1.Epidermolysis Bullosa Acquisita: A Complete Remissions versus Patients with Long-term Persistent Activities.
Dong Kyu HWANG ; Chang Woo LEE
Korean Journal of Dermatology 1999;37(6):715-718
BACKGROUND: In epidermolysis bullosa acquisita, it has been recognized that there exists heterogeneity in the clinical and serologic/immunopathologic features. OBJECTIVE: We examined patients with epidermolysis bullosa acquisita to see if there were any associated clinical and serological features which may predict disease activity or prognosis in the disease. METHODS: Clinical and some serologic features were compared. between 2 groups of patients with epidermolysis bullosa acquisita; one with complete remission of the symptoms and signs of the disease for more than 2 years and the other group with persistent disease activities of longer than 5 years.
Epidermolysis Bullosa Acquisita*
;
Epidermolysis Bullosa*
;
Humans
;
Population Characteristics
;
Prognosis
3.Pattern of Adenomas after Colorectal Cancer Surgery.
Shin HWANG ; Won Young HWANG ; Chang Sik YOO ; Hee Won CHUNG ; Jin Cheon KIM
Korean Journal of Gastrointestinal Endoscopy 1996;16(2):191-198
Postoperative colonoscopy is an effective tool for management of colonic adenomas. Authors analyzed the pattern of colonic adenomas detected during follow-up colonoscopy after colorectal cancer surgery and evaluated the characteristics of adenornas, risk groups, and effective fo1low-up schedule. Study group were 222 patients and colonoscopy was performed 389 times. Patterns of adenornas were analyzed by variables as age, sex, preoperative serum CEA level, location of primary colorectal cancer, Borrmann type, Duke's stage, histologic differentiation, DNA ploidy, recurrence and histology. Metachronous adenomas were detected in 79 patients(35.6%) and both metachronous and syachronous adenomas were observed in 29 cases(13.1%). High risk variables for adenomas were male, old age and presence of synchronous adenoma. There were 2 patients with maligant change of adenomas. Yearly follow-up by complete colonoscopy over 3 years or more is recommended and follow-up interval should be shortened in the high risk groups.
Adenoma*
;
Appointments and Schedules
;
Colon
;
Colonic Neoplasms
;
Colonoscopy
;
Colorectal Neoplasms*
;
DNA
;
Follow-Up Studies
;
Humans
;
Male
;
Ploidies
;
Recurrence
4.The Morphometric Study on the Vermiform Appendix in Korean Adults.
Kyeong Han PARK ; Uhm Mee RYUNG ; Young Il HWANG ; Douk Ho HWANG ; Ka Young CHANG
Korean Journal of Physical Anthropology 1996;9(1):27-34
The anatomical structure of vermiform appendix was studied for 124 Korean adult cadavers and the articles were reviewed with special reference to its position and length. The results are as follows ; 1. On the frequency of positional types based on Wakeley (1933), postileal type was recorded most frequently (37.7%) and retrocecal type was found in 19.7% of cases, showing the difference from other ethnic groups whose most frequent position was retrocecal or pelvic type. 2. In the direction of appendix in relation to the clock, the direction between 1 and 3 o'clock was most frequently found. 3. Appendix of fixed form was found in 22.1% of cases, that of free form 77.9%. In free form, postileal type was found most frequently, but retrocecal type was met most frequently in fixed form. 4. The length of appendix was 5.95±1.64 cm (male ; 6.14±1.67 cm ; female 5.59±1.51 cm). Neither significant difference between sex nor positional type was noted. 5. Positions of appendix are seemed to be set up during fetal stage. The Ethnic variation in the positions of appendix is thought to be determined by inherited physical anthropological factor, not by postnatal one.
Adult*
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Appendix*
;
Cadaver
;
Ethnic Groups
;
Female
;
Humans
5.The comparison of tocolytic effects between MgSO4 and ritodrine HCI in preterm labor.
Keun Young LEE ; Seung Yong LEE ; Sun Tae HWANG ; Chang Hwang HAN ; Seong Weon KANG
Korean Journal of Obstetrics and Gynecology 1993;36(12):3857-3864
No abstract available.
