human limb bud in vivo as a result of Alcian blue staining. The proliferation of chondrogenic cells increased in the first 3 days after culture and then decreased. These results were correlated with the cell cycle analysis of which the number of G degrees/G1 phase increased markedly after 3 days of culture, while the percentage of cells in S phase was decreased, On the other hand, it was rarely differentiated in the mandible. We examined the effects of two PKC modulators such as phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC, and staurosporine (STSN), an inhibitor of PKC. PMA inhibited the chondrogenesis, whereas STSN promoted the chondrogenesis in a dose dependent manner. In addition, PMA exerted no inhibitory effect when the cells were pretreated for 24 h with STSN, implying that the chondrogenic events might be settled at an early step in vitro and PKC may act as a negative modulator, Collectively, these results demonstrate, for the first time, the stage-related chondrogenic potential of human mandibular and limb bud mesenchyme cells and the role of PKC during chondrogenesis in vitro & in vivo.
Alcian Blue
;
Cell Cycle
;
Chondrogenesis
;
Embryonic Structures*
;
Extremities*
;
Hand
;
Humans*
;
Limb Buds*
;
Mandible
;
Mesoderm
;
Protein Kinase C*
;
Protein Kinases*
;
S Phase
;
Staurosporine
10.A study on the Values of Total Serum Cholesterol in Healthy Non-Pregnant and Pregnant Women.
Korean Journal of Preventive Medicine 1990;23(2):167-177
The author investigated the values of total serum cholesterol and its correlation with the physical factors to have potential as a line in the chain of basic investigation to establish maternal health program. The study group was composed of 167 healthy non-pregnant and 209 pregnant women in the age of 20-39 residing in Pusan area. The obtained results were as follows: 1. No significant differences were found in height and systolic and diastolic blood pressure in both groups except for the elevation of Broca's index by gaining the weight in pregnant women. 2. There were significant differences in the total serum cholesterol level of the healthy and pregnant women as 165.9 and 212.6 mg/dl, respectively, not showing the differences in the age. Total serum cholesterol values in both group followed approximately normal distrubution curve. 3. The significant correlation to the values of total serum cholesterol were found between weight and Broca's index in healthy women and between weight, Broca's index and duration of pregnancy in pregnant women. 4. The values of total serum cholesterol in pregnant women showed increasing tendency with the duration of pregnancy as 168.1 in 12 weeks and below, 209.6 mg/dl in 13-26 weeks and 235.4 mg/dl in 27 weeks and above group. Total serum cholesterol values by duration of pregnancy followed normal distribution curve.
Blood Pressure
;
Busan
;
Cholesterol*
;
Female
;
Humans
;
Maternal Health
;
Pregnancy
;
Pregnant Women*