Female
;
Obstetric Labor, Premature*
;
Pregnancy
;
Ritodrine*
;
Tocolytic Agents*
6.Identification of a Novel Gene by EST Clustering and its Expression in Mouse Ovary and Testis.
Sang Joon HWANG ; Chang Eun PARK ; Kyu Chan HWANG ; Kyung Ah LEE
Korean Journal of Fertility and Sterility 2006;33(4):253-263
OBJECTIVE: Identification of the regulatory mechanism for arrest and initiation of primordial follicular growth is crucial for female fertility. Previously, we found 15 expressed sequence tags (ESTs) that were specifically abundant in the day-5-subtracted cDNA library and that the B357 clone was novel. The present study was conducted to obtain the whole sequence of the novel gene including B357 and to characterize its mRNA and protein expression in mouse ovary and testis. METHODS: The extended sequence of the 2,965-bp cDNA fragment for the clone B357 was named 5-day-ovary-specific gene-1 (5DOS1) and submitted to GenBank (accession number AY751521). Expression of 5DOS1 was characterized in both female and male gonads at various developmental stages by Northern blotting, real-time RT-PCR, in situ hybridization, Western blotting, and immunohistochemistry. RESULTS: The 5DOS1 transcript was highly expressed in the adult testis, brain, and muscle as compared to the other tissues. In the ovary, the 5DOS1 transcript was detected in all oocytes from primordial to antral follicles, and highly expressed at day 5 after birth and decreased thereafter. In contrast, expression of 5DOS1 showed a gradual increase during testicular development and its expression was limited to various stages of male germ cells except spermatogonia. CONCLUSIONS: This is the first report on the expression and characterization of the 5DOS1 gene in the mouse gonads. Further functional analysis of the 5DOS1 protein will be required to predict its role in gametogenesis.
Adult
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Animals
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Blotting, Northern
;
Blotting, Western
;
Brain
;
Clone Cells
;
Cluster Analysis*
;
Databases, Nucleic Acid
;
DNA, Complementary
;
Expressed Sequence Tags
;
Female
;
Fertility
;
Gametogenesis
;
Gene Library
;
Germ Cells
;
Gonads
;
Humans
;
Immunohistochemistry
;
In Situ Hybridization
;
Male
;
Mice*
;
Oocytes
;
Ovary*
;
Parturition
;
RNA, Messenger
;
Spermatogonia
;
Testis*
7.A human embryo of two pairs of somites..
Young Il HWANG ; Seung Cheol KIM ; Ka Young CHANG
Korean Journal of Physical Anthropology 1992;5(1):27-36
No abstract available.
Embryonic Structures*
;
Humans*
;
Somites*
8.Paroxysmal Supraventricular Tachycardia in Infants and Children: Clinical Study of 36 Cases.
Yong Seung HWANG ; Yong Soo YOON ; Chang Yee HONG
Korean Circulation Journal 1982;12(2):83-90
Thirty-six cases of paroxysmal supraventricular tachycardia which were observed at the Department of Pediatrics, Seoul National University Hospital from 1976 till October 1982, were analyzed. 1. The sex ratio was 1.8:1, male predominance. Sixteen cases (44.4%) were under 1 year of age and 11 cases (30.6%) were under 4 months of age. 2. Cases without known heart disease were 22(61.6%). Among Known etiology, most frequent one was 7 cases(19.4%) of W-P-W syndrome. 3. The sex ratio of group without known heart disease was 2.1:1, and that of group with known heart disease was 1.3:1. Under 4 months of age, there were more cases without known heart disease(72.7%) and after 4 months of age number of cases with and without known heart disease were similar. 4. Most frequent clinical manifestation was tachydyspnea. hepatomegly, irritability, palipitation, cyanosis and pallor, vomiting, chest pain, edema, abdominal pain, and fever were followed in order of frequency. 5. Congestive heart failure occurred in 22 cases(61%). The incidence was related to the duration of attack of tachycardia, age of patients, and heart rate. The longer the duration of attack and the younger the age of patients and the faster the heart rate, the higher incidence of heart failure was observed. 6. As treatment, vagal reflex stimulation was almost ineffective, and digitalization was effective in most of the cases. Verapamil and electrical cardioversion were tried in small number of cases and proved to be effective. 7. One case (2.8%) expired becase of the supraventricular tachycardia. 8. Eight cases (30.8%) had recurrence. In younger age group, recurrence rate was lower. 9. Digoxin was given in 15 cases for prevention of recurrence and was effective in 12 cases.
Abdominal Pain
;
Chest Pain
;
Child*
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Cyanosis
;
Digoxin
;
Edema
;
Electric Countershock
;
Fever
;
Heart
;
Heart Diseases
;
Heart Failure
;
Heart Rate
;
Humans
;
Incidence
;
Infant*
;
Male
;
Pallor
;
Pediatrics
;
Recurrence
;
Reflex
;
Seoul
;
Sex Ratio
;
Tachycardia
;
Tachycardia, Supraventricular*
;
Verapamil
;
Vomiting
9.Nodular Lesions Seen on CTAP Not on Conventional CT in Known Hepatocellular Carcinoma(HCC) Patients: Positive Predictive Value for HCC or Precusor of HCC.
Yong Woo LEE ; Jae Chun CHANG ; Mi Soo HWANG
Journal of the Korean Radiological Society 1995;32(1):137-143
PURPOSE: To evaluate intrahepatic nodular lesions detected on CTAP but not on conventional contrast CT in regard to its relationship with satellite nodules or borderline malignancies. MATERIALS AND METHODS: From June 1991 to March 1994, CTAP was undertaken in 132 cases with confirmed hepatocellular carcinoma(HCC), of which 35 cases having 82 lesions were suitable for analysis(excluding the cases which had no follow-up studies, showed segmental abnormal portal perfusion, no additional lesions and, or inumerable lesions). The CTAP findings were compared with those on artery dominant imaging studies (angiography, DSA, bolus dynamic CT, arterial CT, Lipiodol CT) taken during the same period(to confirm the presence of lesions) and the findings on follow-up imaging studies(to assess the developemerit of malignancy). RESULTS: Arterial vascularity was identified in 35 of 82 lesions(42.7%) on arterial dominant imaging studies. Developement into malignancy was identified on follow-up imaging studies in 25 of remained 47 lesions(53.2%). CONCLUSION: The total positive predictive value of nodules on CTAP was 73.2%(35+25/82), but the predictive value for HCC by follow-up only was 53.2%. Given'the difficulties in detecting intranodular arterial flow and the short follow-up duration in many patients, the actual positive value might be higher.
Arteries
;
Ethiodized Oil
;
Follow-Up Studies
;
Humans
;
Perfusion
10.Nodular Lesions Seen on CTAP Not on Conventional CT in Known Hepatocellular Carcinoma(HCC) Patients: Positive Predictive Value for HCC or Precusor of HCC.
Yong Woo LEE ; Jae Chun CHANG ; Mi Soo HWANG
Journal of the Korean Radiological Society 1995;32(1):137-143
PURPOSE: To evaluate intrahepatic nodular lesions detected on CTAP but not on conventional contrast CT in regard to its relationship with satellite nodules or borderline malignancies. MATERIALS AND METHODS: From June 1991 to March 1994, CTAP was undertaken in 132 cases with confirmed hepatocellular carcinoma(HCC), of which 35 cases having 82 lesions were suitable for analysis(excluding the cases which had no follow-up studies, showed segmental abnormal portal perfusion, no additional lesions and, or inumerable lesions). The CTAP findings were compared with those on artery dominant imaging studies (angiography, DSA, bolus dynamic CT, arterial CT, Lipiodol CT) taken during the same period(to confirm the presence of lesions) and the findings on follow-up imaging studies(to assess the developemerit of malignancy). RESULTS: Arterial vascularity was identified in 35 of 82 lesions(42.7%) on arterial dominant imaging studies. Developement into malignancy was identified on follow-up imaging studies in 25 of remained 47 lesions(53.2%). CONCLUSION: The total positive predictive value of nodules on CTAP was 73.2%(35+25/82), but the predictive value for HCC by follow-up only was 53.2%. Given'the difficulties in detecting intranodular arterial flow and the short follow-up duration in many patients, the actual positive value might be higher.
Arteries
;
Ethiodized Oil
;
Follow-Up Studies
;
Humans
;
Perfusion